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Review

Diclofenac: an update on its mechanism of action and safety profile

Pages 1715-1731 | Accepted 14 Apr 2010, Published online: 17 May 2010

Keep up to date with the latest research on this topic with citation updates for this article.

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Yavuz Osman Birdane, Hülya Atik, Orkun Atik & Recep Aslan. (2022) Mandarin peel ethanolic extract attenuates diclofenac sodium induced hepatorenal toxicity in rats by mitigating oxidative stress and inflammation. Drug and Chemical Toxicology 0:0, pages 1-11.
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Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Thabat J. Al-Maiahy, Athanasios Alexiou, Nobendu Mukerjee & Gaber El-Saber Batiha. (2022) Prostaglandins and non-steroidal anti-inflammatory drugs in Covid-19. Biotechnology and Genetic Engineering Reviews 0:0, pages 1-21.
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Lyubomir Marinov, Ani Georgieva, Yulian Voynikov, Reneta Toshkova, Irina Nikolova & Martin Malchev. (2021) Cytotoxic and antiproliferative effects of the nonsteroidal anti-inflammatory drug diclofenac in human tumour cell lines. Biotechnology & Biotechnological Equipment 35:1, pages 1118-1126.
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Joseph V. Pergolizzi$suffix/text()$suffix/text(), Peter Magnusson, Robert B. Raffa, Jo Ann LeQuang & Flaminia Coluzzi. (2020) Developments in combined analgesic regimens for improved safety in postoperative pain management. Expert Review of Neurotherapeutics 20:9, pages 981-990.
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Raimunda Sâmia Nogueira Brilhante, Jaiane Alves Brasil, Jonathas Sales de Oliveira, Vandbergue Santos Pereira, Waldemiro de Aquino Pereira-Neto, José Júlio Costa Sidrim & Marcos Fábio Gadelha Rocha. (2020) Diclofenac exhibits synergism with azoles against planktonic cells and biofilms of Candida tropicalis. Biofouling 36:5, pages 528-536.
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Julie Pradal, Coralie M Vallet, Guillaume Frappin, Frédérique Bariguian & Maria Stella Lombardi. (2019) Importance of the formulation in the skin delivery of topical diclofenac: not all topical diclofenac formulations are the same. Journal of Pain Research 12, pages 1149-1154.
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Archana Vyas, Ashok Purohit & Heera Ram. (2019) Assessment of dose-dependent reproductive toxicity of diclofenac sodium in male rats. Drug and Chemical Toxicology 42:5, pages 478-486.
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K. D. Rainsford, Michael S. Roberts, Alessandro Nencioni & Clarence Jones. (2019) Rationale and evidence for the incorporation of heparin into the diclofenac epolamine medicated plaster. Current Medical Research and Opinion 35:6, pages 989-1002.
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E. Giménez-Martín, M. A. López-Andrade & D. Campos. (2019) Nylon fibers coated with diclofenac: adsorption properties. The Journal of The Textile Institute 110:4, pages 515-523.
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G. I. Anuja, V. J. Shine & S. R. Suja. (2018) In vitro anti-inflammatory and free radical scavenging properties of Oldenlandia auricularia. Toxicological & Environmental Chemistry 100:5-7, pages 573-582.
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Zengfu Wang, Dali Chen & Zhongwei Wang. (2018) Effects of diclofenac on the pharmacokinetics of celastrol in rats and its transport. Pharmaceutical Biology 56:1, pages 269-274.
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Kshitij Shah, Omvijay B Chaudhari, Palash Gupta, R Hom Chaudhuri, Ranjan Kamilya, Shreedhar S Kulkarni, S Subbaiah, Zubair H Sorathia & Gauri Billa. (2017) Durapain in symptomatic treatment of severe acute pain: a post-marketing, prospective, multicenter, observational study – PRIME study. Journal of Pain Research 10, pages 1273-1278.
