629
Views
66
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

A systematic review of antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease

, &
Pages 195-211 | Published online: 10 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

. (2021) ALSUntangled 57: Vinpocetine. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 22:3-4, pages 316-319.
Read now
Bedlack Richard. (2021) ALSUntangled 55: vitamin E (α-tocopherol). Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 22:1-2, pages 154-160.
Read now
. (2020) ALSUntangled 53: Carnitine supplements. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 21:5-6, pages 477-483.
Read now
. (2020) ALSUntangled No. 54: “LEAP2BFIT”. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 21:3-4, pages 314-319.
Read now
. (2020) ALSUntangled No. 52: Glutathione. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 21:1-2, pages 154-157.
Read now
Richard Bedlack. (2019) ALSUntangled No. 47: RT001. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 20:3-4, pages 294-297.
Read now
Elisabetta Pupillo, Elisa Bianchi, Adriano Chiò, Federico Casale, Chiara Zecca, Rosanna Tortelli & Ettore Beghi. (2018) Amyotrophic lateral sclerosis and food intake. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 19:3-4, pages 267-274.
Read now
Shyuan T Ngo, Jia D Mi, Robert D Henderson, Pamela A McCombe & Frederik J Steyn. (2017) Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions. Degenerative Neurological and Neuromuscular Disease 7, pages 95-108.
Read now
Verena C Haringer & Summer B Gibson. (2015) Amyotrophic lateral sclerosis: clinical perspectives. Orphan Drugs: Research and Reviews 5, pages 19-31.
Read now
. (2014) ALSUntangled No. 26: Lunasin. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 15:7-8, pages 622-626.
Read now
Martin R. Turner, Robert Bowser, Lucie Bruijn, Luc Dupuis, Albert Ludolph, Michael McGrath, Giovanni Manfredi, Nicholas Maragakis, Robert G. Miller, Seth L. Pullman, Seward B. Rutkove, Pamela J. Shaw, Jeremy Shefner & Kenneth H. Fischbeck. (2013) Mechanisms, models and biomarkers in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 14:sup1, pages 19-32.
Read now
Maria-Carmen Gomez-Cabrera, José Viña & Li Li Ji. (2009) Interplay of Oxidants and Antioxidants During Exercise: Implications for Muscle Health. The Physician and Sportsmedicine 37:4, pages 116-123.
Read now

Articles from other publishers (54)

Nicholas J. Maragakis, Mamede de Carvalho & Michael D. Weiss. (2023) Therapeutic targeting of ALS pathways: Refocusing an incomplete picture . Annals of Clinical and Translational Neurology 10:11, pages 1948-1971.
Crossref
Aida Kamalian, Iman Foroughmand, Lassi Koski, Mahtab Darvish, Amene Saghazadeh, Amirhossein Kamalian, Seyedeh Zahra Emami Razavi, Siamak Abdi, Shahram Rahimi Dehgolan, Akbar Fotouhi & Per M. Roos. (2023) Metal concentrations in cerebrospinal fluid, blood, serum, plasma, hair, and nails in amyotrophic lateral sclerosis: A systematic review and meta-analysis. Journal of Trace Elements in Medicine and Biology 78, pages 127165.
Crossref
Dobrina Tsvetkova, Stefka Ivanova & Danka Obreshkova. (2023)  Neurodegenerative Multioethiology Lou Gehrig’s Disease – Genetic Mutations, Pharmacological Mechanisms and Applications of Rilusole. International Journal of Pharmaceutical Research and Allied Sciences 12:3, pages 61-70.
Crossref
Viviana Moresi, Alessandra Renzini, Giorgia Cavioli, Marilia Seelaender, Dario Coletti, Giuseppe Gigli & Alessia Cedola. (2022) Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy. Metabolites 12:11, pages 1149.
Crossref
Rakesh K. Sindhu, Prabhjot Kaur, Parneet Kaur, Harmanpreet Singh, Gaber El-Saber Batiha & Inderjeet Verma. (2022) Exploring multifunctional antioxidants as potential agents for management of neurological disorders. Environmental Science and Pollution Research 29:17, pages 24458-24477.
Crossref
Liaisan Arslanbaeva & Marco Bisaglia. (2022) Activation of the Nrf2 Pathway as a Therapeutic Strategy for ALS Treatment. Molecules 27:5, pages 1471.
