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Original Article

Effect of Ginkgo biloba extract on lopinavir, midazolam and fexofenadine pharmacokinetics in healthy subjects

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Pages 591-599 | Accepted 20 Dec 2007, Published online: 17 Jan 2008

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Kristina M. Brooks, Jomy M. George & Parag Kumar. (2017) Drug interactions in HIV treatment: complementary & alternative medicines and over-the-counter products. Expert Review of Clinical Pharmacology 10:1, pages 59-79.
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María José Abad Martínez, Luis Miguel Bedoya del Olmo & Paulina Bermejo Benito. 2014. 197 221 .
Shizuo Yamada, Shingen Misaka, Yoshihiko Ito, Hiroshi Watanabe & Keizo Umegaki. 2014. Pharma-Nutrition. Pharma-Nutrition 189 211 .
Jennifer J. Kiser, James R. BurtonJrJr & Gregory T. Everson. (2013) Drug–drug interactions during antiviral therapy for chronic hepatitis C. Nature Reviews Gastroenterology & Hepatology 10:10, pages 596-606.
Crossref
F. Petitet. (2013) Interactions pharmacocinétiques entre préparations à base de plantes et médicaments : une revue des absences d’interactions démontrées cliniquementHerbdrug pharmacokinetic interactions: a review of the absence of interactions with clinical incidence. Phytothérapie 11:5, pages 272-283.
Crossref
Christian Ude, Manfred Schubert-Zsilavecz & Mario Wurglics. (2013) Ginkgo biloba Extracts: A Review of the Pharmacokinetics of the Active Ingredients. Clinical Pharmacokinetics 52:9, pages 727-749.
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Shizuo Yamada, Yuko Taki, Shingen Misaka, Takashi Okura, Yoshiharu Deguchi, Keizo Umegaki, Hiroshi Watanabe, Yasuo Watanabe & Margot Skinner. 2013. Bioactives in Fruit. Bioactives in Fruit 59 79 .
. 2013. Principles and Practice of Phytotherapy. Principles and Practice of Phytotherapy 970 996 .
Jaime A. Yáñez, Nagendra V. Chemuturi, Scott W. Womble, Casey L. Sayre & Neal M. Davies. 2012. FLAVONOID PHARMACOKINETICS. FLAVONOID PHARMACOKINETICS 281 319 .
Maren Blonk, Angela Colbers, Anne Poirters, Bas Schouwenberg & David Burger. (2012) Effect of Ginkgo Biloba on the Pharmacokinetics of Raltegravir in Healthy Volunteers. Antimicrobial Agents and Chemotherapy 56:10, pages 5070-5075.
Crossref
Christine Y. Malati, Sarah M. Robertson, Jennifer D. Hunt, Cheryl Chairez, Raul M. Alfaro, Joseph A. Kovacs & Scott R. Penzak. (2013) Influence of Panax ginseng on Cytochrome P450 (CYP)3A and P‐glycoprotein (P‐gp) Activity in Healthy Participants . The Journal of Clinical Pharmacology 52:6, pages 932-939.
Crossref
F. Petitet. (2012) Interactions pharmacocinétiques entre préparation à base de plantes et médicament : une revue de l’importance cliniqueHerb-drug pharmacokinetic interactions: a review of the clinical incidence. Phytothérapie 10:3, pages 170-182.
Crossref
Alexander V. LyubimovBill Gurley, Kim E. Fifer & Zöe Gardner. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 79 .
Mark Naccarato, Deborah Yoong & Kevin Gough. (2012) A Potential Drug–Herbal Interaction between Ginkgo biloba and Efavirenz . Journal of the International Association of Physicians in AIDS Care 11:2, pages 98-100.
Crossref
Shaojun Shi & Ulrich Klotz. (2012) Drug Interactions with Herbal Medicines. Clinical Pharmacokinetics 51:2, pages 77-104.
Crossref
José Moltó, Cristina Miranda, Sara Malo, Marta Valle, Angels Andreu, Xavier Bonafont & Bonaventura Clotet. (2012) Consumo de plantas medicinales en los pacientes infectados por el virus de la inmunodeficiencia humana. Patrones de uso y factores relacionados. Medicina Clínica 138:3, pages 93-98.
Crossref
Alexander V. LyubimovSheela PaiBir & Sadayappan V. Rahavendran. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 48 .
