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Review

Lipid emulsion improves survival in animal models of local anesthetic toxicity: a meta-analysis

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Pages 617-623 | Received 30 Jul 2016, Accepted 24 Jan 2017, Published online: 17 Feb 2017

Keep up to date with the latest research on this topic with citation updates for this article.

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Matilde Zaballos, Ignacio Fernández, Lucia Rodríguez, Sergio García, Olalla Varela, Oscar Quintela, María-José Anadón & Jesús Almendral. (2022) Effects of intravenous lipid emulsions on the reversal of pacing-induced ventricular arrhythmias and electrophysiological alterations in an animal model of ropivacaine toxicity. Clinical Toxicology 60:8, pages 902-911.
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Michael R. Fettiplace & Adrian B. Pichurko. (2021) Heterogeneity and bias in animal models of lipid emulsion therapy: a systematic review and meta-analysis. Clinical Toxicology 59:1, pages 1-11.
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Michael E. Mullins & Donna L. Seger. (2020) Antidotal use of lipid emulsion – the pendulum swings. Clinical Toxicology 58:12, pages 1281-1283.
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Kariem El-Boghdadly, Amit Pawa & Ki Jinn Chin. (2018) Local anesthetic systemic toxicity: current perspectives. Local and Regional Anesthesia 11, pages 35-44.
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Lotte C. G. Hoegberg, Robert S. Hoffman, Bryan D. Hayes, Valéry Lavergne & Sophie Gosselin. (2017) Letter in response to “Lipid emulsion improves survival in animal models of local anesthetic toxicity: a meta-analysis”. Clinical Toxicology 55:9, pages 1019-1019.
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Articles from other publishers (20)

Danting Jia, Fang Wang, Zhixia Bai & Xuexin Chen. (2023) BDNF-TrkB/proBDNF-p75NTR pathway regulation by lipid emulsion rescues bupivacaine-induced central neurotoxicity in rats. Scientific Reports 13:1.
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Andis Graudins, Hwee Min D. Lee & Lien Kien Roger Tong. (2023) Intravenous Lipid Emulsion does NOT have a role in severe poisoning: CON. British Journal of Clinical Pharmacology 89:6, pages 1719-1723.
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Michael R. Fettiplace & Guy Weinberg. (2023) Lipid emulsion for xenobiotic overdose: PRO. British Journal of Clinical Pharmacology 89:6, pages 1708-1718.
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Christopher L. Norkus. 2023. Advanced Monitoring and Procedures for Small Animal Emergency and Critical Care. Advanced Monitoring and Procedures for Small Animal Emergency and Critical Care 651 663 .
Karim Jaffal, Lucie Chevillard & Bruno Mégarbane. (2023) Lipid Emulsion to Treat Acute Poisonings: Mechanisms of Action, Indications, and Controversies. Pharmaceutics 15:5, pages 1396.
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Milad Karamlou, Iman Asaria, Jaime Barron, Petra Boutros, Vincent Fisher, Rachel Grandinetti, Julian Johnson, Emily Richard, David Susko, Cristobal Urrutia, Bryce Woolsey, Ronald Baumann, James Cottle, Richard Sweaney, Mark Wenzel, John Nusstein & David Hall. (2022) Complications After Dental Sedation: A Myotonic Mystery Case Report. Anesthesia Progress 69:4, pages 26-31.
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Xin Li & Scott O. Trerotola. (2022) Local Anesthesia in Interventional Radiology. Seminars in Interventional Radiology 39:04, pages 381-386.
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S. García-Ramos, I. Fernandez & M. Zaballos. (2022) Lipid emulsions in the treatment of intoxications by local anesthesics and other drugs. Review of mechanisms of action and recommendations for use. Revista Española de Anestesiología y Reanimación (English Edition) 69:7, pages 421-432.
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S. García-Ramos, I. Fernandez & M. Zaballos. (2022) Emulsiones lipídicas en la intoxicación por anestésicos locales y otros fármacos. Revisión sobre mecanismos de acción y recomendaciones de uso. Revista Española de Anestesiología y Reanimación 69:7, pages 421-432.
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Yang Liu, Jing Zhang, Peng Yu, Jiangfeng Niu & Shuchun Yu. (2021) Mechanisms and Efficacy of Intravenous Lipid Emulsion Treatment for Systemic Toxicity From Local Anesthetics. Frontiers in Medicine 8.
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Daniel J. Fletcher & Manuel Boller. (2021) Fluid Therapy During Cardiopulmonary Resuscitation. Frontiers in Veterinary Science 7.
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Divya Garg, Shikha Soni & Rakesh Karnawat. 2020. Topics in Local Anesthetics. Topics in Local Anesthetics.
Hao Nie, Zhixia Bai, Zhenzhou Li, Li Yan & Xue‐Xin Chen. (2020) Intravenous lipid emulsion modifies synaptic transmission in hippocampal CA1 pyramidal neurons after bupivacaine‐induced central nervous system toxicity. Journal of Neurochemistry 154:2, pages 144-157.
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Shiyuan Yu, Shanshan Yu, Lili Zhang, Yanxia Gao, Joseph Walline, Xin Lu, Yong Ma, Huadong Zhu, Xuezhong Yu & Yi Li. (2019) Efficacy and outcomes of lipid resuscitation on organophosphate poisoning patients: A systematic review and meta-analysis. The American Journal of Emergency Medicine 37:9, pages 1611-1617.
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Guy L. Weinberg, Peter Bedocs & Michael R. Fettiplace. (2019) Pigs and Paradigms: Stop Using Swine to Study Lipid Resuscitation. Anesthesia & Analgesia 129:1, pages 4-7.
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Marco Pelizzola, Clara Mattavelli, Roberta Troìa, Elsa Murgia & Massimo Giunti. (2018) Low‐dose intravenous lipid emulsion as a safe treatment for lipophilic intoxications in five cats. Veterinary Record Case Reports 6:4.
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Nicola Bates. (2018) Lipid emulsion in the management of poisoning. Companion Animal 23:4, pages 188-195.
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Michael R. Fettiplace & Guy Weinberg. (2018) The Mechanisms Underlying Lipid Resuscitation Therapy. Regional Anesthesia and Pain Medicine 43:2, pages 138-149.
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Henry L. Nguyen. 2018. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions. A Worldwide Yearly Survey of New Data in Adverse Drug Reactions 175 181 .
G. Weinberg. (2017) Current evidence supports use of lipid rescue therapy in local anaesthetic systemic toxicity. Acta Anaesthesiologica Scandinavica 61:4, pages 365-368.
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