Advanced search
Publication Cover
Expert Review of Clinical Immunology Volume 13, 2017 - Issue 2
Submit an article Journal homepage
1,790
Views
49
CrossRef citations to date
0
Altmetric
Review

Autoimmunity in common variable immunodeficiency: epidemiology, pathophysiology and management

Gholamreza AziziDepartment of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran;Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, IranView further author information
,
Hassan AbolhassaniResearch Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, SwedenView further author information
,
Mohammad Hosein AsgardoonResearch Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;Iranian Student Society for Immunodeficiencies, Student’s Scientific Research Center, Tehran University of Medical Sciences, Tehran, IranView further author information
,
Tina AliniaResearch Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, IranView further author information
,
Reza YazdaniDepartment of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranView further author information
,
Javad MohammadiDepartment of Biomedical Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, IranView further author information
,
Nima RezaeiResearch Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, IranView further author information
,
Hans D. OchsSeattle Children’s Research Institute and Department of Pediatrics, University of Washington, Seattle, WA, USAView further author information
&
Asghar AghamohammadiResearch Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran;Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, IranCorrespondence[email protected]
View further author information
 show all
Pages 101-115 | Received 18 Jun 2016, Accepted 11 Aug 2016, Published online: 16 Sep 2016

Citations (49)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (10)

Niloufar Yazdanpanah & Nima Rezaei. (2022) Autoimmune disorders associated with common variable immunodeficiency: prediction, diagnosis, and treatment. Expert Review of Clinical Immunology 18:12, pages 1265-1283.
Read now
Stelios Vlachiotis & Hassan Abolhassani. (2022) Transcriptional regulation of B cell class-switch recombination: the role in development of noninfectious complications. Expert Review of Clinical Immunology 18:11, pages 1145-1154.
Read now
Limor Rubin, Oded Shamriz, Ori Toker, Ela Kadish, Yaarit Ribak, Aviv Talmon, Alon Y. Hershko & Yuval Tal. (2022) Allergic-like disorders and asthma in patients with common variable immunodeficiency: a multi-center experience. Journal of Asthma 59:3, pages 476-483.
Read now
IM Andersen & SF Jørgensen. (2022) Gut inflammation in CVID: causes and consequences. Expert Review of Clinical Immunology 18:1, pages 31-45.
Read now
Fatema Sadaat Rizvi, Hamed Zainaldain, Hosein Rafiemanesh, Mahnaz Jamee, Nikoo Hossein-Khannazer, Haleh Hamedifar, Araz Sabzevari, Reza Yazdani, Hassan Abolhassani, Asghar Aghamohammadi & Gholamreza Azizi. (2020) Autoimmunity in common variable immunodeficiency: a systematic review and meta-analysis. Expert Review of Clinical Immunology 16:12, pages 1227-1235.
Read now
Fatemeh Kiaee, Gholamreza Azizi, Hosein Rafiemanesh, Hamed Zainaldain, Fatema Sadaat Rizvi, Mahla Alizadeh, Mahnaz Jamee, Sara Mohammadi, Sima Habibi, Laleh Sharifi, Farhad Jadidi-Niaragh, Sabahat Haghi, Reza Yazdani, Hassan Abolhassani & Asghar Aghamohammadi. (2019) Malignancy in common variable immunodeficiency: a systematic review and meta-analysis. Expert Review of Clinical Immunology 15:10, pages 1105-1113.
Read now
Hossein Mozdarani, Fatemeh Kiaee, Saba Fekrvand, Gholamreza Azizi, Reza Yazdani, Majid Zaki-Dizaji, Sahar Mozdarani, Sohail Mozdarani, Hassan Nosrati, Hassan Abolhassani & Asghar Aghamohammadi. (2019) G2-lymphocyte chromosomal radiosensitivity in patients with LPS responsive beige-like anchor protein (LRBA) deficiency. International Journal of Radiation Biology 95:6, pages 680-690.
