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Original Article

Adherence and persistence of single-pill ARB/CCB combination therapy compared to multiple-pill ARB/CCB regimens

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Pages 2877-2887 | Accepted 19 Oct 2010, Published online: 11 Nov 2010

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Luca Degli Esposti, Valentina Perrone, Chiara Veronesi, Marco Gambera, Giulio Nati, Francesco Perone, Paola Fausta Tagliabue, Stefano Buda & Claudio Borghi. (2018) Modifications in drug adherence after switch to fixed-dose combination of perindopril/amlodipine in clinical practice. Results of a large-scale Italian experience. The amlodipine-perindopril in real settings (AMPERES) study. Current Medical Research and Opinion 34:9, pages 1571-1577.
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Lin Xie, Feride Frech-Tamas, Elizabeth Marrett & Onur Baser. (2014) A medication adherence and persistence comparison of hypertensive patients treated with single-, double- and triple-pill combination therapy. Current Medical Research and Opinion 30:12, pages 2415-2422.
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Steen Neldam, Helmut Schumacher, Sverre E. Kjeldsen & Joel M. Neutel. (2014) Telmisartan in combination with hydrochlorothiazide 12.5 mg for the management of patients with hypertension. Current Medical Research and Opinion 30:9, pages 1715-1724.
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Julian Segura & Luis Miguel Ruilope. (2013) A review of the benefits of early treatment initiation with single-pill combinations of telmisartan with amlodipine or hydrochlorothiazide. Vascular Health and Risk Management 9, pages 521-528.
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Danny H Sugimoto, Steven G Chrysant, Michael Melino, James Lee, Victor Fernandez & Reinilde Heyrman. (2013) The TRINITY Study: distribution of systolic blood pressure reductions. Integrated Blood Pressure Control 6, pages 89-99.
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Sripal Bangalore & Ludwin Ley. (2012) Improving treatment adherence to antihypertensive therapy: the role of single-pill combinations. Expert Opinion on Pharmacotherapy 13:3, pages 345-355.
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L. Breitscheidel, B. Ehlken, K. Kostev, M. S. A. Oberdiek, A. Sandberg & R. E. Schmieder. (2012) Real-life treatment patterns, compliance, persistence, and medication costs in patients with hypertension in Germany. Journal of Medical Economics 15:1, pages 155-165.
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Qiran Wei, Jiting Zhou, Hongchao Li, Luying Wang, Yao Wu, Aixia Ma & Xin Guan. (2023) Medication adherence with fixed-dose versus free-equivalent combination therapies: Systematic review and meta-analysis. Frontiers in Pharmacology 14.
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Eun-Seok Jeon, Sang Wook Lim, Seok-Yeon Kim, Hyoung-Mo Yang, Moo Hyun Kim, Moo-Yong Rhee, Seung Hwan Han, Jinho Shin, Kwang-il Kim, Jin-Ok Jeong, Ki Chul Sung, Geu Ru Hong, Hyung-Seop Kim, Kihwan Kwon, Tae-Soo Kang, Hae-Young Lee & Su-Eun Han. (2022) A randomized, double-blind, multicenter, phase III study on the efficacy and safety of a combination treatment involving fimasartan, amlodipine, rosuvastatin in patients with essential hypertension and dyslipidemia who fail to respond adequately to fimasartan monotherapy. Clinical Hypertension 28:1.
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Apichard Sukonthasarn, Yook‐Chin Chia, Ji‐Guang Wang, Jennifer Nailes, Peera Buranakitjaroen, Huynh Van Minh, Narsingh Verma, Satoshi Hoshide, Jinho Shin, Yuda Turana, Jam Chin Tay, Boon Wee Teo, Saulat Siddique, Jorge Sison, Yu‐Qing Zhang, Tzung‐Dau Wang, Chen‐Huan Chen & Kazuomi Kario. (2020) The feasibility of polypill for cardiovascular disease prevention in Asian Population. The Journal of Clinical Hypertension 23:3, pages 545-555.
