Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Volume 21, Issue 1-2 (2020)

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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Volume 21, Issue 1-2 (2020)

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Editorials

Editorial
In pursuit of the normal progressor: the holy grail for ALS clinical trial design?
Ruben P. A. van Eijk & Leonard H. van Den Berg
Pages: 1-2
Published online: 11 Oct 2019
CitationforIn pursuit of the normal progressor: the holy grail for ALS clinical trial design? | Full Text | References | PDF (179 KB) | EPUB
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Editorial
The rise of innovative clinical trial designs: what’s in it for amyotrophic lateral sclerosis?
Ruben P. A. van Eijk & Angela Genge
Pages: 3-4
Published online: 29 Oct 2019
CitationforThe rise of innovative clinical trial designs: what’s in it for amyotrophic lateral sclerosis? | Full Text | References | PDF (120.2 KB) | EPUB
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Clinical Trials

Article
Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial
Jesus S. Mora, Angela Genge, Adriano Chio, Conrado J. Estol, Delia Chaverri, Maria Hernández, Saúl Marín, Javier Mascias, Gabriel E. Rodriguez, Monica Povedano, Andrés Paipa, Raul Dominguez, Josep Gamez, Maria Salvado, Christian Lunetta, Carlos Ballario, Nilo Riva, Jessica Mandrioli, Alain Moussy, Jean-Pierre Kinet, Christian Auclair, Patrice Dubreuil, Vincent Arnold, Colin D. Mansfield, Olivier Hermine & on behalf of the AB10015 STUDY GROUP
Pages: 5-14
Published online: 07 Jul 2019
AbstractforMasitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial | Full Text | References | PDF (811.7 KB) | EPUB | Supplemental
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Open Access
Article
Selection design phase II trial of high dosages of tamoxifen and creatine in amyotrophic lateral sclerosis
Suma Babu, Eric A. Macklin, Katherine E. Jackson, Elizabeth Simpson, Katy Mahoney, Hong Yu, Jason Walker, Zachary Simmons, William S. David, Paul E. Barkhaus, Laura Simionescu, Mazen M. Dimachkie, Alan Pestronk, Johnny S. Salameh, Michael D. Weiss, Benjamin Rix Brooks, David Schoenfeld, Jeremy Shefner, Swati Aggarwal, Merit E. Cudkowicz & Nazem Atassi
Pages: 15-23
Published online: 14 Oct 2019
AbstractforSelection design phase II trial of high dosages of tamoxifen and creatine in amyotrophic lateral sclerosis | Full Text | References | PDF (612.4 KB) | EPUB | Supplemental
  • 418 Views
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Clinical

