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Current Medical Research and Opinion Volume 27, 2011 - Issue 3
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Review

Safety profile of topical diclofenac: a meta-analysis of blinded, randomized, controlled trials in musculoskeletal conditions

R.S. Taylor Peninsula College of Medicine & Dentistry, Universities of Exeter & Plymouth, Exeter, UKCorrespondence[email protected]
,
G. Fotopoulos Novartis Consumer Health, SA, Nyon, Switzerland
&
H. Maibach Prof Dermatology, University of California Medical School, San Francisco, USA
Pages 605-622 | Accepted 20 Dec 2010, Published online: 13 Jan 2011

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Martina Hagen & Mark Baker. (2017) Skin penetration and tissue permeation after topical administration of diclofenac. Current Medical Research and Opinion 33:9, pages 1623-1634.
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Vinicius Tieppo Francio, Saeid Davani, Chris Towery & Tony L. Brown. (2017) Oral Versus Topical Diclofenac Sodium in the Treatment of Osteoarthritis. Journal of Pain & Palliative Care Pharmacotherapy 31:2, pages 113-120.
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John H. Peniston, Morris S. Gold & Lawrence K. Alwine. (2011) An Open-Label, Long-Term Safety and Tolerability Trial of Diclofenac Sodium 1% Gel in Patients with Knee Osteoarthritis. The Physician and Sportsmedicine 39:3, pages 31-38.
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Articles from other publishers (22)

Carmen Maria Ferrer‐Luque, Carmen Solana, Beatriz Aguado, Pilar Baca, María Teresa Arias‐Moliz & Matilde Ruiz‐Linares. (2023) Efficacy of mixed diclofenac solutions against root canal biofilms. Australian Endodontic Journal.
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E.V. Yakusheva, A.S. Dukhanin, D.A. Iskra, A.V. Naumov, N.K. Runikhina & M.A. Strakhov. (2023) Personalized patient-oriented approach to the treatment of musculoskeletal pain syndrome using over-the-counter medications. Resolution of the Expert Council (May 28, 2023). Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 123:8, pages 134.
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Christopher A. Jones, Fred K. Hoehler, Valeria Frangione, Gilbert Ledesma, Paul P. WismanJrJr & Clarence Jones. (2021) Safety and Efficacy of the FLECTOR (Diclofenac Epolamine) Topical System in Children with Minor Soft Tissue Injuries: A Phase IV Non-randomized Clinical Trial. Clinical Drug Investigation 42:1, pages 43-51.
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G. R. Imametdinova, E. V. Igolkina & N. V. Chichasova. (2019) Local forms of diclofenac in the treatment of acute and chronic pain. Medical Council:18, pages 104-108.
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Guillermo Garcia-Lainez, Ana M. Martínez-Reig, Daniel Limones-Herrero, M. Consuelo Jiménez, Miguel A. Miranda & Inmaculada Andreu. (2018) Photo(geno)toxicity changes associated with hydroxylation of the aromatic chromophores during diclofenac metabolism. Toxicology and Applied Pharmacology 341, pages 51-55.
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Tzu‐Chieh Lin, Daniel H. Solomon, Sara K. Tedeschi, Kazuki Yoshida & Yea‐Huei Kao Yang. (2017) Comparative Risk of Cardiovascular Outcomes Between Topical and Oral Nonselective NSAIDs in Taiwanese Patients With Rheumatoid Arthritis. Journal of the American Heart Association 6:11.
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Scott E. Young, Jason D. Bothwell & Ryan M. Walsh. (2016) Safely Managing Acute Osteoarthritis in the Emergency Department: An Evidence-Based Review. The Journal of Emergency Medicine 51:6, pages 648-657.
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Gwendolyn Vuurberg & Gino M M J Kerkhoffs. (2016) Topical NSAIDs significantly reduces pain in adults with acute musculoskeletal injuries. Evidence Based Medicine 21:5, pages 187-188.
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Sheena Derry, Malene Cording, Philip J Wiffen, Simon Law, Tudor Phillips & R Andrew Moore. (2016) Pregabalin for pain in fibromyalgia in adults. Cochrane Database of Systematic Reviews 2019:5.
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Elyad Davidson, Melainie Cameron & Sigrun Chrubasik-Hausmann. (2016) Factors Affecting the Effectiveness of Topical NSAIDs. American Journal of Therapeutics 23:3, pages e977-e978.
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Sheena Derry, Philip Conaghan, José António P Da Silva, Philip J Wiffen & R Andrew Moore. (2016) Topical NSAIDs for chronic musculoskeletal pain in adults. Cochrane Database of Systematic Reviews 2020:2.
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Robert L Barkin. (2015) Topical Nonsteroidal Anti-Inflammatory Drugs. American Journal of Therapeutics 22:5, pages 388-407.
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Linda Long, Simon Briscoe, Chris Cooper, Chris Hyde & Louise Crathorne. (2015) What is the clinical effectiveness and cost-effectiveness of conservative interventions for tendinopathy? An overview of systematic reviews of clinical effectiveness and systematic review of economic evaluations. Health Technology Assessment 19:8, pages 1-134.
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Casilda M Balmaceda. (2014) Evolving guidelines in the use of topical nonsteroidal anti-inflammatory drugs in the treatment of osteoarthritis. BMC Musculoskeletal Disorders 15:1.
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Turgay Efe, Ercan Sagnak, Philip P. Roessler, Alan Getgood, Thilo Patzer, Susanne Fuchs-Winkelmann, Christian D. Peterlein & Markus D. Schofer. (2013) Penetration of topical diclofenac sodium 4 % spray gel into the synovial tissue and synovial fluid of the knee: a randomised clinical trial. Knee Surgery, Sports Traumatology, Arthroscopy 22:2, pages 345-350.
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C. González de Vega, C. Speed, B. Wolfarth & J. González. (2013) Traumeel vs. diclofenac for reducing pain and improving ankle mobility after acute ankle sprain: A multicentre, randomised, blinded, controlled and non‐inferiority trial. International Journal of Clinical Practice 67:10, pages 979-989.
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Magdalena Anitescu, Honorio T. Benzon & Charles E. Argoff. (2013) Advances in topical analgesics. Current Opinion in Anaesthesiology 26:5, pages 555-561.
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Sanford H Roth. (2013) Diclofenac in the treatment of osteoarthritis. International Journal of Clinical Rheumatology 8:2, pages 185-203.
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M. Carrington Reid, Rouzi Shengelia & Samantha J. Parker. (2012) Pharmacologic Management of Osteoarthritis-Related Pain in Older Adults. HSS Journal ® 8:2, pages 159-164.
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Christopher J Derry, Sheena Derry & R Andrew Moore. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Elizaveta Kon, Giuseppe Filardo, Matej Drobnic, Henning Madry, Mislav Jelic, Niek van Dijk & Stefano Della Villa. (2011) Non-surgical management of early knee osteoarthritis. Knee Surgery, Sports Traumatology, Arthroscopy 20:3, pages 436-449.
Crossref
Mary-Ann Fitzcharles & Yoram Shir. (2011) Management of Chronic Pain in the Rheumatic Diseases with Insights for the Clinician. Therapeutic Advances in Musculoskeletal Disease 3:4, pages 179-190.
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