6,260
Views
28
CrossRef citations to date
0
Altmetric
Review Article

Protection for medication-induced hearing loss: the state of the science

&
Pages S87-S95 | Received 16 Mar 2017, Accepted 08 Mar 2018, Published online: 24 Apr 2018

References

  • Astolfi, L., E. Simoni, F. Valente, S. Ghiselli, S. Hatzopoulos, M. Chicca, and A. Martini. 2016. “Coenzyme Q10 Plus Multivitamin Treatment Prevents Cisplatin Ototoxicity in Rats.” PLoS One 11 (9): e0162106. doi:10.1371/journal.pone.0162106.
  • Balis, F.M. 2016. Pilot Study to Prevent Nephrotoxicity of High-dose Methotrexate by Prolonging the Infusion Duration and Prevent Nephrotoxicity and Ototoxicity of Cisplatin with Pantoprazole in Children, Adolescents and Young Adults with Osteosarcoma. https://clinicaltrials.gov (Identification No. NCT01848457).
  • Bock, G.R., G.K. Yates, J.J. Miller, P. Moorjani. 1983. “Effects of N-acetylcysteine on Kanamycin Ototoxicity in the Guinea Pig.” Hearing Research 9 (3): 255–262. doi:10.1016/0378-5955(83)90030-8.
  • Cakil, B., F.S. Basar, S. Atmaca, S.K. Cengel, A. Tekat, Y. Tanyeri. 2012. “The Protective Effect of Ginkgo Biloba Extract Against Experimental Cisplatin Ototoxicity: Animal Research Using Distortion Product Otoacoustic Emissions.” Journal of Laryngology & Otology 126 (11): 1097–1101. doi:10.1017/S0022215112002046.
  • Campbell, K.C.M., ed. Pharmacology and Ototoxicity for Audiologists. Clifton Park, NY: Thompson Delmar Learning.
  • Campbell, K.C.M., and D. Fox. 2016. “Cisplatin-Induced Hearing Loss in Translational Research.” In Audiology, Neurotology, and the Hearing Sciences, edited by Le Prell, Lobarinas, Popper, Fay, 141–164. Springer, Cham: Springer Publishers.
  • Campbell, K.C.M., E. Kelly, N. Targovnik, L. Hughes, C. Van Saders, A.B. Gottlieb, M.B. Dorr, and A. Leighton. 2003. “Audiologic Monitoring for Potential Ototoxicity in a Phase I Clinical Trial of a New Glycopeptide Antibiotic.” Journal of the American Academy of Audiology 14 (3): 157–168; quiz 170–171. doi:10.3109/14992027.2010.540722.
  • Campbell, K.C.M., S.M. Martin, R.P. Meech, T.L. Hargrove, S.J. Verhulst, and D.J. Fox. 2016. “D-methionine (D-met) Significantly Reduces Kanamycin-Induced Ototoxicity in Pigmented Guinea Pigs.” International Journal of Audiology 55 (5): 273–278. doi:10.3109/14992027.2016.1143980.
  • Campbell, K.C.M., R.P. Meech, J.J. Klemens, M.T. Gerberi, S.S.W. Dyrstad, D.L. Larsen, D.L. Mitchell, et al. 2007.” Prevention of Noise- and Drug-induced Hearing Loss with D-Methionine.” Hearing Research 226 (1–2): 92–103. doi:10.1016/j.heares.2006.11.012.
  • Campbell, K.C.M., R.P. Meech, L.P. Rybak, L.F. Hughes. 1999. “D-Methionine Protects Against Cisplatin Damage to the Stria Vascularis.” Hearing Research 138 (1–2): 13–28. doi:10.1016/S0378-5955(99)00142-2.
  • Campbell, K.C.M., R. Nayar, S. Borgonha, L.F. Hughes, A. Rehemtulla, B. Ross, and P. Sunkara. 2009. “Oral D-methionine (MRX-1024) Significantly Protects Against Cisplatin-Induced Hearing Loss: A Phase II Study in Humans.” Abstracts of the Association for Research in Otolaryngology, 32: 7.
