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Research Article

Effect of Microcrystalline Cellulose Grade and Process Variables on Pellets Prepared by Extrusion–Spheronization

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Pages 451-456 | Published online: 16 May 2002

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Read on this site (8)

Yu Xia, Chun-Yang Shi, Jian-Guo Fang & Wen-Qing Wang. (2018) Approaches to developing fast release pellets via wet extrusion-spheronization. Pharmaceutical Development and Technology 23:5, pages 432-441.
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Nikhil C. Loka, Kalyan K. Saripella, Colin A. Pinto & Steven H. Neau. (2018) Use of extrusion aids for successful production of Kollidon® CL-SF pellets by extrusion–spheronization. Drug Development and Industrial Pharmacy 44:4, pages 632-642.
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A. A. Karatzas, S. N. Politis & D. M. Rekkas. (2017) Development of rapidly dissolving pellets within the Quality by Design approach. Drug Development and Industrial Pharmacy 43:5, pages 770-779.
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Gustavo H. C. Varca, Patricia S. Lopes & Humberto G. Ferraz. (2015) Development of papain containing pellets produced by extrusion–spheronization: an operational stage approach. Drug Development and Industrial Pharmacy 41:3, pages 430-435.
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Sin Yee Puah, Hsiu Ni Yap & Cheng Shu Chaw. (2014) Production and characterization of pellets using Avicel CL611 as spheronization aid. Drug Development and Industrial Pharmacy 40:3, pages 418-424.
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Alvaro Goyanes, Consuelo Souto & Ramón Martínez-Pacheco. (2010) Control of drug release by incorporation of sorbitol or mannitol in microcrystalline-cellulose-based pellets prepared by extrusion-spheronization. Pharmaceutical Development and Technology 15:6, pages 626-635.
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Gopal Venktesh Shavi, Usha Nayak, Ranjith Kumar Averineni, Karthik Arumugam, Srinivasa Reddy Meka, Udupa Nayanabhirama & Pandey Sureshwar. (2009) Multiparticulate Drug Delivery System of Aceclofenac: Development and In Vitro Studies. Drug Development and Industrial Pharmacy 35:2, pages 252-258.
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N. Mezreb, Christine Charrueau, P. Boy, P. Allain & J. C. Chaumeil. (2004) Production of Carbopol® 974P and Carbopol® 971P Pellets by Extrusion‐Spheronization: Optimization of the Processing Parameters and Water Content. Drug Development and Industrial Pharmacy 30:5, pages 481-490.
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Articles from other publishers (14)

Doaa Hasan Alshora, Mohamed Abbas Ibrahim, Essam Ezzeldin & Muzaffar Iqbal. (2020) Optimized flurbiprofen sustained-release matrix pellets prepared by extrusion/spheronization. Journal of Drug Delivery Science and Technology 59, pages 101902.
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Adrian Szewczyk & Magdalena Prokopowicz. (2020) Mesoporous silica pellets – A promising oral drug delivery system?. Journal of Drug Delivery Science and Technology 56, pages 101491.
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Mohamed A. Ibrahim, Gamal M. Zayed, Fahd M. Alsharif & Wael A. Abdelhafez. (2019) Utilizing mixer torque rheometer in the prediction of optimal wet massing parameters for pellet formulation by extrusion/spheronization. Saudi Pharmaceutical Journal 27:2, pages 182-190.
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Manuel Kuhs, John Moore, Gayathri Kollamaram, Gavin Walker & Denise Croker. (2017) Predicting optimal wet granulation parameters for extrusion-spheronisation of pharmaceutical pellets using a mixer torque rheometer. International Journal of Pharmaceutics 517:1-2, pages 19-24.
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Margot Fonteyne, Ana Correia, Sofie De Plecker, Jurgen Vercruysse, Ilija Ilić, Qi Zhou, Chris Vervaet, Jean Paul Remon, Fernanda Onofre, Vincent Bulone & Thomas De Beer. (2015) Impact of microcrystalline cellulose material attributes: A case study on continuous twin screw granulation. International Journal of Pharmaceutics 478:2, pages 705-717.
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Fridrun Podczeck & John Michael Newton. (2014) Influence of the standing time of the extrudate and speed of rotation of the spheroniser plate on the properties of pellets produced by extrusion and spheronization. Advanced Powder Technology 25:2, pages 659-665.
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J.L. Gomez-Amoza & R. Martinez-Pacheco. (2010) Influence of microstructure on drug release from extrusion-spheronization pellets. Journal of Drug Delivery Science and Technology 20:4, pages 319-325.
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F.J. Otero-Espinar, A. Luzardo-Alvarez & J. Blanco-Méndez. (2010) Non-MCC materials as extrusion-spheronization aids in pellets production. Journal of Drug Delivery Science and Technology 20:4, pages 303-318.
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A. Gómez-Carracedo, C. Alvarez-Lorenzo, R. Coca, R. Martínez-Pacheco, A. Concheiro & J.L. Gómez-Amoza. (2009) Fractal analysis of SEM images and mercury intrusion porosimetry data for the microstructural characterization of microcrystalline cellulose-based pellets. Acta Materialia 57:1, pages 295-303.
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Hideyoshi Kanbe, Tetsuo Hayashi, Yoichi Onuki & Takashi Sonobe. (2007) Manufacture of fine spherical granules by an extrusion/spheronization method. International Journal of Pharmaceutics 337:1-2, pages 56-62.
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Vivek R. Sinha, Manoj K. Agrawal, Rachna Kumria & Jayant R. Bhinge. (2007) Influence of operational variables on properties of piroxicam pellets prepared by extrusion-spheronization: A technical note. AAPS PharmSciTech 8:1, pages E137-E141.
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. (2004) Extraction Yield of Extruded Ginseng and Granulation of Its Extracts by Cold Extrusion-Spheronization. Journal of the Korean Society of Food Science and Nutrition 33:5, pages 899-904.
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F.O. Costa, A.A.C.C. Pais & J.J.S. Sousa. (2004) Analysis of formulation effects in the dissolution of ibuprofen pellets. International Journal of Pharmaceutics 270:1-2, pages 9-19.
Crossref
Lisardo Alvarez, Angel Concheiro, José Luis Gómez-Amoza, Consuelo Souto & Ramón Martı́nez-Pacheco. (2003) Powdered cellulose as excipient for extrusion–spheronization pellets of a cohesive hydrophobic drug. European Journal of Pharmaceutics and Biopharmaceutics 55:3, pages 291-295.
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