735
Views
74
CrossRef citations to date
0
Altmetric
Original Articles

Human Response to Dioxin: Aryl Hydrocarbon Receptor (AhR) Molecular Structure, Function, and Dose-Response Data for Enzyme Induction Indicate an Impaired Human AhR

&
Pages 147-171 | Published online: 24 Feb 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Oscar Sabuz Vidal, Deepika Deepika, Marta Schuhmacher & Vikas Kumar. (2021) EDC-induced mechanisms of immunotoxicity: a systematic review. Critical Reviews in Toxicology 51:7, pages 634-652.
Read now
Warren G. Foster, Jane A. Evans, Julian Little, Laura Arbour, Aideen Moore, Reg Sauve, Juan Andrés León & Wei Luo. (2017) Human exposure to environmental contaminants and congenital anomalies: a critical review. Critical Reviews in Toxicology 47:1, pages 59-84.
Read now
R. A. Budinsky, D. Schrenk, T. Simon, M. Van den Berg, J. F. Reichard, J. B. Silkworth, L. L. Aylward, A. Brix, T. Gasiewicz, N. Kaminski, G. Perdew, T. B. Starr, N. J. Walker & J. C. Rowlands. (2014) Mode of action and dose–response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study. Critical Reviews in Toxicology 44:1, pages 83-119.
Read now
Chris Kirman, RobertA. Budinsky, Lisa Yost, BenF. Baker, JackM. Zabik, J. Craig Rowlands, TomF. Long & Ted Simon. (2011) Derivation of Soil Clean-Up Levels for 2,3,7,8-Tetrachloro-dibenzo-p-dioxin (TCDD) Toxicity Equivalence (TEQD/F) in Soil Through Deterministic and Probabilistic Risk Assessment of Exposure and Toxicity. Human and Ecological Risk Assessment: An International Journal 17:1, pages 125-158.
Read now

Articles from other publishers (70)

D M Isha Olive Khan, Peer W. F. Karmaus, Anthony Bach, Robert B. Crawford & Norbert E. Kaminski. (2023) An in vitro model of human hematopoiesis identifies a regulatory role for the aryl hydrocarbon receptor. Blood Advances 7:20, pages 6253-6265.
Crossref
Darius Stukas, Aldona Jasukaitiene, Arenida Bartkeviciene, Jason Matthews, Toivo Maimets, Indrek Teino, Kristaps Jaudzems, Antanas Gulbinas & Zilvinas Dambrauskas. (2023) Targeting AHR Increases Pancreatic Cancer Cell Sensitivity to Gemcitabine through the ELAVL1-DCK Pathway. International Journal of Molecular Sciences 24:17, pages 13155.
Crossref
Rongrui Liu, Tim R. Zacharewski, Rory B. Conolly & Qiang Zhang. (2022) A Physiologically Based Pharmacokinetic (PBPK) Modeling Framework for Mixtures of Dioxin-like Compounds. Toxics 10:11, pages 700.
Crossref
Jingwen Wu, Tianyi Pang, Ziyuan Lin, Ming Zhao & Hui Jin. (2022) The key player in the pathogenesis of environmental influence of systemic lupus erythematosus: Aryl hydrocarbon receptor. Frontiers in Immunology 13.
Crossref
Joseph D. Romano, Yun Hao, Jason H. Moore & Trevor M. Penning. (2022) Automating Predictive Toxicology Using ComptoxAI. Chemical Research in Toxicology 35:8, pages 1370-1382.
Crossref
Seyoung Yang, See-Hyoung Park, Sae Woong Oh, Kitae Kwon, Eunbi Yu, Chae Won Lee, Youn Kyoung Son, Changmu Kim, Byoung-Hee Lee, Jae Youl Cho, Youn-Jung Kim & Jongsung Lee. (2022) Antioxidant Activities and Mechanisms of Tomentosin in Human Keratinocytes. Antioxidants 11:5, pages 990.
Crossref
Ge Liu, Jiaoyan Jia, Jianfeng Zhong, Yongqi Yang, Yantao Bao & Qinchang Zhu. (2022) TCDD-induced IL-24 secretion in human chorionic stromal cells inhibits placental trophoblast cell migration and invasion. Reproductive Toxicology 108, pages 10-17.
Crossref
Akhileshwar Kumar Srivastava, Dhruv Kumar, Divya Singh & Rajesh Kumar Singh. 2022. Xenobiotics in Chemical Carcinogenesis. Xenobiotics in Chemical Carcinogenesis 21 35 .