  • Campbell, K.C.M., L.P. Rybak, R.P. Meech, and L. Hughes. 1996. “D-Methionine Provides Excellent Protection from Cisplatin Ototoxicity in the Rat.” Hearing Research 102 (1–2): 90–98. doi:10.1016/S0378-5955(96)00152-9.
  • Chen, Y., W.G. Huang, D.J. Zha, J.H. Qiu, J.L. Wang, S.H. Sha, and J. Schacht. 2007. “Aspirin Attenuates Gentamicin Ototoxicity: from the Laboratory to the Clinic.” Hearing Research 226 (1–2): 178–182. doi:10.1016/j.heares.2006.05.008.
  • Church, M.W., J.A. Kaltenbach, B.W. Blakley, D.L. Burgio. 1995. “The Comparative Effects of Sodium Thiosulfate, Diethyldithiocarbamate, Fosfomycin and WR-2721 on Ameliorating Cisplatin-Induced Ototoxicity.” Hearing Research 86 (1–2): 195–203. doi:10.1016/0378-5955(95)00066-D.
  • Cloven, N.G., A. Re, M.T. McHale, R.A. Burger, P.J. DiSaia, G.S. Rose, K.C. Campbell, and H. Fan. 2000. “Evaluation of D-methionine as a Cytoprotectant in Cisplatin Treatment of an Animal Model for Ovarian Cancer.” Anticancer Research 20 (6B): 4205–4209. doi:10.1016/j.phrs.2008.01.001.
  • Coleman, J., X. Huang, J. Liu, R. Kopke, and R. Jackson. 2010. “Dosing Study on the Effectiveness of Salicylate/N-Acetylcysteine for Prevention of Noise-Induced Hearing Loss.” Noise & Health 12 (48): 159.
  • Conlon, B.J., J.M. Aran, J.P. Erre, and D.W. Smith. 1999. “Attenuation of Aminoglycoside-Induced Cochlear Damage with the Metabolic Antioxidant Alpha-Lipoic Acid.” Hearing Research 128 (1–2): 40–44. doi:10.1016/S0378-5955(98)00195-6.
  • Crabb, S.J., K. Martin, J. Abab, I. Ratcliffe, R. Thornton, B. Lineton, M. Ellis, et al. 2017. “COAST (Cisplatin Ototoxicity Attenuated by Aspirin Trial): A Phase II Double-Blind, Randomized Controlled Trial to Establish if Aspirin Reduces Cisplatin Induced Hearing-Loss.” European Journal of Cancer 87: 75–83. doi:10.1016/j.ejca.2017.09.033.
  • de Castria, T.B., E.M. da Silva, A.F. Gois, and R. Riera. 2013. “Cisplatin Versus Carboplatin in Combination with Third‐Generation Drugs for Advanced Non‐small Cell Lung Cancer.” Cochrane Library 16 (8): CD009256. doi:10.1002/14651858.CD009256.pub2.
  • Dias, M.A. 2010. The protective effect of Ginkgo biloba extract on cisplatin-induced ototoxicity in humans. https://clinicaltrials.gov (Identification No. NCT01139281).
  • Dias, M.A., A.L. Sampaio, A.R. Venosa, A. Meneses Ede, and C.A. Oliveira. 2015. “The Chemopreventive Effect of Ginkgo Biloba Extract 761 Against Cisplatin Ototoxicity: A Pilot Study.” International Tinnitus Journal 19 (2): 12–19. doi:10.5935/0946-5448.20150003.
  • Duval, M., and S.J. Daniel. 2012. “Meta-Analysis of the Efficacy of Amifostine in the Prevention of Cisplatin Ototoxicity.” Journal of Otolaryngology – Head & Neck Surgery 41 (5): 309–315.
  • Fetoni, A.R., S.L. Eramo, R. Rolesi, D. Troiani, and G. Paludetti. 2012. “Antioxidant Treatment with Coenzyme Q-ter in Prevention of Gentamycin Ototoxicity in An Animal Model.” Acta Otorhinolaryngologica Italica 32 (2): 103–110.
