3,580
Views
167
CrossRef citations to date
0
Altmetric
Research Article

Stabilization of Pharmaceuticals to Oxidative Degradation

, , , , , & show all
Pages 1-32 | Received 23 Apr 2001, Accepted 09 Jun 2001, Published online: 22 Apr 2002

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (14)

Nika Jordan, Robert Roškar & Iztok Grabnar. (2021) Design of experiments and multivariate analysis approach to study dissolution stability of a modified-release drug product to support lean design strategies. Drug Development and Industrial Pharmacy 47:9, pages 1481-1488.
Read now
Sorina Morar-Mitrica, Manasi Puri, Alexandra Beumer Sassi, Joshua Fuller, Ping Hu, George Crotts & Douglas Nesta. (2015) Development of a stable low-dose aglycosylated antibody formulation to minimize protein loss during intravenous administration . mAbs 7:4, pages 792-803.
Read now
Umile Gianfranco Spizzirri, Giuseppe Cirillo, Manuela Curcio, Nevio Picci & Francesca Iemma. (2015) Flavonoid-based pH-responsive hydrogels as carrier of unstable drugs in oxidative conditions. Pharmaceutical Development and Technology 20:3, pages 288-296.
Read now
Kyo Kobayashi, Yojiro Maehata, Yasue Okada, Masashi Kusubata, Shunji Hattori, Keisuke Tanaka, Chihiro Miyamoto, Fumihiko Yoshino, Ayaka Yoshida, Fumiaki Tokutomi, Satoko Wada-Takahashi, Tomoko Komatsu, Takero Otsuka, Shun-Suke Takahashi & Masaichi-Chang-Il Lee. (2015) Medical-grade collagen peptide in injectables provides antioxidant protection. Pharmaceutical Development and Technology 20:2, pages 219-226.
Read now
Giuseppe Cirillo, Francesco Puoci, Francesca Iemma, Manuela Curcio, Ortensia Ilaria Parisi, Umile Gianfranco Spizzirri, Ilaria Altimari & Nevio Picci. (2012) Starch-quercetin conjugate by radical grafting: synthesis and biological characterization. Pharmaceutical Development and Technology 17:4, pages 466-476.
Read now
Josias Hamman & Jan Steenekamp. (2012) Excipients with specialized functions for effective drug delivery. Expert Opinion on Drug Delivery 9:2, pages 219-230.
Read now
Yongmei Wu, Mandar Dali, Abhishek Gupta & Krishnaswamy Raghavan. (2009) Understanding drug-excipient compatibility: Oxidation of compound A in a solid dosage form. Pharmaceutical Development and Technology 14:5, pages 556-564.
Read now
Mark A. Polizzi, Dharmendra Singhal & Joshua Colvin. (2008) Mechanoradical-Induced Degradation in a Pharmaceutical Blend during High-Shear Processing. Pharmaceutical Development and Technology 13:6, pages 457-462.
Read now
Fenghe Qiu & Daniel L. Norwood. (2007) Identification of Pharmaceutical Impurities. Journal of Liquid Chromatography & Related Technologies 30:5-7, pages 877-935.
Read now
Linda A. Felton, Jing Yang, Khalid Shah, Hossein Omidian & Jose G. Rocca. (2007) A Rapid Technique to Evaluate the Oxidative Stability of a Model Drug. Drug Development and Industrial Pharmacy 33:6, pages 683-689.
Read now
L. A. Felton & G. S. Timmins. (2006) A Nondestructive Technique to Determine the Rate of Oxygen Permeation into Solid Dosage Forms. Pharmaceutical Development and Technology 11:1, pages 141-147.
Read now
Jinyang Hong, Eva Lee, Joi C. Carter, Jeff A. Masse & Darlene A. Oksanen. (2004) Antioxidant‐Accelerated Oxidative Degradation: A Case Study of Transition Metal Ion Catalyzed Oxidation in Formulation. Pharmaceutical Development and Technology 9:2, pages 171-179.
Read now
Kenneth C. Waterman & Michael C. Roy. (2002) Use of Oxygen Scavengers to Stabilize Solid Pharmaceutical Dosage Forms: A Case Study. Pharmaceutical Development and Technology 7:2, pages 227-234.
Read now

Articles from other publishers (153)

Todd Zelesky, Steven W. Baertschi, Chris Foti, Leonardo R. Allain, Steven Hostyn, Juçara Ribeiro Franca, Yi Li, Stacey Marden, Shikhar Mohan, Mariah Ultramari, Zongyun Huang, Neal Adams, John M. Campbell, Patrick J. Jansen, Dorina Kotoni & Christian Laue. (2023) Pharmaceutical Forced Degradation (Stress Testing) Endpoints: A Scientific Rationale and Industry Perspective. Journal of Pharmaceutical Sciences 112:12, pages 2948-2964.
Crossref
Tyler C. Huang, Gaosheng Chu & Sushma Singh. (2023) Analytical method development, validation, and out-of-specification investigations for polyethylene glycol. Journal of Pharmaceutical and Biomedical Analysis 235, pages 115613.
Crossref
Jayant Iyer, Lucy M. Morgan, Pamela Harrison, Adrian Davis, Andrew Ray, Stefan Mitsche, Ferdinand Hofer, Isha Saraf & Amrit Paudel. (2023) Applying Material Science Principles to Chemical Stability: Modelling Solid State Autoxidation in Mifepristone Containing Different Degrees of Crystal Disorder. Journal of Pharmaceutical Sciences 112:9, pages 2463-2482.
Crossref
Jakub Petřík, David Zůza, Jakub Heřt, Pavel Řezanka, Lukáš Krejčík, Kateřina Hrubcová & František Štěpánek. (2023) Azobisisobutyronitrile loaded on mesoporous silica particles: A new stressor for solid-state oxidative forced degradation studies. Journal of Pharmaceutical and Biomedical Analysis 232, pages 115417.