Ruba Ibrahim, Amy Brix, David E. Malarkey, Abraham Nyska, Michal Asif & Yuval Ramot. (2021) Chemical-Induced Oral Squamous Cell Neoplasms in Rodents: An Overview of NTP 2-Year Cancer Studies. Toxicologic Pathology 49:5, pages 1062-1076.
Crossref
Jac M M J G Aarts, Gerrit M Alink, Henk J Franssen & Wil Roebroeks. (2021) Evolution of Hominin Detoxification: Neanderthal and Modern Human Ah Receptor Respond Similarly to TCDD. Molecular Biology and Evolution 38:4, pages 1292-1305.
Crossref
Daniele S Wikoff, Jonathan D Urban, Caroline Ring, Janice Britt, Seneca Fitch, Robert Budinsky & Laurie C Haws. (2021) Development of a Range of Plausible Noncancer Toxicity Values for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Based on Effects on Sperm Count: Application of Systematic Review Methods and Quantitative Integration of Dose Response Using Meta-Regression. Toxicological Sciences 179:2, pages 162-182.
Crossref
Naoko Nakano, Nobuo Sakata, Yuki Katsu, Daiki Nochise, Erika Sato, Yuta Takahashi, Saori Yamaguchi, Yoko Haga, Souichi Ikeno, Mitsuyoshi Motizuki, Keigo Sano, Kohei Yamasaki, Keiji Miyazawa & Susumu Itoh. (2020) Dissociation of the AhR/ARNT complex by TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity. Journal of Biological Chemistry 295:27, pages 9033-9051.
Crossref
Anne Mahringer, Alexandra Bernd, David S. Miller & Gert Fricker. (2019) Aryl hydrocarbon receptor ligands increase ABC transporter activity and protein expression in killifish ( Fundulus heteroclitus ) renal proximal tubules . Biological Chemistry 400:10, pages 1335-1345.
Crossref
Daniele Wikoff, Laurie Haws, Caroline Ring & Robert Budinsky. (2019) Application of qualitative and quantitative uncertainty assessment tools in developing ranges of plausible toxicity values for 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin. Journal of Applied Toxicology 39:9, pages 1293-1310.
Crossref
Helle Katrine Knutsen, Jan Alexander, Lars Barregård, Margherita Bignami, Beat Brüschweiler, Sandra Ceccatelli, Bruce Cottrill, Michael Dinovi, Lutz Edler, Bettina Grasl‐Kraupp, Christer Hogstrand, Carlo Stefano Nebbia, Isabelle P Oswald, Annette Petersen, Martin Rose, Alain‐Claude Roudot, Tanja Schwerdtle, Christiane Vleminckx, Günter Vollmer, Heather Wallace, Peter Fürst, Helen Håkansson, Thorhallur Halldorsson, Anne‐Katrine Lundebye, Raimo Pohjanvirta, Lars Rylander, Andrew Smith, Henk van Loveren, Ine Waalkens‐Berendsen, Marco Zeilmaker, Marco Binaglia, José Ángel Gómez Ruiz, Zsuzsanna Horváth, Eugen Christoph, Laura Ciccolallo, Luisa Ramos Bordajandi, Hans Steinkellner & Laurentius (Ron) Hoogenboom. (2018) Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food. EFSA Journal 16:11.
Crossref
Martine Aggerbeck & Etienne B. Blanc. (2018) Role of mixtures of organic pollutants in the development of metabolic disorders via the activation of xenosensors. Current Opinion in Toxicology 8, pages 57-65.
Crossref
A. Tkachenko, M. Bermudez, S. Irmer-Stooff, D. Genkinger, F. Henkler-Stephani, G. Wolber & A. Luch. (2017) Nuclear transport of the human aryl hydrocarbon receptor and subsequent gene induction relies on its residue histidine 291. Archives of Toxicology 92:3, pages 1151-1160.
Crossref
Chawon Yun, Karina Katchko, Michael Schallmo, Soyeon Jeong, Jonghwa Yun, Charlotte Chen, Joseph Weiner, Christian Park, Andrew George, Samuel Stupp, Wellington Hsu & Erin Hsu. (2018) Aryl Hydrocarbon Receptor Antagonists Mitigate the Effects of Dioxin on Critical Cellular Functions in Differentiating Human Osteoblast-Like Cells. International Journal of Molecular Sciences 19:1, pages 225.
