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Original Articles

Effects of Soy Intake on Sex Hormone Metabolism in Premenopausal Women

Pages 133-139 | Published online: 18 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Vicky C. Chang, Michelle Cotterchio, Beatrice A. Boucher, David J. A. Jenkins, Lucia Mirea, Susan E. McCann & Lilian U. Thompson. (2019) Effect of Dietary Flaxseed Intake on Circulating Sex Hormone Levels among Postmenopausal Women: A Randomized Controlled Intervention Trial. Nutrition and Cancer 71:3, pages 385-398.
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Yukiko Morimoto, ShannonM. Conroy, IanS. Pagano, Marissa Isaki, AdrianA. Franke, FrankJ. Nordt & Gertraud Maskarinec. (2012) Urinary Estrogen Metabolites During a Randomized Soy Trial. Nutrition and Cancer 64:2, pages 307-314.
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Nadia Obi, Alina Vrieling, Judith Heinz & Jenny Chang-Claude. (2011) Estrogen metabolite ratio: Is the 2-hydroxyestrone to 16α-hydroxyestrone ratio predictive for breast cancer?. International Journal of Women's Health 3, pages 37-51.
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Barry R. Goldin, Edgard Brauner, Herman Adlercreutz, Lynne M. Ausman & Alice H. Lichtenstein. (2005) Hormonal Response to Diets High in Soy or Animal Protein Without and With Isoflavones in Moderately Hypercholesterolemic Subjects. Nutrition and Cancer 51:1, pages 1-6.
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A. Sammartino, C. Di Carlo, V. D. Mandato, G. Bifulco, M. Di Stefano & C. Nappi. (2003) Effects of genistein on the endometrium: ultrasonographic evaluation. Gynecological Endocrinology 17:1, pages 45-49.
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Blakely D. Brown, William Thomas, Andrea Hutchins, Margaret C. Martini & Joanne L. Slavin. (2002) Types of Dietary Fat and Soy Minimally Affect Hormones and Biomarkers Associated With Breast Cancer Risk in Premenopausal Women. Nutrition and Cancer 43:1, pages 22-30.
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Pia K. Verkasalo, Paul N. Appleby, Gwyneth K. Davey & Timothy J. Key. (2001) Soy Milk Intake and Plasma Sex Hormones: A Cross-Sectional Study in Pre- and Postmenopausal Women (EPIC-Oxford). Nutrition and Cancer 40:2, pages 79-86.
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Articles from other publishers (47)

Azadeh Manayi. 2021. Nutraceuticals and Cancer Signaling. Nutraceuticals and Cancer Signaling 419 449 .
Inés Domínguez-López, Maria Yago-Aragón, Albert Salas-Huetos, Anna Tresserra-Rimbau & Sara Hurtado-Barroso. (2020) Effects of Dietary Phytoestrogens on Hormones throughout a Human Lifespan: A Review. Nutrients 12:8, pages 2456.
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Heidi Fritz, Dugald Seely, Gillian Flower, Becky Skidmore, Rochelle Fernandes, Sarah Vadeboncoeur, Deborah Kennedy, Kieran Cooley, Raimond Wong, Stephen Sagar, Elham Sabri & Dean Fergusson. (2013) Soy, Red Clover, and Isoflavones and Breast Cancer: A Systematic Review. PLoS ONE 8:11, pages e81968.
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G Maskarinec, Y Morimoto, S Heak, M Isaki, A Steinbrecher, L Custer & A A Franke. (2012) Urinary estrogen metabolites in two soy trials with premenopausal women. European Journal of Clinical Nutrition 66:9, pages 1044-1049.
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Jeong-Hwan Che, Euna Kwon, Seung-Hyun Kim, Ji-Ran You, Bae-Hwan Kim, Sang Jun Lee, Jin Ho Chung & Byeong-Cheol Kang. (2011) Acute and subchronic toxicity of FCD, a soybean extract combined with l-carnitine, in Sprague–Dawley rats. Regulatory Toxicology and Pharmacology 59:2, pages 285-292.
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Cher Dallal & Emanuela Taioli. (2010) Urinary 2/16 estrogen metabolite ratio levels in healthy women: A review of the literature. Mutation Research/Reviews in Mutation Research 705:2, pages 154-162.
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Barbara J. Fuhrman, Ruth Pfeiffer, Xia Xu, Anna H. Wu, Larissa Korde, Mitchell H. Gail, Larry K. Keefer, Timothy D. Veenstra, Robert N. Hoover & Regina G. Ziegler. (2009) Soy Intake is Associated with Increased 2-Hydroxylation and Decreased 16α-Hydroxylation of Estrogens in Asian-American Women. Cancer Epidemiology, Biomarkers & Prevention 18:10, pages 2751-2760.