  • Finkler, A.D., A. Ferreira da Silveira, G. Munaro, and C.D. Zanrosso. 2012. “Otoprotection in Guinea Pigs Exposed to Pesticides and Ginkgo Biloba.” Brazilian Journal of Otorhinolaryngology 78 (3): 122–128. doi:10.1590/S1808-86942012000300020.
  • Fox, D.J., M.D. Cooper, C.A. Speil, M.H. Roberts, S.C. Yanik, R.P. Meech, T.L. Hargrove, S.J. Verhulst, L.P. Rybak, and K.C. Campbell. 2016. “D-Methionine Reduces Tobramycin-Induced Ototoxicity Without Antimicrobial Interference in Animal Models.” Journal of Cystic Fibrosis 15 (4): 518–530. doi:10.1016/j.jcf.2015.06.005.
  • Freyer, D.R. 2008. Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy. https://clinicaltrials.gov (Identification No. NCT00716976).
  • Freyer, D.R., L. Chen, M.D. Krailo, K. Knight, D. Villaluna, B. Bliss, B.H. Pollock, et al. 2017. “Effects of Sodium Thiosulfate Versus Observation on Development of Cisplatin-Induced Hearing Loss in Children with Cancer (ACCL0431): A Multicentre, Randomised, Controlled, Open-Label, Phase 3 Trial.” Lancet Oncology 18 (1): 63–74. doi:10.1016/S1470-2045(16)30625-8.
  • Fukaya, H., and H. Kanno. 1999. “Experimental Studies of the Protective Effect of Ginkgo Biloba Extract (GBE) on Cisplatin-Induced Toxicity in Rats.” Nihon Jibiinkoka Gakkai Kaiho 102 (7): 907–917. [Japanese]. doi:10.3950/jibiinkoka.102.907.
  • Gilbert, D. 2005. “Aminoglycosides.” In Principles and Practice of Infectious Diseases: Sixth Edition, edited by Mandell, Bennett, Dolin, 328–356. New York: Churchill Livingstone.
  • Hamstra, D.A., A. Eisbruch, M.U. Naidu, G.V. Ramana, P. Sunkara, K.C. Campbell, B.D. Ross, and A. Rehemtulla. 2010. “Pharmacokinetic Analysis and Phase 1 Study of MRX-1024 in Patients Treated with Radiation Therapy With or Without Cisplatinum for Head and Neck Cancer.” Clinical Cancer Research 16 (9): 266–276. doi:10.1158/1078-0432.CCR-09-3318.
  • Harned, T.M., O. Kalous, A. Neuwelt, J. Loera, L. Ji, P. Iovine, R. Sposto, E.A. Neuwelt, and C.P. Reynolds. 2008.” Sodium Thiosulfate Administered Six Hours After Cisplatin Does Not Compromise Antineuroblastoma Activity.” Clinical Cancer Research 14 (2): 533–540. doi:10.1158/1078-0432.CCR-06-2289.
  • Hensley, M.L., K.L. Hagerty, T. Kewalramani, D.M. Green, N.J. Meropol, T.H. Wasserman, G.I. Cohen, et al. 2009. “American Society of Clinical Oncology 2008 Clinical Practice Guideline Update: Use of Chemotherapy and Radiation Therapy Protectants.” Journal of Clinical Oncology 27 (1): 127–145. doi:10.1200/JCO.2008.17.2627.
  • Hochman, J., B.W. Blakley, M. Wellman, and L. Blakley. 2006. “Prevention of Aminoglycoside-Induced Sensorineural Hearing Loss.” Journal of Otolaryngology 35 (3): 153–156.
  • Huang, S., M. Chen, X. Ding, X. Zhang, and X. Zou. 2013. “Proton Pump Inhibitor Selectively Suppresses Proliferation and Restores the Chemosensitivity of Gastric Cancer Cells by Inhibiting STAT3 Signaling Pathway.” International Immunopharmacology 17 (3): 585–592. doi:10.1016/j.intimp.2013.07.021.
