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Chemical penetration enhancers: a patent review

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Pages 969-988 | Published online: 24 Jun 2009

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Emrullah Korkmaz, Stephen C. Balmert, Cara Donahue Carey, Geza Erdos & Louis D. Falo$suffix/text()$suffix/text(). (2021) Emerging skin-targeted drug delivery strategies to engineer immunity: A focus on infectious diseases. Expert Opinion on Drug Delivery 18:2, pages 151-167.
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Anita Kovács, Nikolett Kis, Mária Budai-Szűcs, Attila Gácsi, Erzsébet Csányi, Ildikó Csóka & Szilvia Berkó. (2020) QbD-Based Investigation of Dermal Semisolid in situ Film-Forming Systems for Local Anaesthesia. Drug Design, Development and Therapy 14, pages 5059-5076.
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Kai Zhang, Yanling Zhuang, Jiwen Li, Xiaochang Liu & Shaoheng He. (2020) Poly(Acrylic Acid)-Modified MoS2 Nanoparticle-Based Transdermal Delivery of Atenolol. International Journal of Nanomedicine 15, pages 5517-5526.
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Andrej Kováčik, Monika Kopečná & Kateřina Vávrová. (2020) Permeation enhancers in transdermal drug delivery: benefits and limitations. Expert Opinion on Drug Delivery 17:2, pages 145-155.
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Abdurrahman M. Fahmy, Doaa Ahmed El-Setouhy, Ahmed B. Ibrahim, Basant A. Habib, Saadia A. Tayel & Noha A. Bayoumi. (2018) Penetration enhancer-containing spanlastics (PECSs) for transdermal delivery of haloperidol: in vitro characterization, ex vivo permeation and in vivo biodistribution studies. Drug Delivery 25:1, pages 12-22.
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Gauhar R. Qadri, Abdul Ahad, Mohd. Aqil, Syed S. Imam & Asgar Ali. (2017) Invasomes of isradipine for enhanced transdermal delivery against hypertension: formulation, characterization, and in vivo pharmacodynamic study. Artificial Cells, Nanomedicine, and Biotechnology 45:1, pages 139-145.
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Abdul Ahad, Mohd. Aqil, Kanchan Kohli, Yasmin Sultana & Mohd. Mujeeb. (2016) The ameliorated longevity and pharmacokinetics of valsartan released from a gel system of ultradeformable vesicles. Artificial Cells, Nanomedicine, and Biotechnology 44:6, pages 1457-1463.
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Abdul Ahad, Mohd. Aqil, Kanchan Kohli, Yasmin Sultana & Mohd. Mujeeb. (2016) Nano vesicular lipid carriers of angiotensin II receptor blocker: Anti-hypertensive and skin toxicity study in focus. Artificial Cells, Nanomedicine, and Biotechnology 44:3, pages 1002-1007.
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Abdul Ahad, Abdullah Mohammed Al-Mohizea, Fahad Ibrahim Al-Jenoobi & Mohd. Aqil. (2016) Transdermal delivery of angiotensin II receptor blockers (ARBs), angiotensin-converting enzyme inhibitors (ACEIs) and others for management of hypertension. Drug Delivery 23:2, pages 579-590.
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Abdul Ahad, Mohd. Aqil, Kanchan Kohli, Yasmin Sultana & Mohd. Mujeeb. (2014) Design, formulation and optimization of valsartan transdermal gel containing iso-eucalyptol as novel permeation enhancer: preclinical assessment of pharmacokinetics in Wistar albino rats. Expert Opinion on Drug Delivery 11:8, pages 1149-1162.
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Abdul Ahad, Fahad I Al-Jenoobi, Abdullah M Al-Mohizea, Mohd Aqil & Kanchan Kohli. (2013) Transdermal delivery of calcium channel blockers for hypertension. Expert Opinion on Drug Delivery 10:8, pages 1137-1153.
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Jaspreet Singh Kochhar, Shui Zou, Sui Yung Chan & Lifeng Kang. (2012) Protein encapsulation in polymeric microneedles by photolithography. International Journal of Nanomedicine 7, pages 3143-3154.
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Abdul Ahad, Mohammed Aqil, Kanchan Kohli, Yasmin Sultana, Mohd Mujeeb & Asgar Ali. (2011) Role of novel terpenes in transcutaneous permeation of valsartan: effectiveness and mechanism of action. Drug Development and Industrial Pharmacy 37:5, pages 583-596.
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Naseem Akhtar, Abdul Ahad, Roop Kishan Khar, Manu Jaggi, Mohammed Aqil, Zeenat Iqbal, Farhan Jalees Ahmad & Sushama Talegaonkar. (2011) The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review. Expert Opinion on Therapeutic Patents 21:4, pages 561-576.