Crossref
Zahra Asadzadeh, Hamed Mohammadi, Elham Safarzadeh, Maryam Hemmatzadeh, Ahmad Mahdian-shakib, Farhad Jadidi-Niaragh, Gholamreza Azizi & Behzad Baradaran. (2017) The paradox of Th17 cell functions in tumor immunity. Cellular Immunology 322, pages 15-25.
Crossref
E. V. Kashina, D. Y. Oshchepkov, E. V. Antontseva, M. Y. Shamanina, D. P. Furman & V. A. Mordvinov. (2017) Expression dynamics of the REL, RELA, and IRF1 transcription factors in U937 macrophages after dioxin exposure. Russian Journal of Genetics: Applied Research 7:5, pages 580-584.
Crossref
Majorie B.M. van Duursen, Karin I. van Ede & Martin van den Berg. (2017) One TEF concept does not fit all: The case for human risk assessment of polychlorinated biphenyls. Current Opinion in Toxicology 2, pages 103-108.
Crossref
Sidney Stohs. 2016. Food Toxicology. Food Toxicology 303 314 .
F. Girolami, V. Spalenza, A. Benedetto, L. Manzini, P. Badino, M.C. Abete & C. Nebbia. (2016) Comparative liver accumulation of dioxin-like compounds in sheep and cattle: Possible role of AhR-mediated xenobiotic metabolizing enzymes. Science of The Total Environment 571, pages 1222-1229.
Crossref
Karin I. van Ede, Majorie B. M. van Duursen & Martin van den Berg. (2016) Evaluation of relative effect potencies (REPs) for dioxin-like compounds to derive systemic or human-specific TEFs to improve human risk assessment. Archives of Toxicology 90:6, pages 1293-1305.
Crossref
Younes Aftabi, Abasalt Hosseinzadeh Colagar & Faramarz Mehrnejad. (2016) An in silico approach to investigate the source of the controversial interpretations about the phenotypic results of the human AhR-gene G1661A polymorphism. Journal of Theoretical Biology 393, pages 1-15.
Crossref
Hye-Min Kim, Ji-Woo Kim, Youngjun Choi, Hang-Suk Chun, Ilkyun Im, Yong-Mahn Han, Chang-Woo Song, Seokjoo Yoon & Han-Jin Park. (2016) Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells. Scientific Reports 6:1.
Crossref
Yvonne P. Dragan. 2016. Hepatocellular Carcinoma. Hepatocellular Carcinoma 65 92 .
Richard A. Becker, Grace Patlewicz, Ted W. Simon, J. Craig Rowlands & Robert A. Budinsky. (2015) The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor. Regulatory Toxicology and Pharmacology 73:1, pages 172-190.
Crossref
Jijing Tian, Yu Feng, Hualing Fu, Heidi Qunhui Xie, Joy Xiaosong Jiang & Bin Zhao. (2015) The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals. Environmental Science & Technology 49:16, pages 9518-9531.
Crossref
Michael J. Wourms & Courtney E.W. Sulentic. (2015) The aryl hydrocarbon receptor regulates an essential transcriptional element in the immunoglobulin heavy chain gene. Cellular Immunology 295:1, pages 60-66.
Crossref
D. Y. Oshchepkov, E. V. Kashina, E. V. Antontseva, E. A. Oshchepkova, V. A. Mordvinov & D. P. Furman. (2014) Dynamics of IL-12 cytokine expression in human macrophages after dioxin exposure. Russian Journal of Genetics: Applied Research 4:6, pages 568-574.
Crossref
Dennis J. Paustenbach. 2014. Wiley StatsRef: Statistics Reference Online. Wiley StatsRef: Statistics Reference Online.
Evan G. Williams, Laurent Mouchiroud, Michael Frochaux, Ashutosh Pandey, Pénélope A. Andreux, Bart Deplancke & Johan Auwerx. (2014) An Evolutionarily Conserved Role for the Aryl Hydrocarbon Receptor in the Regulation of Movement. PLoS Genetics 10:9, pages e1004673.
Crossref
Mehdi Ghorbanzadeh, Karin I. van Ede, Malin Larsson, Majorie B. M. van Duursen, Lorenz Poellinger, Sandra Lücke-Johansson, Miroslav Machala, Kateřina Pěnčíková, Jan Vondráček, Martin van den Berg, Michael S. Denison, Tine Ringsted & Patrik L. Andersson. (2014) In Vitro and in Silico Derived Relative Effect Potencies of Ah-Receptor-Mediated Effects by PCDD/Fs and PCBs in Rat, Mouse, and Guinea Pig CALUX Cell Lines . Chemical Research in Toxicology 27:7, pages 1120-1132.
