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Original Article

Vitamin D deficiency, myositis–myalgia, and reversible statin intolerance

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Pages 1683-1690 | Accepted 15 Jun 2011, Published online: 06 Jul 2011

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Read on this site (10)

Vivek Rihal, Heena Khan, Amarjot Kaur & Thakur Gurjeet Singh. (2022) Vitamin D as therapeutic modulator in cerebrovascular diseases: a mechanistic perspectives. Critical Reviews in Food Science and Nutrition 0:0, pages 1-23.
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Michael Wakeman. (2021) A Literature Review of the Potential Impact of Medication on Vitamin D Status. Risk Management and Healthcare Policy 14, pages 3357-3381.
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Uwe Gröber, Joachim Schmidt & Klaus Kisters. (2020) Important drug-micronutrient interactions: A selection for clinical practice. Critical Reviews in Food Science and Nutrition 60:2, pages 257-275.
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Vybhav Jetty, Charles J Glueck, Kevin Lee, Naila Goldenberg, Marloe Prince, Ashwin Kumar, Michael Goldenberg, Ishan Anand & Ping Wang. (2017) Eligibility for alirocumab or evolocumab treatment in 1090 hypercholesterolemic patients referred to a regional cholesterol treatment center with LDL cholesterol ≥70 mg/dL despite maximal-tolerated LDL-cholesterol-lowering therapy. Vascular Health and Risk Management 13, pages 247-253.
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Vana Kolovou, Helen Bilianou & Genovefa Kolovou. (2016) Safe use of statins: focus on muscle toxicity. Clinical Lipidology 11:1, pages 16-22.
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Helen I Keen, Janakan Krishnarajah, Timothy R Bates & Gerald F Watts. (2014) Statin myopathy: the fly in the ointment for the prevention of cardiovascular disease in the 21st century?. Expert Opinion on Drug Safety 13:9, pages 1227-1239.
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Ineke J. Riphagen, Eveline van der Veer, Frits A.J. Muskiet & Mike J.L. DeJongste. (2012) Myopathy during statin therapy in the daily practice of an outpatient cardiology clinic: prevalence, predictors and relation with vitamin D. Current Medical Research and Opinion 28:7, pages 1247-1252.
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Uwe Gröber & Klaus Kisters. (2012) Influence of drugs on vitamin D and calcium metabolism. Dermato-Endocrinology 4:2, pages 158-166.
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Michael S. Kostapanos, Vasilios G. Athyros, Asterios Karagiannis & Dimitri P. Mikhailidis. (2012) Therapeutic options for statin-intolerant patients. Current Medical Research and Opinion 28:3, pages 345-349.
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Claire Meek, Anthony S. Wierzbicki, Christina Jewkes, Patrick J. Twomey, Martin A. Crook, Alan Jones & Adie Viljoen. (2012) Daily and intermittent rosuvastatin 5 mg therapy in statin intolerant patients: an observational study. Current Medical Research and Opinion 28:3, pages 371-378.
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Articles from other publishers (55)

