Advanced search
Publication Cover
Expert Opinion on Drug Discovery Volume 12, 2017 - Issue 10
Submit an article Journal homepage
642
Views
53
CrossRef citations to date
0
Altmetric
Review

Animal inflammation-based models of depression and their application to drug discovery

Li MaNeuroscience Center, HiLIFE, University of Helsinki, Helsinki, FinlandView further author information
,
Konstantin A. DeminUral Federal University, Ekaterinburg, RussiaView further author information
,
Tatyana O. KolesnikovaUral Federal University, Ekaterinburg, RussiaView further author information
,
Sergey L. KharskoUral Federal University, Ekaterinburg, RussiaView further author information
,
Xiaokang ZhuSchool of Pharmaceutical Sciences, Southwest University, Chongqing, ChinaView further author information
,
Xiaodong YuanDepartment of Neurology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, ChinaView further author information
,
Cai SongInstitute for Marine Drugs and Nutrition, Guangdong Ocean University, Zhanjiang, China;Graduate Institute of Biomedical Sciences, College of Medicine, and Department of Medical Research, China Medical University and Hospital, Taichung, TaiwanView further author information
,
Darya A. MeshalkinaInstitute of Translational Biomedicine (ITBM), St. Petersburg State University, St. Petersburg, RussiaView further author information
,
Brian E. LeonardDepartment of Pharmacology, National University of Ireland, Galway, IrelandView further author information
,
Li TianNeuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland;Psychiatry Research Centre, Beijing Huilongguan Hospital, Peking University, Beijing, ChinaCorrespondence[email protected]
View further author information
&
Allan V. KalueffSchool of Pharmaceutical Sciences, Southwest University, Chongqing, China;Institute for Marine Drugs and Nutrition, Guangdong Ocean University, Zhanjiang, China;Institute of Translational Biomedicine (ITBM), St. Petersburg State University, St. Petersburg, Russia;Institute of Chemical Technologies, Ural Federal University, Ekaterinburg, Russia;The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA;ZENEREI Research Center, Slidell, LA, USACorrespondence[email protected]
View further author information
 show all
Pages 995-1009 | Received 27 Apr 2017, Accepted 28 Jul 2017, Published online: 17 Aug 2017

Citations (53)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Hao-Tian Pan, Zi-Qi Xi, Xu-Qiang Wei & Ke Wang. (2022) A network pharmacology approach to predict potential targets and mechanisms of “Ramulus Cinnamomi (cassiae) – Paeonia lactiflora” herb pair in the treatment of chronic pain with comorbid anxiety and depression. Annals of Medicine 54:1, pages 413-425.
Read now
Qinru Sun, Ning Jia, Fei Ren & Xin Li. (2021) Grape seed proanthocyanidins improves depression-like behavior by alleviating oxidative stress and NLRP3 activation in the hippocampus of prenatally-stressed female offspring rats. Journal of Histotechnology 44:2, pages 90-98.
Read now
Konstantin A. Demin, Maxim Sysoev, Maria V. Chernysh, Anna K. Savva, Mamiko Koshiba, Edina A. Wappler-Guzzetta, Cai Song, Murilo S. De Abreu, Brian Leonard, Matthew O. Parker, Brian H. Harvey, Li Tian, Eero Vasar, Tatyana Strekalova, Tamara G. Amstislavskaya, Andrey D. Volgin, Erik T. Alpyshov, Dongmei Wang & Allan V. Kalueff. (2019) Animal models of major depressive disorder and the implications for drug discovery and development. Expert Opinion on Drug Discovery 14:4, pages 365-378.
Read now

Articles from other publishers (50)

Huanhuan Li, Anni Guo, Magdiel Salgado, Juan C. Sáez & Chunyue Geoffrey Lau. (2023) The connexin hemichannel inhibitor D4 produces rapid antidepressant-like effects in mice. Journal of Neuroinflammation 20:1.
