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Toxicology Mechanisms and Methods Volume 13, 2003 - Issue 3
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Research Article

Acrylonitrile-Induced Neurotoxicity in Normal Human Astrocytes: Oxidative Stress and 8-Hydroxy-2′-Deoxyguanosine Formation

Sam Jacob Molecular Toxicology Laboratory, Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
&
Ahmed E. Ahmed Molecular Toxicology Laboratory, Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA
Pages 169-179 | Published online: 30 Sep 2008

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Richard J. Albertini, Christopher R. Kirman & Dale E. Strother. (2023) Acrylonitrile’s genotoxicity profile: mutagenicity in search of an underlying molecular mechanism. Critical Reviews in Toxicology 53:2, pages 69-116.
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Sam Jacob, Bhupendra S. Kaphalia, Nissi Jacob & Ahmed E. Ahmed. (2006) The Water Disinfectant Byproduct Dibromoacetonitrile Induces Apoptosis in Rat Intestinal Epithelial Cells: Possible Role of Redox Imbalance. Toxicology Mechanisms and Methods 16:4, pages 227-234.
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Articles from other publishers (16)

Wojciech Żwierełło, Agnieszka Maruszewska, Marta Skórka-Majewicz, Marta Goschorska, Irena Baranowska-Bosiacka, Karolina Dec, Daniel Styburski, Anna Nowakowska & Izabela Gutowska. (2020) The influence of polyphenols on metabolic disorders caused by compounds released from plastics - Review. Chemosphere 240, pages 124901.
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Pengfei Lin, Jingjing Miao, Luqing Pan, Lei Zheng, Xiufen Wang, Yufei Lin & Jiangyue Wu. (2018) Acute and chronic toxicity effects of acrylonitrile to the juvenile marine flounder Paralichthys olivaceus. Environmental Science and Pollution Research 25:35, pages 35301-35311.
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Samuel Caito, Marion Park & Michael Aschner. (2017) Resistance of mouse primary microglia and astrocytes to acrylonitrile-induced oxidative stress. NeuroToxicology 63, pages 120-125.
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Gary M. Williams, Tetyana Kobets, Jian-Dong Duan & Michael J. Iatropoulos. (2017) Assessment of DNA Binding and Oxidative DNA Damage by Acrylonitrile in Two Rat Target Tissues of Carcinogenicity: Implications for the Mechanism of Action. Chemical Research in Toxicology 30:7, pages 1470-1480.
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Xinzhu Pu, Zemin Wang, Shaoyu Zhou & James E. Klaunig. (2016) Protective effects of antioxidants on acrylonitrile-induced oxidative stress in female F344 rats. Environmental Toxicology 31:12, pages 1808-1818.
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Bai Yu, Yin Changsheng, Zhao Wenjun, Li Ben, Qian Hai, Ma Jing, Xing Guangwei, Wang Shuhua, Li Fang, Michael Aschner & Lu Rongzhu. (2015) Differential protection of pre- versus post-treatment with curcumin, Trolox, and N -acetylcysteine against acrylonitrile-induced cytotoxicity in primary rat astrocytes. NeuroToxicology 51, pages 58-66.
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Jason M. Fritz & April M. Luke. 2015. Hamilton & Hardy's Industrial Toxicology. Hamilton & Hardy's Industrial Toxicology 741 754 .
Samuel W. Caito, Yingchun Yu & Michael Aschner. (2014) Differential inflammatory response to acrylonitrile in rat primary astrocytes and microglia. NeuroToxicology 42, pages 1-7.
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Samuel Caito, Yingchun Yu & Michael Aschner. (2013) Differential response to acrylonitrile toxicity in rat primary astrocytes and microglia. NeuroToxicology 37, pages 93-99.
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Nadia M. Hamdy, Fahad A. Al-Abbasi, Hassan A. Alghamdi, Mai F. Tolba, Ahmed Esmat & Ashraf B. Abdel-Naim. (2012) Role of neutrophils in acrylonitrile-induced gastric mucosal damage. Toxicology Letters 208:2, pages 108-114.
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Piyajit Watcharasit, Sumitra Suntararuks, Daranee Visitnonthachai, Apinya Thiantanawat & Jutamaad Satayavivad. (2010) Acrylonitrile induced apoptosis via oxidative stress in neuroblastoma SH-SY5Y cell. Journal of Applied Toxicology 30:7, pages 649-655.
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Lu Rongzhu, Wang Suhua, Xing Guangwei, Ren Chunlan, Han Fangan, Chen Suxian, Zhang Zhengxian, Zhu Qiuwei & Michael Aschner. (2009) Effects of acrylonitrile on antioxidant status of different brain regions in rats. Neurochemistry International 55:7, pages 552-557.
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Xinzhu Pu, Lisa M. Kamendulis & James E. Klaunig. (2009) Acrylonitrile-Induced Oxidative Stress and Oxidative DNA Damage in Male Sprague-Dawley Rats. Toxicological Sciences 111:1, pages 64-71.
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Wantika Chantara, Piyajit Watcharasit, Apinya Thiantanawat & Jutamaad Satayavivad. (2006) Acrylonitrile-induced extracellular signal-regulated kinase (ERK) activation via protein kinase C (PKC) in SK-N-SH neuroblastoma cells. Journal of Applied Toxicology 26:6, pages 517-523.
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Xinzhu Pu, Lisa M. Kamendulis & James E. Klaunig. (2006) Acrylonitrile-induced oxidative DNA damage in rat astrocytes. Environmental and Molecular Mutagenesis 47:8, pages 631-638.
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Ahmed E. Ahmed, Gerald A. Campbell & Sam Jacob. (2005) Neurological impairment in fetal mouse brain by drinking water disinfectant byproducts. NeuroToxicology 26:4, pages 633-640.
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