Crossref
Michail S. Kukharsky, Veronika I. Skvortsova, Sergey O. Bachurin & Vladimir L. Buchman. (2020) In a search for efficient treatment for amyotrophic lateral sclerosis: Old drugs for new approaches. Medicinal Research Reviews 41:5, pages 2804-2822.
Crossref
Spiro Menounos, Philip M. Hansbro, Ashish D. Diwan & Abhirup Das. (2021) Pathophysiological Correlation between Cigarette Smoking and Amyotrophic Lateral Sclerosis. NeuroSci 2:2, pages 120-134.
Crossref
Cyril Jones Jagaraj, Sonam Parakh & Julie D. Atkin. (2021) Emerging Evidence Highlighting the Importance of Redox Dysregulation in the Pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Frontiers in Cellular Neuroscience 14.
Crossref
Omar Deeb & Maisa Nabulsi. (2020) Exploring Multiple Sclerosis (MS) and Amyotrophic Lateral Scler osis (ALS) as Neurodegenerative Diseases and their Treatments: A Review Study. Current Topics in Medicinal Chemistry 20:26, pages 2391-2403.
Crossref
Daphne Broadhurst, Marie Cooke, Deepa Sriram & Brenda Gray. (2020) Subcutaneous hydration and medications infusions (effectiveness, safety, acceptability): A systematic review of systematic reviews. PLOS ONE 15:8, pages e0237572.
Crossref
Timothy D. Foley. (2019) Reductive Reprogramming: A Not-So-Radical Hypothesis of Neurodegeneration Linking Redox Perturbations to Neuroinflammation and Excitotoxicity. Cellular and Molecular Neurobiology 39:5, pages 577-590.
Crossref
Juan I. SbodioSolomon H. SnyderBindu D. Paul. (2019) Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities. Antioxidants & Redox Signaling 30:11, pages 1450-1499.
Crossref
Carolina A. Ferreira, Dalong Ni, Zachary T. Rosenkrans & Weibo Cai. (2018) Scavenging of reactive oxygen and nitrogen species with nanomaterials. Nano Research 11:10, pages 4955-4984.
Crossref
Sebastiano Giuseppe Crisafulli, Simona Brajkovic, Maria Sara Cipolat Mis, Valeria Parente & Stefania Corti. (2017) Therapeutic Strategies Under Development Targeting Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis. Molecular Neurobiology 55:4, pages 2789-2813.
Crossref
Leila Bond, Kamren Bernhardt, Priyank Madria, Katherine Sorrentino, Hailee Scelsi & Cassie S. Mitchell. (2018) A Metadata Analysis of Oxidative Stress Etiology in Preclinical Amyotrophic Lateral Sclerosis: Benefits of Antioxidant Therapy. Frontiers in Neuroscience 12.
Crossref
Tommaso Filippini, Bernhard Michalke, Jessica Mandrioli, Aristidis M. Tsatsakis, Jennifer Weuve & Marco Vinceti. 2018. Selenium. Selenium 231 248 .
Loqman A. Mohamed, Shashirekha Markandaiah, Silvia Bonanno, Piera Pasinelli & Davide Trotti. (2017) Blood–Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies. The AAPS Journal 19:6, pages 1600-1614.
Crossref
Joanna Kocot, Dorota Luchowska-Kocot, Małgorzata Kiełczykowska, Irena Musik & Jacek Kurzepa. (2017) Does Vitamin C Influence Neurodegenerative Diseases and Psychiatric Disorders?. Nutrients 9:7, pages 659.
Crossref
Katsuhiko Ono, Minkyung Jung, Tianli Zhang, Hiroyasu Tsutsuki, Hiroshi Sezaki, Hideshi Ihara, Fan-Yan Wei, Kazuhito Tomizawa, Takaaki Akaike & Tomohiro Sawa. (2017) Synthesis of l -cysteine derivatives containing stable sulfur isotopes and application of this synthesis to reactive sulfur metabolome. Free Radical Biology and Medicine 106, pages 69-79.
Crossref
Mehmet Akif Topcuoglu & Ethem Murat Arsava. 2017. Nutrition in Neurologic Disorders. Nutrition in Neurologic Disorders 155 206 .
Masoom Raza Siddiqui, Saikh Mohammad Wabaidur, Mohammad Shamsul Ola, Zeid A. AlOthman, Mohammad Zulfiqar Ali Rafiquee & Moonis Ali Khan. (2016) High-Throughput UPLC–MS Method for the Determination of N -Acetyl-l-Cysteine: Application in Tissue Distribution Study in Wistar Rats . Journal of Chromatographic Science 54:7, pages 1244-1252.