Crossref
Yuriy M. Kositsyn, Murilo S. de Abreu, Tatiana O. Kolesnikova, Alexey A. Lagunin, Vladimir V. Poroikov, Hasmik S. Harutyunyan, Konstantin B. Yenkoyan & Allan V. Kalueff. (2023) Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies. International Journal of Molecular Sciences 24:11, pages 9482.
Crossref
Sa’ed H. Zyoud, Muna Shakhshir, Amani S. Abushanab, Amer Koni, Moyad Shahwan, Ammar A. Jairoun & Samah W. Al-Jabi. (2023) Bibliometric mapping of the landscape and structure of nutrition and depression research: visualization analysis. Journal of Health, Population and Nutrition 42:1.
Crossref
Fabiano V. Costa, Tatiana O. Kolesnikova, David S. Galstyan, Nikita P. Ilyin, Murilo S. de Abreu, Elena V. Petersen, Konstantin A. Demin, Konstantin B. Yenkoyan & Allan V. Kalueff. (2023) Current State of Modeling Human Psychiatric Disorders Using Zebrafish. International Journal of Molecular Sciences 24:4, pages 3187.
Crossref
Shrujna Patel, Brooke A. Keating & Russell C. Dale. (2023) Anti-inflammatory properties of commonly used psychiatric drugs. Frontiers in Neuroscience 16.
Crossref
Nasar Ullah Khan Niazi & Song Cai. 2023. Phospholipases in Physiology and Pathology. Phospholipases in Physiology and Pathology 167 188 .
Konstantin A. Demin, Konstantin A. Zabegalov, Tatiana O. Kolesnikova, David S. Galstyan, Yuriy M. H. B. Kositsyn, Fabiano V. Costa, Murilo S. de Abreu & Allan V. Kalueff. 2023. Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders. Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders 91 104 .
Konstantin A. Demin, Nataliya A. Krotova, Nikita P. Ilyin, David S. Galstyan, Tatyana O. Kolesnikova, Tatyana Strekalova, Murilo S. de Abreu, Elena V. Petersen, Konstantin N. Zabegalov & Allan V. Kalueff. (2022) Evolutionarily conserved gene expression patterns for affective disorders revealed using cross-species brain transcriptomic analyses in humans, rats and zebrafish. Scientific Reports 12:1.
Crossref
David S. Galstyan, Tatyana O. Kolesnikova, Yurii M. Kositsyn, Konstantin N. Zabegalov, Mariya A. Gubaidullina, Gleb O. Maslov, Konstantin A. Demin & Allan V. Kalueff. (2022) Despair-like behavior in fish based on the zebrafish (<i>Danio rerio</i>). Reviews on Clinical Pharmacology and Drug Therapy 20:2, pages 157-162.
Crossref
David S. Galstyan, Tatyana O. Kolesnikova, Yurii M. Kositsyn, Konstantin N. Zabegalov, Mariya A. Gubaidullina, Gleb O. Maslov, Konstantin A. Demin, Sergey L. Khatsko & Allan V. Kalueff. (2022) Modeling depression in zebrafish. Reviews on Clinical Pharmacology and Drug Therapy 20:2, pages 149-156.
Crossref
Nina Vindegaard Sørensen, Sonja Orlovska-Waast, Rose Jeppesen, Amalie Wandel Klein-Petersen, Rune Haubo Bojesen Christensen & Michael Eriksen Benros. (2022) Neuroinflammatory Biomarkers in Cerebrospinal Fluid From 106 Patients With Recent-Onset Depression Compared With 106 Individually Matched Healthy Control Subjects. Biological Psychiatry 92:7, pages 563-572.