Read now
Junyue Fang, Li Lin, Dijin Lin, Ruihao Zhang, Xiuli Liu, Di Wang, Chaohui Duan & Xianghua Lin. (2019) The imbalance between regulatory memory B cells reveals possible pathogenesis involvement in pediatric immune thrombocytopenia. Hematology 24:1, pages 473-479.
Read now
José Carlos Jaime-Pérez, Patrizia Elva Aguilar-Calderón, Lorena Salazar-Cavazos & David Gómez-Almaguer. (2018) Evans syndrome: clinical perspectives, biological insights and treatment modalities. Journal of Blood Medicine 9, pages 171-184.
Read now
Gholamreza Azizi, Marzieh Tavakol, Hosein Rafiemanesh, Fatemeh Kiaee, Reza Yazdani, Amin Heydari, Kosar Abouhamzeh, Pardis Anvari, Sara Mohammadikhajehdehi, Laleh Sharifia, Yasser Bagheri, Hamed Mohammadi, Hassan Abolhassani & Asghar Aghamohammadi. (2017) Autoimmunity in a cohort of 471 patients with primary antibody deficiencies. Expert Review of Clinical Immunology 13:11, pages 1099-1106.
Read now

Articles from other publishers (39)

Nadia Somasundaram, Oliver Meyer, Carmen Scheibenbogen, Leif Gunnar Hanitsch, Anna Stittrich, Uwe Kölsch & Kirsten Wittke. (2023) Clinical and immunological characterisation of patients with common variable immunodeficiency related immune thrombocytopenia. Clinical and Experimental Medicine.
Crossref
Maria Isabel Fiel & Thomas D. Schiano. (2023) Systemic Disease and the Liver Part 2. Surgical Pathology Clinics 16:3, pages 485-498.
Crossref
Oksana V. Moskaletc & Yuliya Ju. Tchuksina. (2023) Newly identified common variable immunodeficiency in an elderly patient with rheumatoid arthritis. Kazan medical journal.
Crossref
Gholamreza Azizi, Mina Fattah Hesari, Niusha Sharifinejad, Farimah Fayyaz, Zahra Chavoshzadeh, Seyed Alireza Mahdaviani, Mahnaz Seifi Alan, Mahnaz Jamee, Marzieh Tavakol, Homa Sadri, Ehsan Shahrestanaki, Mohammad Nabavi, Sareh Sadat Ebrahimi, Afshin Shirkani, Ahmad Vosughi Motlagh, Samaneh Delavari, Seyed Erfan Rasouli, Marzie Esmaeili, Fereshte Salami, Reza Yazdani, Nima Rezaei & Hassan Abolhassani. (2023) The Autoimmune Manifestations in Patients with Genetic Defects in the B Cell Development and Differentiation Stages. Journal of Clinical Immunology 43:4, pages 819-834.
Crossref
Jana G. Hashash, Jacqueline Squire, Fadi F. Francis, David G. Binion, Raymond K. Cross & Francis A. Farraye. (2022) An Expert Opinion/Approach: Clinical Presentations, Diagnostic Considerations, and Therapeutic Options for Gastrointestinal Manifestations of Common Variable Immune Deficiency. American Journal of Gastroenterology 117:11, pages 1743-1752.
Crossref
Marta Dafne Cabañero-Navalon, Victor Garcia-Bustos, Maria Nuñez-Beltran, Pascual Císcar Fernández, Lourdes Mateu, Xavier Solanich, Juan Luis Carrillo-Linares, Ángel Robles-Marhuenda, Francesc Puchades-Gimeno, Ana Pelaez Ballesta, Nuria López-Osle, Miguel Ángel Torralba-Cabeza, Ana María Bielsa Masdeu, Jorge Diego Gil, Nuria Tornador Gaya, Guillem Pascual Castellanos, Rosario Sánchez-Martínez, José Manuel Barragán-Casas, Andrés González-García, José Luís Patier de la Peña, Daniel López-Wolf, Antonia Mora Rufete, Alba Canovas Mora, Maria José Forner Giner & Pedro Moral Moral. (2022) Current clinical spectrum of common variable immunodeficiency in Spain: The multicentric nationwide GTEM-SEMI-CVID registry. Frontiers in Immunology 13.
