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Original Research

Clinical cosmeceutical repurposing of melatonin in androgenic alopecia using nanostructured lipid carriers prepared with antioxidant oils

, ORCID Icon, , , &
Pages 927-935 | Received 08 Feb 2018, Accepted 27 Aug 2018, Published online: 10 Sep 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Eman A. Bseiso, Sarah A. AbdEl-Aal, Maha Nasr, Omaima A. Sammour & Nabaweya A. Abd El Gawad. (2022) Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality. Drug Delivery 29:1, pages 2469-2480.
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Shymaa Hatem, Seham A. Elkheshen, Amany O. Kamel, Maha Nasr, Noha H. Moftah, Maha H Ragai, Reham S. Elezaby & Nada M. El Hoffy. (2022) Functionalized chitosan nanoparticles for cutaneous delivery of a skin whitening agent: an approach to clinically augment the therapeutic efficacy for melasma treatment. Drug Delivery 29:1, pages 1212-1231.
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Ghada M. El-Zaafarany & Maha Nasr. (2021) Insightful exploring of advanced nanocarriers for the topical/transdermal treatment of skin diseases. Pharmaceutical Development and Technology 26:10, pages 1136-1157.
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Ghada M. El-Zaafarany, Rasha T.A. Abdel-Aziz, Mahmoud Hamdy Ahmed Montaser & Maha Nasr. (2021) Coenzyme Q10 phospholipidic vesicular formulations for treatment of androgenic alopecia: ex vivo permeation and clinical appraisal. Expert Opinion on Drug Delivery 18:10, pages 1513-1522.
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Mai Shaaban, Maha Nasr, Abeer A. Tawfik, Maha Fadel & Omaima Sammour. (2021) Bergamot oil as an integral component of nanostructured lipid carriers and a photosensitizer for photodynamic treatment of vitiligo: Characterization and clinical experimentation. Expert Opinion on Drug Delivery 18:1, pages 139-150.
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Abdullah Alyoussef, Maha Nasr, Rania F. Ahmed, Omar A. H. Ahmed Farid, Rofanda Bakeer, Hrushikesh Karandikar & Anant Paradkar. (2020) Nicotinamide extrudates as novel anti-aging and collagen promoting platform: a comparative cosmeceutical study versus the gel form. Pharmaceutical Development and Technology 25:9, pages 1139-1149.
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Pietro Gentile, Laura Dionisi, Jacopo Pizzicannella, Barbara de Angelis, Domenico de Fazio & Simone Garcovich. (2020) A randomized blinded retrospective study: the combined use of micro-needling technique, low-level laser therapy and autologous non-activated platelet-rich plasma improves hair re-growth in patients with androgenic alopecia. Expert Opinion on Biological Therapy 20:9, pages 1099-1109.
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Maha Nasr, Hrushikesh Karandikar, Rasha T. A. Abdel-Aziz, Noha Moftah & Anant Paradkar. (2018) Novel nicotinamide skin-adhesive hot melt extrudates for treatment of acne. Expert Opinion on Drug Delivery 15:12, pages 1165-1173.
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Articles from other publishers (41)

Shymaa Hatem & Maha El-Kayal. (2023) Novel anti-psoriatic nanostructured lipid carriers for the cutaneous delivery of luteolin: A comprehensive in-vitro and in-vivo evaluation. European Journal of Pharmaceutical Sciences 191, pages 106612.
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Eman FS. Taha, Noha Sayed Hamed & Sahar Khateeb. (2023) Etoricoxib nanostructured lipid carriers attenuate inflammation by modulating Cyclooxygenase-2 signaling and activation of nuclear factor-κB-p65 pathways in radiation-induced acute cardiotoxicity in rats. European Journal of Pharmacology 957, pages 176029.
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Moon Sung Kang, Tae Eon Park, Hyo Jung Jo, Min Seok Kang, Su Bin Lee, Suck Won Hong, Ki Su Kim & Dong‐Wook Han. (2023) Recent Trends in Macromolecule‐Based Approaches for Hair Loss Treatment. Macromolecular Bioscience 23:10.