Crossref
Konstantin A. Demin, Olga V. Kupriyanova, Vadim A. Shevyrin, Ksenia A. Derzhavina, Nataliya A. Krotova, Nikita P. Ilyin, Tatiana O. Kolesnikova, David S. Galstyan, Yurii M. Kositsyn, Abubakar-Askhab S. Khaybaev, Maria V. Seredinskaya, Yaroslav Dubrovskii, Raziya G. Sadykova, Maria O. Nerush, Mikael S. Mor, Elena V. Petersen, Tatyana Strekalova, Evgeniya V. Efimova, Savelii R. Kuvarzin, Konstantin B. Yenkoyan, Dmitrii V. Bozhko, Vladislav O. Myrov, Sofia M. Kolchanova, Aleksander I. Polovian, Georgii K. Galumov & Allan V. Kalueff. (2022) Acute behavioral and Neurochemical Effects of Novel N -Benzyl-2-Phenylethylamine Derivatives in Adult Zebrafish . ACS Chemical Neuroscience 13:13, pages 1902-1922.
Crossref
Cristina Maria de Arruda, Diego Luiz Doneda, Vinícius Vezzi de Oliveira, Rozielly Aparecida Lemes da Silva, Yohan Alves Victor de Matos, Isadora Luiza Fernandes, Christopher Alecsander Herane Rohden, Giordano Gubert Viola, Fabrício Rios-Santos, Eliângela de Lima, Ziliani da Silva Buss & Samuel Vandresen-Filho. (2022) Involvement of kynurenine pathway and N-methyl-d-aspartate receptors in the antidepressant-like effect of vilazodone in the tail suspension test in mice. Pharmacology Biochemistry and Behavior 218, pages 173433.
Crossref
Li-Hua Cao, Yuan-Yuan Zhao, Ming Bai, David Geliebter, Jan Geliebter, Raj Tiwari, Hong-Juan He, Zhen-zhen Wang, Xing-Yuan Jia, Jin Li, Xiu-Min Li & Ming-San Miao. (2022) Mechanistic Studies of Gypenosides in Microglial State Transition and its Implications in Depression-Like Behaviors: Role of TLR4/MyD88/NF-κB Signaling. Frontiers in Pharmacology 13.
Crossref
Nils Kappelmann, Edward Bullmore & Golam Khandaker. 2021. Textbook of Immunopsychiatry. Textbook of Immunopsychiatry 139 163 .
Bommana Raghunath Reddy, Nukala Sarath Babu, Tapatee Das, Dwaipayan Bhattacharya, Ch. Lakshmi N. Murthy, Arvind Kumar, Mohammed M. Idris & Sumana Chakravarty. (2021) Proteome profile of telencephalon associates attenuated neurogenesis with chronic stress induced mood disorder phenotypes in zebrafish model. Pharmacology Biochemistry and Behavior 204, pages 173170.
Crossref
Felipe Dal-Pizzol, Gabriela Ferreira de Medeiros, Monique Michels, Aurélien Mazeraud, Fernando Augusto Bozza, Cristiane Ritter & Tarek Sharshar. (2021) What Animal Models Can Tell Us About Long-Term Psychiatric Symptoms in Sepsis Survivors: a Systematic Review. Neurotherapeutics 18:2, pages 1393-1413.
Crossref
Konstantin A. Demin, Dmitry A. Smagin, Irina L. Kovalenko, Tatyana Strekalova, David S. Galstyan, Tatyana O. Kolesnikova, Murilo S. De Abreu, Anna G. Galyamina, Alim Bashirzade & Allan V. Kalueff. (2021) CNS genomic profiling in the mouse chronic social stress model implicates a novel category of candidate genes integrating affective pathogenesis. Progress in Neuro-Psychopharmacology and Biological Psychiatry 105, pages 110086.
Crossref
Chun-Hong Liu, Ming-Hao Yang, Guang-Zhong Zhang, Xiao-Xu Wang, Bin Li, Meng Li, Marie Woelfer, Martin Walter & Lihong Wang. (2020) Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression. Journal of Neuroinflammation 17:1.
