65
Views
28
CrossRef citations to date
0
Altmetric
(RG) Obstetrics and Gynaecology

Mutations in the factor V, prothrombin and MTHFR genes are not risk factors for recurrent fetal loss

, , , , , , , , , , & show all
Pages 176-182 | Published online: 07 Jul 2009

References

  • Timbers KA, Feinberg RF. Recurrent pregnancy loss: a review. Nurse Pract 1997;8:77–88
  • Stirrat GM. Recurrent miscarriage [see comments] I: defini-tion and epidemiology. Lancet 1990;336:673–5
  • Stephenson MD. Frequency of factors ass oc iated with habitual abortion in 197 couples. Fertil Steril 1996;66:24–9
  • Ansari AH, Kirkpatrick B. Recurrent pregnancy loss. An update. J Reprod Med 1998;43:806–14
  • Bick RL, Madden J, Heller KB, et al. Recurrent miscarriage: causes, evaluation, and treatment. Medscape Womens Health 1998;3:2
  • Kutteh WH. Recurrent pregnancy loss: an update. Curr Opin Obstet Gynecol 1999;11:435–9
  • Rand JH, Wu X-X, Andree HAM, et al. Pregnancy loss in the ant iphosphol ip id syndrome — a possible thrombogenic mecha-nism. N Engl J Med 1997;337:154–60
  • Letsky E., Swiet M. Maternal hemostasis: coagulation prob-lems of pregnancy. In Lascalzo J, Schafer A, eds. Thrombosis and Hemorrhage. Boston: Blackwell Scientific 1994:965–98
  • Preston FE, Rosendaal FR, Walker ID, et al. Increased fetal loss in women with heritable thrombophilia. Lancet 1996;348: 913–16
  • Kupferminc MJ, Eldor A, Steinman N, et al. Increased fre-quency of genetic thrombophilia in women with complica-tions of pregnancy [see comments]. [Published erratum appears in N Engl J Med 1999;341:384]. [Comment in: N Engl J Med 1999;340:50-2.] N Engl J Med 1999;340: 9–13
  • Greengard JS, Sun X, Xu X, et al. Activated protein C resistance caused by Arg50601n mutation in factor Va. Lancet 1994;343:1361
  • Bertina RM, Koelman BPC, Koster T, et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature (London) 1994;369:64–7
  • Koster T, Rosendaal FR, De Ronder H, et al. Venous thrombo-sis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet 1993;342:1503–6
  • Ridker PM, Hennekens CH, Lindpainter K, et al. Mutation in the gene coding for coagulation factor V and the risk of myo-cardial infarction, stroke, and venous thrombosis. N Engl J Med 1995;332:912–17
  • Grandone E, Margaglione M, Colaizzo D, et al. Genetic sus-ceptibility to pregnancy-related venous thromboembolism: roles of factor V Leiden, prothrombin 020210A, and methyl-ene te trahydrofolate reductase C677T mutations. Am J Obstet Gynecol 1998;179:1324–8
  • Dilley A, Austin H, El-Jamil M, et al. Genetic factors associ-ated with thrombosis in pregnancy in a United States popula-tion. Am J Obstet Gynecol 2000;183:1271–7
  • Dizon-Townson DS, Meline L, Nelson LM, et al. Fetal carriers of the FV Leiden mutation are prone to miscarriage and placental infarction. Am J Obstet Gynecol 1997;177:402–5
  • Ridker PM, MiletichJP, Bur ing JE, et al. FV Leiden mutation as a risk factor for recurrent pregnancy loss. Ann Intern Med 1998;128:1000–3
  • Kutteh WH, Park VM, Deitcher SR. Hypercoagulable state mutation analysis in white patients with early first-trimester recurrent pregnancy loss. Fertil S ter il 1999;71:1048–53
  • Dulicek P, Chrobak L, Kalousek I, et al. Is FV Leiden a risk factor for recurrent fetal loss? Acta Med 1999;42:93–6
  • Dizon-Townson DS, Kinney S, Branch DW, et al. The FV Leiden mutation is not a common cause of recurrent mis-carriage. J Reprod Immunol 1997;34:217–23
  • Grandone E, Margaglione M, Colaizzo D, et al. FV Leiden is associated with repeated and recurrent unexplained fetal losses. Thromb Haemost 1997;77:822–4
  • Zivelin A, Rosenberg N, Faier S, et at. A single genetic origin for the common prothrombotic 020210A polymorphism in
  • Brenner B, Sang 0, Weiner Z, et at. Thrombophilic polymor-phisms are common in women with fetal loss without apparent
  • Foka ZJ, Lambropoulos AF, Saravelos H, et al. FV Leiden and prothrombin 020210A mutations, but not methylenetetra-hydrofolate reductase C677T, are associated with recurrent
  • Frosst P, Blom HJ, Milos R, et at. A candidate genetic risk factor for vascular disease: a common mutation in methylene-
  • Fermo I, D’Angelo SV, Paroni R, et al. Prevalence of moderate hyperhomocysteinema in patients with early-onset venous and arterial occlusive disease. Ann Intern Med 1995;123: 747–53
  • Den Heijer M, Koster T, Blom HJ, et at. Hyperhomocystein-emia as a risk factor for deep-vein thrombosis. N Engl J Med 1996;334:759–62
  • Lissak A, Sharon A, Fruchter 0, et at. Polymorphism for muta-tion of cytosine to thymine at location 677 in the methyl-enetetrahydrofolate reductase gene is associated with recurrent early fetal loss. Am J Obstet Gynecol 1999;181: 126–30
  • Holmes ZR, Regan L, Chilcott I, et at. The C67 7T MTHFR gene mutation is not predictive of risk for recurrent fetal loss. Br J Haematol 1999;105:98–101
  • Murphy RP, Donoghue C, Nallen RJ, et al. Prospective evalua-tion of the risk conferred by FV Leiden and thermolabile methylenetetrahydrofolate reductase polymorphisms in preg-nancy. Arterioscler Thromb V asc Biol 2000;20:266-70 Orandone E, Margaglione M, Colaizzo D, et at. Methylene tetrahydrofolate reductase (MTHFR) 677T—>C mutation and unexplained early pregnancy loss [letter]. Thromb Haemost 1998;79: 1056–7
  • Grandone E, Margaglione M, Colaizzo D, et al. Methylene tetrahydrofolatereductase(MTHFR) 677T®C mutation and unexplained early pregnancy loss [letter]. Thromb Haemost 1998;79:1056–7
  • Durnwald CP, Flora R, Agamanolis D, et at. Hereditary thrombophilia as a cause of fetal loss. Obstet Gynecol 2000; 95 ( Suppl): 11S–12S
  • Martin D, Austin H. An efficient programfor computing con-ditional maximum likelihood estimates and exact confidence limits for a common odds ratio. Epidemiology 1991;2:359–62
  • Lindqvist PO, Svensson PJ, Dahlback B, et at. Factor V Q506 mutation (activated protein C resistance) associated with reduced intrapartum blood loss - a possible evolutionary mechanism. Thromb Haemost 1998;79:69–73
  • Lindqvist PO, Svensson PJ, Marsaal K, et al. Activated protein C resistance (FV:Q506) and pregnancy. Thromb Haemost 1999;81:532–7
  • Zinaman MJ, Clegg ED, Brown CC, et at. Estimates of human fertility and pregnancy loss. Fertil Steril 1996;65:503–9
  • Younis JS, Brenner B, Ohel 0, et at. Activated protein C resistance and factor V Leiden mutation can be as sociatedwith first as well as second-trimester recurrent pregnancy loss. AJRI 2000;43:31-5 39.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.