Article
The revised El Escorial criteria “clinically probable laboratory supported ALS”—once a promising now a superfluous category?
Nathalie Braun, Eric A. Macklin, Ervin Sinani, Alexander Sherman, Markus Weber & the Pooled Resource Open-Access ALS Clinical Trials Consortium
Pages: 24-28
Published online: 27 Sep 2019
AbstractforThe revised El Escorial criteria “clinically probable laboratory supported ALS”—once a promising now a superfluous category? | Full Text | References | PDF (297.7 KB) | EPUB
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Article
Twelve-month duration as an appropriate criterion for flail arm syndrome
Lu Chen, Lu Tang & Dongsheng Fan
Pages: 29-33
Published online: 16 Sep 2019
AbstractforTwelve-month duration as an appropriate criterion for flail arm syndrome | Full Text | References | PDF (260.7 KB) | EPUB
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Article
A speech measure for early stratification of fast and slow progressors of bulbar amyotrophic lateral sclerosis: lip movement jitter
Panying Rong, Yana Yunusova, Marziye Eshghi, Hannah P. Rowe & Jordan R. Green
Pages: 34-41
Published online: 07 Nov 2019
AbstractforA speech measure for early stratification of fast and slow progressors of bulbar amyotrophic lateral sclerosis: lip movement jitter | Full Text | References | PDF (525.7 KB) | EPUB | Supplemental
  • 292 Views
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Article
Reliability and validity of speech & pause measures during passage reading in ALS
Carolina Barnett, Jordan R. Green, Reeman Marzouqah, Kaila L. Stipancic, James D. Berry, Lawrence Korngut, Angela Genge, Christen Shoesmith, Hannah Briemberg, Agessandro Abrahao, Sanjay Kalra, Lorne Zinman & Yana Yunusova
Pages: 42-50
Published online: 06 Dec 2019
AbstractforReliability and validity of speech & pause measures during passage reading in ALS | Full Text | References | PDF (638.2 KB) | EPUB | Supplemental
  • 572 Views
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Article
HSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accumulation
Alessandro Arosio, Riccardo Cristofani, Orietta Pansarasa, Valeria Crippa, Chiara Riva, Riccardo Sirtori, Virginia Rodriguez-Menendez, Nilo Riva, Francesca Gerardi, Christian Lunetta, Cristina Cereda, Angelo Poletti, Carlo Ferrarese, Lucio Tremolizzo & Gessica Sala
Pages: 51-62
Published online: 30 Oct 2019
AbstractforHSC70 expression is reduced in lymphomonocytes of sporadic ALS patients and contributes to TDP-43 accumulation | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Article
CSF angiogenin levels in amyotrophic lateral Sclerosis-Frontotemporal dementia spectrum
C. Morelli, C. Tiloca, C. Colombrita, A. Zambon, D. Soranna, A. Lafronza, F. Solca, L. Carelli, B. Poletti, A. Doretti, F. Verde, L. Maderna, N. Ticozzi, A. Ratti & V. Silani
Pages: 63-69
Published online: 18 Dec 2019
AbstractforCSF angiogenin levels in amyotrophic lateral Sclerosis-Frontotemporal dementia spectrum | Full Text | References | PDF (240.3 KB) | EPUB | Supplemental
  • 298 Views
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Article
Respiratory measurements and airway clearance device prescription over one year in amyotrophic lateral sclerosis
R. Tattersall, D. Murray, M Heverin, J. Rooney, K. Tobin, R. Vance, O. Hardiman & D. Meldrum
Pages: 70-77
Published online: 11 Dec 2019
AbstractforRespiratory measurements and airway clearance device prescription over one year in amyotrophic lateral sclerosis | Full Text | References | PDF (766.9 KB) | EPUB
  • 450 Views
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Cognition

Article
The Edinburgh cognitive and behavioral amyotrophic lateral sclerosis screen (ECAS): sensitivity in differentiating between ALS and Alzheimer’s disease in a Greek population
Panagiotis Kourtesis, Foteini Christidi, Eleni Margioti, Christina Demenega, Michail Rentzos, Ioannis Evdokimidis & Sharon Abrahams
Pages: 78-85
Published online: 30 Aug 2019
AbstractforThe Edinburgh cognitive and behavioral amyotrophic lateral sclerosis screen (ECAS): sensitivity in differentiating between ALS and Alzheimer’s disease in a Greek population | Full Text | References | PDF (507.1 KB) | EPUB | Supplemental
  • 425 Views
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Article
Equivalency and practice effects of alternative versions of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS)
Emmet Costello, Katie Lonergan, Caoifa Madden, Meadhbh O’Sullivan, Iain Mays, Mark Heverin, Marta Pinto-Grau, Orla Hardiman & Niall Pender
Pages: 86-91
Published online: 13 Dec 2019
AbstractforEquivalency and practice effects of alternative versions of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS) | Full Text | References | PDF (810.2 KB) | EPUB | Supplemental
  • 224 Views
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Article
The clinical impact of the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) and neuropsychological intervention in routine ALS care
Faith Hodgins, Sharon Mulhern & Sharon Abrahams
Pages: 92-99
Published online: 15 Oct 2019
AbstractforThe clinical impact of the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) and neuropsychological intervention in routine ALS care | Full Text | References | PDF (262.6 KB) | EPUB | Supplemental
  • 492 Views
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Article
Behavioral manifestations in a Brazilian non-demented C9orf72-negative ALS population
Lucas M. T. Branco, Tamires A. Zanao, Thiago J. R. de Rezende, Isabela B. B. Paraguay, Tauana B. Leoni, Marcio Luiz F. Balthazar & Marcondes C. FranÇa Jr.
Pages: 100-106
Published online: 24 Dec 2019
AbstractforBehavioral manifestations in a Brazilian non-demented C9orf72-negative ALS population | Full Text | References | PDF (471.2 KB) | EPUB
  • 216 Views
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Epidemiology

