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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
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Research Paper

Triple targeting of mutant EGFRL858R/T790M, COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti-inflammatory and anticancer evaluation

Hend Kothayera Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, EgyptCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-2954-0751View further author information
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Samar Rezqb Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt;c Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA;d Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, MS, USA;e Women’s Health Research Center, University of Mississippi Medical Center, Jackson, MS, USA;f Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, MS, USAORCID Iconhttps://orcid.org/0000-0003-4421-0686View further author information
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Ahmed S. Abdelkhaleka Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, EgyptORCID Iconhttps://orcid.org/0000-0003-2198-0549View further author information
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Damian G. Romeroc Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA;d Mississippi Center of Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, MS, USA;e Women’s Health Research Center, University of Mississippi Medical Center, Jackson, MS, USA;f Cardiovascular-Renal Research Center, University of Mississippi Medical Center, Jackson, MS, USAORCID Iconhttps://orcid.org/0000-0002-7268-9690View further author information
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Samar S. Elbaramawia Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, EgyptORCID Iconhttps://orcid.org/0000-0001-8658-1296View further author information
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Article: 2199166 | Received 29 Dec 2022, Accepted 30 Mar 2023, Published online: 11 Apr 2023

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Mahmoud G. Abo Al-Hamd, Haytham O. Tawfik, Omeima Abdullah, Koki Yamaguchi, Masaharu Sugiura, Ahmed B. M. Mehany, Mervat H. El-Hamamsy & Tarek F. El-Moselhy. (2023) Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R). Journal of Enzyme Inhibition and Medicinal Chemistry 38:1.
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Articles from other publishers (7)

Ahmed S. Abdelkhalek, Hend Kothayer, Mostafa K. Soltan, Samy M. Ibrahim & Samar S. Elbaramawi. (2024) Novel 2‐[thio]acetamide linked quinazoline/1,2,4‐triazole/chalcone hybrids: Design, synthesis, and anticancer activity as EGFR inhibitors and apoptotic inducers. Archiv der Pharmazie.
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Abdul-Saleem Amoah, Nikolay B. Pestov, Tatyana V. Korneenko, Igor A. Prokhorenko, Georgy F. Kurakin & Nickolai A. Barlev. (2024) Lipoxygenases at the Intersection of Infection and Carcinogenesis. International Journal of Molecular Sciences 25:7, pages 3961.
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Mohamed E. Hegazy, Ehab S. Taher, Adel H. Ghiaty & Ashraf H. Bayoumi. (2024) Tailored quinoline hybrids as promising COX-2/15-LOX dual inhibitors endowed with diverse safety profile: Design, synthesis, SAR, and histopathological study. Bioorganic Chemistry 145, pages 107244.
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Xueqi Liu, Junli Zhang, Wenwu Sun, Jianping Cao & Zhuang Ma. (2024) COX‐2 in lung cancer: Mechanisms, development, and targeted therapies. Chronic Diseases and Translational Medicine.
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Yang Song, Zhichun Wang, Hang Ji, Zhongyou Jiang, Xiujuan Li, Zhongyao Du, Song Wei & Yang Sun. (2024) Fatty acid modification of casein bioactive peptides nano-assemblies, synthesis, characterization and anticarcinogenic effect. International Journal of Biological Macromolecules 254, pages 127718.
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Ahmed S. Abdelkhalek, Hend Kothayer, Samar Rezq, Khaled Y. Orabi, Damian G. Romero & Osama I. El-Sabbagh. (2023) Synthesis of new multitarget-directed ligands containing thienopyrimidine nucleus for inhibition of 15-lipoxygenase, cyclooxygenases, and pro-inflammatory cytokines. European Journal of Medicinal Chemistry 256, pages 115443.
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Aleksandra Redzicka, Benita Wiatrak, Izabela Jęśkowiak-Kossakowska, Andrzej Kochel, Remigiusz Płaczek & Żaneta Czyżnikowska. (2023) Design, Synthesis, Biological Evaluation, and Molecular Docking Study of 4,6-Dimethyl-5-aryl/alkyl-2-[2-hydroxy-3-(4-substituted-1-piperazinyl)propyl]pyrrolo[3,4-c]pyrrole-1,3(2H,5H)-diones as Anti-Inflammatory Agents with Dual Inhibition of COX and LOX. Pharmaceuticals 16:6, pages 804.
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