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Tong J Gan, Neil Singla, Stephen E Daniels, Douglas A Hamilton, Peter G Lacouture, Christian RD Reyes & Daniel B Carr. (2017) Postoperative opioid sparing with injectable hydroxypropyl-β-cyclodextrin-diclofenac: pooled analysis of data from two Phase III clinical trials. Journal of Pain Research 10, pages 15-29.
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Martina Hagen & Mark Baker. (2017) Skin penetration and tissue permeation after topical administration of diclofenac. Current Medical Research and Opinion 33:9, pages 1623-1634.
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Shelly Jain, Preety Ghanghas, Chandan Rana & S. N. Sanyal. (2017) Role of GSK-3β in Regulation of Canonical Wnt/β-catenin Signaling and PI3-K/Akt Oncogenic Pathway in Colon Cancer. Cancer Investigation 35:7, pages 473-483.
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Vinicius Tieppo Francio, Saeid Davani, Chris Towery & Tony L. Brown. (2017) Oral Versus Topical Diclofenac Sodium in the Treatment of Osteoarthritis. Journal of Pain & Palliative Care Pharmacotherapy 31:2, pages 113-120.
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Jennifer L. Plahovinsak, Matthew A. Buccellato, Frances M. Reid & John S. Graham. (2016) Selection of non-steroidal anti-inflammatory drug and treatment regimen for sulfur mustard-induced cutaneous lesions. Cutaneous and Ocular Toxicology 35:3, pages 208-217.
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Utkan Sevuk, Erkan Baysal, Rojhat Altindag, Baris Yaylak, Mehmet Sahin Adiyaman, Nurettin Ay, Vahhac Alp & Unal Beyazit. (2015) Role of diclofenac in the prevention of postpericardiotomy syndrome after cardiac surgery. Vascular Health and Risk Management 11, pages 373-378.
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Jun Zheng Goh, Sook Nai Tang, Hoe Siong Chiong, Yoke Keong Yong, Ahmad Zuraini & Muhammad Nazrul Hakim. (2015) Evaluation of antinociceptive activity of nanoliposome-encapsulated and free-form diclofenac in rats and mice. International Journal of Nanomedicine 10, pages 297-303.
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Hiren Patel, Abhay Joshi, Amit Joshi & Grazia Stagni. (2015) Effect of microporation on passive and iontophoretic delivery of diclofenac sodium. Drug Development and Industrial Pharmacy 41:12, pages 1962-1967.
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Renan G Brito, Adriano AS Araújo, Jullyana SS Quintans, Kathleen A Sluka & Lucindo J Quintans-Júnior. (2015) Enhanced analgesic activity by cyclodextrins – a systematic review and meta-analysis. Expert Opinion on Drug Delivery 12:10, pages 1677-1688.
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Roy D. Altman, Vibeke Strand, Marc C. Hochberg, Allan Gibofsky, Joseph A. Markenson, William E. Hopkins, Byron Cryer, Alan Kivitz, Jennifer Nezzer, Olaolu Imasogie & Clarence L. Young. (2015) Low-dose SoluMatrix diclofenac in the treatment of osteoarthritis: A 1-year, open-label, Phase III safety study. Postgraduate Medicine 127:5, pages 517-528.
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Allan Gibofsky, Roy Altman, Stephen Daniels, Olaolu Imasogie & Clarence Young. (2015) Low-dose SoluMatrix diclofenac: a review of safety across two Phase III studies in patients with acute and osteoarthritis pain. Expert Opinion on Drug Safety 14:8, pages 1327-1339.
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Stephen E. Daniels, Dennis Riff, Eric Diamond, Francis Clark & Stephen E. Boesing. (2012) An assessment of the efficacy and safety of diclofenac potassium liquid-filled capsules in patients with various levels of baseline pain intensity. Current Medical Research and Opinion 28:6, pages 953-961.
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John R. Zuniga, Robert J. Noveck, William K. Schmidt, Stephen E. Boesing & Elliot V. Hersh. (2011) Onset of action of diclofenac potassium liquid-filled capsules in dental surgery patients. Current Medical Research and Opinion 27:9, pages 1733-1739.
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