  • Huang, T., A.G. Cheng, H. Stupak, W. Liu, A. Kim, H. Staecker, P.P. Lefebvre, et al. 2000. “Oxidative Stress-Induced Apoptosis of Cochlear Sensory Cells: Otoprotective Strategies.” International Journal of Developmental Neuroscience 18 (2–3): 259–270. doi:10.1016/S0736-5748(99)00094-5.
  • Huang, X., C.A. Whitworth, and L.P. Rybak. 2007. “Ginkgo Biloba Extract (EGb 761) Protects Against Cisplatin-Induced Ototoxicity in Rats.” Otology & Neurotology 28 (6): 828–833. doi:10.1097/MAO.0b013e3180430163.
  • Husain, K., C. Whitworth, S.M. Somani, and L.P. Rybak. 2005. “Partial Protection by Lipoic Acid Against Carboplantin-Induced Ototoxicity in Rats.” Biomedical and Environmental Sciences 18 (3): 198–206.
  • Jamesdaniel, S., R. Rathinam, and W.L. Neumann. 2016. “Targeting Nitrative Stress for Attenuating Cisplatin-Induced Downregulation of Cochlear LIM Domain only 4 and Ototoxicity.” Redox Biology 10: 257–265. doi:10.1016/j.redox.2016.10.016.
  • Jin, Z., and W.S. El-Deiry. 2005. “Overview of Cell Death Signaling Pathways.” Cancer Biology & Therapy 4 (2): 139–163.
  • Johnson, A.-C., and T. Morata. 2010. “Occupational Exposure to Chemicals and Hearing Impairment.” Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 44 (4): 1–190.
  • Jones, M.M., M.A. Basinger, and M.A. Holscher. 1991. “Relative Effectiveness of Some Compounds for the Control of Cisplatin-Induced Nephrotoxicity.” Toxicology 68 (3): 227–247. doi:10.1016/0300-483X(91)90072-9.
  • Kil, J. 2016a. Safety and Efficacy Study of SPI-1005 for Prevention of Chemotherapy Induced Hearing Loss. https://clinicaltrials.gov (Identification No. NCT01451853).
  • Kil, J. 2016b. SPI-1005 for Prevention and Treatment of Aminoglycoside Induced Ototoxicity. https://clinicaltrials.gov (Identification No. NCT02819856).
  • Kil, J., E. Lobarinas, C. Spankovich, S.K. Griffiths, P.J. Antonelli, E.D. Lynch, and C.G. Le Prell. 2017. “Safety and Efficacy of Ebselen for the Prevention of Noise-Induced Hearing Loss: A Randomised, Double-Blind, Placebo-Controlled, Phase 2 Trial.” Lancet 390 (10098): 969–979. doi:10.1016/S0140-6736(17)31791-9.
  • Kim, S.J., C. Park, A.L. Han, M.J. Youn, J.H. Lee, Y. Kim, E.S. Kim, et al. 2009. “Ebselen Attenuates Cisplatin-Induced ROS Generation Through Nrf2 Activation in Auditory Cells.” Hearing Research 251 (1–2): 70–82. doi:10.1016/j.heares.2009.03.003.
  • Kocyigit, I. 2011. Protective Effect of N-acetylcysteine Against Ototoxicity. https://clinicaltrials.gov (Identification No. NCT01271088).
  • Kopke, R.D., W. Liu, R. Gabaizadeh, A. Jacono, J. Feghali, D. Spray, P. Garcia, H. Steinman, B. Malgrange, R.J. Ruben, and L. Rybak. 1997. “Use of Organotypic Cultures of Corti's Organ to Study the Protective Effects of Antioxidant Molecules on Cisplatin-Induced Damage of Auditory Hair Cells.” American Journal of Otolaryngology 18 (5): 559–571.
  • Kopke, R., K.A. Allen, D. Henderson, M. Hoffer, D.M. Frenz, and T. Van De Water. 1999. “A Radical Demise: Toxins and Trauma Share Common Pathways in Hair Cell Death.” Annals of the New York Academy of Sciences 884 (1): 171–191. doi:10.1111/j.1749-6632.1999.tb08641.x.