Crossref
Hideyuki J. Majima, Hiroko P. Indo, Ikuo Nakanishi, Shigeaki Suenaga, Ken-ichiro Matsumoto, Hirofumi Matsui, Yukiko Minamiyama, Hiroshi Ichikawa, Hsiu-Chuan Yen, Clare L. Hawkins, Michael J. Davies, Toshihiko Ozawa & Daret K. St Clair. (2016) Chasing great paths of Helmut Sies “Oxidative Stress”. Archives of Biochemistry and Biophysics 595, pages 54-60.
Crossref
Brittany M. Edens, Nimrod Miller & Yong-Chao Ma. (2016) Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration. Frontiers in Cellular Neuroscience 10.
Crossref
Diane Moujalled & Anthony R. White. (2016) Advances in the Development of Disease-Modifying Treatments for Amyotrophic Lateral Sclerosis. CNS Drugs 30:3, pages 227-243.
Crossref
Natalia Niedziela, Monika Adamczyk-Sowa, Jacek T. Niedziela, Bogdan Mazur, Ewa Kluczewska, Paweł Sowa & Mariusz Gąsior. (2016) Assessment of Serum Nitrogen Species and Inflammatory Parameters in Relapsing-Remitting Multiple Sclerosis Patients Treated with Different Therapeutic Approaches. BioMed Research International 2016, pages 1-11.
Crossref
Izaskun Buendia, Patrycja Michalska, Elisa Navarro, Isabel Gameiro, Javier Egea & Rafael León. (2016) Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacology & Therapeutics 157, pages 84-104.
Crossref
Emma L. Scotter, Han-Jou Chen & Christopher E. Shaw. (2015) TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets. Neurotherapeutics 12:2, pages 352-363.
Crossref
Kristopher G. Hooten, David R. Beers, Weihua Zhao & Stanley H. Appel. (2015) Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis. Neurotherapeutics 12:2, pages 364-375.
Crossref
Zamanzima Mazibuko, Yahya E. Choonara, Pradeep Kumar, Lisa C. Du Toit, Girish Modi, Dinesh Naidoo & Viness Pillay. (2015) A Review of the Potential Role of Nano-Enabled Drug Delivery Technologies in Amyotrophic Lateral Sclerosis: Lessons Learned from Other Neurodegenerative Disorders. Journal of Pharmaceutical Sciences 104:4, pages 1213-1229.
Crossref
Anna M. Fan & Marco Vinceti. 2015. Hamilton & Hardy's Industrial Toxicology. Hamilton & Hardy's Industrial Toxicology 205 228 .
Carolina Allers, Janet A Jones, Gabriel P Lasala & José J Minguell. (2014) Mesenchymal stem cell therapy for the treatment of amyotrophic lateral sclerosis: signals for hope?. Regenerative Medicine 9:5, pages 637-647.
Crossref
Steve Vucic, Jeffrey D. Rothstein & Matthew C. Kiernan. (2014) Advances in treating amyotrophic lateral sclerosis: insights from pathophysiological studies. Trends in Neurosciences 37:8, pages 433-442.
Crossref
Ernesto Miquel, Adriana Cassina, Laura Martínez-Palma, José M. Souza, Carmen Bolatto, Sebastián Rodríguez-Bottero, Angela Logan, Robin A.J. Smith, Michael P. Murphy, Luis Barbeito, Rafael Radi & Patricia Cassina. (2014) Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis. Free Radical Biology and Medicine 70, pages 204-213.
Crossref
Cristina Cleide dos Santos Salvioni, Patricia Stanich, Claudinéa S. Almeida & Acary Souza Bulle Oliveira. (2014) Nutritional care in motor neurone disease/ amyotrophic lateral sclerosis. Arquivos de Neuro-Psiquiatria 72:2, pages 157-163.
Crossref
Akshay Anand, Keshav Thakur & Pawan Kumar Gupta. (2013) ALS and Oxidative Stress: The Neurovascular Scenario. Oxidative Medicine and Cellular Longevity 2013, pages 1-14.
Crossref
Sonam Parakh, Damian M. Spencer, Mark A. Halloran, Kai Y. Soo & Julie D. Atkin. (2013) Redox Regulation in Amyotrophic Lateral Sclerosis. Oxidative Medicine and Cellular Longevity 2013, pages 1-12.