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Kousalya Prabahar, Ubaidulla Uthumansha, Nehal Elsherbiny & Mona Qushawy. (2023) Enhanced Skin Permeation and Controlled Release of β-Sitosterol Using Cubosomes Encrusted with Dissolving Microneedles for the Management of Alopecia. Pharmaceuticals 16:4, pages 563.
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Shan Zhang & Xu Yao. (2023) Mechanism of action and promising clinical application of melatonin from a dermatological perspective. Journal of Translational Autoimmunity 6, pages 100192.
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Komal Padule, Sonali Shinde, Sohan Chitlange, Prabhanjan Giram & Dheeraj Nagore. (2022) The Advancement of Herbal-Based Nanomedicine for Hair. Cosmetics 9:6, pages 118.
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Sara Barakat, Maha Nasr, Rania F. Ahmed, Sabry Badawy & Nahed Mortada. (2022) Recent Formulation Advances of Mangiferin. Revista Brasileira de Farmacognosia 32:6, pages 871-882.
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Eman A. Bseiso, Sarah A. Abd El-Aal, Maha Nasr, Omaima A. Sammour & Nabaweya A. Abd El Gawad. (2022) Intranasally administered melatonin core-shell polymeric nanocapsules: A promising treatment modality for cerebral ischemia. Life Sciences 306, pages 120797.
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Dalia O. Saleh, Maha Nasr, Azza Hassan, Sally A. El‐Awdan & Gehad A. Abdel Jaleel. (2022) Curcumin nanoemulsion ameliorates brain injury in diabetic rats. Journal of Food Biochemistry 46:7.
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Ghada Yasin, Maha Nasr, Sara A. Abdel Gaber, Dirk Hüttenberger & Maha Fadel. (2022) Response surface methodological approach for optimization of photodynamic therapy of onychomycosis using chlorin e6 loaded nail penetration enhancer vesicles. Journal of Photochemistry and Photobiology B: Biology 232, pages 112461.
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Sowon Bae, Yoo Gyeong Yoon, Ji Yea Kim, In-Chul Park, Sungkwan An, Jae Ho Lee & Seunghee Bae. (2022) Melatonin increases growth properties in human dermal papilla spheroids by activating AKT/GSK3β/β-Catenin signaling pathway. PeerJ 10, pages e13461.
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Natnicha Leelaviwat, Poemlarp Mekraksakit, Kristina M. Cross, Dylan M. Landis, Madison McLain, Laveena Sehgal & J. Drew Payne. (2022) Melatonin: Translation of Ongoing Studies Into Possible Therapeutic Applications Outside Sleep Disorders. Clinical Therapeutics 44:5, pages 783-812.
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Yueting Gu, Qiong Bian, Yanjun Zhou, Qiaoling Huang & Jianqing Gao. (2022) Hair follicle-targeting drug delivery strategies for the management of hair follicle-associated disorders. Asian Journal of Pharmaceutical Sciences 17:3, pages 333-352.
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Alec Sevilla, Jérémy Chéret, Radomir M. Slominski, Andrzej T. Slominski & Ralf Paus. (2022) Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective. Journal of Pineal Research 72:3.
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Mohamed Fawzi Kabil, Maha Nasr, Ismail T. Ibrahim, Yasser A. Hassan & Ibrahim M. El-Sherbiny. (2022) New repurposed rolapitant in nanovesicular systems for lung cancer treatment: Development, in-vitro assessment and in-vivo biodistribution study. European Journal of Pharmaceutical Sciences 171, pages 106119.
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Mihaela Stoia & Simona Oancea. (2022) Low-Molecular-Weight Synthetic Antioxidants: Classification, Pharmacological Profile, Effectiveness and Trends. Antioxidants 11:4, pages 638.