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Clemens B. Tempfer, Georg Froese, Georg Heinze, Eva-Katrin Bentz, Lukas A. Hefler & Johannes C. Huber. (2009) Side Effects of Phytoestrogens: A Meta-analysis of Randomized Trials. The American Journal of Medicine 122:10, pages 939-946.e9.
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J. Mark Cline & Charles E. Wood. (2009) Estrogen/isoflavone interactions in cynomolgus macaques ( Macaca fascicularis ) . American Journal of Primatology 71:9, pages 722-731.
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L. Hooper, J.J. Ryder, M.S. Kurzer, J.W. Lampe, M.J. Messina, W.R. Phipps & A. Cassidy. (2009) Effects of soy protein and isoflavones on circulating hormone concentrations in pre- and post-menopausal women: a systematic review and meta-analysis. Human Reproduction Update 15:4, pages 423-440.
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Shelley S. Tworoger & Susan E. Hankinson. (2008) Prolactin and Breast Cancer Etiology: An Epidemiologic Perspective. Journal of Mammary Gland Biology and Neoplasia 13:1, pages 41-53.
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Alison M. Hill, Heather I. Katcher, Brent D. Flickinger & Penny M. Kris-Etherton. 2008. Soybeans. Soybeans 725 772 .
Karl K. Rozman, Jatinder Bhatia, Antonia M. Calafat, Christina Chambers, Martine Culty, Ruth A. Etzel, Jodi A. Flaws, Deborah K. Hansen, Patricia B. Hoyer, Elizabeth H. Jeffery, James S. Kesner, Sue Marty, John A. Thomas & David Umbach. (2006) NTP‐CERHR Expert Panel Report on the reproductive and developmental toxicity of soy formula. Birth Defects Research Part B: Developmental and Reproductive Toxicology 77:4, pages 280-397.
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MaryFran R Sowers, Sybil Crawford, Daniel S McConnell, John F RandolphJrJr, Ellen B Gold, Margaret K Wilkin & Bill Lasley. (2006) Selected Diet and Lifestyle Factors Are Associated with Estrogen Metabolites in a Multiracial/Ethnic Population of Women. The Journal of Nutrition 136:6, pages 1588-1595.
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Seiichiro Yamamoto & Shoichiro Tsugane. 2005. Soy in Health and Disease Prevention. Soy in Health and Disease Prevention 43 72 .
Max Bingham & Glenn Gibson. 2005. Nutrigenomics. Nutrigenomics 327 340 .
Jennifer A. Nettleton, Kristin A. Greany, William Thomas, Kerry E. Wangen, Herman Adlercreutz & Mindy S. Kurzer. (2005) The Effect of Soy Consumption on the Urinary 2:16-Hydroxyestrone Ratio in Postmenopausal Women Depends on Equol Production Status but Is Not Influenced by Probiotic Consumption. The Journal of Nutrition 135:3, pages 603-608.
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Tieraona Low Dog. 2005. Women's Health in Complementary and Integrative Medicine. Women's Health in Complementary and Integrative Medicine 247 270 .
Heather Patisaul & Patricia Whitten. 2004. Endocrine Disruptors. Endocrine Disruptors 135 173 .
Gertraud Maskarinec, Adrian A. Franke, Andrew E. Williams, Sandra Hebshi, Caryn Oshiro, Suzanne Murphy & Frank Z. Stanczyk. (2004) Effects of a 2-Year Randomized Soy Intervention on Sex Hormone Levels in Premenopausal Women. Cancer Epidemiology, Biomarkers & Prevention 13:11, pages 1736-1744.
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Jennifer D Brooks, Wendy E Ward, Jacqueline E Lewis, John Hilditch, Leslie Nickell, Evelyn Wong & Lilian U Thompson. (2004) Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy. The American Journal of Clinical Nutrition 79:2, pages 318-325.
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E M CURRAN, B M JUDY, L G NEWTON, D B LUBAHN, G E ROTTINGHAUS, R S MACDONALD, C FRANKLIN & D M ESTES. (2004) Dietary soy phytoestrogens and ER α signalling modulate interferon gamma production in response to bacterial infection . Clinical and Experimental Immunology 135:2, pages 219-225.
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Bob Safford, Andrea Dickens, Nadine Halleron, David Briggs, Philip Carthew & Valerie Baker. (2003) A model to estimate the oestrogen receptor mediated effects from exposure to soy isoflavones in food. Regulatory Toxicology and Pharmacology 38:2, pages 196-209.