Crossref
Stefanie R. Bailey, Michelle H. Nelson, Richard A. Himes, Zihai Li, Shikhar Mehrotra & Chrystal M. Paulos. (2014) Th17 Cells in Cancer: The Ultimate Identity Crisis. Frontiers in Immunology 5.
Crossref
Karin I. van Ede, Konrad P.J. Gaisch, Martin van den Berg & Majorie B.M. van Duursen. (2014) Differential relative effect potencies of some dioxin-like compounds in human peripheral blood lymphocytes and murine splenic cells. Toxicology Letters 226:1, pages 43-52.
Crossref
Stéphane Pierre, Aline Chevallier, Fatima Teixeira-Clerc, Ariane Ambolet-Camoit, Linh-Chi Bui, Anne-Sophie Bats, Jean-Christophe Fournet, Pedro Fernandez-Salguero, Martine Aggerbeck, Sophie Lotersztajn, Robert Barouki & Xavier Coumoul. (2014) Aryl Hydrocarbon Receptor–Dependent Induction of Liver Fibrosis by Dioxin. Toxicological Sciences 137:1, pages 114-124.
Crossref
Wolfgang Dekant & Thomas Colnot. (2013) Endocrine effects of chemicals: Aspects of hazard identification and human health risk assessment. Toxicology Letters 223:3, pages 280-286.
Crossref
João H. Duarte, Paola Di Meglio, Keiji Hirota, Helena Ahlfors & Brigitta Stockinger. (2013) Differential Influences of the Aryl Hydrocarbon Receptor on Th17 Mediated Responses in vitro and in vivo. PLoS ONE 8:11, pages e79819.
Crossref
Patricio Godoy, Nicola J. Hewitt, Ute Albrecht, Melvin E. Andersen, Nariman Ansari, Sudin Bhattacharya, Johannes Georg Bode, Jennifer Bolleyn, Christoph Borner, Jan Böttger, Albert Braeuning, Robert A. Budinsky, Britta Burkhardt, Neil R. Cameron, Giovanni Camussi, Chong-Su Cho, Yun-Jaie Choi, J. Craig Rowlands, Uta Dahmen, Georg Damm, Olaf Dirsch, María Teresa Donato, Jian Dong, Steven Dooley, Dirk Drasdo, Rowena Eakins, Karine Sá Ferreira, Valentina Fonsato, Joanna Fraczek, Rolf Gebhardt, Andrew Gibson, Matthias Glanemann, Chris E. P. Goldring, María José Gómez-Lechón, Geny M. M. Groothuis, Lena Gustavsson, Christelle Guyot, David Hallifax, Seddik Hammad, Adam Hayward, Dieter Häussinger, Claus Hellerbrand, Philip Hewitt, Stefan Hoehme, Hermann-Georg Holzhütter, J. Brian Houston, Jens Hrach, Kiyomi Ito, Hartmut Jaeschke, Verena Keitel, Jens M. Kelm, B. Kevin Park, Claus Kordes, Gerd A. Kullak-Ublick, Edward L. LeCluyse, Peng Lu, Jennifer Luebke-Wheeler, Anna Lutz, Daniel J. Maltman, Madlen Matz-Soja, Patrick McMullen, Irmgard Merfort, Simon Messner, Christoph Meyer, Jessica Mwinyi, Dean J. Naisbitt, Andreas K. Nussler, Peter Olinga, Francesco Pampaloni, Jingbo Pi, Linda Pluta, Stefan A. Przyborski, Anup Ramachandran, Vera Rogiers, Cliff Rowe, Celine Schelcher, Kathrin Schmich, Michael Schwarz, Bijay Singh, Ernst H. K. Stelzer, Bruno Stieger, Regina Stöber, Yuichi Sugiyama, Ciro Tetta, Wolfgang E. Thasler, Tamara Vanhaecke, Mathieu Vinken, Thomas S. Weiss, Agata Widera, Courtney G. Woods, Jinghai James Xu, Kathy M. Yarborough & Jan G. Hengstler. (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Archives of Toxicology 87:8, pages 1315-1530.
Crossref
Toshio Tanaka & Ryo Takahashi. (2013) Flavonoids and Asthma. Nutrients 5:6, pages 2128-2143.