Crossref
Flávia Dufloth Chiaradia, Lara Richter, Letícia Tavares, Daiane Cobianchi da Costa, Edneia Casagranda Bueno & Alexandre Geraldo. (2022) Imunodeficiência de imunoglobulinas IgG subclasse 3. Serviço Social e Saúde 21:00, pages e022005.
Crossref
O. V. Moskalets. (2022) Complicated ways of diagnosing common variable immune deficiency (case report). Russian Journal of Immunology 25:4, pages 461-464.
Crossref
Salah Aref, Nadia El Menshawy, Ahmad Darwish & Nora A. Farag. (2022) Predictive Value of Breg and Serum IL-10 Concentration Levels for Acute ITP Progression to Chronic Phase. Journal of Pediatric Hematology/Oncology 44:6, pages 336-341.
Crossref
Sanchi Chawla, Prabal Barman, Rahul Tyagi, Ankur Kumar Jindal, Saniya Sharma, Amit Rawat & Surjit Singh. (2022) Autoimmune Cytopenias in Common Variable Immunodeficiency Are a Diagnostic and Therapeutic Conundrum: An Update. Frontiers in Immunology 13.
Crossref
Adriana Motta-Raymundo, Pedro Rosmaninho, Diana F. Santos, Ruben D. Ferreira, Sara P. Silva, Cristina Ferreira, Ana E. Sousa & Susana L. Silva. (2022) Contribution of Helicobacter pylori to the Inflammatory Complications of Common Variable Immunodeficiency. Frontiers in Immunology 13.
Crossref
Giuliana Giardino, Emilia Cirillo, Rosaria Prencipe, Roberta Romano, Francesca Cillo, Elisabetta Toriello, Veronica De Rosa & Claudio Pignata. 2022. Translational Autoimmunity. Translational Autoimmunity 73 95 .
Aleksandra Szczawinska-Poplonyk, Katarzyna Jonczyk-Potoczna, Marcin Mikos, Lidia Ossowska & Renata Langfort. (2021) Granulomatous Lymphocytic Interstitial Lung Disease in a Spectrum of Pediatric Primary Immunodeficiencies. Pediatric and Developmental Pathology 24:6, pages 504-512.
Crossref
Rohan Ameratunga, Caroline Allan, Klaus Lehnert & See-Tarn Woon. (2021) Perspective: Application of the American College of Medical Genetics Variant Interpretation Criteria to Common Variable Immunodeficiency Disorders. Clinical Reviews in Allergy & Immunology 61:2, pages 226-235.
Crossref
Pierre Thoré, Xavier Jaïs, Laurent Savale, Peter Dorfmuller, Athénaïs Boucly, Matthieu Devilder, Olivier Meyrignac, Jérémie Pichon, Julie Mankikian, Marianne Riou, Emmanuel Boiffard, Clément Boissin, Pascal De Groote, Céline Chabanne, Frédéric Gagnadoux, Anne Bergeron, Nicolas Noel, Olivier Sitbon, Marc Humbert & David Montani. (2021) Pulmonary Hypertension in Patients with Common Variable Immunodeficiency. Journal of Clinical Immunology 41:7, pages 1549-1562.
Crossref
Zhanna Dauyey & Dimitri Poddighe. (2021) Diagnostic Barriers in Children with Immunodeficiencies in Central Asia: A Case-Based Discussion. Pediatric Reports 13:3, pages 483-489.
Crossref
Ida Judyta Malesza, Michał Malesza, Iwona Krela-Kaźmierczak, Aleksandra Zielińska, Eliana B. Souto, Agnieszka Dobrowolska & Piotr Eder. (2020) Primary Humoral Immune Deficiencies: Overlooked Mimickers of Chronic Immune-Mediated Gastrointestinal Diseases in Adults. International Journal of Molecular Sciences 21:15, pages 5223.
Crossref
S. Haleh Hosseini, Nadia Sharafkandi, Narges Seyfizadeh, Maryam Hemmatzadeh, Faroogh Marofi, Navid Shomali, Mohammad Karimi & Hamed Mohammadi. (2019) Progression or suppression: Two sides of the innate lymphoid cells in cancer. Journal of Cellular Biochemistry 121:4, pages 2739-2755.
