3,740
Views
26
CrossRef citations to date
0
Altmetric
Review

Lipid emulsion improves survival in animal models of local anesthetic toxicity: a meta-analysis

ORCID Icon & ORCID Icon
Pages 617-623 | Received 30 Jul 2016, Accepted 24 Jan 2017, Published online: 17 Feb 2017

References

  • Fettiplace MR, Weinberg G. Past, present, and future of lipid resuscitation therapy. JPEN J Parenter Enteral Nutr. 2015;39:72S–83S.
  • Barrington MJ, Kluger R. Ultrasound guidance reduces the risk of local anesthetic systemic toxicity following peripheral nerve blockade. Reg Anesth Pain Med. 2013;38:289–297.
  • Gosselin S, Morris M, Miller-Nesbitt A, et al. Methodology for AACT evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning. Clin Toxicol. 2015;53:557–564.
  • Hoegberg L, Bania T, Lavergne V, et al. Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity. Clin Toxicol. 2016;54:167–193.
  • Bonfim MR, De Simone Melo M, Dreyer E, et al. Lipid therapy with two agents in ropivacaine-induced toxicity: experimental study in swine. Rev Bras Anestesiol. 2012;62:685–695.
  • Buckenmaier CC, Capacchione J, Mielke AR, et al. The effect of lipid emulsion infusion on postmortem ropivacaine concentrations in swine: endeavoring to comprehend a soldier's death. Anesth Analg. 2012;114:894–900.
  • Bushey BA, Auld VH, Volk JE, et al. Combined lipid emulsion and ACLS resuscitation following bupivacaine- and hypoxia-induced cardiovascular collapse in unanesthetized swine. AANA J. 2011;79:129–138.
  • Candela D, Louart G, Bousquet PJ, et al. Reversal of bupivacaine-induced cardiac electrophysiologic changes by two lipid emulsions in anesthetized and mechanically ventilated piglets. Anesth Analg. 2010;110:1473–1479.
  • De Queiroz Siqueira M, Chassard D, Musard H, et al. Resuscitation with lipid, epinephrine, or both in levobupivacaine-induced cardiac toxicity in newborn piglets. Br J Anaesth. 2014;112:729–734.
  • De Simone Melo M, Bonfim MR, Dreyer E, et al. Hemodynamic changes in lipid emulsion therapy (SMOFlipid) for bupivacaine toxicity in swines. Acta Cir Bras. 2012;27:318–324.
  • Di Gregorio G, Schwartz D, Ripper R, et al. Lipid emulsion is superior to vasopressin in a rodent model of resuscitation from toxin-induced cardiac arrest. Crit Care Med. 2009;37:993–999.
  • Fettiplace MR, Akpa BS, Ripper R, et al. Resuscitation with lipid emulsion: dose-dependent recovery from cardiac pharmacotoxicity requires a cardiotonic effect. Anesthesiology. 2014;120:915–925.
  • Fettiplace MR, Ripper R, Lis K, et al. Intraosseous lipid emulsion: an effective alternative to IV delivery in emergency situations. Crit Care Med. 2014;42:e157–e160.
  • Gokahmetoglu G, Aksu R, Bicer C, et al. The effect of levosimendan combined with 20% lipid emulsion treatment on survival from bupivacaine induced toxicity in experiment. Bratisl Lek Listy. 2014;115:275–297.
  • Hicks SD, Salcido DD, Logue ES, et al. Lipid emulsion combined with epinephrine and vasopressin does not improve survival in a swine model of bupivacaine-induced cardiac arrest. Anesthesiology. 2009;111:138–146.
  • Hiller DB, Di Gregorio G, Ripper R, et al. Epinephrine impairs lipid resuscitation from bupivacaine overdose: a threshold effect. Anesthesiology. 2009;111:498–505.
  • Karci A, AykaC Ibisoglu A, Oransay K, et al. The effects of lipid treatment on levobupivacaine induced cardiotoxicity in rats [abstract]. Eur J Anaesthesiol. 2009;108.
  • Karcıoğlu M, Tuzcu K, Sefil F, et al. Efficacy of resuscitation with Intralipid in a levobupivacaine-induced cardiac arrest model. Turk J Med Sci. 2014;44:330–336.
  • Li Z, Xia Y, Dong X, et al. Lipid resuscitation of bupivacaine toxicity: long-chain triglyceride emulsion provides benefits over long- and medium-chain triglyceride emulsion. Anesthesiology. 2011;115:1219–1228.
  • Li B, Yan J, Shen Y, et al. Association of sustained cardiovascular recovery with epinephrine in the delayed lipid-based resuscitation from cardiac arrest induced by bupivacaine overdose in rats. Br J Anaesth. 2012;108:857–863.