Crossref
Milan Decorte, Niloofar Moazami Goudarzi, Matthieu N. Boone, Ben Van Hove, Florentina-Maria Preda, Ellen Verheyen, Chris Vervaet & Valérie Vanhoorne. (2023) The effect of particle size on the sublimation behavior of butylhydroxytoluene as antioxidant in tablets during storage and coating. International Journal of Pharmaceutics 643, pages 123264.
Crossref
Milan Decorte, Moazami Goudarzi Niloofar, Matthieu N. Boone, Ben Van Hove, Florentina-Maria Preda, Ellen Verheyen, Chris Vervaet & Valérie Vanhoorne. (2023) The effect of particle size on the sublimation behavior of butylhydroxytoluene as antioxidant in tablets during storage and coating. International Journal of Pharmaceutics: X, pages 100198.
Crossref
Kailash Ahirwar & Rahul Shukla. 2023. Drug Formulation Design. Drug Formulation Design.
Munir Muhammad UsamaSaeed Muhammad AsadMasood ZeeshanNazia AslamM. Farooq. (2023) Physicochemical, Phytochemical Evaluation and Pharmacological Investigation of Roystonea regia. Research Journal of Pharmacy and Technology, pages 1738-1742.
Crossref
Primawan Putra Nugrahadi, Wouter L. J. Hinrichs, Henderik W. Frijlink, Christian Schöneich & Christina Avanti. (2023) Designing Formulation Strategies for Enhanced Stability of Therapeutic Peptides in Aqueous Solutions: A Review. Pharmaceutics 15:3, pages 935.
Crossref
Raghavendhar R. Kotha, Fakir Shahidullah Tareq, Elif Yildiz & Devanand L. Luthria. (2022) Oxidative Stress and Antioxidants—A Critical Review on In Vitro Antioxidant Assays. Antioxidants 11:12, pages 2388.
Crossref
Raghavendhar R. Kotha, Kelly Zhang, Peter Yehl & Archana Kumar. (2022) Oxidative degradation in pharmaceuticals: Mechanism and stabilization of a spray-dried amorphous drug – A case study. Journal of Pharmaceutical and Biomedical Analysis 220, pages 114962.
Crossref
Annika M. Träff, Jenny Ottosson & Thomas Andersson. (2022) The Degradation Map Process – A Tool for Obtaining a Lean Stability Strategy in Drug Development. Journal of Pharmaceutical Sciences 111:7, pages 1918-1925.
Crossref
Célia Boukoufi, Ariane Boudier, Philippe Maincent, Jean Vigneron & Igor Clarot. (2022) Food-inspired innovations to improve the stability of active pharmaceutical ingredients. International Journal of Pharmaceutics 623, pages 121881.
Crossref
Hubert Hettegger, Jiaping Zhang, Mitsuharu Koide, Uwe Rinner, Antje Potthast, Yasuo Gotoh & Thomas Rosenau. (2022) Fiber Spinning from Cellulose Solutions in Imidazolium Ionic Liquids: Effects of Natural Antioxidants on Molecular Weight, Dope Discoloration, and Yellowing Behavior. Fibers 10:6, pages 50.
Crossref
Julian David Friedl, Richard Wibel, Zeynep Burcu Akkuş-Dağdeviren & Andreas Bernkop-Schnürch. (2022) Reactive oxygen species (ROS) in colloidal systems: Are “PEG-free” surfactants the answer?. Journal of Colloid and Interface Science 616, pages 571-583.
Crossref
Farooq Saleem, Rashad Mehmood, Tahir Javed Khan, Saeed-ul Hassen, Saima Maher, Sarfraz Ahmad, Shagufta Perveen & Muhammad Azeem. (2022) Physicochemical and Bioassay Directed GC-MS Analyses of Chloroform Extract of Pteris cretica L.. Pharmaceutical Chemistry Journal 56:3, pages 387-395.
Crossref
Ameya R. Kirtane, Christina Karavasili, Aniket Wahane, Dylan Freitas, Katelyn Booz, Dao Thi Hong LeTiffany HuaStephen Scala, Aaron LopesKaitlyn HessJoy CollinsSiddartha Tamang, Keiko Ishida, Johannes L. P. KuosmanenNetra Unni Rajesh, Nhi V. Phan, Junwei Li, Annlyse Krogmann, Jochen K. Lennerz, Alison Hayward, Robert Langer & Giovanni Traverso. (2022) Development of oil-based gels as versatile drug delivery systems for pediatric applications. Science Advances 8:21.
Crossref
Jasmine Musakhanian, Jean-David Rodier & Masumi Dave. (2022) Oxidative Stability in Lipid Formulations: a Review of the Mechanisms, Drivers, and Inhibitors of Oxidation. AAPS PharmSciTech 23:5.
Crossref
Liyu Liu, Jian-Rong Wang & Xuefeng Mei. (2022) Enhancing the stability of active pharmaceutical ingredients by the cocrystal strategy. CrystEngComm 24:11, pages 2002-2022.
Crossref
Yuriy A. Abramov, Guangxu Sun & Qun Zeng. (2022) Emerging Landscape of Computational Modeling in Pharmaceutical Development. Journal of Chemical Information and Modeling 62:5, pages 1160-1171.
Crossref
Alen Gabrič, Žiga Hodnik & Stane Pajk. (2022) Oxidation of Drugs during Drug Product Development: Problems and Solutions. Pharmaceutics 14:2, pages 325.
Crossref
Hannah L. O’Mary & Zhengrong Cui. 2022. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 217 252 .
Lingyi Huang, Yu Zhou, Yizhi Wang & Min Lin. (2021) Optimization of S-Nitrosocaptopril Monohydrate Storage Conditions Based on Response Surface Method. Molecules 26:24, pages 7533.
Crossref
Silke Henry, Lien De Vadder, Milan Decorte, Susanna Francia, Magali Van Steenkiste, Jan Saevels, Valérie Vanhoorne & Chris Vervaet. (2021) Development of a 3D-Printed Dosing Platform to Aid in Zolpidem Withdrawal Therapy. Pharmaceutics 13:10, pages 1684.
