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Amyotrophic Lateral Sclerosis Volume 9, 2008 - Issue 4
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ORIGINAL ARTICLE

A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS

Paul H. Gordon From the Departments of Neurology, , , , , USACorrespondence[email protected]
,
Ying-Kuen Cheung Biostatistics, Columbia University, , New York, , USA
,
Bruce Levin Biostatistics, Columbia University, , New York, , USA
,
Howard Andrews Biostatistics, Columbia University, , New York, , USA
,
Carolyn Doorish From the Departments of Neurology, , , , , USA
,
Robert B. Macarthur Research Pharmacy, , , , USA
,
Jacqueline Montes From the Departments of Neurology, , , , , USA
,
Kate Bednarz From the Departments of Neurology, , , , , USA
,
Julaine Florence Washington University, , Montana, , USA
,
Julie Rowin University of Illinois, , Illinois, , USA
,
Kevin Boylan Mayo Clinic Jacksonville, , Florida, , USA
,
Tahseen Mozaffar University of California Irvine, , California, , USA
,
Rup Tandan University of Vermont, , Vermont, , USA
,
Hiroshi Mitsumoto From the Departments of Neurology, , , , , USA
,
Elizabeth A. Kelvin Biostatistics, Columbia University, , New York, , USA
,
John Chapin University of New Mexico, , New Mexico, , USA
,
Richard Bedlack Duke University, , , , USA
,
Michael Rivner Medical College of Georgia, , Georgia, , USA
,
Leo F. Mccluskey University of Pennsylvania, , Pennsylvania, , USA
,
Alan Pestronk Washington University, , Montana, , USA
,
Michael Graves University of California Los Angeles, , California, , USA
,
Eric J. Sorenson Mayo Clinic Rochester, , Minnesota, , USA
,
Richard J. Barohn University of Kansas, , Kansas, , USA
,
Jerry M. Belsh UMDNJ-Robert Wood Johnson Medical School, , New Jersey, , USA
,
Jau-Shin Lou Oregon Health and Science University, , Oregon, , USA
,
Todd Levine Phoenix Neurological Associates, , Arizona, , USA
,
David Saperstein Phoenix Neurological Associates, , Arizona, , USA
,
Robert G. Miller California Pacific Medical Center, , California, , USA
,
Stephen N. Scelsa Departments of Neurology, Beth Israel Medial Center, , New York, , USA
&
The Combination Drug Selection Trial Study Group From the Departments of Neurology, , , , , USA
 show all
Pages 212-222 | Received 12 Mar 2008, Published online: 10 Jul 2009

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Suma Babu, Eric A. Macklin, Katherine E. Jackson, Elizabeth Simpson, Katy Mahoney, Hong Yu, Jason Walker, Zachary Simmons, William S. David, Paul E. Barkhaus, Laura Simionescu, Mazen M. Dimachkie, Alan Pestronk, Johnny S. Salameh, Michael D. Weiss, Benjamin Rix Brooks, David Schoenfeld, Jeremy Shefner, Swati Aggarwal, Merit E. Cudkowicz & Nazem Atassi. (2020) Selection design phase II trial of high dosages of tamoxifen and creatine in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 21:1-2, pages 15-23.
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Bello Hamidou, Benoit Marin, Geraldine Lautrette, Marie Nicol, William Camu, Philippe Corcia, Marie-Christine Arnes-Bes, Christine Tranchant, Pierre Clavelou, Didier Hannequin, Giroud Maurice, Katell Beauvais, Jean-Christophe Antoine, Véronique Danel-Brunaud, Fausto Viader, Pierre-Marie Preux & Philippe Couratier. (2017) Exploring the diagnosis delay and ALS functional impairment at diagnosis as relevant criteria for clinical trial enrolment*. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 18:7-8, pages 519-527.
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H Blasco, F Patin, CR Andres, P Corcia & PH Gordon. (2016) Amyotrophic Lateral Sclerosis, 2016: existing therapies and the ongoing search for neuroprotection. Expert Opinion on Pharmacotherapy 17:12, pages 1669-1682.
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Abigail DeLoach, Michael Cozart, Arianna Kiaei & Mahmoud Kiaei. (2015) A retrospective review of the progress in amyotrophic lateral sclerosis drug discovery over the last decade and a look at the latest strategies. Expert Opinion on Drug Discovery 10:10, pages 1099-1118.
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Robert M. Nelson, Michelle Roth-Cline, Kevin Prohaska, Edward Cox, Luciana Borio & Robert Temple. (2015) Right Job, Wrong Tool: A Commentary on Designing Clinical Trials for Ebola Virus Disease. The American Journal of Bioethics 15:4, pages 33-36.
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Philippe Corcia & Paul H Gordon. (2012) Amyotrophic lateral sclerosis and the clinical potential of dexpramipexole. Therapeutics and Clinical Risk Management 8, pages 359-366.
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Ali Aamer Habib & Hiroshi Mitsumoto. (2011) Emerging drugs for amyotrophic lateral sclerosis. Expert Opinion on Emerging Drugs 16:3, pages 537-558.
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Benjamin C. Cheah, Steve Vucic, Arun V. Krishnan, Robert A. Boland & Matthew C. Kiernan. (2011) Neurophysiological index as a biomarker for ALS progression: Validity of mixed effects models. Amyotrophic Lateral Sclerosis 12:1, pages 33-38.
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Merit E. Cudkowicz, Jon Katz, Dan H. Moore, Gilmore O’neill, Jonathan D. Glass, Hiroshi Mitsumoto, Stanley Appel, Bernard Ravina, Karl Kieburtz, Ira Shoulson, Petra Kaufmann, Jaffar Khan, Ericka Simpson, Jeremy Shefner, Bruce Levin, Valerie Cwik, David Schoenfeld, Swati Aggarwal, Michael P. McDermott & Robert G. Miller. (2010) Toward more efficient clinical trials for amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis 11:3, pages 259-265.
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Stefano Zoccolella, Andrea Santamato & Paolo Lamberti. (2009) Current and emerging treatments for amyotrophic lateral sclerosis. Neuropsychiatric Disease and Treatment 5, pages 577-595.
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Hari Manev & Radmila Manev. (2009) Interactions with GluR1 AMPA receptors could influence the therapeutic usefulness of minocycline in ALS. Amyotrophic Lateral Sclerosis 10:5-6, pages 416-417.
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Paul H. Gordon, Ying-Kuen Cheung, Bruce Levin, Howard Andrews & Hiroshi Mitsumoto. (2009) Response to commentary on a novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS. Amyotrophic Lateral Sclerosis 10:1, pages 61-61.
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