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Christine Duffy & Michele Cyr. (2003) Phytoestrogens: Potential Benefits and Implications for Breast Cancer Survivors. Journal of Women's Health 12:7, pages 617-631.
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Lawrence Kushi & Elisa Bandera. 2003. Reviews in Food and Nutrition Toxicity. Reviews in Food and Nutrition Toxicity 63 87 .
Darlene M. Dreon, Joanne L. Slavin & Stephen D. Phinney. (2003) Oral contraceptive use and increased plasma concentration of C-reactive protein. Life Sciences 73:10, pages 1245-1252.
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Colleen E. Piersen. (2016) Phytoestrogens in Botanical Dietary Supplements: Implications for Cancer. Integrative Cancer Therapies 2:2, pages 120-138.
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Charles V. Clevenger, Priscilla A. Furth, Susan E. Hankinson & Linda A. Schuler. (2003) The Role of Prolactin in Mammary Carcinoma. Endocrine Reviews 24:1, pages 1-27.
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P.H.M. Peeters, L. Keinan-Boker, Y.T. van der Schouw & D.E. Grobbee. (2003) Phytoestrogens and Breast Cancer Risk. Breast Cancer Research and Treatment 77:2, pages 171-183.
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Kirsi Syrjäkoski, Eija-R. Hyytinen, Tuula Kuukasjärvi, Anssi Auvinen, Olli-P. Kallioniemi, Tommi Kainu & Pasi A. Koivisto. (2003) Androgen Receptor Gene Alterations in Finnish Male Breast Cancer. Breast Cancer Research and Treatment 77:2, pages 167-170.
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Sidika E Kasim-Karakas, Rogelio U Almario, Laura Gregory, Heather Todd, Rodney Wong & Bill L Lasley. (2002) Effects of prune consumption on the ratio of 2-hydroxyestrone to 16α-hydroxyestrone. The American Journal of Clinical Nutrition 76:6, pages 1422-1427.
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D. Tsangalis, J.F. Ashton, A.E.J. Mcgill & N.P. Shah. (2006) Enzymic Transformation of Isoflavone Phytoestrogens in Soymilk by β‐Glucosidase‐Producing Bifidobacteria. Journal of Food Science 67:8, pages 3104-3113.
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Rachel S Rosenberg Zand, David J.A Jenkins & Eleftherios P Diamandis. (2002) Flavonoids and steroid hormone-dependent cancers. Journal of Chromatography B 777:1-2, pages 219-232.
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David JA Jenkins, Cyril WC Kendall, Chung-Ja C Jackson, Philip W Connelly, Tina Parker, Dorothea Faulkner, Edward Vidgen, Stephen C Cunnane, Lawrence A Leiter & Robert G Josse. (2002) Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women,,. The American Journal of Clinical Nutrition 76:2, pages 365-372.
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Herman Adlercreutz, Witold Mazur, Satu-Maarit Heinonen & Katariina Stumpf. 2002. Breast Cancer. Breast Cancer 527 554 .
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H. LEON BRADLOW & DANIEL W. SEPKOVIC. (2006) Diet and Breast Cancer. Annals of the New York Academy of Sciences 963:1, pages 247-267.
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Herman Adlercreutz. (2002) Phyto-oestrogens and cancer. The Lancet Oncology 3:6, pages 364-373.
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Mindy S. Kurzer. (2002) Hormonal Effects of Soy in Premenopausal Women and Men. The Journal of Nutrition 132:3, pages 570S-573S.
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Nagi B. Kumar, Alan Cantor, Kathy Allen, Diane Riccardi & Charles E. Cox. (2002) The specific role of isoflavones on estrogen metabolism in premenopausal women. Cancer 94:4, pages 1166-1174.
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William R. Phipps, Alison M. Duncan & Mindy S. Kurzer. (2002) Isoflavones and Postmenopausal Women. Treatments in Endocrinology 1:5, pages 293-311.
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Mark J. Messina & Charles L. Loprinzi. (2001) Soy for Breast Cancer Survivors: A Critical Review of the Literature. The Journal of Nutrition 131:11, pages 3095S-3108S.
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Manami Inoue, Kazuo Tajima, Mitsuhiro Mizutani, Hiroji Iwata, Takuji Iwase, Shigeto Miura, Kaoru Hirose, Nobuyuki Hamajima & Suketami Tominaga. (2001) Regular consumption of green tea and the risk of breast cancer recurrence: follow-up study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC), Japan. Cancer Letters 167:2, pages 175-182.
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S. I. Nikolaropoulos, P. Nicolopoulou-Stamati & M. A. Pitsos. 2001. Endocrine Disrupters. Endocrine Disrupters 39 68 .
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