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Research Article

Oral or Intravenous N-Acetylcysteine: Which Is the Treatment of Choice for Acetaminophen (Paracetamol) Poisoning?

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Pages 759-767 | Published online: 18 Nov 2004

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Slobodan M. Janković. (2022) Acetaminophen toxicity and overdose: current understanding and future directions for NAC dosing regimens. Expert Opinion on Drug Metabolism & Toxicology 18:11, pages 745-753.
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J. C. Lewis, M. Lim, L. Lai, E. Mendoza, T. E. Albertson & J. A. Chenoweth. (2022) Evaluation of N-acetylcysteine dose for the treatment of massive acetaminophen ingestion. Clinical Toxicology 60:4, pages 507-513.
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Robert G. Hendrickson. (2019) What is the most appropriate dose of N-acetylcysteine after massive acetaminophen overdose?. Clinical Toxicology 57:8, pages 686-691.
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Angela L. Chiew, Geoffrey K. Isbister, Katharine A. Kirby, Colin B. Page, Betty S. H. Chan & Nicholas A. Buckley. (2017) Massive paracetamol overdose: an observational study of the effect of activated charcoal and increased acetylcysteine dose (ATOM-2). Clinical Toxicology 55:10, pages 1055-1065.
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Mahmoud Hussein Hassan Ali, Basim Anwar Shehata Messiha & Hekma Abdel-Tawab Abdel-Latif. (2016) Protective effect of ursodeoxycholic acid, resveratrol, and N-acetylcysteine on nonalcoholic fatty liver disease in rats. Pharmaceutical Biology 54:7, pages 1198-1208.
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M. J. Hodgman. (2014) Seeking a role, Psi and APAP×AT as acetaminophen risk assessment tools. Clinical Toxicology 52:5, pages 451-453.
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S. B. Duffull & G. K. Isbister. (2013) Predicting the requirement for N-acetylcysteine in paracetamol poisoning from reported dose. Clinical Toxicology 51:8, pages 772-776.
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Wendy Klein-Schwartz & Suzanne Doyon. (2011) Intravenous acetylcysteine for the treatment of acetaminophen overdose. Expert Opinion on Pharmacotherapy 12:1, pages 119-130.
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Jay L. Martello, Tara L. Pummer & Edward P. Krenzelok. (2010) Cost minimization analysis comparing enteral N-acetylcysteine to intravenous acetylcysteine in the management of acute acetaminophen toxicity. Clinical Toxicology 48:1, pages 79-83.
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Albert Marchetti & Richard Rossiter. (2009) Managing acute acetaminophen poisoning with oral versus intravenous N-acetylcysteine: a provider-perspective cost analysis. Journal of Medical Economics 12:4, pages 384-391.
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E.A. Sandilands & D.N. Bateman. (2009) Adverse reactions associated with acetylcysteine. Clinical Toxicology 47:2, pages 81-88.
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Ian M. Whyte, Barbara Francis & Andrew H. Dawson. (2007) Safety and efficacy of intravenous N‐acetylcysteine for acetaminophen overdose: analysis of the Hunter Area Toxicology Service (HATS) database. Current Medical Research and Opinion 23:10, pages 2359-2368.
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Marco L. A Sivilotti, Angela M. Good, Mark C. Yarema, David N. Juurlink & David W. Johnson. (2005) A New Predictor of Toxicity Following Acetaminophen Overdose Based on Pretreatment Exposure. Clinical Toxicology 43:4, pages 229-234.
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Ian M. Whyte, Nicholas A. Buckley & Andrew H. Dawson. (2002) Data Collection in Clinical Toxicology: Are There Too Many Variables?*. Journal of Toxicology: Clinical Toxicology 40:3, pages 223-230.
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Nicholas A. Buckley, Nicholas Buckley, Ian M Whyte, Dianne L O'Connell & Andrew H Dawson. (1999) Activated Charcoal Reduces the Need for N-Acetylcysteine Treatment After Acetaminophen (Paracetamol) Overdose. Journal of Toxicology: Clinical Toxicology 37:6, pages 753-757.
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Articles from other publishers (88)

Nafiseh Alizadeh, Amir‐Mohammad Yaryari, Amir Hossein Behnoush, Kosar Raoufinejad & Behnam Behnoush. (2023) Late N ‐acetylcysteine for successful recovery of acetaminophen‐related acute liver failure: A case report . Clinical Case Reports 11:9.
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Anna Licata, Maria Giovanna Minissale, Simona Stankevičiūtė, Judith Sanabria-Cabrera, Maria Isabel Lucena, Raul J Andrade & Piero Luigi Almasio. (2022) N-Acetylcysteine for Preventing Acetaminophen-Induced Liver Injury: A Comprehensive Review. Frontiers in Pharmacology 13.
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Wen Gao, Lin Guo, Yan Yang, Yu Wang, Shuang Xia, Hui Gong, Bi-Kui Zhang & Miao Yan. (2022) Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity. Frontiers in Cell and Developmental Biology 9.
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Jephte Y. Akakpo, Anup Ramachandran, Steven C. Curry, Barry H. Rumack & Hartmut Jaeschke. (2022) Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. Archives of Toxicology 96:2, pages 453-465.
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John Rague. 2022. History of Modern Clinical Toxicology. History of Modern Clinical Toxicology 201 212 .
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Apu Chowdhury, Jahan Nabila, Isaac Adelusi Temitope & Sicen Wang. (2020) Current etiological comprehension and therapeutic targets of acetaminophen-induced hepatotoxicity. Pharmacological Research 161, pages 105102.
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D. Nicholas Bateman & James W. Dear. (2019) Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use. Toxicology Research 8:4, pages 489-498.
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