Article
Is the incidence of motor neuron disease higher in French military personnel?
Tim Vlaar, Alexis Elbaz & Frédéric Moisan
Pages: 107-115
Published online: 17 Oct 2019
AbstractforIs the incidence of motor neuron disease higher in French military personnel? | Full Text | References | PDF (738.2 KB) | EPUB | Supplemental
  • 170 Views
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Article
An epidemiological profile of dysarthria incidence and assistive technology use in the living population of people with MND in Scotland
Elizabeth Elliott, Judith Newton, Phillipa Rewaj, Jenna M. Gregory, Lynda Tomarelli, Shuna Colville, Siddharthan Chandran, Suvankar Pal & On behalf of the Care-Mnd Consortium
Pages: 116-122
Published online: 09 Oct 2019
AbstractforAn epidemiological profile of dysarthria incidence and assistive technology use in the living population of people with MND in Scotland | Full Text | References | PDF (341.2 KB) | EPUB | Supplemental
  • 904 Views
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Article
Atlanta metropolitan area amyotrophic lateral sclerosis (ALS) surveillance: incidence and prevalence 2009–2011 and survival characteristics through 2015
Reshma Punjani, Laurie Wagner, Kevin Horton & Wendy Kaye
Pages: 123-130
Published online: 04 Dec 2019
AbstractforAtlanta metropolitan area amyotrophic lateral sclerosis (ALS) surveillance: incidence and prevalence 2009–2011 and survival characteristics through 2015 | Full Text | References | PDF (204.8 KB) | EPUB
  • 1928 Views
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Open Access
Article
Epidemiological and clinical features of amyotrophic lateral sclerosis in a Tunisian cohort
Imen Kacem, Ikram Sghaier, Sabrine Bougatef, Amina Nasri, Amina Gargouri, Senda Ajroud-Driss & Riadh Gouider
Pages: 131-139
Published online: 20 Dec 2019
AbstractforEpidemiological and clinical features of amyotrophic lateral sclerosis in a Tunisian cohort | Full Text | References | PDF (402.9 KB) | EPUB
  • 333 Views
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Short Reports

Report
Stage-specific riluzole effect in amyotrophic lateral sclerosis: a retrospective study
Nimish J. Thakore, Brittany R. Lapin, Erik P. Pioro & Pooled Resource Open-Access Als Clinical Trials Consortium
Pages: 140-143
Published online: 27 Aug 2019
AbstractforStage-specific riluzole effect in amyotrophic lateral sclerosis: a retrospective study | Full Text | References | PDF (650.7 KB) | EPUB
  • 464 Views
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Report
Adult onset Sandhoff disease: a rare mimicker of amyotrophic lateral sclerosis
Maria Khoueiry, Elia Malek & Johnny S. Salameh
Pages: 144-146
Published online: 12 Sep 2019
AbstractforAdult onset Sandhoff disease: a rare mimicker of amyotrophic lateral sclerosis | Full Text | References | PDF (111.8 KB) | EPUB
  • 203 Views
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Report
Progressive deterioration of sensory cortex excitability in advanced amyotrophic lateral sclerosis with invasive ventilation
Toshio Shimizu, Yuki Nakayama, Asuka Funai, Ryo Morishima, Kentaro Hayashi, Kota Bokuda, Yasuhiro Nakata & Eiji Isozaki
Pages: 147-149
Published online: 18 Dec 2019
AbstractforProgressive deterioration of sensory cortex excitability in advanced amyotrophic lateral sclerosis with invasive ventilation | Full Text | References | PDF (485.3 KB) | EPUB
  • 254 Views
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ALS Untangled

ALSUntangled 51: RCH4
The ALSUntangled Group
Pages: 150-153
Published online: 10 Oct 2019
First Page PreviewforALSUntangled 51: RCH4 | Full Text | References | PDF (142.6 KB) | EPUB
  • 3184 Views
  • 1 CrossRef citations
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Free Access
ALSUntangled No. 52: Glutathione
THE ALSUNTANGLED GROUP
Pages: 154-157
Published online: 29 Nov 2019
First Page PreviewforALSUntangled No. 52: Glutathione | Full Text | References | PDF (124.6 KB) | EPUB
  • 5621 Views
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Free Access

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