  • Korver, K.D., L.P. Rybak, C. Whitworth, and K.C. Campbell. 2002. “Round Window Application of D-Methionine Provides Complete Cisplatin Otoprotection.” Otolaryngology – Head and Neck Surgery 126: 683–689. doi:10.1067/mhn.2002.125299.
  • Kramer, S., L. Dreisbach, J. Lockwood, K. Baldwin, R. Kopke, S. Scranton, and M. O'Leary. 2006. “Efficacy of the Antioxidant N-Acetylcysteine (NAC) in Protecting Ears Exposed to Loud Music.” Journal of the American Academy of Audiology 17(4): 265–278. doi:10.3766/jaaa.17.4.5.
  • Kranzer, K., W.F. Elamin, H. Cox, J.A. Seddon, N. Ford, and F. Drobniewski. 2015. “A Systematic Review and Meta-Analysis of the Efficacy and Safety of N-Acetylcysteine in Preventing Aminoglycoside-Induced Ototoxicity: Implications for the Treatment of Multidrug-Resistant TB.” Thorax 70 (11): 1070–1077. doi:10.1136/thoraxjnl-2015-207245.
  • Le Bars, P.L., and J. Kastelan. 2000. “Efficacy and Safety of a Ginkgo Biloba Extract.” Public Health Nutrion 3 (4A): 495–499.
  • Le Prell, C.G., L.F. Hughes, and J.M. Miller. 2007. “Free Radical Scavengers Vitamins A, C, and E Plus Magnesium Reduce Noise Trauma.” Free Radical Biology and Medicine 42 (9): 1454–1463. doi:10.1016/j.freeradbiomed.2007.02.008.
  • Le Prell, C.G., A.C. Johnson, A.C. Lindblad, Å., Skjönsberg, M. Ulfendahl, K. Guire, G.E. Green, K.C.M. Campbell, and J.M. Miller. 2011. “Increased Vitamin Plasma Levels in Swedish Military Personnel Treated with Nutrients Prior to Automatic Weapon Training. Noise and Health 13 (55): 432. doi:10.4103/1463-1741.90317.
  • Le Prell, C.G., C. Ojano-Dirain, E.W. Rudnick, M.A. Nelson, S.J. DeRemer, D.M. Prieskorn, and J.M. Miller. 2014. “Assessment of Nutrient Supplement to Reduce Gentamicin-Induced Ototoxicity.” Journal of the Association for Research in Otolaryngology 15 (3): 375–393. doi:10.1007/s10162-014-0448-x.
  • Lerner, S.A., B.A. Schmitt, R. Seligsohn, and G.J. Matz. 1986. “Comparative Study of Ototoxicity and Nephrotoxicity in Patients Randomly Assigned to Treatment with Amikacin or Gentamicin.” American Journal of Medicine 80 (6B): 98–104. doi:10.1016/0002-9343(86)90486-9.
  • Lockwood, D.S., D.L. Ding, J. Wang, and R.J. Salvi. 2000. “D-Methionine Attenuates Inner Hair Cell Loss in Carboplatin-Treated Chinchillas.” Audiology and Neurotology 5 (5): 263–266. doi:10.1159/000013890.
  • Lorito, G., S. Hatzopoulos, G. Laurell, K.C.M. Campbell, J. Petruccelli, P. Giordano, K. Kochanek, et al. 2011. “Dose-Dependent Protection on Cisplatin-Induced Ototoxicity – An Electrophysiological Study on the Effect of Three Antioxidants in the Sprague–Dawley Rat Animal Model.” Medical Science Monitor 17 (8): BR179–BR186. doi:10.12659/MSM.881894.
  • Luciani, F., M. Spada, A. De Milito, A. Molinari, L. Rivoltini, A. Montinaro, M. Marra, et al. 2004. “Effect of Proton Pump Inhibitor Pretreatment on Resistance of Solid Tumors to Cytotoxic Drugs.” Journal of the National Cancer Institute 96 (22): 1702–1713. doi:10.1093/jnci/djh305.