Yumiko Tsushima & Betul Hatipoglu. (2023) Statin Intolerance: A Review and Update. Endocrine Practice 29:7, pages 566-571.
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Giosiana Bosco, Francesco Di Giacomo Barbagallo, Salvatore Spampinato, Lorena Lanzafame, Antonino Di Pino, Salvatore Piro, Francesco Purrello & Roberto Scicali. (2023) Management of Statin Intolerant Patients in the Era of Novel Lipid Lowering Therapies: A Critical Approach in Clinical Practice. Journal of Clinical Medicine 12:6, pages 2444.
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Ricardo Hernández Balboa, Luis Miguel Torres Morera, Sara Borrego Martín, Ramón Eizaga Rebollar & Rafael Garcia Hernandez. (2023) ¿Podría la Vitamina D ser una aliada en la Lucha contra el Dolor Crónico? ¿Qué dice la evidencia?. Multidisciplinary Pain Journal.
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Mark A. Hlatky, Pedro Engel Gonzalez, JoAnn E. Manson, Julie E. Buring, I-Min Lee, Nancy R. Cook, Samia Mora, Vadim Bubes & Neil J. Stone. (2023) Statin-Associated Muscle Symptoms Among New Statin Users Randomly Assigned to Vitamin D or Placebo. JAMA Cardiology 8:1, pages 74.
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Mark A. Tarnopolsky. (2022) Metabolic Myopathies. CONTINUUM: Lifelong Learning in Neurology 28:6, pages 1752-1777.
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Claudio CaralloAlessandro Capozza & Agostino Gnasso. (2022) Effects of Vitamin D Supplementation in Patients with Statin-Associated Muscle Symptoms and Low Vitamin D Levels. Metabolic Syndrome and Related Disorders 20:10, pages 567-575.
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Ateş Ş, Alkan Bozkaya T, İncir S, Çakıcı Ç, Yiğitbaşı T & Emekli N. (2022) Effects of vitamin D level and oxidant-antioxidant balance on postoperative morbidity in diabetic and non-diabetic patients undergoing off-pump bypass surgery. Advances in Tissue Engineering & Regenerative Medicine: Open Access 8:1, pages 11-16.
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Mary Katherine Cheeley, Joseph J. Saseen, Anandita Agarwala, Sudha Ravilla, Nicole Ciffone, Terry A. Jacobson, Dave L. Dixon & Kevin C. Maki. (2022) NLA scientific statement on statin intolerance: a new definition and key considerations for ASCVD risk reduction in the statin intolerant patient. Journal of Clinical Lipidology 16:4, pages 361-375.
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Chong Boon Teo, Pek Yan Tan, Ryan Yong Kiat Tay, Joan Khoo, Gerald F. Watts & Wann Jia Loh. (2022) Association Between Vitamin D Supplementation and Statin-Associated Muscle Symptoms: A Systematic Review. High Blood Pressure & Cardiovascular Prevention 29:4, pages 337-351.
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Qingtao Hou, Caishuang Pang & Yuqin Chen. (2021) Association Between Vitamin D and Statin-Related Myopathy: A Meta-analysis. American Journal of Cardiovascular Drugs 22:2, pages 183-193.
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Michele Malaguarnera. 2022. Features and Assessments of Pain, Anaesthesia, and Analgesia. Features and Assessments of Pain, Anaesthesia, and Analgesia 539 549 .
David J.A. Jenkins, J. David Spence, Edward L. Giovannucci, Young-in Kim, Robert G. Josse, Reinhold Vieth, Sandhya Sahye-Pudaruth, Melanie Paquette, Darshna Patel, Sonia Blanco Mejia, Effie Viguiliouk, Stephanie K. Nishi, Meaghan Kavanagh, Tom Tsirakis, Cyril W.C. Kendall, Sathish C. Pichika & John L. Sievenpiper. (2021) Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment. Journal of the American College of Cardiology 77:4, pages 423-436.
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Allyson M. Schweitzer, Molly A. Gingrich, Thomas J. Hawke & Irena A. Rebalka. (2020) The impact of statins on physical activity and exercise capacity: an overview of the evidence, mechanisms, and recommendations. European Journal of Applied Physiology 120:6, pages 1205-1225.
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Stefano Bellosta, Alberto Corsini & Nicola Ferri. 2020. Statin-Associated Muscle Symptoms. Statin-Associated Muscle Symptoms 51 61 .
Peter P. Toth. 2020. Statin-Associated Muscle Symptoms. Statin-Associated Muscle Symptoms 5 19 .
Pramod Reddy & Linda R. Edwards. (2019) Magnesium Supplementation in Vitamin D Deficiency. American Journal of Therapeutics 26:1, pages e124-e132.
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Parth Shah. (2018) Economic Evaluation of the PCSK9 Inhibitors in Prevention of the Cardiovascular Diseases. Current Cardiology Reports 20:7.
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Emily Mohn, Hua Kern, Edward Saltzman, Susan Mitmesser & Diane McKay. (2018) Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update. Pharmaceutics 10:1, pages 36.
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Joshua Choi, Amir M Khan, Michael Jarmin, Naila Goldenberg, Charles J Glueck & Ping Wang. (2017) Efficacy and safety of proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors, alirocumab and evolocumab, a post-commercialization study. Lipids in Health and Disease 16:1.
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Parth Shah, Charles J. Glueck, Naila Goldenberg, Sarah Min, Chris Mahida, Ilana Schlam, Matan Rothschild, Ali Huda & Ping Wang. (2017) Efficacy, safety, Low density lipoprotein cholesterol lowering, and calculated 10-year cardiovascular risk reduction of alirocumab and evolocumab in addition to maximal tolerated cholesterol lowering therapy: a post-commercialization study. Lipids in Health and Disease 16:1.
