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Review Article

Protection for medication-induced hearing loss: the state of the science

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Pages S87-S95 | Received 16 Mar 2017, Accepted 08 Mar 2018, Published online: 24 Apr 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Judith S Kempfle & David H. Jung. (2023) Experimental drugs for the prevention or treatment of sensorineural hearing loss. Expert Opinion on Investigational Drugs 32:7, pages 643-654.
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Kathleen C. M. Campbell, Nicole Cosenza, Robert Meech, Michael Buhnerkempe, Jun Qin, Leonard Rybak & Daniel J. Fox. (2023) D-methionine administered as late as 36 hours post-noise exposure rescues from permanent threshold shift and dose-dependently increases serum antioxidant levels. International Journal of Audiology 62:2, pages 151-158.
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Kathleen C. Campbell, Alnawez Rehemtulla, Prasad Sunkara, Daniel Hamstra, Michael Buhnerkempe & Brian Ross. (2022) Oral D-methionine protects against cisplatin-induced hearing loss in humans: phase 2 randomized clinical trial in India. International Journal of Audiology 61:8, pages 621-631.
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Articles from other publishers (25)

Winston J. T. Tan & Srdjan M. Vlajkovic. (2023) Molecular Characteristics of Cisplatin-Induced Ototoxicity and Therapeutic Interventions. International Journal of Molecular Sciences 24:22, pages 16545.
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Winston J.T. Tan & Lei Song. (2023) Role of mitochondrial dysfunction and oxidative stress in sensorineural hearing loss. Hearing Research 434, pages 108783.
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Cheng-Yu Hsieh, Jia-Ni Lin, Ting-Ya Kang, Yu-Hsuan Wen, Szu-Hui Yu, Chen-Chi Wu & Hung-Pin Wu. (2023) Otoprotective Effects of Fucoidan Reduce Cisplatin-Induced Ototoxicity in Mouse Cochlear UB/OC-2 Cells. International Journal of Molecular Sciences 24:4, pages 3561.
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Yu-Bei Dai, Xiang Gao, Dong Liu & Jie Gong. (2023) The role of Rho GTPase family in cochlear hair cells and hearing. Neural Regeneration Research 18:10, pages 2167.
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Alejandro Barrallo-Gimeno & Jordi Llorens. (2022) Hair cell toxicology: With the help of a little fish. Frontiers in Cell and Developmental Biology 10.
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Michael Lewkowicz, Melissa Jones, Bozica Kovacevic, Corina Mihaela Ionescu, Susbin Raj Wagle, Thomas Foster, Momir Mikov, Armin Mooranian & Hani Al-Salami. (2022) Potentials and limitations of pharmaceutical and pharmacological applications of bile acids in hearing loss treatment. Therapeutic Delivery 13:10, pages 477-488.
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Colleen G. Le Prell. (2022) Prevention of Noise-Induced Hearing Loss Using Investigational Medicines for the Inner Ear: Previous Trial Outcomes Should Inform Future Trial Design. Antioxidants & Redox Signaling 36:16-18, pages 1171-1202.
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Peter F. Kador & Richard Salvi. (2022) Multifunctional Redox Modulators Protect Auditory, Visual, and Cognitive Function. Antioxidants & Redox Signaling 36:16-18, pages 1136-1157.
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Jacqueline M. Ogier, Yujing Gao, Eileen M. Dunne, Michael A. Wilson, Sarath C. Ranganathan, Gregory H. Tesch, David J. Nikolic Paterson, Alain Dabdoub, Rachel A. Burt, Bryony A. Nayagam & Paul J. Lockhart. (2022) ASK1 is a novel molecular target for preventing aminoglycoside-induced hair cell death. Journal of Molecular Medicine 100:5, pages 797-813.
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Hande KÜSEN, Faik ÖZDENGÜL, Z Işık SOLAK GÖRMÜŞ & Aysu ŞEN. (2022) Physiopathological effects of noise: Recent approaches to the treatment of hearing loss. Journal of Surgery and Medicine 6:4, pages 1-1.