  • Lynch, E.D., R. Gu, C. Pierce, and J. Kil. 2005a. “Combined Oral Delivery of Ebselen and Allopurinol Reduces Multiple Cisplatin Toxicities in Rat Breast and Ovarian Cancer Models While Enhancing Anti-tumor Activity.” Anticancer Drugs 16 (5): 569–579. doi:10.1097/00001813-200506000-00013.
  • Lynch, E.D., R. Gu, C. Pierce, and J. Kil. 2005b. “Reduction of Acute Cisplatin Ototoxicity and Nephrotoxicity in Rats by Oral Administration of Allopurinol and Ebselen.” Hearing Research 201 (1–2): 81–89. doi:10.1016/j.heares.2004.08.002.
  • Lynch, E.D., and J. Kil. 2009. “Development of Ebselen, A Glutathione Peroxidase Mimis, for the Prevention and Treatment of Noise-Induced Hearing Loss.” Seminars in Hearing 30 (1): 47–55. doi:10.1055/s-0028-1111106.
  • Ma, W., J. Hu, Y. Cheng, J. Wang, X. Zhang, and M. Xu. 2015. “Ginkgolide B Protects Against Cisplatin-Induced Ototoxicity: Enhancement of Akt–Nrf2–HO-1 Signaling and Reduction of NADPH Oxidase.” Cancer Chemotherapy and Pharmacology 75: 949–959. doi:10.1007/s00280-015-2716-9.
  • Marshak, T.M., M. Steiner, M. Kaminer, L. Levy, and A., Shupak. 2014. “Prevention of Cisplatin-Induced Hearing Loss by Intratympanic Dexamethasone: A Randomized Controlled Study.” Otolaryngology – Head and Neck Surgery 150 (6): 983–990. doi:10.1177/0194599814524894.
  • Marshak, T.M. 2015. Prevention of cisplatin-induced hearing loss by intratympanic dexamethasone treatment. https://clinicaltrials.gov (Identification No. NCT01372904).
  • Martin, D.L. 2014. Alpha-lipoic acid in preventing hearing loss in cancer patients undergoing treatment with cisplatin. https://clinicaltrials.gov (Identification No. NCT00477607).
  • Mason, J.R. 1999. Amifostine Followed by High Dose Chemotherapy in Treating Patients With Hematologic Cancer or Solid Tumors. https://clinicaltrials.gov (Identification No. NCT 00003269).
  • McKenna, D.J., K. Jones, and K. Hughes. 2001. “Efficacy, Safety, and Use of Ginkgo Biloba in Clinical and Preclinical Applications.” Alternative Therapies in Health And Medicine 7 (5): 70–86, 88–90.
  • Meyer, F. 2016. Efficacy of trans-tympanic injections of a sodium thiosulfate gel to prevent cisplatin-induced ototoxicity (STS001). https://clinicaltrials.gov (Identification No. NCT02281006).
  • Miman, M.C., O. Ozturan, M. Iraz, T., Erdem, and E. Olmez. 2002. “Amikacin Ototoxicity Enhanced by Ginkgo Biloba Extract (EGb 761).” Hearing Research 169 (1–2): 121–129. doi:10.1016/S0378-5955(02)00385-4.
  • Muldoon, L.L., M.A. Pagel, R.A. Kroll, R.E. Brummett, N.D. Doolittle, E.G. Zuhowski, M.J. Egorin and E.A. Neuwelt. 2000. “Delayed Administration of Sodium Thiosulfate in Animal Models Reduces Platinum Ototoxicity Without Reduction of Antitumor Activity.” Clinical Cancer Research 6 (1): 309–315.
  • Neuwelt, E.A., R.E. Brummett, L.G. Remsen, R.A. Kroll, M.A. Pagel, C.I. McCormick, S. Guitjens, and L.L. Muldoon. 1996. “In vitro and Animal Studies of Sodium Thiosulfate as A Potential Chemoprotectant Against Carboplatin-Induced Ototoxicity.” Cancer Research 56 (4): 706–709.