  • Litonius ES, Niiya T, Neuvonen PJ, et al. Intravenous lipid emulsion only minimally influences bupivacaine and mepivacaine distribution in plasma and does not enhance recovery from intoxication in pigs. Anesth Analg. 2012;114:901–906.
  • Mauch J, Jurado OM, Spielmann N, et al. Resuscitation strategies from bupivacaine-induced cardiac arrest. Paediatr Anaesth. 2012;22:124–129.
  • Mauch J, Martin Jurado O, Spielmann N, et al. Comparison of epinephrine vs lipid rescue to treat severe local anesthetic toxicity - an experimental study in piglets. Paediatr Anaesth. 2011;21:1103–1108.
  • Mayr VD, Mitterschiffthaler L, Neurauter A, et al. A comparison of the combination of epinephrine and vasopressin with lipid emulsion in a porcine model of asphyxial cardiac arrest after intravenous injection of bupivacaine. Anesth Analg. 2008;106:1566–1571.
  • Shi K, Xia Y, Wang Q, et al. The effect of lipid emulsion on pharmacokinetics and tissue distribution of bupivacaine in rats. Anesth Analg. 2013;116:804–809.
  • Wat C, Yuen M, Li R, et al. Lipid emulsion infusion vs standard cardiac resuscitation in managemnet of ropivacaine cardiac toxicity in pigs [abstract]. Anaesth Intensive Care. 2009;37:661–662.
  • Weinberg G, Paisanthasan C, Feinstein D, et al. The effect of bupivacaine on myocardial tissue hypoxia and acidosis during ventricular fibrillation. Anesth Analg. 2004;98:790–795.
  • Weinberg G, Ripper R, Feinstein DL, et al. Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med. 2003;28:198–202.
  • Weinberg GL, Di Gregorio G, Ripper R, et al. Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. Anesthesiology. 2008;108:907–913.
  • Yoshimoto M, Horiguchi T, Nishikawa T. Eddicacy of lipid resuscitation in cardiac arrest induced by bupivacaine-glucose mixture in rats [abstract]. Eur J Anaesthesiol. 2014;31:210.
  • Deeks JJ, Higgins JPT. Statistical algorithms in Review Manager 5 on behalf of the Statistical Methods Group of The Cochrane Collaboration. Event (London). 2010;2010:1–11.
  • Huedo-Medina TB, Sánchez-Meca J, Marín-Martínez F, et al. Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychol Methods. 2006;11:193–206.
  • Egger M, Smith GD, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ. 2011;315:629–634.
  • Albright G. Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. Anesthesiology. 1979;51:285–287.
  • Mayer E. The toxic effects following the use of local anesthetics: an analysis of the reports of forty-three deaths submitted to the committee for the study of toxic effects of local anesthetics of the american medical association, and the recommendations of the C. JAMA. 1924;82:876–885.
  • Groban L, Deal DD, Vernon JC, et al. Cardiac resuscitation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine in anesthetized dogs. Anesth Analg. 2001;92:37–43.
  • Cave G, Harrop-Griffiths W, Harbey M, et al. AAGBI safety guideline: management of severse local anaesthetic toxicity. AAGBI. 2010.
  • Neal JM, Bernards CM, Butterworth JF, et al. ASRA practice advisory on local anesthetic systemic toxicity. Reg Anesth Pain Med. 2010;35:152–161.
  • Harvey M, Cave G, Kazemi A. Intralipid infusion diminishes return of spontaneous circulation after hypoxic cardiac arrest in rabbits. Anesth Analg. 2009;108:1163–1168.
  • Fettiplace MR, Lis K, Ripper R, et al. Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion. J Control Release. 2015;198:62–70.
  • Fettiplace MR, Kowal K, Ripper R, et al. Insulin signaling in bupivacaine-induced cardiac toxicity: sensitization during recovery and potentiation by lipid emulsion. Anesthesiology. 2016;124:428–442.
  • Heinonen JA, Litonius E, Salmi T, et al. Intravenous lipid emulsion given to volunteers does not affect symptoms of lidocaine brain toxicity. Basic Clin Pharmacol Toxicol. 2015;116:378–383.
  • Dureau P, Charbit B, Nicolas N, et al. Effect of intralipid® on the dose of ropivacaine or levobupivacaine tolerated by volunteers: a clinical and pharmacokinetic study. Anesthesiology. 2016;125:474–483.