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Current Medical Research and Opinion Volume 25, 2009 - Issue 11
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Original Article

Efficacy and tolerability of amlodipine/valsartan combination therapy in hypertensive patients not adequately controlled on amlodipine monotherapy

H Schunkert Universitaetsklinikum Schleswig-Holstein, Campus Luebeck, Medizinische Klinik II, Ratzeburger Allee 160, 23538 Luebeck, GermanyCorrespondence[email protected]
,
R.D. Glazer Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ 07936-1080, USA
,
M. Wernsing Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ 07936-1080, USA
,
J. Yen Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ 07936-1080, USA
,
C.E. Macarie Institutul de Boli Cardiovasculare, Cardiology 1, 258 Fundeni Avenue, 2 Bucharest 022322, Romania
,
M.M. Vintila Spitalul Sf. Pantelimon, Internal Medicine and Cardiology, 340 Pantelimon Avenue, 2 Bucharest 012659, Romania
&
J Romanova Cardiology Department, P. Stradins University Hospital, Riga, Latvia, LV 1002
 show all
Pages 2655-2662 | Accepted 30 Jul 2009, Published online: 14 Sep 2009

Citations (21)

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Read on this site (9)

Manuel Gorostidi & Alejandro de la Sierra. (2018) Combination therapies for hypertension – why we need to look beyond RAS blockers. Expert Review of Clinical Pharmacology 11:9, pages 841-853.
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Jorge Sison, Rosa María Ríos Vega, Hu Dayi, Giovanni Bader & Patrick Brunel. (2018) Efficacy and effectiveness of valsartan/amlodipine and valsartan/amlodipine/hydrochlorothiazide in hypertension: randomized controlled versus observational studies. Current Medical Research and Opinion 34:3, pages 501-515.
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Jocelyn D Jones, Sylvia H Jackson & Charlie Colquitt. (2013) Azilsartan alone and in combination for the treatment of hypertension – clinical utility and patient considerations. Research Reports in Clinical Cardiology 4, pages 125-133.
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Shu-Meng Cheng, Guang-Yuan Mar, Shih-Chung Huang, Chung-Sen Chen, Chih-Min Hsieh, Lien-Chi Huang & Kwo-Chang Ueng. (2012) Post-marketing surveillance study of valsartan/amlodipine combination in Taiwanese hypertensive patients. Blood Pressure 21:sup1, pages 11-19.
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Steen Neldam, Colin Edwards & Russell Jones. (2011) Switching patients with uncontrolled hypertension on amlodipine 10 mg to single-pill combinations of telmisartan and amlodipine: results of the TEAMSTA-10 study. Current Medical Research and Opinion 27:11, pages 2145-2153.
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Rainer Düsing. (2010) Valsartan/amlodipine single pill combination for the treatment of hypertension. Expert Review of Clinical Pharmacology 3:6, pages 739-746.
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Jean-Jacques Mourad, Sylvain Le Jeune, Anthony Pirollo, Clarisse Mourad, Yann Gaudouen & Marilucy Lopez-Sublet. (2010) Combinations of inhibitors of the renin–angiotensin system with calcium channel blockers for the treatment of hypertension: focus on perindopril/amlodipine. Current Medical Research and Opinion 26:9, pages 2263-2276.
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Ramón C. Hermida, Diana E. Ayala, María J. Fontao, Artemio Mojón & José R. Fernández. (2010) CHRONOTHERAPY WITH VALSARTAN/AMLODIPINE FIXED COMBINATION: IMPROVED BLOOD PRESSURE CONTROL OF ESSENTIAL HYPERTENSION WITH BEDTIME DOSING. Chronobiology International 27:6, pages 1287-1303.
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YuanNan Ke, DingLiang Zhu, HuaShan Hong, JunRen Zhu, RuoNan Wang, Pamela Cardenas & Ying Zhang. (2010) Efficacy and safety of a single-pill combination of amlodipine/valsartan in Asian hypertensive patients inadequately controlled with amlodipine monotherapy. Current Medical Research and Opinion 26:7, pages 1705-1713.
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Articles from other publishers (12)