  • Oishi, N., A. Kendall, and J. Schacht. 2014. “Metformin Protects Against Gentamicin-Induced Hair Cell Death in Vitro but not Ototoxicity in Vivo.” Neuroscience Letters 583: 65–59. doi:10.1016/j.neulet.2014.09.028.
  • Omenn, G.S. 1998. “Chemoprevention of Lung Cancer: The Rise and Demise of Beta-Carotene.” Annual Review of Public Health 19: 73–99. doi:10.1146/annurev.publhealth.19.1.73.
  • Omenn, G.S. 2007. “Chemoprevention of Lung Cancers: Lessons from CARET, the Beta-Carotene and Retinol Efficacy Trial, and Prospects for the Future.” European Journal of Cancer Prevention 16 (3): 184–191. doi:10.1097/01.cej.0000215612.98132.18.
  • Otto, W.C., R.D. Brown, L. Gage-White, S. Kupetz, M. Anniko, J.E. Penny, and C.M. Henley. 1988. “Effects of Cisplatin and Thiosulfate Upon Auditory Brainstem Responses of Guinea Pigs.” Hearing Research 35 (1): 79–85. doi:10.1016/0378-5955(88)90042-1.
  • Özel, H.E., F. Özdoğan, S.G. Gürgen, E. Esen, S. Genç, and A. Selçuk. 2016. “Comparison of the Protective Effects of Intratympanic Dexamethasone and Methylprednisolone Against Cisplatin-Induced Ototoxicity.” Journal of Laryngology & Otology 130 (3): 225–234. doi:10.1017/S0022215115003473.
  • Petremann, M., C.T. Van Ba, A. Broussy, C. Romanet, and J. Dyhrfjeld-Johnsen. 2017. Oral Administration of Clinical Stage Drug Candidate SENS-401 Effectively Reduces Cisplatin-induced Hearing Loss in Rats. Otology and Neurotology 38 (9): 1355–1361. doi:10.1097/MAO.0000000000001546.
  • Pouyatos, B., C. Gearhart, A. Nelson-Miller, S. Fulton, and L. Fechter. 2007. “Oxidative Stress Pathways in the Potentiation of Noise-Induced Hearing Loss by Acrylonitrile.” Hearing Research 224 (1–2): 61–74. doi:10.1016/j.heares.2006.11.009.
  • Rabau, S. 2015. The Effect of Coenzyme Q10 on Hearing and Tinnitus Characteristics of Chronic Tinnitus Patients. https://clinicaltrials.gov (Identification No. NCT02353650).
  • Riga, M.G., L. Chelis, S. Kakolyris, S. Papadopoulos, S. Stathakidou, E. Chamalidou, N. Xenidis, et al. 2013. “Transtympanic Injections of N-Acetylcysteine for the Prevention of Cisplatin-Induced Ototoxicity: A Feasible Method with Promising Efficacy.” American Journal of Clinical Oncology 36 (1): 1–6. doi:10.1097/COC.0b013e31822e006d.
  • Rybak, L.P., K. Husain, C. Morris, C. Whitworth, and S. Somani. 2000. “Effect of Protective Agents Against Cisplatin Ototoxicity.” American Journal of Otolaryngology 21 (4): 513–520.
  • Rybak, L.P., K. Husain, C. Whitworth, and S.M. Somani. 1999. “Dose Dependent Protection by Lipoic Acid Against Cisplatin-Induced Ototoxicity in Rats: Antioxidant Defense System. Toxicological Sciences 47 (2): 195–202. doi:10.1093/toxsci/47.2.195.
  • Rybak, L.P., C.A. Whitworth, D. Mukherjea, and V. Ramkumar. 2007. “Mechanisms of Cisplatin-Induced Ototoxicity and Prevention.” Hearing Research 226 (1–2): 157–167. doi:10.1016/j.heares.2006.09.015.
  • Rybak, L.P., C. Whitworth, S. Somani. 1999. “Application of Antioxidants and Other Agents to Prevent Cisplatin Ototoxicity.” Laryngoscope 109 (11): 1740–1744. doi:10.1097/00005537-199911000-00003.
