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Research Article

Direct Pelletization in a Rotary Processor Controlled by Torque Measurements. I. Influence of Process Variables

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Pages 247-256 | Received 15 Feb 1999, Accepted 30 Sep 1999, Published online: 19 Apr 2000

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Nuha I. Abou Obaid, Fahad I. Al-Jenoobi, Mohamed A. Ibrahim & Mohd A. Alam. (2020) Losartan potassium sustained release pellets with improved in vitro and in vivo performance. Pharmaceutical Development and Technology 25:9, pages 1031-1042.
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Walid F. Sakr, Mohamed A. Ibrahim, Fars K. Alanazi & Adel A. Sakr. (2012) Upgrading wet granulation monitoring from hand squeeze test to mixing torque rheometry. Saudi Pharmaceutical Journal 20:1, pages 9-19.
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M. Pašić, G. Betz, Š. Hadžidedić, S. Kocova El-Arini & H. Leuenberger. (2010) Investigation and development of robust process for direct pelletization of lansoprazole in fluidized bed rotary processor using experimental design. Journal of Drug Delivery Science and Technology 20:5, pages 367-376.
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G.M. Mahrous, M.A. Ibarhim, M. El-Badry & F.K. Al-Anazi. (2010) Indomethacin sustained release pellets prepared by extrusion-spheronization. Journal of Drug Delivery Science and Technology 20:2, pages 119-125.
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J. Bouffard, H. Dumont, F. Bertrand & R. Legros. (2007) Optimization and scale-up of a fluid bed tangential spray rotogranulation process. International Journal of Pharmaceutics 335:1-2, pages 54-62.
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Peter Kleinebudde & Klaus Knop. 2007. Granulation. Granulation 779 811 .
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Jakob Kristensen. (2014) Investigation of a 2-step agglomeration process performed in a rotary processor using polyethylene glycol solutions as the primary binder liquid. AAPS PharmSciTech 7:4, pages E46-E53.
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Jakob Kristensen & Vibeke Wallaert Hansen. (2017) Wet granulation in rotary processor and fluid bed: Comparison of granule and tablet properties. AAPS PharmSciTech 7:1, pages E153-E162.
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Jakob Kristensen. (2005) Direct pelletization in a rotary processor controlled by torque measurements. III. Investigation of microcrystalline cellulose and lactose grade. AAPS PharmSciTech 6:3, pages E495-E503.
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S. Almeida Prieto, J. Blanco Méndez & F.J. Otero Espinar. (2005) Starch–dextrin mixtures as base excipients for extrusion–spheronization pellets. European Journal of Pharmaceutics and Biopharmaceutics 59:3, pages 511-521.
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A. M. Bouwman, M. J. Henstra, J. J. M. E. Hegge, Z. Zhang, A. Ingram, J. P. K. Seville & H. W. Frijlink. (2005) The Relation Between Granule Size, Granule Stickiness, and Torque in the High-Shear Granulation Process. Pharmaceutical Research 22:2, pages 270-275.
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Thomas Vilhelmsen, Jakob Kristensen & Torben Schæfer. (2004) Melt pelletization with polyethylene glycol in a rotary processor. International Journal of Pharmaceutics 275:1-2, pages 141-153.
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Hans Leuenberger. (2001) New trends in the production of pharmaceutical granules: the classical batch concept and the problem of scale-up. European Journal of Pharmaceutics and Biopharmaceutics 52:3, pages 279-288.
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Jakob Kristensen, Torben Schæfer & Peter Kleinebudde. (2000) Direct pelletization in a rotary processor controlled by torque measurements. II: Effects of changes in the content of microcrystalline cellulose. AAPS PharmSci 2:3, pages 45-52.
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