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Nisreen Hassan, Abdul Ahad, Mushir Ali & Javed Ali. (2010) Chemical permeation enhancers for transbuccal drug delivery. Expert Opinion on Drug Delivery 7:1, pages 97-112.
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B Geusens, N Sanders, T Prow, M Van Gele & J Lambert. (2009) Cutaneous short-interfering RNA therapy. Expert Opinion on Drug Delivery 6:12, pages 1333-1349.
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Articles from other publishers (60)

Hafiz Muhammad Usman Abid, Muhammad Hanif, Khalid Mahmood, Sobia Abid, Mehran Khan, Umair Khurshid, Muhammad Azeem, Nabeela Ameer, Fazal Rahman Sajid Chughtai, Kapil Pandey, Muhammad Qaiser, Zeeshan Danish & Ghulam Razaque. (2023) Exploring the Potent Combination of Quercetin–Boronic Acid, Epalrestat, and Urea Containing Nanoethosomal Keratolytic Gel for the Treatment of Diabetic Neuropathic Pain: In Vitro and In Vivo Studies. Molecular Pharmaceutics 20:7, pages 3623-3631.
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Syeda Nashvia Adin, Isha Gupta, Asad Ali, Mohd Aqil, Mohd Mujeeb & Yasmin Sultana. (2022) Investigation on utility of some novel terpenes on transungual delivery of fluconazole for the management of onychomycosis. Journal of Cosmetic Dermatology 21:10, pages 5103-5110.
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Ines Nikolić, Mitar Simić, Ivana Pantelić, Goran Stojanović, Jelena Antić Stanković, Bojan Marković & Snežana Savić. (2022) Chemical vs. Physical Methods to Improve Dermal Drug Delivery: A Case Study with Nanoemulsions and Iontophoresis. Pharmaceutics 14:6, pages 1144.
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Dipak Kumar Gupta, Abdul Ahad, Ayesha Waheed, Mohd. Aqil, Fahad I. Al-Jenoobi & Abdullah M. Al-Mohizea. 2022. Systems of Nanovesicular Drug Delivery. Systems of Nanovesicular Drug Delivery 293 309 .
Abdul Ahad, Naseem Akhtar, Dipak Kumar Gupta, Ayesha Waheed, Mohd. Aqil, Fahad I. Al-Jenoobi & Abdullah M. Al-Mohizea. 2022. Systems of Nanovesicular Drug Delivery. Systems of Nanovesicular Drug Delivery 221 237 .
Jungen Chen, Junxing Bian, Basil M. Hantash, Lamyaa Albakr, David E. Hibbs, Xiaoqiang Xiang, Peng Xie, Chunyong Wu & Lifeng Kang. (2021) Enhanced skin retention and permeation of a novel peptide via structural modification, chemical enhancement, and microneedles. International Journal of Pharmaceutics 606, pages 120868.
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Quamrul Hoda, Mohd. Aqil, Abdul Ahad, Syed Sarim Imam, Arshiya Praveen, Abdul Qadir & Zeenat Iqbal. (2021) Optimization of valencene containing lipid vesicles for boosting the transungual delivery of itraconazole. 3 Biotech 11:3.
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Noriyuki Uchida, Masayoshi Yanagi & Hiroki Hamada. (2021) Physical Enhancement? Nanocarrier? Current Progress in Transdermal Drug Delivery. Nanomaterials 11:2, pages 335.
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Kai Zhang, Ying Zhao, Linlin Wang, Lili Zhao, Xiaochang Liu & Shaoheng He. (2020) NIR-responsive transdermal delivery of atenolol based on polyacrylamide-modified MoS2 nanoparticles. Inorganic Chemistry Communications 122, pages 108277.
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Cuong Viet Pham, Mao Can Van, Hue Pham Thi, Chung Đang Thanh, Bao Tran Ngoc, Ba Nguyen Van, Giap Le Thien, Bang Nguyen Van & Chien Ngoc Nguyen. (2020) Development of ibuprofen-loaded solid lipid nanoparticle-based hydrogels for enhanced in vitro dermal permeation and in vivo topical anti-inflammatory activity. Journal of Drug Delivery Science and Technology 57, pages 101758.
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XueKe Lin, ZhenHua Wang, HuiLong Ou, Samir Mitragotri & Ming Chen. (2020) Correlations Between Skin Barrier Integrity and Delivery of Hydrophilic Molecules in the Presence of Penetration Enhancers. Pharmaceutical Research 37:6.