Crossref
A. P. Hall, C. R. Elcombe, J. R. Foster, T. Harada, W. Kaufmann, A. Knippel, K. Küttler, D. E. Malarkey, R. R. Maronpot, A. Nishikawa, T. Nolte, A. Schulte, V. Strauss & M. J. York. (2012) Liver Hypertrophy. Toxicologic Pathology 40:7, pages 971-994.
Crossref
Michael B. Black, Robert A. Budinsky, Alan Dombkowski, Daniela Cukovic, Edward L. LeCluyse, Stephen S. Ferguson, Russell S. Thomas & J. Craig Rowlands. (2012) Cross-species Comparisons of Transcriptomic Alterations in Human and Rat Primary Hepatocytes Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Toxicological Sciences 127:1, pages 199-215.
Crossref
Min-Cong Huang, Fei-Yun Chen, Mou-Tsy Chou & Jyan-Gwo J. Su. (2012) Fluoranthene enhances p53 expression and decreases mutagenesis induced by benzo[a]pyrene. Toxicology Letters 208:3, pages 214-224.
Crossref
Jyan-Gwo Joseph Su, Min-Cong Huang & Fei-Yun Chen. (2011) 2,3,7,8-Tetrachlorodibenzo- p -dioxin’s Suppression of 1-Nitropyrene-Induced p53 Expression Is Mediated by Cytochrome P450 1A1 . Chemical Research in Toxicology 24:12, pages 2167-2175.
Crossref
Michael S. Denison, Anatoly A. Soshilov, Guochun He, Danica E. DeGroot & Bin Zhao. (2011) Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor. Toxicological Sciences 124:1, pages 1-22.
Crossref
Simone Helmig, Jens Udo Seelinger, Juliane Döhrel & Joachim Schneider. (2011) RNA expressions of AHR, ARNT and CYP1B1 are influenced by AHR Arg554Lys polymorphism. Molecular Genetics and Metabolism 104:1-2, pages 180-184.
Crossref
Brigitta Stockinger, Keiji Hirota, Joao Duarte & Marc Veldhoen. (2011) External influences on the immune system via activation of the aryl hydrocarbon receptor. Seminars in Immunology 23:2, pages 99-105.
Crossref
D L Gibbons & J Spencer. (2011) Mouse and human intestinal immunity: same ballpark, different players; different rules, same score. Mucosal Immunology 4:2, pages 148-157.
Crossref
Stéphane Pierre, Anne-Sophie Bats, Aline Chevallier, Linh-Chi Bui, Ariane Ambolet-Camoit, Michèle Garlatti, Martine Aggerbeck, Robert Barouki & Xavier Coumoul. (2011) Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation. Biochemical Pharmacology 81:2, pages 304-313.
Crossref
Kathrin Gassmann, Josef Abel, Hanno Bothe, Thomas Haarmann-Stemmann, Hans F. Merk, Kim N. Quasthoff, Thomas Dino Rockel, Timm Schreiber & Ellen Fritsche. (2010) Species-Specific Differential AhR Expression Protects Human Neural Progenitor Cells against Developmental Neurotoxicity of PAHs. Environmental Health Perspectives 118:11, pages 1571-1577.
Crossref
Robert A. Budinsky, Edward L. LeCluyse, Stephen S. Ferguson, J. Craig Rowlands & Ted Simon. (2010) Human and Rat Primary Hepatocyte CYP1A1 and 1A2 Induction with 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,3,7,8-Tetrachlorodibenzofuran, and 2,3,4,7,8-Pentachlorodibenzofuran. Toxicological Sciences 118:1, pages 224-235.
Crossref
Trine Celius & Jason Matthews. (2010) Functional analysis of six human aryl hydrocarbon receptor variants in human breast cancer and mouse hepatoma cell lines. Toxicology 277:1-3, pages 59-65.
Crossref
Craig J. Rowlands, Daniele F. Staskal, Bhaskar Gollapudi & Robert Budinsky. (2010) The human AHR: identification of single nucleotide polymorphisms from six ethnic populations. Pharmacogenetics and Genomics 20:5, pages 283-290.
Crossref
Carolyn D. DuSell, Erik R. Nelson, Bryan M. Wittmann, Jackie A. Fretz, Dmitri Kazmin, Russell S. Thomas, J. Wesley Pike & Donald P. McDonnell. (2010) Regulation of Aryl Hydrocarbon Receptor Function by Selective Estrogen Receptor Modulators. Molecular Endocrinology 24:1, pages 33-46.