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Jie Kong, Weidong Qiang, Jingyi Jiang, Xingli Hu, Yining Chen, YongXin Guo, Hongxiang Liu, Siming Sun, Hongtao Gao, Yuan Zhang, Yanyan Gao, Xiuming Liu, Xin Liu & Haiyan Li. (2022) Safflower oil body nanoparticles deliver hFGF10 to hair follicles and reduce microinflammation to accelerate hair regeneration in androgenetic alopecia. International Journal of Pharmaceutics 616, pages 121537.
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Maha Nasr, Hend Abd-Allah, Omar A H Ahmed-Farid, Rofanda M Bakeer, Nabila S Hassan & Rania F Ahmed. (2022) A comparative study between curcumin and curcumin nanoemulsion on high-fat, high-fructose diet-induced impaired spermatogenesis in rats. Journal of Pharmacy and Pharmacology 74:2, pages 268-281.
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Georgeta Bocheva, Radomir M. Slominski, Zorica Janjetovic, Tae-Kang Kim, Markus Böhm, Kerstin Steinbrink, Russel J. Reiter, Konrad Kleszczyński & Andrzej T. Slominski. (2022) Protective Role of Melatonin and Its Metabolites in Skin Aging. International Journal of Molecular Sciences 23:3, pages 1238.
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S. M. Shaheedha. 2022. Handbook of Research on Nanoemulsion Applications in Agriculture, Food, Health, and Biomedical Sciences. Handbook of Research on Nanoemulsion Applications in Agriculture, Food, Health, and Biomedical Sciences 466 493 .
Serkan Yener, Kazime Gonca Akbulut, Resul Karakuş, Deniz Erdoğan & Füsun Acartürk. (2022) Development of melatonin loaded pectin nanoparticles for the treatment of inflammatory bowel disease: In vitro and in vivo studies. Journal of Drug Delivery Science and Technology 67, pages 102861.
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Priya Mishra, Mayank Handa, Rewati R. Ujjwal, Vanshikha Singh, Prashant Kesharwani & Rahul Shukla. (2021) Potential of nanoparticulate based delivery systems for effective management of alopecia. Colloids and Surfaces B: Biointerfaces 208, pages 112050.
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Natalie Kash, Matt Leavitt, Adam Leavitt, Spencer D. Hawkins & Rahil B. Roopani. (2021) Clinical Patterns of Hair Loss in Men. Dermatologic Clinics 39:3, pages 361-370.
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Luiz Gustavo de Almeida Chuffa, Fábio Rodrigues Ferreira Seiva, Adriana Alonso Novais, Vinícius Augusto Simão, Virna Margarita Martín Giménez, Walter Manucha, Debora Aparecida Pires de Campos Zuccari & Russel J. Reiter. (2021) Melatonin-Loaded Nanocarriers: New Horizons for Therapeutic Applications. Molecules 26:12, pages 3562.
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Maha Fadel, Maha Nasr, Reem Mostafa Hassan & Sarah Salah Thabet. (2021) Cationic zinc (II) phthalocyanine nanoemulsions for photodynamic inactivation of resistant bacterial strains. Photodiagnosis and Photodynamic Therapy 34, pages 102301.
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Mona Soliman, Manal Salah, Maha Fadel, Maha Nasr & Heba El-Azab. (2020) Contrasting the efficacy of pulsed dye laser and photodynamic methylene blue nanoemulgel therapy in treating acne vulgaris. Archives of Dermatological Research 313:3, pages 173-180.
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Nada M. El Hoffy, Engy A. Abdel Azim, Rania M. Hathout, Marwa A. Fouly & Seham A. Elkheshen. (2021) Glaucoma: Management and Future Perspectives for Nanotechnology-Based Treatment Modalities. European Journal of Pharmaceutical Sciences 158, pages 105648.
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Sara A. Abosabaa, Mona G. Arafa & Aliaa Nabil ElMeshad. (2020) Drug delivery systems integrated with conventional and advanced treatment approaches toward cellulite reduction. Journal of Drug Delivery Science and Technology 60, pages 102084.
