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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
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Research Paper

New benzothiazole hybrids as potential VEGFR-2 inhibitors: design, synthesis, anticancer evaluation, and in silico study

Mohammad M. Al-Saneaa Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaCorrespondence[email protected]
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Abdelrahman Hamdib Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, EgyptView further author information
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Ahmed A. B. Mohamedc Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, EgyptCorrespondence[email protected]
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Hamed W. El-Shafeyb Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, EgyptView further author information
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Mahmoud Moustafad Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, EgyptView further author information
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Abdullah A. Elgazare Department of Pharmacognosy, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, EgyptView further author information
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Wagdy M. Eldehnaf Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, EgyptORCID Iconhttps://orcid.org/0000-0001-6996-4017View further author information
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Hidayat Ur Rahmang Department of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaView further author information
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Della G. T. Parambia Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0002-3954-4879View further author information
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Rehab M. Elbargisyh Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaView further author information
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Samy Selimi Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi ArabiaView further author information
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Syed Nasir Abbas Bukharia Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaView further author information
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Omnia Magdy Hendawyj Department of Pharmacology, College of Pharmacy, Jouf University, Aljouf, Saudi ArabiaView further author information
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Samar S. Tawfikb Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, EgyptView further author information
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Article: 2166036 | Received 27 Sep 2022, Accepted 03 Jan 2023, Published online: 24 Jan 2023

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S. Gupta, M. Kashyap, Y. Bansal & G. Bansal. (2024) In silico insights into design of novel VEGFR-2 inhibitors: SMILES-based QSAR modelling, and docking studies on substituted benzo-fused heteronuclear derivatives. SAR and QSAR in Environmental Research 35:4, pages 265-284.
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Mai H. ElNaggar, Abdullah A. Elgazar, Ghada Gamal, Shimaa M. Hamed, Zainab M. Elsayed, Mohamed K. El-Ashrey, Amira Abood, Mahmoud A. El Hassab, Ahmed M. Soliman, Ramadan A. El-Domany, Farid A. Badria, Claudiu T. Supuran & Wagdy M. Eldehna. (2023) Identification of sulphonamide-tethered N-((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Abdelrahman Hamdi, Muhammad Yaseen, Wafaa A. Ewes, Mashooq Ahmad Bhat, Noha I. Ziedan, Hamed W. El-Shafey, Ahmed A. B. Mohamed, Mohamed R. Elnagar, Abdullah Haikal, Dina I. A. Othman, Abdullah A. Elgazar, Ahmed H. A. Abusabaa, Kamal S. Abdelrahman, Osama M. Soltan & Mostafa M. Elbadawi. (2023) Development of new thiazolidine-2,4-dione hybrids as aldose reductase inhibitors endowed with antihyperglycaemic activity: design, synthesis, biological investigations, and in silico insights. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Moataz A. Shaldam, Hadia Almahli, Andrea Angeli, Rehab Mustafa Badi, Eman F. Khaleel, Abdelrahman I. Zain-Alabdeen, Zainab M. Elsayed, Eslam B. Elkaeed, Rofaida Salem, Claudiu T. Supuran, Wagdy M. Eldehna & Haytham O. Tawfik. (2023) Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Sumeer Ahmed, Ajmal R. Bhat, Aziz Kalilur Rahiman, Rajendra S. Dongre, Aso Hameed Hasan, Vidya Niranjan, Lavanya C, S. A. Sheikh, Joazaizulfazli Jamalis, Malika Berredjem & Sarkar M. A. Kawsar. (2023) Green synthesis, antibacterial and antifungal evaluation of new thiazolidine-2,4-dione derivatives: molecular dynamic simulation, POM study and identification of antitumor pharmacophore sites. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-17.
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Marwa I. Serag, Samar S. Tawfik, Sahar M. I. Badr & Hassan M. Eisa. (2024) New oxadiazole and pyrazoline derivatives as anti-proliferative agents targeting EGFR-TK: design, synthesis, biological evaluation and molecular docking study. Scientific Reports 14:1.
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Abdullah A. Elgazar, Ramadan A. El-Domany, Wagdy M. Eldehna & Farid A. Badria. (2023) 3-Acetyl-11-keto-β-boswellic Acid-Based Hybrids Alleviate Acetaminophen-Induced Hepatotoxicity in HepG2 by the Regulation of Inflammatory and Oxidative Stress Pathways: An Integrated Approach. ACS Omega 8:42, pages 39490-39510.
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