Crossref
Konstantin A. Demin, Anton M. Lakstygal, Nataliya A. Krotova, Alexey Masharsky, Natsuki Tagawa, Maria V. Chernysh, Nikita P. Ilyin, Alexander S. Taranov, David S. Galstyan, Ksenia A. Derzhavina, Nataliia A. Levchenko, Tatiana O. Kolesnikova, Mikael S. Mor, Marina L. Vasyutina, Evgeniya V. Efimova, Nataliia Katolikova, Andrey D. Prjibelski, Raul R. Gainetdinov, Murilo S. de Abreu, Tamara G. Amstislavskaya, Tatyana Strekalova & Allan V. Kalueff. (2020) Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish. Scientific Reports 10:1.
Crossref
Lei Zhang, Chen Liu & Mei Yuan. (2020) Eriodictyol produces antidepressant-like effects and ameliorates cognitive impairments induced by chronic stress. NeuroReport 31:15, pages 1111-1120.
Crossref
Xiaorui Shi, Yuan Gao, Li Song, Penghui Zhao, Yipu Zhang, Yuanjian Ding, Ruoxuan Sun, Yuru Du, Miao Gong, Qiang Gao, Yun Shi, Qingjun Guo & Haishui Shi. (2020) Sulfur dioxide derivatives produce antidepressant- and anxiolytic-like effects in mice. Neuropharmacology 176, pages 108252.
Crossref
Sophie Ouabbou, Ying He, Keith Butler & Ming Tsuang. (2020) Inflammation in Mental Disorders: Is the Microbiota the Missing Link?. Neuroscience Bulletin 36:9, pages 1071-1084.
Crossref
Murilo S. de Abreu, Ana C.V.V. Giacomini, Rafael Genario, Nathália Rech, Júlia Carboni, Anton M. Lakstygal, Tamara G. Amstislavskaya, Konstantin A. Demin, Brian E. Leonard, Marli Vlok, Brian H. Harvey, Angelo Piato, Leonardo J.G. Barcellos & Allan V. Kalueff. (2020) Non-pharmacological and pharmacological approaches for psychiatric disorders: Re-appraisal and insights from zebrafish models. Pharmacology Biochemistry and Behavior 193, pages 172928.
Crossref
Ingrid Prata Mendonça, Eduardo Duarte-Silva, Adriano José Maia Chaves-Filho, Belmira Lara da Silveira Andrade da Costa & Christina Alves Peixoto. (2020) Neurobiological findings underlying depressive behavior in Parkinson’s disease: A review. International Immunopharmacology 83, pages 106434.
Crossref
Yoshiki Matsuda, Nobuyuki Ozawa, Takiko Shinozaki, Ken-ichi Wakabayashi, Kosuke Suzuki, Yusuke Kawano, Iwao Ohtsu & Yoshitaka Tatebayashi. (2020) Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances. Translational Psychiatry 10:1.
Crossref
Jiah Pearson-Leary, Chunyu Zhao, Kyle Bittinger, Darrell Eacret, Sandra Luz, Abigail S. Vigderman, Gabriel Dayanim & Seema Bhatnagar. (2019) The gut microbiome regulates the increases in depressive-type behaviors and in inflammatory processes in the ventral hippocampus of stress vulnerable rats. Molecular Psychiatry 25:5, pages 1068-1079.
Crossref
Konstantin A. Demin, Anton M. Lakstygal, Maria V. Chernysh, Natalia A. Krotova, Aleksandr S. Taranov, Nikita P. Ilyin, Maria V. Seredinskaya, Natsuki Tagawa, Anna K. Savva, Mikael S. Mor, Marina L. Vasyutina, Evgeniya V. Efimova, Tatyana O. Kolesnikova, Raul R. Gainetdinov, Tatyana Strekalova, Tamara G. Amstislavskaya, Murilo S. de Abreu & Allan V. Kalueff. (2020) The zebrafish tail immobilization (ZTI) test as a new tool to assess stress-related behavior and a potential screen for drugs affecting despair-like states. Journal of Neuroscience Methods 337, pages 108637.