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Anik R. Patel, Gail F. Schwartz, Joanna H. Campbell, Chi-Chang Chen, Catherine B. McGuiness, Jasjit K. Multani, Vanessa Shih & Oluwatosin U. Smith. (2021) Economic and Clinical Burden Associated With Intensification of Glaucoma Topical Therapy: A US Claims-based Analysis. Journal of Glaucoma 30:3, pages 242-250.
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Gianfranco Parati, Sverre Kjeldsen, Antonio CocaWilliam C. Cushman & Jiguang Wang. (2021) Adherence to Single-Pill Versus Free-Equivalent Combination Therapy in Hypertension. Hypertension 77:2, pages 692-705.
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Ana Baumgartner, Katarina Drame, Stijn Geutjens & Marja Airaksinen. (2020) Does the Polypill Improve Patient Adherence Compared to Its Individual Formulations? A Systematic Review. Pharmaceutics 12:2, pages 190.
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Anna F. Dominiczak, Martine de Champvallins, Romualda Brzozowska-Villatte & Roland Asmar. (2019) Efficacy of a new single-pill combination of a thiazide-like diuretic and a calcium channel blocker (indapamide sustained release/amlodipine) in essential hypertension. Journal of Hypertension 37:11, pages 2280-2289.
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Seung Jae Kim, Oh Deog Kwon, BeLong Cho, Seung-Won Oh, Cheol Min Lee & Ho-Chun Choi. (2019) Effects of combination drugs on antihypertensive medication adherence in a real-world setting: a Korean Nationwide Study. BMJ Open 9:6, pages e029862.
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Sofa D. Alfian, Ivan S. Pradipta, Eelko Hak & Petra Denig. (2019) A systematic review finds inconsistency in the measures used to estimate adherence and persistence to multiple cardiometabolic medications. Journal of Clinical Epidemiology 108, pages 44-53.
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Priti P. Pednekar, Tamás Ágh, Maria Malmenäs, Amit D. Raval, Bryan M. Bennett, Bijan J. Borah, David S. Hutchins, Elizabeth Manias, Allison F. Williams, Mickaël Hiligsmann, Adina Turcu-Stiolica, John E. Zeber, Lusine Abrahamyan, Thomas J. Bunz & Andrew M. Peterson. (2019) Methods for Measuring Multiple Medication Adherence: A Systematic Review–Report of the ISPOR Medication Adherence and Persistence Special Interest Group. Value in Health 22:2, pages 139-156.
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Stelina Alkagiet & Konstantinos Tziomalos. (2018) Suboptimal Adherence to Antihypertensive Treatment: Causes and Management. The Open Hypertension Journal 10:1, pages 41-45.
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Benoit Imbeault & Michel Vallée. (2018) Single-Pill Combinations in the Treatment of Hypertension in Adults: Beyond Convenience. Canadian Journal of Diabetes 42:2, pages 205-208.
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Idir Hamdidouche, Vincent Jullien, Stéphane Laurent & Michel Azizi. 2018. Drug Adherence in Hypertension and Cardiovascular Protection. Drug Adherence in Hypertension and Cardiovascular Protection 185 197 .
Andrea L. Schaffer, Nicholas A. Buckley & Sallie-Anne Pearson. (2017) Who benefits from fixed-dose combinations? Two-year statin adherence trajectories in initiators of combined amlodipine/atorvastatin therapy. Pharmacoepidemiology and Drug Safety 26:12, pages 1465-1473.
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Chen-Pei Ho, Jih-I Yeh, Shu-Hui Wen & Tony Jer-Fu Lee. (2017) Associations among medication regimen complexity, medical specialty, and medication possession ratio in newly diagnosed hypertensive patients. Medicine 96:45, pages e8497.
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Jennifer S. Albrecht, Bilal Khokhar, Ting-Ying Huang, Yu-Jung Wei, Ilene Harris, Patience Moyo, Peter Hur, Susan W. Lehmann, Giora Netzer & Linda Simoni-Wastila. (2017) Adherence and healthcare utilization among older adults with COPD and depression. Respiratory Medicine 129, pages 53-58.