Crossref
Takuya Kanno, Kazunori Tanaka, Yoshiko Yanagisawa, Kaori Yasutake, Shinji Hadano, Fumihito Yoshii, Noriaki Hirayama & Joh-E Ikeda. (2012) A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2–ARE pathway: Therapeutic implications for ALS. Free Radical Biology and Medicine 53:11, pages 2028-2042.
Crossref
Jin Hee Shin, Young Ae Lee, Jae Keun Lee, Yong Beom Lee, Woong Cho, Doo Soon Im, Jin Hwan Lee, Bok Sun Yun, Joe E. Springer & Byoung Joo Gwag. (2012) Concurrent blockade of free radical and microsomal prostaglandin E synthase‐1‐mediated PGE 2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis . Journal of Neurochemistry 122:5, pages 952-961.
Crossref
Maria Carolina O. Rodrigues, Júlio C. Voltarelli, Paul R. Sanberg, Cesario V. Borlongan & Svitlana Garbuzova-Davis. (2012) Immunological Aspects in Amyotrophic Lateral Sclerosis. Translational Stroke Research 3:3, pages 331-340.
Crossref
Helen NightingaleKevin KempElizabeth GrayKelly HaresElizabeth MallamNeil ScoldingAlastair Wilkins. (2012) Changes in Expression of the Antioxidant Enzyme SOD3 Occur Upon Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells In Vitro. Stem Cells and Development 21:11, pages 2026-2035.
Crossref
Risa Isonaka, Hiromi Hiruma, Takashi Katakura & Tadashi Kawakami. (2011) Inhibition of superoxide dismutase selectively suppresses growth of rat spinal motor neurons: Comparison with phosphorylated neurofilament-containing spinal neurons. Brain Research 1425, pages 13-19.
Crossref
Peter I. Joyce, Pietro Fratta, Elizabeth M. C. Fisher & Abraham Acevedo-Arozena. (2011) SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments. Mammalian Genome 22:7-8, pages 420-448.
Crossref
Mario David Cordero, Manuel de Miguel & Ana María Moreno-Fernández. (2011) La disfunción mitocondrial en la fibromialgia y su implicación en la patogénesis de la enfermedad. Medicina Clínica 136:6, pages 252-256.
Crossref
Mari Carmen Gomez-Cabrera, Fabian Sanchis-Gomar, Vladimir Essau Martinez-Bello, Sandra Ibanez-Sania, Ana Lucia Nascimento, Li Li Ji & Jose Vina. 2011. Studies on Experimental Models. Studies on Experimental Models 531 542 .
Richard S Bedlack. (2010) Amyotrophic lateral sclerosis: current practice and future treatments. Current Opinion in Neurology 23:5, pages 524-529.
Crossref
Uzma I. Zakai, Galina Bikzhanova, Daryl Staveness, Stephen Gately & Robert West. (2009) Synthesis of lipophilic sila derivatives of N ‐acetylcysteineamide, a cell permeating thiol . Applied Organometallic Chemistry 24:3, pages 189-192.
Crossref
Luc Dupuis. (2009) Oxidative stress sensitivity in ALS muscle cells. Experimental Neurology 220:2, pages 219-223.
Crossref
. (2009) Current World Literature. Current Opinion in Neurology 22:5, pages 554-561.
Crossref
Daniele Orsucci, Massimiliano Filosto, Gabriele Siciliano & Michelangelo Mancuso. (2009) Electron transfer mediators and other metabolites and cofactors in the treatment of mitochondrial dysfunction. Nutrition Reviews 67:8, pages 427-438.
Crossref
Barrie J. CarterPervin AnklesariaStephanie ChoiJohn F. Engelhardt. (2009) Redox Modifier Genes and Pathways in Amyotrophic Lateral Sclerosis. Antioxidants & Redox Signaling 11:7, pages 1569-1586.
Crossref
Ryosuke Takahashi. (2009) Edaravone in ALS. Experimental Neurology 217:2, pages 235-236.
Crossref
Hussni O. Mohammed, Simon R. Starkey, Korona Stipetic, Thomas J. Divers, Brian A. Summers & Alexander de Lahunta. (2008) The Role of Dietary Antioxidant Insufficiency on the Permeability of the Blood-Brain Barrier. Journal of Neuropathology & Experimental Neurology 67:12, pages 1187-1193.
Crossref
Zachary Simmons. (2008) What's in the Literature?. Journal of Clinical Neuromuscular Disease 10:2, pages 70-75.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.