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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
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RESEARCH PAPER

Design and biological evaluation of 3-substituted quinazoline-2,4(1H,3H)-dione derivatives as dual c-Met/VEGFR-2-TK inhibitors

Abdelfattah Hassana Department of Medicinal Chemistry, Faculty of Pharmacy, South Valley University, Qena, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8539-662XView further author information
ORCID Icon,
Fawzy A. F. Mubarakb Department of Chemistry, Faculty of Science, South Valley University, Qena, EgyptView further author information
,
Ihsan A. Shehadic Department of Chemistry, College of Sciences, Pure and Applied Chemistry Research Group, University of Sharjah, Sharjah, United Arab EmiratesView further author information
,
Ahmed M. Mosallamb Department of Chemistry, Faculty of Science, South Valley University, Qena, EgyptView further author information
,
Hussain Temairkb Department of Chemistry, Faculty of Science, South Valley University, Qena, EgyptView further author information
,
Mohamed Badrd Department of Biochemistry, Faculty of Pharmacy, Menoufia University, Menoufia, EgyptORCID Iconhttps://orcid.org/0000-0003-3596-1664View further author information
ORCID Icon &
Aboubakr H. Abdelmonsefb Department of Chemistry, Faculty of Science, South Valley University, Qena, EgyptCorrespondence[email protected]
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Article: 2189578 | Received 06 Nov 2022, Accepted 06 Mar 2023, Published online: 15 Mar 2023

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Hesham Haffez, Nosaiba A. Elsayed, Marwa F. Ahmed, Samar S. Fatahala, Eman F. Khaleel, Rehab Mustafa Badi, Eslam B. Elkaeed, Mahmoud A. El Hassab, Sherif F. Hammad, Wagdy M. Eldehna, Nicolas Masurier & Radwan El-Haggar. (2023) Novel N-Arylmethyl-aniline/chalcone hybrids as potential VEGFR inhibitors: synthesis, biological evaluations, and molecular dynamic simulations. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Articles from other publishers (6)

Wen HouXin‐Liang XuLe‐Jun HuangZhen‐Yu ZhangZhi‐Nuo ZhouJin‐Yang WangXi OuyangSu‐Ya XinZi‐Yun ZhangYi XiongHao HuangJin‐Xia Lan. (2024) Bioactivities and Action Mechanisms of Ellipticine Derivatives Reported Prior to 2023. Chemistry & Biodiversity.
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Heba T. Abdel-Mohsen, Manal M. Anwar, Nesreen S. Ahmed, Somaia S. Abd El-Karim & Sameh H. Abdelwahed. (2024) Recent Advances in Structural Optimization of Quinazoline-Based Protein Kinase Inhibitors for Cancer Therapy (2021–Present). Molecules 29:4, pages 875.
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Refaie M. Kassab, Magdi E. A. Zaki, Sami A. Al-Hussain, Aboubakr H. Abdelmonsef & Zeinab A. Muhammad. (2024) Two Novel Regioisomeric Series of Bis-pyrazolines: Synthesis, In Silico Study, DFT Calculations, and Comparative Antibacterial Potency Profile against Drug-Resistant Bacteria; MSSA, MRSA, and VRSA . ACS Omega.
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Wen Hou, Le-Jun Huang, Hao Huang, Sheng-Lan Liu, Wei Dai, Zeng-Min Li, Zhen-Yu Zhang, Su-Ya Xin, Jin-Yang Wang, Zi-Yun Zhang, Xi Ouyang & Jin-Xia Lan. (2023) Bioactivities and Mechanisms of Action of Diphyllin and Its Derivatives: A Comprehensive Systematic Review. Molecules 28:23, pages 7874.
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Abdelfattah Hassan, Ahmed M. Mosallam, Amal O. A. Ibrahim, Mohamed Badr & Aboubakr H. Abdelmonsef. (2023) Novel 3-phenylquinazolin-2,4(1H,3H)-diones as dual VEGFR-2/c-Met-TK inhibitors: design, synthesis, and biological evaluation. Scientific Reports 13:1.
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Wen Hou, Wei Dai, Hao Huang, Sheng-Lan Liu, Jun Liu, Le-Jun Huang, Xian-Hua Huang, Jun-Lin Zeng, Zhi-Wei Gan, Zhen-Yu Zhang & Jin-Xia Lan. (2023) Pharmacological activity and mechanism of pyrazines. European Journal of Medicinal Chemistry 258, pages 115544.
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