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Jonathan Kil, E. Emily Harruff & Ryan J. Longenecker. (2022) Development of ebselen for the treatment of sensorineural hearing loss and tinnitus. Hearing Research 413, pages 108209.
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Colleen G. Le Prell. (2022) Investigational Medicinal Products for the Inner Ear: Review of Clinical Trial Characteristics in ClinicalTrials.gov. Journal of the American Academy of Audiology 32:10, pages 670-694.
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Christine Little, Jennifer Kelly & Maura K. Cosetti. (2021) Progressive and Degenerative Peripheral Vestibular Disorders. Otolaryngologic Clinics of North America 54:5, pages 959-971.
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Ryan J. Longenecker, Rende Gu, Jennifer Homan & Jonathan Kil. (2021) Development of Tinnitus and Hyperacusis in a Mouse Model of Tobramycin Cochleotoxicity. Frontiers in Molecular Neuroscience 14.
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Chih-Hao Chen, Chii-Yuan Huang, Heng-Yu Haley Lin, Mao-Che Wang, Chun-Yu Chang & Yen-Fu Cheng. (2021) Association of Sodium Thiosulfate With Risk of Ototoxic Effects From Platinum-Based Chemotherapy. JAMA Network Open 4:8, pages e2118895.
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Christine LittleMaura K. Cosetti. (2021) A Narrative Review of Pharmacologic Treatments for COVID ‐19: Safety Considerations and Ototoxicity . The Laryngoscope 131:7, pages 1626-1632.
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Rende Gu, Ryan J Longenecker, Jennifer Homan & Jonathan Kil. (2021) Ebselen attenuates tobramycin-induced ototoxicity in mice. Journal of Cystic Fibrosis 20:2, pages 271-277.
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Colleen G Le Prell, Troy A Hackett & Ramnarayan Ramachandran. (2020) Noise-induced hearing loss and its prevention: current issues in mammalian hearing. Current Opinion in Physiology 18, pages 32-36.
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Ryan J. Longenecker, Rende Gu, Jennifer Homan & Jonathan Kil. (2020) A Novel Mouse Model of Aminoglycoside-Induced Hyperacusis and Tinnitus. Frontiers in Neuroscience 14.
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Hyeon Jin Ju, Mina Park, Ji Hoon Park, Gi Ru Shin, Hak Soo Choi, Myung-Whan Suh & Moon Suk Kim. (2020) In Vivo Imaging of Click-Crosslinked Hydrogel Depots Following Intratympanic Injection. Materials 13:14, pages 3070.
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Sylvie Favrelière, Paul Delaunay, Jean‐Pascal Lebreton, Franck Rouby, Martine Atzenhoffer, Claire Lafay‐Chebassier & Marie Christine Pérault‐Pochat. (2020) Drug‐induced hearing loss: a case/non‐case study in the French pharmacovigilance database. Fundamental & Clinical Pharmacology 34:3, pages 397-407.
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Chaitanya Mamillapalli, Asmita Dhukhwa, Sandeep Sheth, Debashree Mukherjea, Leonard P. Rybak & Vickram Ramkumar. 2020. New Therapies to Prevent or Cure Auditory Disorders. New Therapies to Prevent or Cure Auditory Disorders 51 87 .
Gaëlle Naert, Marie-Pierre Pasdelou & Colleen G. Le Prell. (2019) Use of the guinea pig in studies on the development and prevention of acquired sensorineural hearing loss, with an emphasis on noise. The Journal of the Acoustical Society of America 146:5, pages 3743-3769.
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Quintin A. Hecht, Tanisha L. Hammill, Paul T. Calamia, Christopher J. Smalt & Douglas S. Brungart. (2019) Characterization of acute hearing changes in United States military populations. The Journal of the Acoustical Society of America 146:5, pages 3839-3848.
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Christopher Spankovich & Colleen G. Le Prell. (2019) The role of diet in vulnerability to noise-induced cochlear injury and hearing loss. The Journal of the Acoustical Society of America 146:5, pages 4033-4043.
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