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The Journal of Maternal-Fetal & Neonatal Medicine Volume 11, 2002 - Issue 3
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(RG) Obstetrics and Gynaecology

Mutations in the factor V, prothrombin and MTHFR genes are not risk factors for recurrent fetal loss

A. Dilley Division of AIDS, STD, and Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA
,
C. Benito Division of Maternal- Fetal Medicine, Department of Obstetrics and Gynecology, UMDNJ - Robert Wood J ohnson Medical School, New Brunswick, New J ersey, USA
,
W. C. Hooper Division of AIDS, STD, and Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA
,
H. Austin Division of AIDS, STD, and Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA; Department of Epidemiology, Rollins School of Public Health of Emory University, Atlanta, Georgia, USA
,
C. Miller Division of AIDS, STD, and Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA
,
M. El-Jamil Division of AIDS, STD, and Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA; Department of Epidemiology, Rollins School of Public Health of Emory University, Atlanta, Georgia, USA
,
S. Cottrell Division of AIDS, STD, and Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA
,
J. Benson Division of AIDS, STD, and Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA
,
B. L. Evatt Division of AIDS, STD, and Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA
,
A. Patterson-Barnett Northside Women’s Specialists, Atlanta, Georgia, USA
,
D. Eller Northside Women’s Specialists, Atlanta, Georgia, USA
&
C. Philipp Division of Hematology, UMDNJ - Robert Wood J ohnson Medical School, New Brunswick, New J ersey, USA
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Pages 176-182 | Published online: 07 Jul 2009

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Britt J. P. Kos, Shalem Y. Leemaqz, Catherine D. McCormack, Prabha H. Andraweera, Denise L. Furness, Claire T. Roberts & Gustaaf A. Dekker. (2020) The association of parental methylenetetrahydrofolate reductase polymorphisms (MTHFR 677C > T and 1298A > C) and fetal loss: a case–control study in South Australia. The Journal of Maternal-Fetal & Neonatal Medicine 33:5, pages 752-757.
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Gian Carlo di Renzo. (2002) Editorial. The Journal of Maternal-Fetal & Neonatal Medicine 11:3, pages 145-145.
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Articles from other publishers (26)

