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Pharmaceutical Development and Technology Volume 4, 1999 - Issue 4
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Research Article

Modeling Methods for Mixture-of-Mixtures Experiments Applied to a Tablet Formulation Problem

Greg F. Piepel Pacific Northwest Division, P.O. Box 999, Statistics Group, Battelle, Richland, Washington, 99352, U.S.A.
Pages 593-606 | Received 11 Nov 1998, Accepted 19 Feb 1999, Published online: 20 Oct 1999

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Sumin Shen, Lulu Kang & Xinwei Deng. (2020) Additive Heredity Model for the Analysis of Mixture-of-Mixtures Experiments. Technometrics 62:2, pages 265-276.
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Lulu Kang, V. Roshan Joseph & William A. Brenneman. (2011) Design and Modeling Strategies for Mixture-of-Mixtures Experiments. Technometrics 53:2, pages 125-136.
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Madhusudan Hariharan. (1999) Optimization of Sustained-Release Tablet Formulations: A Four-Component Mixture Experiment. Pharmaceutical Development and Technology 4:4, pages 39-60.
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Articles from other publishers (19)

Gabriel S. Aruwajoye, Alaika Kassim, Akshay K. Saha & Evariste B. Gueguim Kana. (2020) Prospects for the Improvement of Bioethanol and Biohydrogen Production from Mixed Starch-Based Agricultural Wastes. Energies 13:24, pages 6609.
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Bryan A. Stanfill, Greg F. Piepel, John D. Vienna & Scott K. Cooley. (2019) Nonlinear logistic regression mixture experiment modeling for binary data using dimensionally reduced components. Quality and Reliability Engineering International 36:1, pages 33-49.
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Wannes G.M. Akkermans, Hans Coppenolle & Peter Goos. (2017) Optimal design of experiments for excipient compatibility studies. Chemometrics and Intelligent Laboratory Systems 171, pages 125-139.
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Maria Christaki, Pieter Verboven, Tim Van Dyck, Bart Nicolaï, Peter Goos & Johan Claes. (2017) The predictive power of batter rheological properties on cake quality - The effect of pregelatinized flour, leavening acid type and mixing time. Journal of Cereal Science 77, pages 219-227.
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Ezequiel Morzan, Jorge Stripeikis, Hector Goicoechea & Mabel Tudino. (2016) A novel combination of experimental design and artificial neural networks as an analytical tool for improving performance in thermospray flame furnace atomic absorption spectrometry. Chemometrics and Intelligent Laboratory Systems 151, pages 44-50.
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Hanen Hanna & Walter Tinsson. (2014) A new class of designs for mixture-of-mixture experiments. Statistical Papers 56:2, pages 311-331.
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Greg F. Piepel. 2014. Wiley StatsRef: Statistics Reference Online. Wiley StatsRef: Statistics Reference Online.
John A. Cornell. 2011. A Primer on Experiments with Mixtures. A Primer on Experiments with Mixtures 95 158 .
John A. Cornell. 2011. A Primer on Experiments with Mixtures. A Primer on Experiments with Mixtures 299 315 .
Peter Goos & Bradley Jones. 2011. Optimal Design of Experiments. Optimal Design of Experiments 277 282 .
Octavian IordacheOctavian Iordache. 2010. Polystochastic Models for Complexity. Polystochastic Models for Complexity 275 293 .
Hongfei Yin, Zhigang Chen, Zhenxin Gu & Yongbin Han. (2009) Optimization of natural fermentative medium for selenium-enriched yeast by d-optimal mixture design. LWT - Food Science and Technology 42:1, pages 327-331.
Crossref
Greg F. Piepel. 2007. Encyclopedia of Statistics in Quality and Reliability. Encyclopedia of Statistics in Quality and Reliability.
Cleber N. Borges, Roy E. Bruns, Aline A. Almeida & Ieda S. Scarminio. (2007) Mixture–mixture design for the fingerprint optimization of chromatographic mobile phases and extraction solutions for Camellia sinensis. Analytica Chimica Acta 595:1-2, pages 28-37.
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Caroline Didier, Marina Etcheverrigaray, Ricardo Kratje & Héctor C. Goicoechea. (2007) Crossed mixture design and multiple response analysis for developing complex culture media used in recombinant protein production. Chemometrics and Intelligent Laboratory Systems 86:1, pages 1-9.
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Christine M. Anderson‐Cook, Heidi B. Goldfarb, Connie M. Borror, Douglas C. Montgomery, Kelly G. Canter & John N. Twist. (2004) Mixture and mixture–process variable experiments for pharmaceutical applications. Pharmaceutical Statistics 3:4, pages 247-260.
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Gunvor Dingstad, Bjørg Egelandsdal & Tormod Næs. (2003) Modeling methods for crossed mixture experiments—a case study from sausage production. Chemometrics and Intelligent Laboratory Systems 66:2, pages 175-190.
Crossref
John A. Cornell. 2002. Experiments with Mixtures. Experiments with Mixtures 132 222 .
John A. Cornell. 2002. Experiments with Mixtures. Experiments with Mixtures 589 603 .

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