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Wei-Han Cheng, Étienne Gaudette & Dana P. Goldman. (2017) PCSK9 Inhibitors Show Value for Patients and the US Health Care System. Value in Health 20:10, pages 1270-1278.
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Maria Helde-Frankling & Linda Björkhem-Bergman. (2017) Vitamin D in Pain Management. International Journal of Molecular Sciences 18:10, pages 2170.
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Jenny H. Kang, Quynh-Nhu Nguyen, Juleann Mutka & Quang A. Le. (2016) Rechallenging Statin Therapy in Veterans With Statin-Induced Myopathy Post Vitamin D Replenishment. Journal of Pharmacy Practice 30:5, pages 521-527.
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Nikhil Sharma, Rachel Cooper, Diana Kuh & Imran Shah. (2017) Associations of statin use with motor performance and myalgia may be modified by 25-hydroxyvitamin D: findings from a British birth cohort. Scientific Reports 7:1.
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Leonardo Calza, Eleonora Magistrelli, Vincenzo Colangeli, Marco Borderi, Ilaria Contadini, Isabella Bon, Maria Carla Re & Pierluigi Viale. (2017) Significant association between statin-associated myalgia and vitamin D deficiency among treated HIV-infected patients. AIDS 31:5, pages 681-688.
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Charles J. Glueck, Kevin Lee, Marloe Prince, Alexander Milgrom, Frini Makadia & Ping Wang. (2017) Low serum vitamin D, statin associated muscle symptoms, vitamin D supplementation. Atherosclerosis 256, pages 125-127.
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Parth Shah, Charles J. Glueck, Vybhav Jetty, Naila Goldenberg, Matan Rothschild, Rashid Riaz, Gregory Duhon & Ping Wang. (2016) Pharmacoeconomics of PCSK9 inhibitors in 103 hypercholesterolemic patients referred for diagnosis and treatment to a cholesterol treatment center. Lipids in Health and Disease 15:1.
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Charles J. Glueck, Parth Shah, Naila Goldenberg, Marloe Prince, Kevin Lee, Vybhav Jetty, Ashwin Kumar, Michael Goldenberg & Ping Wang. (2016) Eligibility for PCSK9 treatment in 734 Hypercholesterolemic patients referred to a regional cholesterol treatment center with LDL cholesterol ≥70 mg/dl despite maximal tolerated cholesterol lowering therapy. Lipids in Health and Disease 15:1.
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Krista D. Riche, Justin Arnall, Kristin Rieser, Honey E. East & Daniel M. Riche. (2016) Impact of vitamin D status on statin-induced myopathy. Journal of Clinical & Translational Endocrinology 6, pages 56-59.
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Claudia Alejandra Pereda & Maria Betina Nishishinya. (2016) Is There Really a Relationship Between Serum Vitamin D (25OHD) Levels and the Musculoskeletal Pain Associated With Statin Intake? A Systematic Review. Reumatología Clínica (English Edition) 12:6, pages 331-335.
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Claudia Alejandra Pereda & Maria Betina Nishishinya. (2016) ¿Existe relación entre los niveles séricos de vitamina D (25OHD) y el dolor musculoesquelético relacionado con la ingesta de estatinas? Revisión sistemática. Reumatología Clínica 12:6, pages 331-335.
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G. Mpandzou, E. Aït Ben Haddou, W. Regragui, A. Benomar & M. Yahyaoui. (2016) Vitamin D deficiency and its role in neurological conditions: A review. Revue Neurologique 172:2, pages 109-122.
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Michael J. Wilkinson, Luke J. Laffin & Michael H. Davidson. (2014) Overcoming toxicity and side-effects of lipid-lowering therapies. Best Practice & Research Clinical Endocrinology & Metabolism 28:3, pages 439-452.
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Peter J. Little, Alan Chait, Andrzej S. Januszewski, Alex Bobik, David O’Neal & Alicia J. Jenkins. 2014. Lipoproteins in Diabetes Mellitus. Lipoproteins in Diabetes Mellitus 435 453 .
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Dimitrios Samaras, Nikolaos Samaras, Pierre-Olivier Lang, Laurence Genton, Emilia Frangos & Claude Pichard. (2013) Effects of widely used drugs on micronutrients: A story rarely told. Nutrition 29:4, pages 605-610.
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Crossref
Miao Hu, Bernard M.Y. Cheung & Brian Tomlinson. (2012) Safety of statins: an update. Therapeutic Advances in Drug Safety 3:3, pages 133-144.
Crossref
Sivakumar Sathasivam. (2012) Statin induced myotoxicity. European Journal of Internal Medicine 23:4, pages 317-324.
Crossref
Muhammad Haroon & Oliver FitzGerald. (2012) Vitamin D Deficiency: Subclinical and Clinical Consequences on Musculoskeletal Health. Current Rheumatology Reports 14:3, pages 286-293.
Crossref
Niki Katsiki, Vasilios G. Athyros, Asterios Karagiannis & Dimitri P. Mikhailidis. (2012) Efficacy and tolerability of once-weekly rosuvastatin in patients with previous statin intolerance. Journal of Clinical Lipidology 6:1, pages 93.
Crossref

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