Crossref
Abd El Kader Ait Tayeb, Laurent Becquemont, Khalil El‐Asmar, Kaïna Mahmoudi, Romain Colle, Severine Trabado, Florence Gressier, Bruno Feve, Emmanuelle Corruble & Céline Verstuyft. (2020) SOD2 genetic polymorphism (rs4880) has no impact on 6‐month response to antidepressant treatment and inflammatory biomarkers in depressed patients . Basic & Clinical Pharmacology & Toxicology 126:3, pages 289-295.
Crossref
Daan Mes, Arjan P. Palstra, Christiaan V. Henkel, Ian Mayer & Marco A. Vindas. (2020) Swimming exercise enhances brain plasticity in fish. Royal Society Open Science 7:1, pages 191640.
Crossref
Angela J. Grippo. 2020. Cardiovascular Implications of Stress and Depression. Cardiovascular Implications of Stress and Depression 35 60 .
Xinxin Li, Ning Sun, Chunxia Yang, Zhifen Liu, Xinrong Li & Kerang Zhang. (2019) C-Reactive Protein Gene Variants in Depressive Symptoms & Antidepressants Efficacy. Psychiatry Investigation 16:12, pages 940-947.
Crossref
Qianxu Wang, Mengzhen Jia, Yihang Zhao, Yan Hui, Junru Pan, Hongfei Yu, Shikai Yan, Xiaoshuang Dai, Xuebo Liu & Zhigang Liu. (2019) Supplementation of Sesamin Alleviates Stress-Induced Behavioral and Psychological Disorders via Reshaping the Gut Microbiota Structure. Journal of Agricultural and Food Chemistry 67:45, pages 12441-12451.
Crossref
Xi Wang, Zi Xiu, Yuru Du, Yiming Li, Juxiang Yang, Yuan Gao, Fangfang Li, Xi Yin & Haishui Shi. (2019) Brazilin Treatment Produces Antidepressant- and Anxiolytic-Like Effects in Mice. Biological and Pharmaceutical Bulletin 42:8, pages 1268-1274.
Crossref
Solomon Habtemariam. (2019) Antioxidant and Anti-inflammatory Mechanisms of Neuroprotection by Ursolic Acid: Addressing Brain Injury, Cerebral Ischemia, Cognition Deficit, Anxiety, and Depression. Oxidative Medicine and Cellular Longevity 2019, pages 1-18.
Crossref
Anton M. Lakstygal, Tatiana O. Kolesnikova, Sergey L. Khatsko, Konstantin N. Zabegalov, Andrey D. Volgin, Konstantin A. Demin, Vadim A. Shevyrin, Edina A. Wappler-Guzzetta & Allan V. Kalueff. (2018) DARK Classics in Chemical Neuroscience: Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens. ACS Chemical Neuroscience 10:5, pages 2144-2159.
Crossref
Murilo S. de Abreu, Ana C.V.V. Giacomini, Maksim Sysoev, Konstantin A. Demin, Polina A. Alekseeva, Sean T. Spagnoli & Allan V. Kalueff. (2019) Modeling gut-brain interactions in zebrafish. Brain Research Bulletin 148, pages 55-62.
Crossref
Marco A. Vindas, Siri H. Helland-Riise, Göran E. Nilsson & Øyvind Øverli. (2019) Depression-like state behavioural outputs may confer beneficial outcomes in risky environments. Scientific Reports 9:1.
Crossref
Bushra Shal, Adnan Khan, Muhammad Naveed, Naseem Ullah Khan, Ihsan-Ul-Haq, Shakir D AlSharari, Yeong Shik Kim & Salman Khan. (2019) Effect of 25-methoxy hispidol A isolated from Poncirus trifoliate against bacteria-induced anxiety and depression by targeting neuroinflammation, oxidative stress and apoptosis in mice. Biomedicine & Pharmacotherapy 111, pages 209-223.