Crossref
Ilaria Maccora, Edoardo Marrani, Silvia Ricci, Chiara Azzari, Gabriele Simonini, Rolando Cimaz & Teresa Giani. (2019) Common variable immunodeficiency presenting as sarcoidosis in a 9‐year‐old child. International Journal of Rheumatic Diseases 23:3, pages 448-453.
Crossref
Farhad Babaie, Hamed Mohammadi, Maryam Hemmatzadeh, Mehrdad Ebrazeh, Shahram Torkamandi, Mehdi Yousefi, Mehrzad Hajaliloo, Alireza Rezaiemanesh, Sorayya Salimi, Reza Salimi, Elham Safarzadeh, Behzad Baradaran & Zohreh Babaloo. (2020) Evaluation of ERAP1 gene single nucleotide polymorphisms in immunomodulation of pro-inflammatory and anti-inflammatory cytokines profile in ankylosing spondylitis. Immunology Letters 217, pages 31-38.
Crossref
Boshra Afshar, Zahra Khalifehzadeh-Esfahani, Narges Seyfizadeh, Gholamreza Rezaei Danbaran, Maryam Hemmatzadeh & Hamed Mohammadi. (2019) The role of immune regulatory molecules in multiple sclerosis. Journal of Neuroimmunology 337, pages 577061.
Crossref
Tamar Getter, Raanan Margalit, Shirin Kahremany, Laura Levy, Eliav Blum, Netaly Khazanov, Nimrod Y. Keshet-Levy, Tigist Y. Tamir, M. Ben Major, Ron Lahav, Sofia Zilber, Hanoch Senderowitz, Paul Bradfield, Beat A. Imhof, Evgenia Alpert & Arie Gruzman. (2019) Novel inhibitors of leukocyte transendothelial migration. Bioorganic Chemistry 92, pages 103250.
Crossref
V. Lacombe, P. Lozac’h, C. Orvain, C. Lavigne, C. Miot, I. Pellier & G. Urbanski. (2019) Traitement du PTI et de l’AHAI au cours du DICV : revue systématique de la littérature. La Revue de Médecine Interne 40:8, pages 491-500.
Crossref
Quindelyn S. Cook, Carlton J. Zdanski, Craig N. Burkhart, Paul B. Googe, Patrick Thompson & Eveline Y. Wu. (2019) Idiopathic, Refractory Sweet’s Syndrome Associated with Common Variable Immunodeficiency: a Case Report and Literature Review. Current Allergy and Asthma Reports 19:6.
Crossref
Laura Amaya-Uribe, Manuel Rojas, Gholamreza Azizi, Juan-Manuel Anaya & M. Eric Gershwin. (2019) Primary immunodeficiency and autoimmunity: A comprehensive review. Journal of Autoimmunity 99, pages 52-72.
Crossref
Roozbeh Sanaei, Nima Rezaei, Asghar Aghamohammadi, Ali-Akbar Delbandi, Shahram Teimourian, Reza Yazdani, Parsova Tavasolian, Fatemeh Kiaee & Nader Tajik. (2018) Evaluation of the TLR negative regulatory network in CVID patients. Genes & Immunity 20:3, pages 198-206.
Crossref
G. Azizi, Y. Bagheri, R. Yazdani, M. Zaki-Dizaji, M. Jamee, F. Jadidi-Niaragh, A.N. Kamali, H. Abolhassani & A. Aghamohammadi. (2019) The profile of IL-4, IL-5, IL-10 and GATA3 in patients with LRBA deficiency and CVID with no known monogenic disease: Association with disease severity. Allergologia et Immunopathologia 47:2, pages 172-178.
Crossref
S. Afshar-Ghasemlou, N. Esmaeil, R. Sherkat, R. Yazdani, F. Abbasi-Rad, M. Ganjalikhani-Hakemi & A. Rezaei. (2019) Increased IRF4 expression in isolated B cells from common variable immunodeficiency (CVID) patients. Allergologia et Immunopathologia 47:1, pages 52-59.
