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Research Article

Ibuprofen Agglomerates Preparation by Phase Separation

Pages 297-305 | Published online: 22 Feb 1999

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Nizar Al-Zoubi, Faten Odeh, Ioannis Partheniadis, Shadi Gharaibeh & Ioannis Nikolakakis. (2021) Spray drying of naproxen and naproxen sodium for improved tableting and dissolution – physicochemical characterization and compression performance. Pharmaceutical Development and Technology 26:2, pages 193-208.
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Maryam Maghsoodi & Ali Nokhodchi. (2018) Agglomeration of celecoxib by quasi-emulsion solvent diffusion method without stabilizer: effect of good solvent. Pharmaceutical Development and Technology 23:10, pages 1037-1046.
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Claudia Al-Karawi, Thorsten Cech, Florian Bang & Claudia S. Leopold. (2018) Investigation of the tableting behavior of Ibuprofen DC 85 W. Drug Development and Industrial Pharmacy 44:8, pages 1262-1272.
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F. Nicodemi & R. Haber. (2015) Effect of agglomerate size on extrudability of titania pastes. Advances in Applied Ceramics 114:5, pages 243-249.
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Maryam Maghsoodi & Ali Hajipour. (2014) Effect of binder liquid type on spherical crystallization. Drug Development and Industrial Pharmacy 40:11, pages 1468-1475.
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Mihir K. Raval, Kishor R. Sorathiya, Narendra P. Chauhan, Jaydeep M. Patel, Rajesh K. Parikh & Navin R. Sheth. (2013) Influence of polymers/excipients on development of agglomerated crystals of secnidazole by crystallo-co-agglomeration technique to improve processability. Drug Development and Industrial Pharmacy 39:3, pages 437-446.
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M. Maghsoodi & A.S. Tajalli Bakhsh. (2011) Evaluation of physico-mechanical properties of drug-excipients agglomerates obtained by crystallization. Pharmaceutical Development and Technology 16:3, pages 243-249.
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M. Maghsoodi, D. Hassan-Zadeh, M. Barzegar-Jalali, A. Nokhodchi & Gary Martin. (2007) Improved Compaction and Packing Properties of Naproxen Agglomerated Crystals Obtained by Spherical Crystallization Technique. Drug Development and Industrial Pharmacy 33:11, pages 1216-1224.
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N. Rasenack & B. W. Müller. (2002) Properties of Ibuprofen Crystallized Under Various Conditions: A Comparative Study. Drug Development and Industrial Pharmacy 28:9, pages 1077-1089.
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Articles from other publishers (22)