Crossref
Xu-Ben Yu, Hai-Na Zhang, Ying Dai, Zi-Ye Zhou, Ren-ai Xu, Lu-Feng Hu, Chun-Hong Zhang, Hui-Qin Xu, Yun-Qi An, Cong-Rong Tang & Guan-Yang Lin. (2019) Simvastatin prevents and ameliorates depressive behaviors via neuroinflammatory regulation in mice. Journal of Affective Disorders 245, pages 939-949.
Crossref
Li Jianguo, Jia Xueyang, Wang Cui, Wu Changxin & Qin Xuemei. (2019) Altered gut metabolome contributes to depression-like behaviors in rats exposed to chronic unpredictable mild stress. Translational Psychiatry 9:1.
Crossref
Shuo Yin, Juan Shao, Xinhao Wang, Xi Yin, Wenjing Li, Yuan Gao, Omar Israel Velez de-la-Paz, Haishui Shi & Shuangcheng Li. (2019) Methylene blue exerts rapid neuroprotective effects on lipopolysaccharide-induced behavioral deficits in mice. Behavioural Brain Research 356, pages 288-294.
Crossref
Murilo S. de Abreu, Ashton J. Friend, Konstantin A. Demin, Tamara G. Amstislavskaya, Wandong Bao & Allan V. Kalueff. (2018) Zebrafish models: do we have valid paradigms for depression?. Journal of Pharmacological and Toxicological Methods 94, pages 16-22.
Crossref
Román Darío Moreno-Fernández, Andrea Nieto-Quero, Francisco Javier Gómez-Salas, Jerold Chun, Guillermo Estivill-Torrús, Fernando Rodríguez de Fonseca, Luis Javier Santín, Margarita Pérez-Martín & Carmen Pedraza. (2018) Effects of genetic deletion versus pharmacological blockade of the LPA1 receptor on depression-like behaviour and related brain functional activity. Disease Models & Mechanisms 11:9.
Crossref
Eder Gambeta, Marcio Augusto Batista, Gabriel Paz Maschio, Joelle de Melo Turnes, Erika Ivanna Araya & Juliana Geremias Chichorro. (2018) Anxiety- but not depressive-like behaviors are related to facial hyperalgesia in a model of trigeminal neuropathic pain in rats. Physiology & Behavior 191, pages 131-137.
Crossref
Murilo S. de Abreu, Ana C.V.V. Giacomini, Rodrigo Zanandrea, Bruna E. dos Santos, Rafael Genario, Gabriel G. de Oliveira, Ashton J. Friend, Tamara G. Amstislavskaya & Allan V. Kalueff. (2018) Psychoneuroimmunology and immunopsychiatry of zebrafish. Psychoneuroendocrinology 92, pages 1-12.
Crossref
Konstantin N. Zabegalov, Tatiana O. Kolesnikova, Sergey L. Khatsko, Andrey D. Volgin, Oleg A. Yakovlev, Tamara G. Amstislavskaya, Polina A. Alekseeva, Darya A. Meshalkina, Ashton J. Friend, Wandong Bao, Konstantin A. Demin, Raul R. Gainetdinov & Allan V. Kalueff. (2018) Understanding antidepressant discontinuation syndrome (ADS) through preclinical experimental models. European Journal of Pharmacology 829, pages 129-140.
Crossref
E.H. Taniguti, Y.S. Ferreira, I.J.V. Stupp, E.B. Fraga-Junior, C.B. Mendonça, F.L. Rossi, H.N. Ynoue, D.L. Doneda, L. Lopes, E. Lima, Z.S. Buss & S. Vandresen-Filho. (2018) Neuroprotective effect of melatonin against lipopolysaccharide-induced depressive-like behavior in mice. Physiology & Behavior 188, pages 270-275.
Crossref
Dan J. Stein, Petrus J. Naudé & Michael Berk. (2018) Stress, Depression, and Inflammation: Molecular and Microglial Mechanisms. Biological Psychiatry 83:1, pages 5-6.
Crossref
Ian B. Hickie, Joanne S. Carpenter & Elizabeth M. Scott. 2018. Inflammation and Immunity in Depression. Inflammation and Immunity in Depression 427 443 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.