Mengxin Xie, Tianjiao Tang & Hongsheng Liang. (2023) Efficacy of single‐pill combination in uncontrolled essential hypertension: A systematic review and network meta‐analysis. Clinical Cardiology.
Crossref
Ji-Guang Wang, Kimihiko Yukisada, Antonio Sibulo, Kudsia Hafeez, Yan Jia & Jack Zhang. (2017) Efficacy and safety of sacubitril/valsartan (LCZ696) add-on to amlodipine in Asian patients with systolic hypertension uncontrolled with amlodipine monotherapy. Journal of Hypertension 35:4, pages 877-885.
Crossref
Wenbo He, Zhibing Lu & Hong Jiang. (2017) Clinical Utility of Amlodipine/Valsartan Fixed-Dose Combination in the Management of Hypertension in Chinese Patients. Cardiovascular Innovations and Applications 2:2.
Crossref
Jidong SungJin-Ok JeongSung Uk KwonKyung Heon WonByung Jin KimByung Ryul ChoMyeong-Kon KimSahng LeeHak Jin KimSeong-Hoon LimSeung Woo ParkJeong Euy Park. (2016) Valsartan 160 mg/Amlodipine 5 mg Combination Therapy versus Amlodipine 10 mg in Hypertensive Patients with Inadequate Response to Amlodipine 5 mg Monotherapy. Korean Circulation Journal 46:2, pages 222.
Crossref
Lars C. Rump, Bettina Ammentorp, Petra Laeis & Jürgen Scholze. (2015) Adding Hydrochlorothiazide to Olmesartan/Amlodipine Increases Efficacy in Patients With Inadequate Blood Pressure Control on Dual‐Combination Therapy. The Journal of Clinical Hypertension 18:1, pages 60-69.
Crossref
Dayi Hu, Lisheng Liu & Weimin Li. (2014) Efficacy and Safety of Valsartan/Amlodipine Single-Pill Combination in 11,422 Chinese Patients with Hypertension: an Observational Study. Advances in Therapy 31:7, pages 762-775.
Crossref
Dingliang Zhu, Kan Yang, Ningling Sun, Pingjin Gao, Ruonan Wang, Amie Grosso & Ying Zhang. (2013) Amlodipine/valsartan 5/160mg versus valsartan 160mg in Chinese hypertensives. International Journal of Cardiology 167:5, pages 2024-2030.
Crossref
Manuel Gorostidi & Alejandro de la Sierra. (2013) Combination Therapy in Hypertension. Advances in Therapy 30:4, pages 320-336.
Crossref
Bum-Kee Hong, Chang Gyu Park, Ki Sik Kim, Myeong Ho Yoon, Ho Joong Yoon, Jeong Han Yoon, Joo Young Yang, Young Jin Choi & Seung Yun Cho. (2012) Comparison of the Efficacy and Safety of Fixed-Dose Amlodipine/Losartan and Losartan in Hypertensive Patients Inadequately Controlled with Losartan. American Journal Cardiovascular Drugs 12:3, pages 189-195.
Crossref
Steen Neldam, Margreet Lang & Russell Jones. (2011) Telmisartan and Amlodipine Single-Pill Combinations vs Amlodipine Monotherapy for Superior Blood Pressure Lowering and Improved Tolerability in Patients With Uncontrolled Hypertension: Results of the TEAMSTA-5 Study. The Journal of Clinical Hypertension 13:7, pages 459-466.
Crossref
Harikrishna Makani, Sripal Bangalore, Jorge Romero, Nay Htyte, Ronaldo S Berrios, Hetal Makwana & Franz H Messerli. (2011) Peripheral edema associated with calcium channel blockers: incidence and withdrawal rate – a meta-analysis of randomized trials. Journal of Hypertension 29:7, pages 1270-1280.
Crossref
Harikrishna Makani, Sripal Bangalore, Jorge Romero, Omar Wever-Pinzon & Franz H. Messerli. (2011) Effect of Renin-Angiotensin System Blockade on Calcium Channel Blocker-Associated Peripheral Edema. The American Journal of Medicine 124:2, pages 128-135.
Crossref

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