  • Sha, S.H., J.H. Qiu, and J. Schacht. 2006. “Aspirin to Prevent Gentamicin-Induced Hearing Loss.” New England Journal of Medicine 354 (17): 1856–1857. doi:10.1056/NEJMc053428.
  • Sha, S.H., and J. Schacht. 1999. Salicylate Attenuates Gentamicin-induced Ototoxicity. Laboratory Investigation 79: 807–813.
  • Sha, S. H., and J. Schacht. 2000. “Antioxidants Attenuate Gentamicin-Induced Free Radical Formation in Vitro and Ototoxicity in Vivo: D-Methionine is a Potential Protectant.” Hearing Research 142 (1–2): 34–40. doi:10.1016/S0378-5955(00)00003-4.
  • Stewart, L. 1999. “Chemotherapy for Advanced Ovarian Cancer.” Cochrane Library. 1: CD001418. doi:10.1002/14651858.CD001418.
  • Stypulkowski, P.H. 1990. “Mechanisms of Salicylate Ototoxicity.” Hearing Research 46 (1–2): 113–145. doi:10.1016/0378-5955(90)90144-E.
  • Sun, C., X. Wang, D. Chen, X. Lin, D. Yu, and H. Wu. 2016. “Dexamethasone Loaded Nanoparticles Exert Protective Effects Against Cisplatin-Induced Hearing Loss by Systemic Administration.” Neuroscience Letters 619: 142–148. doi:10.1016/j.neulet.2016.03.012.
  • Takumida, M., R. Popa, and M. Anniko. 1999. “Free Radicals in the Guinea Pig Inner Ear Following Gentamicin Exposure.” Journal for Oto-Rhino-Laryngology and Its Related Specialties 61 (2): 63–70. doi:10.1159/000027643.
  • Tokgoz, B., C. Ucar, I. Kocyigit, M. Somdas, A. Unal, A. Vural, M. Sipahioglu, et al. 2011. “Protective Effect of N-Acetylcysteine from Drug-Induced Ototoxicity in Uraemic Patients with CAPD Peritonitis.” Nephrology Dialysis Transplantation 26 (12): 4073–4078. doi:10.1093/ndt/gfr211.
  • Villani, V., C. Zucchella, G. Cristalli, E. Galiè, F. Bianco, D. Giannarelli, S. Carpano, G. Spriano, and A. Pace. 2016. “Vitamin E Neuroprotection Against Cisplatin Ototoxicity: Preliminary Results from a Randomized, Placebo‐Controlled Ttrial.” Head & Neck 38 (S1): E2118. doi:10.1002/hed.24396.
  • Waissbluth, S., P. Salehi, X. He, S.J. Daniel. 2013. “Systemic Dexamethasone for the Prevention of Cisplatin-Induced Ototoxicity.” European Archives of Oto-Rhino-Laryngology 270 (5): 1597–1605. doi:10.1007/s00405-012-2150-0.
  • Wang, J., J.-L. Puel. 2008. “From Cochlear Cell Death Pathways to New Pharmacological Therapies.” Mini-Reviews in Medicinal Chemistry 8 (10): 1006–1019. doi:10.2174/138955708785740599.
  • Yamashita, D., H.Y. Jiang, C.G. Le Prell, J. Schacht, and J.M. Miller. 2005. “Post-exposure Treatment Attenuates Noise-Induced Hearing Loss.” Neuroscience 134 (2): 633–642. doi:10.1016/j.neuroscience.2005.04.015.
  • Yamasoba, T., A.L. Nuttall, C. Harris, Y. Raphael, and J.M. Miller. 1998. “Role of Glutathione in Protection Against Noise-Induced Hearing Loss.” Brain Research 784 (1–2): 82–90. doi:10.1016/S0006-8993(97)01156-6.
  • Yoo, J., S.J. Hamilton, D. Angel, K. Fung, J. Franklin, L.S. Parnes, D. Lewis, et al. 2014. “Cisplatin Otoprotection Using Transtympanic L-N-Acetylcysteine: A Pilot Randomized Study in Head and Neck Cancer Patients. Laryngoscope 124 (3): E87–E94. doi:10.1002/lary.24360.