Crossref
L. Recio & M.J. Cunningham. 2010. Comprehensive Toxicology. Comprehensive Toxicology 389 410 .
Ted Simon, Lesa L. Aylward, Christopher R. Kirman, J. Craig Rowlands & Robert A. Budinsky. (2009) Estimates of Cancer Potency of 2,3,7,8-Tetrachlorodibenzo(p)dioxin Using Linear and Nonlinear Dose-Response Modeling and Toxicokinetics. Toxicological Sciences 112:2, pages 490-506.
Crossref
Dagmara P. Furman, Eugenia A. Oshchepkova, Dmitry Yu. Oshchepkov, Marina Yu. Shamanina & Viatcheslav A. Mordvinov. (2009) Promoters of the genes encoding the transcription factors regulating the cytokine gene expression in macrophages contain putative binding sites for aryl hydrocarbon receptor. Computational Biology and Chemistry 33:6, pages 465-468.
Crossref
Charlotte Esser, Agneta Rannug & Brigitta Stockinger. (2009) The aryl hydrocarbon receptor in immunity. Trends in Immunology 30:9, pages 447-454.
Crossref
Colin A. Flaveny, Iain A. Murray, Chris R. Chiaro & Gary H. Perdew. (2009) Ligand Selectivity and Gene Regulation by the Human Aryl Hydrocarbon Receptor in Transgenic Mice. Molecular Pharmacology 75:6, pages 1412-1420.
Crossref
Raimo Pohjanvirta. (2009) Transgenic mouse lines expressing rat AH receptor variants — A new animal model for research on AH receptor function and dioxin toxicity mechanisms. Toxicology and Applied Pharmacology 236:2, pages 166-182.
Crossref
Ming Qi Fan, Alex R. Bell, David R. Bell, Sally Clode, Alwyn Fernandes, Paul M.D. Foster, Jeffrey R. Fry, Tao Jiang, George Loizou, Alan MacNicoll, Brian G. Miller, Martin Rose, Osama Shaikh-Omar, Lang Tran & Shaun White. (2009) Recombinant expression of aryl hydrocarbon receptor for quantitative ligand-binding analysis. Analytical Biochemistry 384:2, pages 279-287.
Crossref
Sheeno P. Thyparambil, Ricky D. Edmondson & Yvonne P. Dragan. 2010. Hepatocellular Carcinoma. Hepatocellular Carcinoma 55 107 .
Kimberly L Mahler, Jessica L Fleming, Amy M Dworkin, Nicholas Gladman, Hee-Yeon Cho, Jian-Hua Mao, Allan Balmain & Amanda Ewart Toland. (2008) Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus. BMC Genomics 9:1.
Crossref
Ted Simon, Christopher R. Kirman, Lesa L. Aylward, Robert A. Budinsky, J. Craig Rowlands & Tom F. Long. (2008) Estimates of Cancer Potency of 2,3,4,7,8-Pentachlorodibenzofuran Using Both Nonlinear and Linear Approaches. Toxicological Sciences 106:2, pages 519-537.
Crossref
Lesa L. Aylward, Julie E. Goodman, Gail Charnley & Lorenz R. Rhomberg. (2008) A Margin-of-Exposure Approach to Assessment of Noncancer Risks of Dioxins Based on Human Exposure and Response Data. Environmental Health Perspectives 116:10, pages 1344-1351.
Crossref
Dennis J. Paustenbach. 2007. Encyclopedia of Quantitative Risk Analysis and Assessment. Encyclopedia of Quantitative Risk Analysis and Assessment.
David R. Bell, Sally Clode, Ming Qi Fan, Alwyn Fernandes, Paul M. D. Foster, Tao Jiang, George Loizou, Alan MacNicoll, Brian G. Miller, Martin Rose, Lang Tran & Shaun White. (2007) Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the Developing Male Wistar(Han) Rat. II: Chronic Dosing Causes Developmental Delay. Toxicological Sciences 99:1, pages 224-233.
Crossref
Renate D. Kimbrough & Gail Charnley. (2007) To the Editor. Environmental Research 103:1, pages 145-146.
Crossref
Gail Charnley & Renate D. Kimbrough. (2006) Overview of exposure, toxicity, and risks to children from current levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds in the USA. Food and Chemical Toxicology 44:5, pages 601-615.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.