109
Views
34
CrossRef citations to date
0
Altmetric
Research Article

Direct Pelletization in a Rotary Processor Controlled by Torque Measurements. I. Influence of Process Variables

, &
Pages 247-256 | Received 15 Feb 1999, Accepted 30 Sep 1999, Published online: 19 Apr 2000

REFERENCES

  • Wan L. S. C., Heng P. W. S., Liew C. V. The role of moisture and gap air pressure in the formation of spherical granules by rotary processing. Drug Dev. Ind. Pharm. 1994; 20: 2551–2561
  • Holm P., Bonde M., Wigmore T. Pelletization by granulation in a Roto-Processor RP-2. Part I: Effects of process and product variables on granule growth. Pharm. Technol. Eur. 1996; 8(8)22–36
  • Vertommen J., Kinget R. The influence of five selected processing and formulation variables on the particle size, particle size distribution, and friability of pellets produced in a rotary processor. Drug Dev. Ind. Pharm. 1997; 23: 39–46
  • Robinson R. L., Hollenbeck R. G. Manufacture of spherical acetaminophen pellets: comparison of rotary processing with multiple-step extrusion and spheronization. Pharm. Technol. 1991; 15(5)48–56
  • Sienkiewicz G., Pereira R., Rudnic E. M., Lausier J. M., Rhodes C. T. Spheronization of theophylline-avicel combinations using a fluidized-bed rotogranulation technique. Drug Dev. Ind. Pharm. 1997; 23: 173–185
  • Vertommen J., Jaucot B., Rombaut P., Kinget R. Improvement of the material motion in a rotary processor. Pharm. Dev. Technol. 1996; 1: 365–371
  • Holm P. Pelletization by granulation in a Roto-Processor RP-2. Part II: Effects of process and product variables on agglomerates' shape and porosity. Pharm. Technol. Eur. 1996; 8(9)38–45
  • Vertommen J., Rombaut P., Kinget R. Internal and external structure of pellets made in a rotary processor. Int. J. Pharm. 1998; 161: 225–236
  • Vertommen J., Rombaut P., Kinget R. Shape and surface smoothness of pellets made in a rotary processor. Int. J. Pharm. 1997; 146: 21–29
  • Holm P. Pelletization by granulation in a Roto-Processor RP-2. Part III: Methods of process control and the effect of microcrystalline cellulose on wet granulation. Pharm. Technol. Eur. 1996; 8(10)36–46
  • Vertommen J., Rombaut P., Michoel A., Kinget R. Estimation of the amount of water removed by gap and atomization air streams during pelletization in a rotary processor. Pharm. Dev. Technol. 1998; 3: 63–72
  • Wan L. S. C., Heng P. W. S., Liew C. C. The influence of liquid spray rate and atomizing pressure on the size of spray droplets and spheroids. Int. J. Pharm. 1995; 118: 213–219
  • Heng P. W. S., Wan L. S. C., Tan Y. T. F. Optimization of spheroid production by centrifugal rotary processing. Int. J. Pharm. 1996; 143: 107–112
  • Watano S., Terashita K., Miyanami K. Determination of end-point with a complex granulation applying infrared moisture sensor. Chem. Pharm. Bull. 1991; 39: 1013–1017
  • Leuenberger H., Luy B., Studer J. New development in the control of moist agglomeration and pelletization process. S.T.P. Pharma 1990; 6: 303–309
  • Schæfer T., Mathiesen C. Melt pelletization in a high shear mixer. VIII. Effects of binder viscosity. Int. J. Pharm. 1996; 139: 125–138
  • Kleinebudde P. Shrinking and swelling of pellets containing microcrystalline cellulose (MCC) and low substituted hydroxypropylcellulose (L-HPC). Part I: Shrinking properties. Int. J. Pharm. 1994; 109: 221–227

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.