Crossref
Pauline Legrand, Rabah Gahoual, Pascal Houzé & Sophie Dufaÿ. (2021) Accelerated Stability Assessment Program to Predict Long-term Stability of Drugs: Application to Ascorbic Acid and to a Cyclic Hexapeptide. AAPS PharmSciTech 22:7.
Crossref
Daoli Zhao, Lin Wang, Rasangi M. Wimalasinghe, Jingzhi Tian & Abu Rustum. (2021) Investigation to Identify the Root Cause of Out-of-Specification Results for Color of a Topical Pour-on Drug Product: A Case Study. Chromatographia 84:10, pages 905-915.
Crossref
Manish Kumar Sharma, Komal Pandey, Ravi P. Shah, Dinesh Kumar & Pinaki Sengupta. (2021) A mechanistic explanation on degradation behavior of flibanserin for identification and characterization of its potential degradants using LC-DAD/ESI/APCI-Q-TOF-MS/MS. Microchemical Journal 167, pages 106281.
Crossref
Harjeet S. Soor, Diego B. Diaz, Katherine I. Burton & Andrei K. Yudin. (2021) Synthesis of Fluorinated Aminoalkylboronic Acids from Amphoteric α‐Boryl Aldehydes. Angewandte Chemie International Edition 60:30, pages 16366-16371.
Crossref
Harjeet S. Soor, Diego B. Diaz, Katherine I. Burton & Andrei K. Yudin. (2021) Synthesis of Fluorinated Aminoalkylboronic Acids from Amphoteric α‐Boryl Aldehydes. Angewandte Chemie 133:30, pages 16502-16507.
Crossref
Zijun Dai, Chunmei Zhu, Chunfeng Liu, Jinyuan Lyu, Jiajian Xu, Haoxiang Wu & Fuli Zhang. (2021) Effect of Packaging Materials and the Leached Iron on the Stability of Butorphanol Tartrate Injection. AAPS PharmSciTech 22:5.
Crossref
Lidija Kovač, Martin Črnugelj, Robert Roškar, Tina Trdan Lušin & Zdenko Časar. (2021) Understanding of cabotegravir degradation through isolation and characterization of key degradation products and kinetic studies. Journal of Pharmaceutical and Biomedical Analysis 201, pages 114096.
Crossref
Nor El Houda Medigue, Zohra Bouakouk-Chitti, Lina Linda Bechohra & Safia Kellou-Taïri. (2021) Theoretical study of the impact of metal complexation on the reactivity properties of Curcumin and its diacetylated derivative as antioxidant agents. Journal of Molecular Modeling 27:6.
Crossref
Jonathan J. Novak, Woodrow Burchett & Li Di. (2021) Effects of low temperature on blood‐to‐plasma ratio measurement. Biopharmaceutics & Drug Disposition 42:5, pages 234-241.
Crossref
Donald J. AbrahamTian Wu, Darren L. Reid & David J. Semin. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 31 .
W. Shu, G.W. Price, R. Jamieson & C. Lake. (2021) Biodegradation kinetics of individual and mixture non-steroidal anti-inflammatory drugs in an agricultural soil receiving alkaline treated biosolids. Science of The Total Environment 755, pages 142520.
Crossref
Pranav Shah, Rinkal Jariwala, Swinal Kapadiya, Vidya P. Sabale, Priya Patel & Pallavi M. Chaudhari. 2021. Nanocarriers: Drug Delivery System. Nanocarriers: Drug Delivery System 201 226 .
Barbara Żuromska-Witek, Paweł Żmudzki, Marek Szlósarczyk, Anna Maślanka & Urszula Hubicka. (2020) Development and Validation of Stability-Indicating HPLC Methods for the Estimation of Lomefloxacin and Balofloxacin Oxidation Process under ACVA, H2O2, or KMnO4 Treatment. Kinetic Evaluation and Identification of Degradation Products by Mass Spectrometry. Molecules 25:22, pages 5251.
Crossref
Dhaval R. Kalaria, Keith Parker, Gavin K. Reynolds & Johanna Laru. (2020) An industrial approach towards solid dosage development for first-in-human studies: Application of predictive science and lean principles. Drug Discovery Today 25:3, pages 505-518.
Crossref
Dong Han Won, Heejun Park, Eun-Sol Ha, Yong Min Kim, Hyung Don Hwang, Sun Woo Jang & Min-Soo Kim. (2020) Effect of Formulation Factors and Oxygen Levels on the Stability of Aqueous Injectable Solution Containing Pemetrexed. Pharmaceutics 12:1, pages 46.
Crossref
Ankit Sharma. 2019. Innovative Dosage Forms. Innovative Dosage Forms 91 118 .
Antonio Lopalco, Rodney Deeken, Justin Douglas, Nunzio Denora & Valentino J. Stella. (2019) Some Preformulation Studies of Pyruvic Acid and Other α-Keto Carboxylic Acids in Aqueous Solution: Pharmaceutical Formulation Implications for These Peroxide Scavengers. Journal of Pharmaceutical Sciences 108:10, pages 3281-3288.
Crossref
Jeanette L. Voelz, Nathan W. Johnson, Chan Lan Chun, William A. Arnold & R. Lee Penn. (2019) Quantitative Dissolution of Environmentally Accessible Iron Residing in Iron-Rich Minerals: A Review. ACS Earth and Space Chemistry 3:8, pages 1371-1392.
Crossref
E. Halevas, C.M. Nday, D. Eleftheriadou, G. Jackson, V. Psycharis, C.P. Raptopoulou, D.G. Reid, K. Ypsilantis, G. Litsardakis & A. Salifoglou. (2019) Synthesis and encapsulation of V(IV,V) compounds in silica nanoparticles targeting development of antioxidant and antiradical nanomaterials. Journal of Inorganic Biochemistry 194, pages 180-199.
