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OncoImmunology Volume 7, 2018 - Issue 11
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Original Research

Whole cell melanoma vaccine genetically modified to stem cells like phenotype generates specific immune responses to ALDH1A1 and long-term survival in advanced melanoma patients

Eliza Kwiatkowska-Borowczyka Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland;b Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, Poznan, PolandORCID Iconhttps://orcid.org/0000-0003-1620-7965View further author information
ORCID Icon,
Patrycja Czerwińskaa Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland;b Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, Poznan, PolandORCID Iconhttps://orcid.org/0000-0003-2400-1174View further author information
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Jacek Mackiewiczb Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, Poznan, Poland;c Department of Medical and Experimental Oncology, Heliodor Swiecicki University Hospital, Poznan University of Medical Sciences, Poznan, PolandView further author information
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Katarzyna Gryskaa Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, PolandView further author information
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Urszula Kazimierczaka Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, PolandView further author information
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Katarzyna Tomelaa Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, PolandORCID Iconhttps://orcid.org/0000-0002-3622-7229View further author information
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Anna Przybyłaa Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, PolandView further author information
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Anna Karolina Kozłowskaa Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, PolandORCID Iconhttps://orcid.org/0000-0003-2465-217XView further author information
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Łukasz Galusc Department of Medical and Experimental Oncology, Heliodor Swiecicki University Hospital, Poznan University of Medical Sciences, Poznan, Poland;d Department of Chemotherapy, Greater Poland Cancer Centre, Poznan, PolandView further author information
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Łukasz Kwintad Department of Chemotherapy, Greater Poland Cancer Centre, Poznan, PolandView further author information
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Ewelina Dondajewskaa Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, PolandORCID Iconhttps://orcid.org/0000-0001-9078-2015View further author information
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Agnieszka Gąbka-Buszeka Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, PolandView further author information
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Monika Żakowskaa Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, PolandORCID Iconhttps://orcid.org/0000-0003-4657-4352View further author information
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Andrzej Mackiewicza Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland;b Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, Poznan, PolandCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8570-0863View further author information
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Article: e1509821 | Received 07 May 2018, Accepted 04 Aug 2018, Published online: 24 Aug 2018

Citations (12)

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Patrycja Czerwinska, Marcin Rucinski, Nikola Wlodarczyk, Anna Jaworska, Iga Grzadzielewska, Katarzyna Gryska, Lukasz Galus, Jacek Mackiewicz & Andrzej Mackiewicz. (2020) Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6. OncoImmunology 9:1.
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Articles from other publishers (11)

Zhilei Zhang, Yonghua Wang, Zhijuan Liang, Zhaoyuan Meng, Xiangyan Zhang, Guofeng Ma, Yuanbin Chen, Mingxin Zhang, Yinjie Su, Zhiqiang Li, Ye Liang & Haitao Niu. (2023) Modification of lysine-260 2-hydroxyisobutyrylation destabilizes ALDH1A1 expression to regulate bladder cancer progression. iScience 26:11, pages 108142.
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Mariusz Kaczmarek, Justyna Poznańska, Filip Fechner, Natasza Michalska, Sara Paszkowska, Adrianna Napierała & Andrzej Mackiewicz. (2023) Cancer Vaccine Therapeutics: Limitations and Effectiveness—A Literature Review. Cells 12:17, pages 2159.
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Hui Luo, Zhehao Xiao, Cheng Huang, Wei Wu & Qingbin Xie. (2023) ERCC6 plays a promoting role in the progression of non-small cell lung cancer. Biochemistry and Cell Biology 101:3, pages 246-258.
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Katarzyna Tomela, Bernadeta Pietrzak, Łukasz Galus, Jacek Mackiewicz, Marcin Schmidt, Andrzej Adam Mackiewicz & Mariusz Kaczmarek. (2023) Myeloid-Derived Suppressor Cells (MDSC) in Melanoma Patients Treated with Anti-PD-1 Immunotherapy. Cells 12:5, pages 789.
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Chen Xue, Ganglei Li, Qiuxian Zheng, Xinyu Gu, Zhengyi Bao, Juan Lu & Lanjuan Li. (2022) The functional roles of the circRNA/Wnt axis in cancer. Molecular Cancer 21:1.
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Xiaoyi Hu, Weilin Zhou, Ruyu Pi, Xia Zhao & Wei Wang. (2022) Genetically modified cancer vaccines: Current status and future prospects. Medicinal Research Reviews 42:4, pages 1492-1517.
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Hanxun Yue, Zenan Hu, Rui Hu, Zeying Guo, Ya Zheng, Yuping Wang & Yongning Zhou. (2022) ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory Mechanism. Frontiers in Oncology 12.
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Ioan Ovidiu Sirbu, Aimée Rodica Chiş & Alexander Radu Moise. (2020) Role of carotenoids and retinoids during heart development. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865:11, pages 158636.
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Agnieszka Gąbka-Buszek, Eliza Kwiatkowska-Borowczyk, Jakub Jankowski, Anna Karolina Kozłowska & Andrzej Mackiewicz. (2020) Novel Genetic Melanoma Vaccines Based on Induced Pluripotent Stem Cells or Melanosphere-Derived Stem-Like Cells Display High Efficacy in a murine Tumor Rejection Model. Vaccines 8:2, pages 147.
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Anastas Pashov & Thomas Kieber-Emmons. 2019. Cancer Immunotherapy and Biological Cancer Treatments. Cancer Immunotherapy and Biological Cancer Treatments.
Jacek Mackiewicz, Tomasz Burzykowski, Dariusz Iżycki & Andrzej Mackiewicz. (2018) Re-induction using whole cell melanoma vaccine genetically modified to melanoma stem cells-like beyond recurrence extends long term survival of high risk resected patients - updated results. Journal for ImmunoTherapy of Cancer 6:1.
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