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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
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Research Paper

Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators

Mohammed Farrag El-Behairya Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Menoufiya, EgyptORCID Iconhttps://orcid.org/0000-0001-7843-1423View further author information
ORCID Icon,
Walaa Hamada Abd-Allahb Pharmaceutical Chemistry Department, Collage of Pharmaceutical Science and Drug Manufacturing, Misr University for Science and Technology, Giza, EgyptView further author information
,
Mohamed M. Khalifac Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0002-8146-993XView further author information
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Mohamed S. Nafied Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, EgyptORCID Iconhttps://orcid.org/0000-0003-4454-6390View further author information
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Mohamed A. Salehe Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, The United Arab Emirates;f Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, EgyptView further author information
,
Mohammed S. Abdel-Maksoudg Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (ID: 60014618), Giza, EgyptView further author information
,
Tarfah Al-Warhih Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaView further author information
,
Wagdy M. Eldehnai Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, EgyptORCID Iconhttps://orcid.org/0000-0001-6996-4017View further author information
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Ahmed A. Al‐Karmalawyj Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8173-6073View further author information
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Article: 2157825 | Received 24 Sep 2022, Accepted 07 Dec 2022, Published online: 11 Jan 2023

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Ahmed A Gaber, Marwa Sharaky, Ayman Abo Elmaaty, Mohamed M Hammouda, Ahmed AE Mourad, Samy Y Elkhawaga, Mahmoud Mohamed Mokhtar, Amr S Abouzied, Mai AE Mourad & Ahmed A Al-Karmalawy. (2023) Design and Synthesis of Novel Pyrazolopyrimidine Candidates As Promising EGFR-T790M Inhibitors and Apoptosis Inducers. Future Medicinal Chemistry 15:19, pages 1773-1790.
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Ahmed A. Al-Karmalawy, Mahmoud Rashed, Marwa Sharaky, Hamada S. Abulkhair, Mohamed M. Hammouda, Haytham O. Tawfik & Moataz A. Shaldam. (2023) Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments. European Journal of Medicinal Chemistry 259, pages 115661.
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