Crossref
Sang Gon Lee, Dong Jun Shin, Eun Seok Lee, Yoon Tae Goo, Chang Hyun Kim, Ho Yub Yoon, Min Won Lee, Hyoweon Bang, Seong Jun Seo & Young Wook Choi. (2018) Enhanced Chemical Stability of Hirsutenone Incorporated into a Nanostructured Lipid Carrier Formulation Containing Antioxidants. Bulletin of the Korean Chemical Society 39:11, pages 1287-1293.
Crossref
Sangwoo Ryu, Jonathan J. Novak, Roshan Patel, Phillip Yates & Li Di. (2018) The impact of low temperature on fraction unbound for plasma and tissue. Biopharmaceutics & Drug Disposition 39:9, pages 437-442.
Crossref
Haichen Nie & Stephen R. Byrn. 2018. Pharmaceutical Crystals. Pharmaceutical Crystals 169 221 .
Anton J. P. van Heugten, Wouter S. de Vries, Marian M. A. Markesteijn, Roland J. Pieters & H. Vromans. (2018) The Role of Excipients in the Stability of Triamcinolone Acetonide in Ointments. AAPS PharmSciTech 19:3, pages 1448-1453.
Crossref
Kelly Zhang, Jackson D. Pellett, Ajit S. Narang, Y. John Wang & Yonghua Taylor Zhang. (2018) Reactive impurities in large and small molecule pharmaceutical excipients – A review. TrAC Trends in Analytical Chemistry 101, pages 34-42.
Crossref
A.J.P. van Heugten, W. de Boer, W.S. de Vries, C.M.A. Markesteijn & H. Vromans. (2018) Development and validation of a stability-indicating HPLC-UV method for the determination of triamcinolone acetonide and its degradation products in an ointment formulation. Journal of Pharmaceutical and Biomedical Analysis 149, pages 265-270.
Crossref
M.V. Krishna, M. Sowhardhra, M.S. Kumar, G. Madhavi, T. Jadhav & D. Thakkar. (2018) Effect of surfactants and hydrophilic polymers on the stability of an antihypertensive drug candesartan cilexetil: Evaluation by HPLC. Annales Pharmaceutiques Françaises 76:1, pages 32-43.
Crossref
Mark C. Manning, Jun Liu, Tiansheng Li & Ryan E. Holcomb. 2018. Therapeutic Proteins and Peptides. Therapeutic Proteins and Peptides 1 59 .
. 2017. Pharmaceutical Analysis for Small Molecules. Pharmaceutical Analysis for Small Molecules 116 126 .
Andrew Teasdale, David Elder, James Harvey & Steven Spanhaak. 2017. ICH Quality Guidelines. ICH Quality Guidelines 167 198 .
Wei Wu, Hangtian Song, Thomas Slaney, Richard Ludwig, Li Tao & Tapan Das. 2017. Protein Analysis using Mass Spectrometry. Protein Analysis using Mass Spectrometry 221 249 .
Teddy J. Zbacnik, Ryan E. Holcomb, Derrick S. Katayama, Brian M. Murphy, Robert W. Payne, Richard C. Coccaro, Gabriel J. Evans, James E. Matsuura, Charles S. Henry & Mark Cornell Manning. (2017) Role of Buffers in Protein Formulations. Journal of Pharmaceutical Sciences 106:3, pages 713-733.
Crossref
Nicholas Drachman, Stephen Kadlecek, Ian Duncan & Rahim Rizi. (2017) Quantifying reaction kinetics of the non-enzymatic decarboxylation of pyruvate and production of peroxymonocarbonate with hyperpolarized 13 C-NMR . Physical Chemistry Chemical Physics 19:29, pages 19316-19325.
Crossref
J.A. Maguire, W. Jiang & L.X. Yu. 2017. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 1095 1126 .
D. Zhou, W.R. Porter & G.G.Z. Zhang. 2017. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 113 149 .
Gary R. Kelm. 2016. Handbook of Formulating Dermal Applications. Handbook of Formulating Dermal Applications 425 462 .
David Good & Yongmei Wu. 2016. Pharmaceutical Excipients. Pharmaceutical Excipients 1 49 .
Susana Torres, Roland Brown, Todd Zelesky, Garry Scrivens, Roman Szucs, Joel M. Hawkins & Mark R. Taylor. (2016) Electrochemical oxidation coupled with liquid chromatography and mass spectrometry to study the oxidative stability of active pharmaceutical ingredients in solution: A comparison of off-line and on-line approaches. Journal of Pharmaceutical and Biomedical Analysis 131, pages 71-79.
Crossref
Daniel T. HallinanJr.Jr., Alexander Rausch & Brandon McGill. (2016) An electrochemical approach to measuring oxidative stability of solid polymer electrolytes for lithium batteries. Chemical Engineering Science 154, pages 34-41.
Crossref
Gleysson De Paula Terra, Marcus Vinícius De Farias, Marcello Garcia Trevisan & Jerusa Simone Garcia. (2016) Evaluation of pancreatin stability through enzyme activity determination. Acta Pharmaceutica 66:3, pages 423-431.
Crossref
Antonio Lopalco & Valentino J. Stella. (2016) Effect of Molecular Structure on the Relative Hydrogen Peroxide Scavenging Ability of Some α-Keto Carboxylic Acids. Journal of Pharmaceutical Sciences 105:9, pages 2879-2885.
Crossref
Onyekachi Oparaji, Xiaobing Zuo & Daniel T. HallinanJr.Jr.. (2016) Crystallite dissolution in PEO-based polymers induced by water sorption. Polymer 100, pages 206-218.
Crossref
Feng Zhang, Fan Meng, Joseph Lubach, Joseph Koleng & N.A. Watson. (2016) Properties and mechanisms of drug release from matrix tablets containing poly(ethylene oxide) and poly(acrylic acid) as release retardants. European Journal of Pharmaceutics and Biopharmaceutics 105, pages 97-105.