Crossref
R. Yazdani, S. Shapoori, M. Rezaeepoor, R. Sanaei, M. Ganjalikhani-Hakemi, G. Azizi, W. Rae, A. Aghamohammadi & N. Rezaei. (2019) Features and roles of T helper 9 cells and interleukin 9 in immunological diseases. Allergologia et Immunopathologia 47:1, pages 90-104.
Crossref
Junmin Song, Ana Lleo, Guo Xiang Yang, Weici Zhang, Christopher L. Bowlus, M. Eric Gershwin & Patrick S. C. Leung. (2017) Common Variable Immunodeficiency and Liver Involvement. Clinical Reviews in Allergy & Immunology 55:3, pages 340-351.
Crossref
Vern L. Schramm. (2018) Enzymatic Transition States and Drug Design. Chemical Reviews 118:22, pages 11194-11258.
Crossref
Gholamreza Azizi, Abbas Mirshafiey, Hassan Abolhassani, Reza Yazdani, Alireza Ghanavatinejad, Farshid Noorbakhsh, Nima Rezaei & Asghar Aghamohammadi. (2018) The imbalance of circulating T helper subsets and regulatory T cells in patients with LRBA deficiency: Correlation with disease severity. Journal of Cellular Physiology 233:11, pages 8767-8777.
Crossref
Gholamreza Azizi, Reza Yazdani, Wiliam Rae, Hassan Abolhassani, Manuel Rojas, Asghar Aghamohammadi & Juan-Manuel Anaya. (2018) Monogenic polyautoimmunity in primary immunodeficiency diseases. Autoimmunity Reviews 17:10, pages 1028-1039.
Crossref
G. Azizi, F. Kiaee, E. Hedayat, R. Yazdani, E. Dolatshahi, T. Alinia, L. Sharifi, H. Mohammadi, H. Kavosi, F. Jadidi-Niaragh, V. Ziaee, H. Abolhassani & A. Aghamohammadi. (2018) Rheumatologic complications in a cohort of 227 patients with common variable immunodeficiency. Scandinavian Journal of Immunology 87:5, pages e12663.
Crossref
Gülsüm Alkan, Sevgi Keles & İsmail Reisli. (2018) Evaluation of Clinical and Immunological Characteristics of Children with Common Variable Immunodeficiency. International Journal of Pediatrics 2018, pages 1-8.
Crossref
A. Valizadeh, R. Yazdani, G. Azizi, H. Abolhassani & A. Aghamohammadi. (2017) A Comparison of Clinical and Immunologic Phenotypes in Familial and Sporadic Forms of Common Variable Immunodeficiency. Scandinavian Journal of Immunology 86:4, pages 239-247.
Crossref
Gholamreza Azizi, Hassan Abolhassani, Seyed Alireza Mahdaviani, Zahra Chavoshzadeh, Peyman Eshghi, Reza Yazdani, Fatemeh Kiaee, Mohammadreza Shaghaghi, Javad Mohammadi, Nima Rezaei, Lennart Hammarström & Asghar Aghamohammadi. (2017) Clinical, immunologic, molecular analyses and outcomes of iranian patients with LRBA deficiency: A longitudinal study. Pediatric Allergy and Immunology 28:5, pages 478-484.
Crossref
Gholamreza Azizi, Mohsen Rastegar Pouyani, Hassan Abolhassani, Laleh Sharifi, Majid Zaki dizaji, Javad Mohammadi, Abbas Mirshafiey & Asghar Aghamohammadi. (2016) Cellular and molecular mechanisms of immune dysregulation and autoimmunity. Cellular Immunology 310, pages 14-26.
Crossref
Gholamreza Azizi, Moslem Ahmadi, Hassan Abolhassani, Reza Yazdani, Hamed Mohammadi, Abbas Mirshafiey, Nima Rezaei & Asghar Aghamohammadi. (2016) Autoimmunity in Primary Antibody Deficiencies. International Archives of Allergy and Immunology 171:3-4, pages 180-193.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.