Dong Hee Na, Hye Young Ji, Eun Ji Park, Myung Sun Kim, Kwang-Hyeon Liu & Hye Suk Lee. (2011) Evaluation of metabolism-mediated herb-drug interactions. Archives of Pharmacal Research 34:11, pages 1829-1842.
Crossref
Ge Lin, Zhong Zuo, Na Li & Li Zhang. 2011. Oral Bioavailability. Oral Bioavailability 233 251 .
Lesley A. Braun & Marc Cohen. (2011) Use of Complementary Medicines by Cardiac Surgery Patients; Undisclosed and Undetected. Heart, Lung and Circulation 20:5, pages 305-311.
Crossref
. 2011. A Guide to Evidence-based Integrative and Complementary Medicine. A Guide to Evidence-based Integrative and Complementary Medicine 841 854 .
Scott R. Penzak. 2011. Drug Interactions in Infectious Diseases. Drug Interactions in Infectious Diseases 131 165 .
Kathrin Mandery, Krystyna Bujok, Ingrid Schmidt, Markus Keiser, Werner Siegmund, Bettina Balk, Jörg König, Martin F. Fromm & Hartmut Glaeser. (2010) Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. Biochemical Pharmacology 80:11, pages 1746-1753.
Crossref
Charle Maritz, Sharon Byrne & Vivian Pribram. 2010. Nutrition and HIV. Nutrition and HIV 345 359 .
Scott R. Penzak, Sarah M. Robertson, Jennifer D. Hunt, Cheryl Chairez, Christine Y. Malati, Raul M. Alfaro, James M. Stevenson & Joseph A. Kovacs. (2012) Echinacea purpurea Significantly Induces Cytochrome P450 3A Activity but Does Not Alter Lopinavir‐Ritonavir Exposure in Healthy Subjects . Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 30:8, pages 797-805.
Crossref
Panel de expertos de Gesida & Plan Nacional sobre el Sida. (2010) Documento de consenso del Grupo de Estudio de Sida/Plan Nacional sobre el Sida respecto al tratamiento antirretroviral en adultos infectados por el virus de la inmunodeficiencia humana (actualización enero 2010). Enfermedades Infecciosas y Microbiología Clínica 28:6, pages 362.e1-362.e91.
Crossref
Melonie L. Stanton, Melanie S. Joy & Reginald F. Frye. (2010) Validation and application of a liquid chromatography–tandem mass spectrometric method for quantification of the drug transport probe fexofenadine in human plasma using 96-well filter plates. Journal of Chromatography B 878:3-4, pages 497-501.
Crossref
Rommel G. Tirona. 2010. Enzyme- and Transporter-Based Drug-Drug Interactions. Enzyme- and Transporter-Based Drug-Drug Interactions 75 105 .
Thomas D. Nolin, Reginald F. Frye, Phuong Le, Hooman Sadr, Judith Naud, Francois A. Leblond, Vincent Pichette & Jonathan Himmelfarb. (2009) ESRD Impairs Nonrenal Clearance of Fexofenadine but not Midazolam. Journal of the American Society of Nephrology 20:10, pages 2269-2276.
Crossref
Angelo A. Izzo & Edzard Ernst. (2009) Interactions Between Herbal Medicines and Prescribed Drugs. Drugs 69:13, pages 1777-1798.
Crossref
He-Ping Lei, Wei Ji, Jian Lin, Hao Chen, Zhi-Rong Tan, Dong-Li Hu, Li-Juan Liu & Hong-Hao Zhou. (2009) Effects of Ginkgo biloba extract on the pharmacokinetics of bupropion in healthy volunteers . British Journal of Clinical Pharmacology 68:2, pages 201-206.
Crossref
Lan Fan, Gong-You Tao, Guo Wang, Yao Chen, Wei Zhang, Yi-Jing He, Qing Li, He-Ping Lei, Feng Jiang, Dong-Li Hu, Yuan-Fei Huang & Hong-Hao Zhou. (2009) Effects of Ginkgo biloba Extract Ingestion on the Pharmacokinetics of Talinolol in Healthy Chinese Volunteers. Annals of Pharmacotherapy 43:5, pages 944-949.
Crossref
Linhao Li, Joseph D. Stanton, Antonia H. Tolson, Yuan Luo & Hongbing Wang. (2008) Bioactive Terpenoids and Flavonoids from Ginkgo Biloba Extract Induce the Expression of Hepatic Drug-Metabolizing Enzymes Through Pregnane X Receptor, Constitutive Androstane Receptor, and Aryl hydrocarbon Receptor-Mediated Pathways. Pharmaceutical Research 26:4, pages 872-882.
Crossref
Eugene Y. H. Yeung, Tatsuya Sueyoshi, Masahiko Negishi & Thomas K. H. Chang. (2008) Identification of Ginkgo biloba as a Novel Activator of Pregnane X Receptor . Drug Metabolism and Disposition 36:11, pages 2270-2276.
Crossref

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