Crossref
Geoffrey P. F. Wood, Alavattam Sreedhara, Jamie M. Moore, John Wang & Bernhardt L. Trout. (2016) Mechanistic Insights into Radical-Mediated Oxidation of Tryptophan from ab Initio Quantum Chemistry Calculations and QM/MM Molecular Dynamics Simulations. The Journal of Physical Chemistry A 120:18, pages 2926-2939.
Crossref
Martin Kuentz, René Holm & David P. Elder. (2016) Methodology of oral formulation selection in the pharmaceutical industry. European Journal of Pharmaceutical Sciences 87, pages 136-163.
Crossref
Job Ubbink. (2016) Structural and thermodynamic aspects of plasticization and antiplasticization in glassy encapsulation and biostabilization matrices. Advanced Drug Delivery Reviews 100, pages 10-26.
Crossref
Monica L. Adams, Vijayata Sharma, Madhushree Gokhale, Yande Huang, Kevin Stefanski, Ching Su & Munir A. Hussain. (2016) Dehydration and Stabilization of a Reactive Tertiary Hydroxyl Group in Solid Oral Dosage Forms of BMS-779788. Journal of Pharmaceutical Sciences 105:4, pages 1478-1488.
Crossref
Antonio Lopalco, Gautam Dalwadi, Sida Niu, Richard L. Schowen, Justin Douglas & Valentino J. Stella. (2016) Mechanism of Decarboxylation of Pyruvic Acid in the Presence of Hydrogen Peroxide. Journal of Pharmaceutical Sciences 105:2, pages 705-713.
Crossref
Youssef W. Naguib, Hannah L. O’Mary, Zhengrong Cui & Alan B. Watts. 2016. Formulating Poorly Water Soluble Drugs. Formulating Poorly Water Soluble Drugs 257 293 .
Stephen J. Franklin & Paul B. Myrdal. (2015) Solid-State and Solution Characterization of Myricetin. AAPS PharmSciTech 16:6, pages 1400-1408.
Crossref
Katrin Roßteuscher-Carl, Sabine Fricke, Michael C. Hacker & Michaela Schulz-Siegmund. (2015) Influence of in line monitored fluid bed granulation process parameters on the stability of Ethinylestradiol. International Journal of Pharmaceutics 496:2, pages 751-758.
Crossref
Eileen Schütze, Engy Ahmed, Annekatrin Voit, Michael Klose, Matthias Greyer, Aleš Svatoš, Dirk Merten, Martin Roth, Sara J. M. Holmström & Erika Kothe. (2014) Siderophore production by streptomycetes—stability and alteration of ferrihydroxamates in heavy metal-contaminated soil. Environmental Science and Pollution Research 22:24, pages 19376-19383.
Crossref
Marcela Nefliu, Todd Zelesky, Patrick Jansen, Gregory W. Sluggett, Christopher Foti, Steven W. Baertschi & Paul A. Harmon. (2015) Artifacts Generated During Azoalkane Peroxy Radical Oxidative Stress Testing of Pharmaceuticals Containing Primary and Secondary Amines. Journal of Pharmaceutical Sciences 104:12, pages 4287-4298.
Crossref
Ajit S. Narang, Divyakant Desai & Sherif Badawy. 2015. Excipient Applications in Formulation Design and Drug Delivery. Excipient Applications in Formulation Design and Drug Delivery 93 137 .
Jeffrey N. Hemenway, Thiago C. Carvalho, Rao V. Mantri, Yongmei Wu, Jaquan K. Levons, Ajit S. Narang, Srinivasa R. Paruchuri, Howard J. Stamato & Sailesh A. Varia. 2015. Excipient Applications in Formulation Design and Drug Delivery. Excipient Applications in Formulation Design and Drug Delivery 67 91 .
Marion dC. Molina, Nicole M. Payton & Thomas J. Anchordoquy. 2015. Lyophilized Biologics and Vaccines. Lyophilized Biologics and Vaccines 211 254 .
Mark H. Kleinman, Steven W. Baertschi, Karen M. Alsante, Darren L. Reid, Mark D. Mowery, Roman Shimanovich, Chris Foti, William K. Smith, Dan W. Reynolds, Marcela Nefliu & Martin A. Ott. (2014) In Silico Prediction of Pharmaceutical Degradation Pathways: A Benchmarking Study. Molecular Pharmaceutics 11:11, pages 4179-4188.
Crossref
Zhihong Liu, Minghao Zheng, Xin Yan, Qiong Gu, Johann Gasteiger, Johan Tijhuis, Peter Maas, Jiabo Li & Jun Xu. (2014) ChemStable: a web server for rule-embedded naïve Bayesian learning approach to predict compound stability. Journal of Computer-Aided Molecular Design 28:9, pages 941-950.
Crossref
Rossana Canavesi, Silvio Aprile, Elena Varese & Giorgio Grosa. (2014) Development and validation of a stability-indicating LC–UV method for the determination of pantethine and its degradation product based on a forced degradation study. Journal of Pharmaceutical and Biomedical Analysis 97, pages 141-150.
Crossref
Thomas Andersson, Anders Broo & Emma Evertsson. (2014) Prediction of Drug Candidates' Sensitivity Toward Autoxidation: Computational Estimation of C-H Dissociation Energies of Carbon-Centered Radicals. Journal of Pharmaceutical Sciences 103:7, pages 1949-1955.
Crossref
Parbir Grewal, Mary Mallaney, Kimberly Lau & Alavattam Sreedhara. (2014) Screening Methods to Identify Indole Derivatives That Protect against Reactive Oxygen Species Induced Tryptophan Oxidation in Proteins. Molecular Pharmaceutics 11:4, pages 1259-1272.
Crossref
Riccardo Torosantucci, Christian Schöneich & Wim Jiskoot. (2013) Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences. Pharmaceutical Research 31:3, pages 541-553.
Crossref
Yilma T. Adem, Patricia Molina, Hongbin Liu, Thomas W. Patapoff, Alavattam Sreedhara & Osigwe Esue. (2014) Hexyl Glucoside and Hexyl Maltoside Inhibit Light-Induced Oxidation of Tryptophan. Journal of Pharmaceutical Sciences 103:2, pages 409-416.