Prerna Hemant Sidwadkar, Nitin Hindurao Salunkhe, Kailas Krishnat Mali, Vijay Bapu Metkari & Durgesh Paresh Bidye. (2023) Nicotinamide-based agglomerates of ibuprofen: formulation, solid state characterization and evaluation of tableting performance with in-silico investigation. Future Journal of Pharmaceutical Sciences 9:1.
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Darpan Shah, Jatin Rawat & Hetal Thakkar. (2023) Spherical crystal agglomeration technique for improved flow properties and oral bioavailability of atazanavir sulphate. Therapeutic Delivery.
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Shuo Wang, Yanbo Liu, Shilin Guo, Hui Yan, Kangli Li, Li Tong, Tao Li, Mingyang Chen, Zhenguo Gao & Junbo Gong. (2022) Design of Single and Multicomponent Drug Spherical Particles with Improved Powder Properties in Water Instead of Organic Solvents: A Case Study of Gemfibrozil. ACS Sustainable Chemistry & Engineering 10:37, pages 12411-12422.
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P.L. Xiao, S. Mansouri, V. Suriya Hena, Y.K. Bong, K. Hapgood & M.W. Woo. (2019) Spontaneous ethanol–water emulsification as a precursor for porous particle formation: Understanding the role of dissolved carbohydrates. Particuology 44, pages 44-53.
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Lisa Löbnitz, Marius Böser & Hermann Nirschl. (2018) Influence of Filtration on the Agglomeration Degree of Two Crystalline Amino Acids. Chemie Ingenieur Technik 90:4, pages 464-471.
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Kate Pitt, Ramon Peña, Jonathan D. Tew, Kanjakha Pal, Rachel Smith, Zoltan K. Nagy & James D. Litster. (2018) Particle design via spherical agglomeration: A critical review of controlling parameters, rate processes and modelling. Powder Technology 326, pages 327-343.
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Claudia Al-Karawi, Ivana Lukášová, Albrecht Sakmann & Claudia S. Leopold. (2017) Novel aspects on the direct compaction of ibuprofen with special focus on sticking. Powder Technology 317, pages 370-380.
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Janki Fadke, Jagruti Desai & Hetal Thakkar. (2015) Formulation Development of Spherical Crystal Agglomerates of Itraconazole for Preparation of Directly Compressible Tablets with Enhanced Bioavailability. AAPS PharmSciTech 16:6, pages 1434-1444.
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Abdur Rashid, Edward T. White, Tony Howes, James D. Litster & Ivan Marziano. (2014) Effect of Solvent Composition and Temperature on the Solubility of Ibuprofen in Aqueous Ethanol. Journal of Chemical & Engineering Data 59:9, pages 2699-2703.
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Huiquan Wu, Maury White, Robert Berendt, Ryan D. Foringer & Mansoor Khan. (2014) Integrated Process Analytical Technology Approach for Nucleation Induction Time Measurement and Nucleation Mechanism Assessment for a Dynamic Multicomponent Pharmaceutical Antisolvent Crystallization System. Industrial & Engineering Chemistry Research 53:4, pages 1688-1701.
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Simone Schrank, Birthe Kann, Maike Windbergs, Benjamin J. Glasser, Andreas Zimmer, Johannes Khinast & Eva Roblegg. (2013) Microstructure of Calcium Stearate Matrix Pellets: A Function of the Drying Process. Journal of Pharmaceutical Sciences 102:11, pages 3987-3997.
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Kevin C. Garala, Jaydeep M. Patel, Anjali P. Dhingani & Abhay T. Dharamsi. (2013) Quality by design (QbD) approach for developing agglomerates containing racecadotril and loperamide hydrochloride by crystallo-co-agglomeration. Powder Technology 247, pages 128-146.
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Kevin C. Garala, Jaydeep M. Patel, Anjali P. Dhingani & Abhay T. Dharamsi. (2013) Preparation and evaluation of agglomerated crystals by crystallo-co-agglomeration: An integrated approach of principal component analysis and Box–Behnken experimental design. International Journal of Pharmaceutics 452:1-2, pages 135-156.
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E. Hari Krishna, V. Rama Mohan Gupta, Mohana Krishna, S. Jyothi & Rajanikar Dasari. (2013) Preparation and evaluation of sodium CMC zaltoprofen spherical agglomerates for direct compression. Journal of Pharmacy Research 6:1, pages 61-67.
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Simone Schrank, Aden Hodzic, Andreas Zimmer, Benjamin J. Glasser, Johannes Khinast & Eva Roblegg. (2012) Ibuprofen-Loaded Calcium Stearate Pellets: Drying-Induced Variations in Dosage Form Properties. AAPS PharmSciTech 13:2, pages 686-698.
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Subrata Mallick, Saroj Kumar Pradhan, Muronia Chandran, Manoj Acharya, Tanmayee Digdarsini & Rajaram Mohapatra. (2011) Study of particle rearrangement, compression behavior and dissolution properties after melt dispersion of ibuprofen, Avicel and Aerosil. Results in Pharma Sciences 1:1, pages 1-10.
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Rieke Witzleb, Venkata-Rangarao Kanikanti, Hans-Jürgen Hamann & Peter Kleinebudde. (2011) Influence of needle-shaped drug particles on the solid lipid extrusion process. Powder Technology 207:1-3, pages 407-413.
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A. Nokhodchi & M. Maghsoodi. (2008) Preparation of Spherical Crystal Agglomerates of Naproxen Containing Disintegrant for Direct Tablet Making by Spherical Crystallization Technique. AAPS PharmSciTech 9:1, pages 54-59.
Crossref
Emile Pefferkorn. 2007. Particle Breakage. Particle Breakage 741 791 .
Madelaine R Whelan, James L Ford & Mark W Powell. (2002) Simultaneous determination of ibuprofen and hydroxypropylmethylcellulose (HPMC) using HPLC and evaporative light scattering detection. Journal of Pharmaceutical and Biomedical Analysis 30:4, pages 1355-1359.
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Norbert Rasenack & Bernd W Müller. (2002) Crystal habit and tableting behavior. International Journal of Pharmaceutics 244:1-2, pages 45-57.
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Y Tatek, S Stoll & E Pefferkorn. (2001) Internal cohesion of agglomerates. Powder Technology 115:3, pages 226-233.
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