Yuanjia Wen, Haodong He & Kai Zhao. (2023) Thrombophilic gene polymorphisms and recurrent pregnancy loss: a systematic review and meta-analysis. Journal of Assisted Reproduction and Genetics 40:7, pages 1533-1558.
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Anna Paola Capra, Alessio Ardizzone, Silvana Briuglia, Maria Angela La Rosa, Stefania Mondello, Michela Campolo & Emanuela Esposito. (2022) A Systematic Review and Meta-Analysis of the Association between the FV H1299R Variant and the Risk of Recurrent Pregnancy Loss. Biology 11:11, pages 1608.
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F. U. Ramazanova, V. E. Radzinsky, M. B. Khamoshina, M. M. Azova & A. Ismailova. (2022) Role of polymorphic loci <i>VDR</i> rs10735810, <i>MTHFR</i> rs1801131, <i>MTHFR</i> rs1801133, <i>MTR</i> rs1805087,<i> MTRR</i> rs1801394 AND <i>VEGFA</i> rs3025039 in missed abortion: A prospective cohort study. Kuban Scientific Medical Bulletin 29:3, pages 46-61.
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Xiaoling Liu, Yan Chen, Changxiang Ye, Dexiu Xing, Rong Wu, Fang Li, Lizhang Chen & Tingting Wang. (2021) Hereditary thrombophilia and recurrent pregnancy loss: a systematic review and meta-analysis. Human Reproduction 36:5, pages 1213-1229.
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Yan ZhangWenli ZhanQianyi DuLi WuHongke DingFenghua LiuAihua Yin. (2020) Variants c.677 C>T, c.1298 A>C in MTHFR , and c.66 A>G in MTRR Affect the Occurrence of Recurrent Pregnancy Loss in Chinese Women . Genetic Testing and Molecular Biomarkers 24:11, pages 717-722.
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R R N ReddyDeepti MutrejaNikhil Moorchung & Indrayani Mukhopadhyay. (2019) Recurrent pregnancy loss: can factor V Leiden mutations be a cause. Obstetrics & Gynecology Science 62:3, pages 179.
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Yunlei Cao, Jianhua Xu, Zhaofeng Zhang, Xianliang Huang, Aiping Zhang, Jian Wang, Qiupeng Zheng, Lingyuan Fu & Jing Du. (2013) Association study between methylenetetrahydrofolate reductase polymorphisms and unexplained recurrent pregnancy loss: A meta-analysis. Gene 514:2, pages 105-111.
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John A. Heit. 2013. Consultative Hemostasis and Thrombosis. Consultative Hemostasis and Thrombosis 205 239 .
Farah Idali, Said Zareii, Afsane Mohammad-Zadeh, Fakhreddin Reihany-Sabet, Zoreh Akbarzadeh-Pasha, Hamid-Reza Khorram-Khorshid, Amir-Hassan Zarnani & Mahmood Jeddi-Tehrani. (2012) Plasminogen Activator Inhibitor 1 and Methylenetetrahydrofolate Reductase Gene mutations in Iranian Women with Polycystic Ovary Syndrome. American Journal of Reproductive Immunology 68:5, pages 400-407.
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Xiaoming WuLanjun ZhaoHui ZhuDajian HeWenru TangYing Luo. (2012) Association Between the MTHFR C677T Polymorphism and Recurrent Pregnancy Loss: A Meta-Analysis . Genetic Testing and Molecular Biomarkers 16:7, pages 806-811.
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Fátima Serrano, Maria Luísa Lima, Cristina Lopes, João Paulo Almeida & Jorge Branco. (2011) Factor V Leiden and prothrombin G20210A in Portuguese women with recurrent miscarriage: is it worthwhile to investigate?. Archives of Gynecology and Obstetrics 284:5, pages 1127-1132.
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Mahmood Jeddi-Tehrani, Raheleh Torabi, Amir H. Zarnani, Afsaneh Mohammadzadeh, Soheila Arefi, Hojjat Zeraati, Mohammad M. Akhondi, Leili Chamani-Tabriz, Farah Idali, Shaghayegh Emami & Saeed Zarei. (2011) Analysis of Plasminogen Activator Inhibitor-1, Integrin Beta3, Beta Fibrinogen, and Methylenetetrahydrofolate Reductase Polymorphisms in Iranian Women with Recurrent Pregnancy Loss. American Journal of Reproductive Immunology 66:2, pages 149-156.
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Silke MonienOliver Kadecki, Susanne Baumgarten, Abdulgabar Salama, Thomas Dörner & Holger Kiesewetter. (2009) Use of Heparin in Women With Early and Late Miscarriages With and Without Thrombophilia. Clinical and Applied Thrombosis/Hemostasis 15:6, pages 636-644.
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C. Ciacci, R. Tortora, O. Scudiero, R. Di Fiore, F. Salvatore & G. Castaldo. (2009) Early pregnancy loss in celiac women: The role of genetic markers of thrombophilia. Digestive and Liver Disease 41:10, pages 717-720.
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Charles J. Lockwood & Robert M. Silver. 2009. Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice. Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice 825 854 .
Bettina Toth, Franziska Vocke, Nina Rogenhofer, Klaus Friese, Christian J. Thaler & Peter Lohse. (2008) ORIGINAL ARTICLE: Paternal Thrombophilic Gene Mutations Are Not Associated with Recurrent Miscarriage. American Journal of Reproductive Immunology 60:4, pages 325-332.
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John A. Heit. 2007. Consultative Hemostasis and Thrombosis. Consultative Hemostasis and Thrombosis 211 244 .
Harold Fox & Neil J. Sebire. 2007. Pathology of the Placenta. Pathology of the Placenta 277 302 .
Aiguo Ren & Juan Wang. (2006) Methylenetetrahydrofolate reductase C677T polymorphism and the risk of unexplained recurrent pregnancy loss: A meta-analysis. Fertility and Sterility 86:6, pages 1716-1722.
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Linda Sharp, Zosia Miedzybrodzka, Amanda H. Cardy, Julie Inglis, Londale Madrigal, Simon Barker, David Chesney, Caroline Clark & Nicola Maffulli. (2006) The C677T Polymorphism in the Methylenetetrahydrofolate Reductase Gene (MTHFR), Maternal Use of Folic Acid Supplements, and Risk of Isolated Clubfoot: A Case-Parent-Triad Analysis. American Journal of Epidemiology 164:9, pages 852-861.
Crossref
Salim Sehirali, M. Murat Inal, Yusuf Yildirim, Zuhal Balim, Buket Kosova, Tulin Karamizrak, Muzaffer Sanci, Nejat Topcuoglu & Sivekar Tinar. (2005) Prothrombin G20210A mutation in cases with recurrent miscarriage: a study of the mediterranean population. Archives of Gynecology and Obstetrics 273:3, pages 170-173.
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F.M. van Dunné, C.J.M. Doggen, M. Heemskerk, F.R. Rosendaal & F.M. Helmerhorst. (2005) Factor V Leiden mutation in relation to fecundity and miscarriage in women with venous thrombosis. Human Reproduction 20:3, pages 802-806.
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Ineke Krabbendam, Arie Franx, Michiel L. Bots, Rob Fijnheer & Hein W. Bruinse. (2005) Thrombophilias and recurrent pregnancy loss: a critical appraisal of the literature. European Journal of Obstetrics & Gynecology and Reproductive Biology 118:2, pages 143-153.
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Charles J. Glueck, Ping Wang, Naila Goldenberg & Luann Sieve. (2016) Pregnancy Loss, Polycystic Ovary Syndrome, Thrombophilia, Hypofibrinolysis, Enoxaparin, Metformin. Clinical and Applied Thrombosis/Hemostasis 10:4, pages 323-334.
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M. Marietta, F. Facchinetti, L. Sgarbi, L. Simoni, M. Bertesi, G. Torelli & A. Volpe. (2003) Elevated plasma levels of factor VIII in women with early recurrent miscarriage. Journal of Thrombosis and Haemostasis 1:12, pages 2536-2539.
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Charles J Glueck, Ping Wang, Seref Bornovali, Naila Goldenberg & Luann Sieve. (2003) Polycystic ovary syndrome, the G1691A factor V Leiden mutation, and plasminogen activator inhibitor activity: associations with recurrent pregnancy loss. Metabolism 52:12, pages 1627-1632.
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