Crossref
Yi-Ling Hsieh, Weili Yu, Yanqiao Xiang, Weitao Pan, Kenneth C. Waterman, Evgenyi Y. Shalaev, Sheri L. Shamblin & Lynne S. Taylor. (2014) Impact of sertraline salt form on the oxidative stability in powder blends. International Journal of Pharmaceutics 461:1-2, pages 322-330.
Crossref
Lawrence M. Martin & Ali R. Rajabi-Siahboomi. 2014. Hydrophilic Matrix Tablets for Oral Controlled Release. Hydrophilic Matrix Tablets for Oral Controlled Release 123 141 .
Christopher Foti, Karen Alsante, Guilong Cheng, Todd Zelesky & Mark Zell. (2013) Tools and workflow for structure elucidation of drug degradation products. TrAC Trends in Analytical Chemistry 49, pages 89-99.
Crossref
Umile Gianfranco Spizzirri, Giuseppe Cirillo, Manuela Curcio, Ilaria Altimari, Nevio Picci & Francesca Iemma. (2013) Stabilization of oxidable vitamins by flavonoid-based hydrogels. Reactive and Functional Polymers 73:8, pages 1030-1037.
Crossref
Yuanjie Pan, Rohan V. Tikekar & N. Nitin. (2013) Effect of antioxidant properties of lecithin emulsifier on oxidative stability of encapsulated bioactive compounds. International Journal of Pharmaceutics 450:1-2, pages 129-137.
Crossref
Michael A. Watkins, Steven Pitzenberger & Paul A. Harmon. (2013) Direct Evidence of 2-Cyano-2-Propoxy Radical Activity During AIBN-Based Oxidative Stress Testing in Acetonitrile–Water Solvent Systems. Journal of Pharmaceutical Sciences 102:5, pages 1554-1568.
Crossref
Barry Fairand & Dusan Razem. 2012. Pharmaceutical Dosage Forms - Parenteral Medications. Pharmaceutical Dosage Forms - Parenteral Medications 268 296 .
Ajit S. Narang, Divyakant Desai & Sherif Badawy. (2012) Impact of Excipient Interactions on Solid Dosage Form Stability. Pharmaceutical Research 29:10, pages 2660-2683.
Crossref
Min Li. 2012. Organic Chemistry of Drug Degradation. Organic Chemistry of Drug Degradation 48 109 .
Orazio Vittorio, Giuseppe Cirillo, Francesca Iemma, Giovanni Di Turi, Emanuela Jacchetti, Michele Curcio, Serena Barbuti, Niccola Funel, Ortensia Ilaria Parisi, Francesco Puoci & Nevio Picci. (2012) Dextran-Catechin Conjugate: A Potential Treatment Against the Pancreatic Ductal Adenocarcinoma. Pharmaceutical Research 29:9, pages 2601-2614.
Crossref
Jeffrey N. Hemenway, Thiago C. Carvalho, Venkatramana M. Rao, Yongmei Wu, Jaquan K. Levons, Ajit S. Narang, Srinivasa R. Paruchuri, Howard J. Stamato & Sailesh A. Varia. (2012) Formation of Reactive Impurities in Aqueous and Neat Polyethylene Glycol 400 and Effects of Antioxidants and Oxidation Inducers. Journal of Pharmaceutical Sciences 101:9, pages 3305-3318.
Crossref
Gregory K. Webster, Robert A. CraigIIII, Cynthia A. Pommerening & Ian N. Acworth. (2012) Selection of Pharmaceutical Antioxidants by Hydrodynamic Voltammetry. Electroanalysis 24:6, pages 1394-1400.
Crossref
Yuan‐Hon Kiang, Darren L. Reid & Janan Jona. 2012. ADME‐Enabling Technologies in Drug Design and Development. ADME‐Enabling Technologies in Drug Design and Development 473 483 .
Shuxia Zhou, Brad Evans, Christian Schöneich & Satish K. Singh. (2012) Biotherapeutic Formulation Factors Affecting Metal Leachables from Stainless Steel Studied by Design of Experiments. AAPS PharmSciTech 13:1, pages 284-294.
Crossref
Eiji Ueyama, Fumie Takahashi, Jyunji Ohashi, Tomonori Konse, Naoyuki Kishi & Kenji Kano. (2012) Mechanistic study on degradation of azelnidipine solution under radical initiator-based oxidative conditions. Journal of Pharmaceutical and Biomedical Analysis 61, pages 277-283.
Crossref
Dan W. Reynolds, Marina Galvani, Simon R. Hicks, Biren J. Joshi, Sonya A. Kennedy-Gabb, Mark H. Kleinman & Paresh Z. Parmar. (2012) The Use Of N-Methylpyrrolidone as a Cosolvent and Oxidant in Pharmaceutical Stress Testing. Journal of Pharmaceutical Sciences 101:2, pages 761-776.
Crossref
Alexander V. LyubimovPaul H. Gamache & Ian N. Acworth. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 18 .
Padma Narayan. (2011) Overview of Drug Product Development. Current Protocols in Pharmacology 55:1.
Crossref
Changkang Pan, Frances Liu & Michael Motto. 2011. Characterization of Impurities and Degradants Using Mass Spectrometry. Characterization of Impurities and Degradants Using Mass Spectrometry 279 335 .
Changkang Pan, Frances Liu & Michael Motto. (2011) Identification of Pharmaceutical Impurities in Formulated Dosage Forms. Journal of Pharmaceutical Sciences 100:4, pages 1228-1259.
Crossref
Shuxia Zhou, Christian Schöneich & Satish K. Singh. (2011) Biologics Formulation Factors Affecting Metal Leachables from Stainless Steel. AAPS PharmSciTech 12:1, pages 411-421.