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Idir Hamdidouche, Vincent Jullien, Pierre Boutouyrie, Eliane Billaud, Michel Azizi & Stéphane Laurent. (2017) Drug adherence in hypertension. Journal of Hypertension 35:6, pages 1133-1144.
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Alberto Mazza, Salvatore Lenti, Laura Schiavon, Antonella Paola Sacco, Fabio Dell’Avvocata, Gianluca Rigatelli & Emilio Ramazzina. (2017) Fixed-Dose Triple Combination of Antihypertensive Drugs Improves Blood Pressure Control: From Clinical Trials to Clinical Practice. Advances in Therapy 34:4, pages 975-985.
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Andrea L. Schaffer, Sallie-Anne Pearson & Nicholas A. Buckley. (2016) How does prescribing for antihypertensive products stack up against guideline recommendations? An Australian population-based study (2006-2014). British Journal of Clinical Pharmacology 82:4, pages 1134-1145.
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François Després, Amélie Forget, Fatima-Zohra Kettani & Lucie Blais. (2016) Impact of Patient Reimbursement Timing and Patient Out-of-Pocket Expenses on Medication Adherence in Patients Covered by Private Drug Insurance Plans. Journal of Managed Care & Specialty Pharmacy 22:5, pages 539-547.
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O. V. Machilskaya. (2016) The factors determining adherence to treatment in arterial hypertension patients (literature review). Kardiologiya i serdechno-sosudistaya khirurgiya 9:3, pages 55.
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Yasunari Mano, Shota Fukushima, Hisayuki Kuroda, Hiroyuki Ohshima, Yoshinori Kato, Kaori Ohuchi, Kayoko Maezawa, Yasuyuki Momose, Shunya Ikeda & Mariko Asahi. (2015) Adherence to changing from brand-name to generic atorvastatin in newly treated patients: a retrospective cohort study using health insurance claims. Journal of Pharmaceutical Health Care and Sciences 1:1.
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Stéphane Laurent. (2015) Achieving Goal Blood Pressure. High Blood Pressure & Cardiovascular Prevention 22:S1, pages 5-9.
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Lynda McEvoy. (2015) Hypertension Care: It’s Time to Act. EMJ Cardiology, pages 2-10.
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Ai Theng Cheong, Salmiah Mohd Said & Norliza Muksan. (2013) Time to Achieve First Blood Pressure Control After Diagnosis Among Hypertensive Patients at Primary Health Care Clinics. Asia Pacific Journal of Public Health 27:2, pages NP485-NP494.
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Robert J. Romanelli & Jodi B. Segal. (2014) Predictors of Statin Compliance after Switching from Branded to Generic Agents among Managed-Care Beneficiaries. Journal of General Internal Medicine 29:10, pages 1372-1378.
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A. Lawrence Gould, S. Unniachan & D. Wu. (2014) Indirect treatment comparison between fixed-dose-combinations of amlodipine/losartan and amlodipine/valsartan in blood pressure control. International Journal of Clinical Practice 68:2, pages 163-172.
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Jingjing Qian, Linda Simoni‐Wastila, Gail B. Rattinger, Ilene H. Zuckerman, Susan Lehmann, Yu‐Jung J. Wei & Bruce Stuart. (2013) Association between depression and maintenance medication adherence among Medicare beneficiaries with chronic obstructive pulmonary disease. International Journal of Geriatric Psychiatry 29:1, pages 49-57.
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Manabu Akazawa & Katsushi Fukuoka. (2013) Economic impact of switching to fixed-dose combination therapy for Japanese hypertensive patients: a retrospective cost analysis. BMC Health Services Research 13:1.
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Joel M. Neutel & David H. G. Smith. (2013) Hypertension Management: Rationale for Triple Therapy Based on Mechanisms of Action. Cardiovascular Therapeutics 31:5, pages 251-258.
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