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Shymaa Hatem, Nada M. El Hoffy, Reham S. Elezaby, Maha Nasr, Amany O. Kamel & Seham A. Elkheshen. (2020) Background and different treatment modalities for melasma: Conventional and nanotechnology-based approaches. Journal of Drug Delivery Science and Technology 60, pages 101984.
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Ali M. Nasr, Sameh S. Elhady, Shady A. Swidan & Noha M. Badawi. (2020) Celecoxib Loaded In-Situ Provesicular Powder and Its In-Vitro Cytotoxic Effect for Cancer Therapy: Fabrication, Characterization, Optimization and Pharmacokinetic Evaluation. Pharmaceutics 12:12, pages 1157.
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Viviane Lopes Rocha Correa, Juliana Assis Martins, Tainara Ribeiro de Souza, Gabriel de Castro Nunes Rincon, Marina Pacheco Miguel, Liliana Borges de Menezes & Andre Correa Amaral. (2020) Melatonin loaded lecithin-chitosan nanoparticles improved the wound healing in diabetic rats. International Journal of Biological Macromolecules 162, pages 1465-1475.
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Maha Nasr. (2020) Commentary on “Non-Steroidal Anti-inflammatory Drugs Loaded Liposomes for Topical Treatment of Inflammatory and Degenerative Conditions” by Carla Matos, FP-ENAS-UFP Energy, Environment and Health Research Unit/CEBIMED-Centro de Estudos em Biomedicina, Fernando Pessoa University, Porto, Portugal Challenges and Prospects of Topical Treatment of Inflammatory and Degenerative Conditions: A Vesicular Approach. Current Medicinal Chemistry 27:27, pages 4577-4578.
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Maha Nasr & Rawan Al-Karaki. (2020) Nanotechnological Innovations Enhancing the Topical Therapeutic Efficacy of Quercetin: A Succinct Review. Current Drug Delivery 17:4, pages 270-278.
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Min Si, Qianshu Sun, Hongcheng Ding, Chengcheng Cao, Mingwei Huang, Qian Wang, Hua Yang & Yi Yao. (2020) Melatonin-Loaded Nanoparticles for Enhanced Antidepressant Effects and HPA Hormone Modulation. Advances in Polymer Technology 2020, pages 1-9.
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Saed Aldalaen, Maha Nasr & Riham I. El-Gogary. (2020) Angiogenesis and collagen promoting nutraceutical-loaded nanovesicles for wound healing. Journal of Drug Delivery Science and Technology 56, pages 101548.
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Sandra Sherif Amer, Maha Nasr, Rasha T.A. Abdel-Aziz, Noha H. Moftah, Amr El Shaer, Elena Polycarpou, Wael Mamdouh & Omaima Sammour. (2020) Cosm-nutraceutical nanovesicles for acne treatment: Physicochemical characterization and exploratory clinical experimentation. International Journal of Pharmaceutics 577, pages 119092.
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Sara M. Abdel Samie & Maha Nasr. 2020. Drug Delivery Aspects. Drug Delivery Aspects 227 245 .
Maha Nasr, Riham I. El-Gogary, Hend Abd-Allah & Mona Abdel-Mottaleb. 2020. Nanopharmaceuticals. Nanopharmaceuticals 73 90 .
Iryna Rusanova, Laura Martínez-Ruiz, Javier Florido, César Rodríguez-Santana, Ana Guerra-Librero, Darío Acuña-Castroviejo & Germaine Escames. (2019) Protective Effects of Melatonin on the Skin: Future Perspectives. International Journal of Molecular Sciences 20:19, pages 4948.
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Enas Elmowafy, Riham I. El-Gogary, Maha H. Ragai & Maha Nasr. (2019) Novel antipsoriatic fluidized spanlastic nanovesicles: In vitro physicochemical characterization, ex vivo cutaneous retention and exploratory clinical therapeutic efficacy. International Journal of Pharmaceutics 568, pages 118556.
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Tobias W. Fischer. (2019) Behandlung der Alopecia androgenetica. ästhetische dermatologie & kosmetologie 11:4, pages 34-42.
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