Crossref
Maxim E. Darvin, Joachim W. Fluhr, Martina C. Meinke, Leonhard Zastrow, Wolfram Sterry & Juergen Lademann. (2011) Topical beta-carotene protects against infra-red-light-induced free radicals. Experimental Dermatology 20:2, pages 125-129.
Crossref
H. Abdelkader, Z. Wu, R. Al-Kassas, J.E. Brown & R.G. Alany. (2011) Preformulation characteristics of the opioid growth factor antagonist-naltrexone hydrochloride: stability and lipophilicity studies. Journal of Drug Delivery Science and Technology 21:2, pages 157-163.
Crossref
Karen M. Alsante, Steven W. Baertschi, Michael Coutant, Brian L. Marquez, Thomas R. Sharp & Todd C. Zelesky. 2011. Handbook of Modern Pharmaceutical Analysis. Handbook of Modern Pharmaceutical Analysis 59 169 .
F. Lagrange. (2010) Déconditionnement et stabilité des formes orales sèches solides : états des connaissances. Annales Pharmaceutiques Françaises 68:6, pages 332-358.
Crossref
Mannching Sherry Ku. 2010. Oral Controlled Release Formulation Design and Drug Delivery. Oral Controlled Release Formulation Design and Drug Delivery 47 69 .
Feroz Jameel, Chakradhar Padala & Theodore W. Randolph. 2010. Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals. Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals 677 704 .
Mark Cornell Manning, Danny K. Chou, Brian M. Murphy, Robert W. Payne & Derrick S. Katayama. (2010) Stability of Protein Pharmaceuticals: An Update. Pharmaceutical Research 27:4, pages 544-575.
Crossref
Emmanuel O. Akala. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 46 .
Maxim E. Darvin, Wolfram Sterry & Jürgen Lademann. (2009) Resonance Raman spectroscopy as an effective tool for the determination of antioxidative stability of cosmetic formulations. Journal of Biophotonics 3:1-2, pages 82-88.
Crossref
Lian Huang, Jinquan Dong & Shyam Karki. 2009. Evaluation of Drug Candidates for Preclinical Development. Evaluation of Drug Candidates for Preclinical Development 185 217 .
Li Di & Edward H. Kerns. (2009) Stability Challenges in Drug Discovery. Chemistry & Biodiversity 6:11, pages 1875-1886.
Crossref
Yoko Kawaguchi-Murakami, Naoto Fukutsu, Toshi Kajiro, Tetsuya Araki, Tomonori Murakami, Takao Kawasaki, Naoyuki Kishi & Michiko Konno. (2009) A prediction system of oxidation reaction as a solid-state stress condition: Applied to a pyrrole-containing pharmaceutical compound. Journal of Pharmaceutical and Biomedical Analysis 50:3, pages 328-335.
Crossref
Jia Yao, Dushyanth K. Dokuru, Matthew Noestheden, SungAe S. Park, Bruce A. Kerwin, Janan Jona, Drazen Ostovic & Darren L. Reid. (2009) A Quantitative Kinetic Study of Polysorbate Autoxidation: The Role of Unsaturated Fatty Acid Ester Substituents. Pharmaceutical Research 26:10, pages 2303-2313.
Crossref
Hongfei Yue, Xin Bu, Ming-Hsing Huang, Joel Young & Thomas Raglione. (2009) Quantitative determination of trace levels of hydrogen peroxide in crospovidone and a pharmaceutical product using high performance liquid chromatography with coulometric detection. International Journal of Pharmaceutics 375:1-2, pages 33-40.
Crossref
Ricardo J. Solá & Kai Griebenow. (2009) Effects of glycosylation on the stability of protein pharmaceuticals. Journal of Pharmaceutical Sciences 98:4, pages 1223-1245.
Crossref
Mary T. Am Ende, Daniel O. Blackwood, Daniel S. Gierer & Christopher P. Neu. 2009. Formulation and Analytical Development for Low‐Dose Oral Drug Products. Formulation and Analytical Development for Low‐Dose Oral Drug Products 117 157 .
Wenlei Jiang & Lawrence X. Yu. 2009. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 885 901 .
Deliang Zhou, William R. Porter & Geoff G.Z. Zhang. 2009. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 87 124 .
Paul H. Gamache, David F. Meyer, Michael C. Granger & Ian N. Acworth. 2008. Mass Spectrometry in Drug Metabolism and Pharmacokinetics. Mass Spectrometry in Drug Metabolism and Pharmacokinetics 275 293 .
Alan R. Oyler, Barbara L. Armstrong, Richard Dunphy, Lori Alquier, Cynthia A. Maryanoff, Judith H. Cohen, Mel Merciadez, Ada Khublall, Rajshekhar Mehta, Ashesh Patel & Yuri V. Il’ichev. (2008) Mass balance in rapamycin autoxidation. Journal of Pharmaceutical and Biomedical Analysis 48:5, pages 1368-1374.
Crossref
Marion D.C. Molina & Thomas J. Anchordoquy. (2008) Formulation strategies to minimize oxidative damage in lyophilized lipid/DNA complexes during storage. Journal of Pharmaceutical Sciences 97:12, pages 5089-5105.
Crossref
Yimei Bao, Xiaopeng Mo, Xiaoying Xu, Yuyu He, Xiao Xu & Haoyun An. (2008) Stability studies of anticancer agent bis(4-fluorobenzyl)trisulfide and synthesis of related substances. Journal of Pharmaceutical and Biomedical Analysis 48:3, pages 664-671.
Crossref
Sridhar Thumma, Mahmoud A. ElSohly, Shuang-Qing Zhang, Waseem Gul & Michael A. Repka. (2008) Influence of plasticizers on the stability and release of a prodrug of Δ9-tetrahydrocannabinol incorporated in poly (ethylene oxide) matrices. European Journal of Pharmaceutics and Biopharmaceutics 70:2, pages 605-614.
