Oral or Intravenous N-Acetylcysteine: Which Is the Treatment of Choice for Acetaminophen (Paracetamol) Poisoning?

REFERENCES

• Prescott L F, Illingworth R N, Critchley J AJH, Stewart M J, Adam R D. Proudfoot AT. Intravenous N-acetylcysteine: The treatment of choice for paracetamol poisoning. Br Med J 1979; 2: 1097–1100
   PubMed Web of Science ®Google Scholar
• Smilkstein M J, Knapp G L, Kulig K W, Rumack B H. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose: Analysis of the national multicenter study (1976 to 1985). N Engl J Med 1988; 319: 1557–1562
   PubMed Web of Science ®Google Scholar
• Rumack B H, Peterson R G. Acetaminophen overdose: Incidence, diagnosis and management in 416 patients. Pediatrics 1978; 62: 898–903
   PubMed Web of Science ®Google Scholar
• Ekins B R, Ford D C, Thompson M I, et al. The effect of activated charcoal on N-acetylcysteine absorption in normal subjects. Am J Emerg Med 1987; 5: 483–487
   PubMed Web of Science ®Google Scholar
• Parker D, White J P, Paton D, Routledge P A. Safety of late acetylcysteine treatment in paracetamol poisoning. Hum Exp Toxicol 1990; 9: 25–27
   PubMed Web of Science ®Google Scholar
• Harrison P M, Keays R, Bray G P, Alexander G JM, Williams R. Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine. Lancet 1990; 335: 1572–1573
   PubMed Web of Science ®Google Scholar
• Harrison P M, Wendon J A, Gimson A ES, Alexander G JM, Williams R. Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. N Engl J Med 1991; 324: 1852–1857
   PubMed Web of Science ®Google Scholar
• Buckley N A, Dawson A H, Whyte I M, McManus P, Ferguson N. Six years of self-poisoning in Newcastle 1987–1992. Med J Aust 1995; 162: 190–193
   PubMed Web of Science ®Google Scholar
• Rumack B H, Peterson R C, Koch G G, Amara I A. Acetaminophen overdose: 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med 1981; 141: 380–385
   PubMed Web of Science ®Google Scholar
• Der Simonian R, Laird N. Meta-analysis in clinical trials. Cont Clin Trials 1986; 7: 177–188
   PubMedGoogle Scholar
• Smilkstein M J, Bronstein A C, Linden C, Augenstein W L, Kulig K W, Rumack B H. Acetaminophen overdose: A 48-hour intravenous N-acetylcysteine treatment protocol. Ann Emerg Med 1991; 20: 1058–1063
   PubMed Web of Science ®Google Scholar
• Oh T E, Shenfield G M. Intravenous N-Acetylcysteine for paracetamol poisoning. Med J Aust 1980; 1: 664–665
   PubMed Web of Science ®Google Scholar
• Prescott L F, Donovan J W, Jarvie D R, Proudfoot A T. The disposition and kinetics of intravenous N-Acetylcysteine in patients with paracetamol overdosage. Eur J Clin Pharmacol 1989; 37: 501–506
   PubMed Web of Science ®Google Scholar
• Beckett G J, Donovan J W, Hussey A J, Proudfoot A T, Prescott L F. Intravenous N-acetylcysteine, hepatotoxicity and plasma glutathione S-transferase in patients with paracetamol overdosage. Hum Exp Toxicol 1990; 9: 183–186
   PubMed Web of Science ®Google Scholar
• Beckett G J, Foster G R, Hussey A J, et al. Plasma glutathione S-transferase and F protein are more sensitive than alanine aminotransferase as markers of paracetamol (acetaminophen)-induced liver damage. Clin Chem 1989; 35: 2186–2189
   PubMed Web of Science ®Google Scholar
• Chan T YK. Critchley JAJH. Adverse reactions to intravenous N-acetylcysteine in Chinese patients with paracetamol (acetaminophen) poisoning. Hum Exp Toxicol 1994; 13: 542–544
   PubMed Web of Science ®Google Scholar
• Chan T YK, Chan A YW. Critchley JAJH. Paracetamol poisoning and hepatotoxicity in Chinese—The Prince of Wales Hospital (Hong Kong) experience. Singapore Med J 1993; 34: 299–302
   PubMedGoogle Scholar
• Riggs B S, Bronstein A C, Kulig K, Archer P G, Rumack B H. Acute acetaminophen overdose during pregnancy. Obstet Gynaecol 1989; 74: 247–253
   PubMed Web of Science ®Google Scholar
• Perry H E, Shannon M W. Efficacy of oral versus intravenous N-acetylcysteine in acetaminophen overdose: Results of an open-label, clinical trial. J Pediatr 1998; 132: 149–152
   PubMed Web of Science ®Google Scholar
• Singer A J, Carracio T R, Mofenson H C. The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction. Ann Emerg Med 1995; 26: 49–53
   PubMed Web of Science ®Google Scholar
• Oren R, Levy M. Paracetamol overdose in Jerusalem, 1984–89. Isr J Med Sci 1992; 28: 795–796
   PubMedGoogle Scholar
• Levy M, Oren R. Paracetamol overdose in Jerusalem. Isr J Med Sci 1985; 21: 36–39
   PubMedGoogle Scholar
• Brotodihardjo A E, Batey R G, Farrell G C, Byth K. Hepatotoxicity from paracetamol self-poisoning in western Sydney: A continuing challenge. Med J Aust 1992; 157: 382–385
   PubMed Web of Science ®Google Scholar
• Spiller H A, Krenzelok E P, Grande G A, Safir E F, Diamond J J. A prospective evaluation of the effect of activated charcoal before oral N-acetylcysteine in acetaminophen overdose. Ann Emerg Med 1994; 23: 519–523
   PubMed Web of Science ®Google Scholar
• Prescott L F, Park J, Ballantyne A, Adriaenssens P, Proudfoot A T. Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet 1977; 2: 432–434
   PubMed Web of Science ®Google Scholar
• Rumack B H, Peterson R G. N-acetylcysteine therapy of childhood acetaminophen overdose. Pediatr Res 1978; 12: II
   Google Scholar
• Slattery J T, Levy G. Acetaminophen kinetics in acutely poisoned patients. Clin Pharmacol Ther 1979; 25: 184–195
   PubMed Web of Science ®Google Scholar
• Prescott L F, Wright N. The effects of hepatic and renal damage on paracetamol metabolism and excretion following overdosage. A pharmacokinetic study. Br J Pharmacol 1973; 49: 602–613
   PubMed Web of Science ®Google Scholar
• Prescott L F, Wright N, Roscoe P, Brown S S. Plasma paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage. Lancet 1971; 1: 519–522
   PubMed Web of Science ®Google Scholar
• Dawson A H, Henry D A, McEwen J. Adverse reactions to N-acetylcysteine during treatment for paracetamol poisoning. Med J Aust 1989; 150: 329–331
   PubMed Web of Science ®Google Scholar
• Chamberlain J M, Oderda G M, Klein-Schwartz W, Klein B L. Use of activated charcoal in a simulated poisoning with acetaminophen: A new loading dose for N-acetylcysteine. Ann Emerg Med 1993; 22: 45–49
   Google Scholar
• Brent J. Are activated charcoal N-acetylcysteine interactions of clinical significance?. Ann Emerg Med 1993; 22: 84–86
   Google Scholar