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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Volume 21, 2020 - Issue 1-2
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Clinical Trials

Selection design phase II trial of high dosages of tamoxifen and creatine in amyotrophic lateral sclerosis

Suma Babu1 Department of Neurology, Sean M Healey & AMG Center for ALS at Massachusetts General Hospital, Neurological Clinical Research Institute, Boston, MA, USA, Correspondence[email protected]
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,
Eric A. Macklin2 Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, View further author information
,
Katherine E. Jackson3 Office of the Prescription Drug Monitoring Program, Maryland Department of Health, Baltimore, MD, USA, View further author information
,
Elizabeth Simpson4 McCance Center for Brain Health at Massachusetts General Hospital, Boston, MA, USA, View further author information
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Katy Mahoney1 Department of Neurology, Sean M Healey & AMG Center for ALS at Massachusetts General Hospital, Neurological Clinical Research Institute, Boston, MA, USA, View further author information
,
Hong Yu1 Department of Neurology, Sean M Healey & AMG Center for ALS at Massachusetts General Hospital, Neurological Clinical Research Institute, Boston, MA, USA, View further author information
,
Jason Walker1 Department of Neurology, Sean M Healey & AMG Center for ALS at Massachusetts General Hospital, Neurological Clinical Research Institute, Boston, MA, USA, View further author information
,
Zachary Simmons5 Penn State Health Hershey Medical Center, Hershey, PA, USA, View further author information
,
William S. David1 Department of Neurology, Sean M Healey & AMG Center for ALS at Massachusetts General Hospital, Neurological Clinical Research Institute, Boston, MA, USA, View further author information
,
Paul E. Barkhaus6 Medical College of Wisconsin, Milwaukee, WI, USA, View further author information
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Laura Simionescu7 SUNY Upstate Medical Center, Syracuse, NY, USA, View further author information
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Mazen M. Dimachkie8 University of Kansas Medical Center, Kansas City, KS, USA, View further author information
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Alan Pestronk9 Washington University School of Medicine, St. Louis, MO, USA, View further author information
,
Johnny S. Salameh10 American University of Beirut Medical Center, Beirut, Lebanon, View further author information
,
Michael D. Weiss11 University of Washington Medical Center, Seattle, WA, USA, View further author information
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Benjamin Rix Brooks12 Atrium Health Neurosciences Institute, Carolinas Medical Center, University of North Carolina School of Medicine, Charlotte, NC, USA, andView further author information
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David Schoenfeld2 Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA, View further author information
,
Jeremy Shefner13 Barrow Neurological Institute and University of Arizona College of Medicine, Phoenix, AZ, USAView further author information
,
Swati Aggarwal1 Department of Neurology, Sean M Healey & AMG Center for ALS at Massachusetts General Hospital, Neurological Clinical Research Institute, Boston, MA, USA, View further author information
,
Merit E. Cudkowicz1 Department of Neurology, Sean M Healey & AMG Center for ALS at Massachusetts General Hospital, Neurological Clinical Research Institute, Boston, MA, USA, View further author information
&
Nazem Atassi1 Department of Neurology, Sean M Healey & AMG Center for ALS at Massachusetts General Hospital, Neurological Clinical Research Institute, Boston, MA, USA, View further author information
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Pages 15-23 | Received 18 Jan 2019, Accepted 16 Sep 2019, Published online: 14 Oct 2019

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Richard Bedlack, Sky Kihuwa-mani, Paul E. Barkhaus, Michael Bereman, James B. Caress, Jesse Crayle, Gary L. Pattee, Terry Heiman Patterson, Paul Wicks, Neta Zach, Gregory T. Carter & Kristiana Salmon. (2021) ALSUntangled 59: Tamoxifen. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 22:7-8, pages 595-598.
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Helene Blasco, Debora Lanznaster, Charlotte Veyrat-Durebex, Rudolf Hergesheimer, Patrick Vourch, Francois Maillot, Christian R. Andres, Pierre-François Pradat & Phillipe Corcia. (2020) Understanding and managing metabolic dysfunction in Amyotrophic Lateral Sclerosis. Expert Review of Neurotherapeutics 20:9, pages 907-919.
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Ruben P. A. van Eijk & Angela Genge. (2020) The rise of innovative clinical trial designs: what’s in it for amyotrophic lateral sclerosis?. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 21:1-2, pages 3-4.
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Articles from other publishers (8)

Nicholas J. Maragakis, Mamede de Carvalho & Michael D. Weiss. (2023) Therapeutic targeting of ALS pathways: Refocusing an incomplete picture . Annals of Clinical and Translational Neurology 10:11, pages 1948-1971.
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Victoria Maneu, Pedro Lax, Antonio Miguel G. De Diego, Nicolás Cuenca & Antonio G. García. (2022) Combined drug triads for synergic neuroprotection in retinal degeneration. Biomedicine & Pharmacotherapy 149, pages 112911.
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Megan Dubowsky, Stephanie R Shepheard & Mary-Louise Rogers. 2022. Handbook of Neurotoxicity. Handbook of Neurotoxicity 1893 1929 .
Megan Dubowsky, Stephanie R Shepheard & Mary-Louise Rogers. 2021. Handbook of Neurotoxicity. Handbook of Neurotoxicity 1 37 .
Isabella Orienti, Monica Armida, Gabriella Dobrowolny, Rita Pepponi, Gabriella Sollazzini, Antonella Pezzola, Irene Casola, Antonio Musarò, Patrizia Popoli & Rosa Luisa Potenza. (2021) Fenretinide Beneficial Effects on Amyotrophic Lateral Sclerosis-associated SOD1G93A Mutant Protein Toxicity: In Vitro and In Vivo Evidences. Neuroscience 473, pages 1-12.
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Silvia Scaricamazza, Illari Salvatori, Alberto Ferri & Cristiana Valle. (2021) Skeletal Muscle in ALS: An Unappreciated Therapeutic Opportunity?. Cells 10:3, pages 525.
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Matthew C. Kiernan, Steve Vucic, Kevin Talbot, Christopher J. McDermott, Orla Hardiman, Jeremy M. Shefner, Ammar Al-Chalabi, William Huynh, Merit Cudkowicz, Paul Talman, Leonard H. Van den Berg, Thanuja Dharmadasa, Paul Wicks, Claire Reilly & Martin R. Turner. (2020) Improving clinical trial outcomes in amyotrophic lateral sclerosis. Nature Reviews Neurology 17:2, pages 104-118.
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Suma Babu, Baileigh G. Hightower, James Chan, Nicole R. Zürcher, Pia Kivisäkk, Chieh-En J. Tseng, Danica L. Sanders, Ashley Robichaud, Haruhiko Banno, Armineuza Evora, Akshata Ashokkumar, Lindsay Pothier, Sabrina Paganoni, Sheena Chew, Joanna Dojillo, Kazuko Matsuda, Mark Gudesblatt, James D. Berry, Merit E. Cudkowicz, Jacob M Hooker & Nazem Atassi. (2021) Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial. NeuroImage: Clinical 30, pages 102672.
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