Crossref
Jean-Bernard PouvreauFrédéric TaranPhilippe RosaSerge PinJoël FleurencePierre Pondaven. (2008) Antioxidant and Free Radical Scavenging Properties of Marennine, a Blue-Green Polyphenolic Pigment from the Diatom Haslea ostrearia (Gaillon/Bory) Simonsen Responsible for the Natural Greening of Cultured Oysters . Journal of Agricultural and Food Chemistry 56:15, pages 6278-6286.
Crossref
Alenka Šauperl, Janko Klasinc & Simona Lužar. (2008) Components of abstracts: Logical structure of scholarly abstracts in pharmacology, sociology, and linguistics and literature. Journal of the American Society for Information Science and Technology 59:9, pages 1420-1432.
Crossref
R. Roškar, M. Vivoda & V. Kmetec. (2008) Use of isothermal microcalorimetry for prediction of oxidative stability of several amino acids. Journal of Thermal Analysis and Calorimetry 92:3, pages 791-794.
Crossref
Kenneth C. Waterman, William B. Arikpo, Michael B. Fergione, Timothy W. Graul, Barbara A. Johnson, Bruce C. MacDonald, Michael C. Roy & Robert J. Timpano. (2008) N‐Methylation and N‐Formylation of a Secondary Amine Drug (Varenicline) in an Osmotic Tablet. Journal of Pharmaceutical Sciences 97:4, pages 1499-1507.
Crossref
M. A. Tallon, E. G. Malawer, N. I. Machnicki, P. J. Brush, C. S. Wu & J. P. Cullen. (2008) The effect of crosslinker structure upon the rate of hydroperoxide formation in dried, crosslinked poly(vinylpyrrolidone). Journal of Applied Polymer Science 107:5, pages 2776-2785.
Crossref
Margaret S. Landis. (2007) The use of mixed-mode ion-exchange solid phase extraction to characterize pharmaceutical drug degradation. Journal of Pharmaceutical and Biomedical Analysis 44:5, pages 1029-1039.
Crossref
David L. Pole, Howard Y. Ando & Sean T. Murphy. (2007) Prediction of Drug Degradants Using DELPHI:  An Expert System for Focusing Knowledge. Molecular Pharmaceutics 4:4, pages 539-549.
Crossref
Tao Yi, Hao Zhang, Jing Xie & Dan Xue. (2007) A new procedure for the preparative separation and isolation of Z ‐ligustilide from the roots of Angelica sinensis . Journal of Separation Science 30:12, pages 1973-1978.
Crossref
David P. Elder. 2007. Analysis of Drug Impurities. Analysis of Drug Impurities 21 46 .
Marion d.C. Molina & Thomas J. Anchordoquy. (2007) Metal contaminants promote degradation of lipid/DNA complexes during lyophilization. Biochimica et Biophysica Acta (BBA) - Biomembranes 1768:3, pages 669-677.
Crossref
E.H. Kerns & L. Di. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 489 507 .
Manish Munjal, Mahmoud A. ElSohly & Michael A. Repka. (2006) Polymeric Systems for Amorphous Δ9-Tetrahydrocannabinol Produced by a Hot-melt Method. Part II: Effect of Oxidation Mechanisms and Chemical Interactions on Stability. Journal of Pharmaceutical Sciences 95:11, pages 2473-2485.
Crossref
Randal A. Seburg, John M. Ballard, Tsang-Lin Hwang & Caitlin M. Sullivan. (2006) Photosensitized degradation of losartan potassium in an extemporaneous suspension formulation. Journal of Pharmaceutical and Biomedical Analysis 42:4, pages 411-422.
Crossref
Eric D. Nelson, Paul A. Harmon, Renee C. Szymanik, Martin G. Teresk, Li Li, Randal A. Seburg & Robert A. Reed. (2006) Evaluation of Solution Oxygenation Requirements for Azonitrile-Based Oxidative Forced Degradation Studies of Pharmaceutical Compounds. Journal of Pharmaceutical Sciences 95:7, pages 1527-1539.
Crossref
Daniel Mufson, Madhu Pudipeddi & Abu Serajuddin. 2006. The Process of New Drug Discovery and Development, Second Edition. The Process of New Drug Discovery and Development, Second Edition 15 51 .
Xue-Qing Chen, Melissa D. Antman, Christoph Gesenberg & Olafur S. Gudmundsson. (2006) Discovery pharmaceutics—Challenges and opportunities. The AAPS Journal 8:2, pages E402-E408.
Crossref
Kenneth C. Waterman & Roger C. Adami. (2005) Accelerated aging: Prediction of chemical stability of pharmaceuticals. International Journal of Pharmaceutics 293:1-2, pages 101-125.
Crossref
Seema Betigeri, Ajit Thakur & Krishnaswamy Raghavan. (2005) Use of 2,2?-Azobis(2-Amidinopropane) Dihydrochloride as a Reagent Tool for Evaluation of Oxidative Stability of Drugs. Pharmaceutical Research 22:2, pages 310-317.
Crossref
Rajiv Mahajan, Allen Templeton, Amy Harman, Robert A. Reed & Rey T. Chern. (2005) The Effect of Inert Atmospheric Packaging on Oxidative Degradation in Formulated Granules. Pharmaceutical Research 22:1, pages 128-140.
Crossref
M. López-Hoyos, G. Fernández-Fresnedo, H. López-Escribano & A.L.M. de Francisco. (2004) Antigenicidad de las proteínas recombinantes. Gaceta Médica de Bilbao 101:1, pages 17-21.
Crossref
Bernard A. Olsen & Steven W. Baertschi. 2004. Handbook of Isolation and Characterization of Impurities in Pharmaceuticals. Handbook of Isolation and Characterization of Impurities in Pharmaceuticals 89 117 .
Kenneth C. Waterman, Roger C. Adami & Jin Yang Hong. 2004. Handbook of Isolation and Characterization of Impurities in Pharmaceuticals. Handbook of Isolation and Characterization of Impurities in Pharmaceuticals 75 88 .
Jefferson D Knight & Roger C Adami. (2003) Stabilization of DNA utilizing divalent cations and alcohol. International Journal of Pharmaceutics 264:1-2, pages 15-24.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.