Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 38, 2023 - Issue 1
Submit an article Journal homepage
994
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers

Samar El-Kalyoubia Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, EgyptView further author information
,
Mohamed M. Khalifab Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, EgyptView further author information
,
Mahmoud T. Abo-Elfadlc Biochemistry Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt;d Cancer Biology and Genetics Laboratory, Centre of Excellence for Advanced Sciences, National Research Centre, Cairo, EgyptView further author information
,
Ahmed A. El-Sayede Photochemistry Department, Chemical Industries Research Institute, National Research Centre, Giza, EgyptView further author information
,
Ahmed Elkamhawyf College of Pharmacy, BK21 FOUR Team and Integrated Research Institute for Drug Development, Dongguk University—Seoul, Goyang, Republic of Korea;g Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, EgyptCorrespondence[email protected]
View further author information
,
Kyeong Leef College of Pharmacy, BK21 FOUR Team and Integrated Research Institute for Drug Development, Dongguk University—Seoul, Goyang, Republic of KoreaView further author information
&
Ahmed A. Al-Karmalawyh Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, EgyptORCID Iconhttps://orcid.org/0000-0002-8173-6073View further author information
ORCID Icon show all
Article: 2242714 | Received 24 May 2023, Accepted 26 Jul 2023, Published online: 18 Aug 2023

Citations (7)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Ahmed A Gaber, Marwa Sharaky, Ayman Abo Elmaaty, Mohamed M Hammouda, Ahmed AE Mourad, Samy Y Elkhawaga, Mahmoud Mohamed Mokhtar, Amr S Abouzied, Mai AE Mourad & Ahmed A Al-Karmalawy. (2023) Design and Synthesis of Novel Pyrazolopyrimidine Candidates As Promising EGFR-T790M Inhibitors and Apoptosis Inducers. Future Medicinal Chemistry 15:19, pages 1773-1790.
Read now

Articles from other publishers (6)

Norhan M. Eid, Ahmed A. Al‐Karmalawy, Taha M. A. Eldebss & Heba K. A. Elhakim. (2024) Investigating the Promising Anticancer Activity of Cetuximab and Fenbendazole Combination as Dual CBS and VEGFR‐2 Inhibitors and Endowed with Apoptotic Potential. Chemistry & Biodiversity 21:4.
Crossref
Norhan A. Abdelrahman, Ahmed A. Al-Karmalawy, Maiy Y. Jaballah, Galal Yahya, Marwa Sharaky & Khaled A. M. Abouzid. (2024) Design and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy. RSC Medicinal Chemistry 15:3, pages 981-997.
Crossref
Ulviye Acar Çevik, Betül Kaya, Ismail Celik, Mithun Rudrapal, Gourav Rakshit, Arzu Karayel, Serkan Levent, Derya Osmaniye, Begüm Nurpelin Sağlık Özkan, Merve Baysal, Özlem Atlı Ekliog̈lu, Yusuf Özkay & Zafer Asım Kaplancıklı. (2024) New Benzimidazole-Triazole Derivatives as Topoisomerase I Inhibitors: Design, Synthesis, Anticancer Screening, and Molecular Modeling Studies. ACS Omega.
Crossref
Faten Farouk, Ibrahim M. Ibrahim, Salma Sherif, Heba Gamal Abdelhamed, Marwa Sharaky & Ahmed A. Al‐Karmalawy. (2024) Investigating the effect of polymerase inhibitors on cellular proliferation: Computational studies, cytotoxicity, CDK1 inhibitory potential, and LC‐MS / MS cancer cell entrapment assays . Chemical Biology & Drug Design 103:3.
Crossref
Ahmed A. Al-Karmalawy, Mai H. A. Mousa, Marwa Sharaky, Mai A. E. Mourad, Ahmed M. El-Dessouki, Amir O. Hamouda, Radwan Alnajjar, Abdelmoneim A. Ayed, Moataz A. Shaldam & Haytham O. Tawfik. (2023) Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments. Journal of Medicinal Chemistry 67:1, pages 492-512.
Crossref
Eslam M. Abbass, Ahmed A. Al-Karmalawy, Marwa Sharaky, Muhammad Khattab, Abdullah Yahya Abdullah Alzahrani & Aya I. Hassaballah. (2024) Rational design and eco-friendly one-pot multicomponent synthesis of novel ethylidenehydrazineylthiazol-4(5H)-ones as potential apoptotic inducers targeting wild and mutant EGFR-TK in triple negative breast cancer. Bioorganic Chemistry 142, pages 106936.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.