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Noriyuki Uchida, Masayoshi Yanagi & Hiroki Hamada. (2020) Size-Tunable Paclitaxel Nanoparticles Stabilized by Anionic Phospholipids for Transdermal Delivery Applications. Natural Product Communications 15:3, pages 1934578X1990068.
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Ines Nikolic, Evgenia Mitsou, Ivana Pantelic, Danijela Randjelovic, Bojan Markovic, Vassiliki Papadimitriou, Aristotelis Xenakis, Dominique Jasmin Lunter, Ana Zugic & Snezana Savic. (2020) Microstructure and biopharmaceutical performances of curcumin-loaded low-energy nanoemulsions containing eucalyptol and pinene: Terpenes’ role overcome penetration enhancement effect?. European Journal of Pharmaceutical Sciences 142, pages 105135.
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Chandrashekhar Voshavar, Praveen Kumar Vemula & Srujan Marepally. 2019. Imaging Technologies and Transdermal Delivery in Skin Disorders. Imaging Technologies and Transdermal Delivery in Skin Disorders 169 200 .
Sanyog Jain, Pragati Khare, Tushar Date, Sameer S Katiyar, Varun Kushwah, Mahesh K Katariya & Rajan Swami. (2019) Mechanistic insights into high permeation vesicle-mediated synergistic enhancement of transdermal drug permeation. Nanomedicine 14:16, pages 2227-2241.
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Ayesha Waheed, Mohd Aqil, Abdul Ahad, Syed Sarim Imam, Thasleem Moolakkadath, Zeenat Iqbal & Asgar Ali. (2019) Improved bioavailability of raloxifene hydrochloride using limonene containing transdermal nano-sized vesicles. Journal of Drug Delivery Science and Technology 52, pages 468-476.
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Jaspreet Singh Kochhar, Justin J. Y. Tan, Yee Chin Kwang & Lifeng KangJaspreet Singh Kochhar, Justin J. Y. Tan, Yee Chin Kwang & Lifeng Kang. 2019. Microneedles for Transdermal Drug Delivery. Microneedles for Transdermal Drug Delivery 1 30 .
Pooja Bakshi, Ying Jiang, Takahiro Nakata, Junji Akaki, Nobuya Matsuoka & Ajay K. Banga. (2018) Formulation Development and Characterization of Nanoemulsion-Based Formulation for Topical Delivery of Heparinoid. Journal of Pharmaceutical Sciences 107:11, pages 2883-2890.
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S. Ramkanth, C. Madhusudhana Chetty, Y. Sudhakar, V.S. Thiruvengadarajan, P. Anitha & C. Gopinath. (2018) Development, characterization & invivo evaluation of proniosomal based transdermal delivery system of Atenolol. Future Journal of Pharmaceutical Sciences 4:1, pages 80-87.
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Ning Li, Peng Quan, XiaoCao Wan, Chao Liu, Xiaochang Liu & Liang Fang. (2017) Mechanistic insights of the enhancement effect of sorbitan monooleate on olanzapine transdermal patch both in release and percutaneous absorption processes. European Journal of Pharmaceutical Sciences 107, pages 138-147.
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Abdul Ahad, Abdulmohsen A. Al-Saleh, Abdullah M. Al-Mohizea, Fahad I. Al-Jenoobi, Mohammad Raish, Alaa Eldeen B. Yassin & Mohd Aftab Alam. (2017) Pharmacodynamic study of eprosartan mesylate-loaded transfersomes Carbopol® gel under Dermaroller® on rats with methyl prednisolone acetate-induced hypertension. Biomedicine & Pharmacotherapy 89, pages 177-184.
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Yasunari Michinaka. 2017. Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds. Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds 121 135 .
Syed Sarim Imam & Mohammed Aqil. 2017. Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin. Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin 337 353 .
Qingliang Zhao, Cuixia Dai, Shanhui Fan, Jing Lv & Liming Nie. (2016) Synergistic efficacy of salicylic acid with a penetration enhancer on human skin monitored by OCT and diffuse reflectance spectroscopy. Scientific Reports 6:1.
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Pollyana S.S. Lima, Angélica M. Lucchese, Heitor G. Araújo-Filho, Paula P. Menezes, Adriano A.S. Araújo, Lucindo J. Quintans-Júnior & Jullyana S.S. Quintans. (2016) Inclusion of terpenes in cyclodextrins: Preparation, characterization and pharmacological approaches. Carbohydrate Polymers 151, pages 965-987.
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E. G. Kuznetsova, V. A. Ryzhikova, L. A. Salomatina & V. I. Sevastianov. (2016) TRANSDERMAL DRUG DELIVERY AND METHODS TO ENHANCE IT. Russian Journal of Transplantology and Artificial Organs 18:2, pages 152-162.
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Mohd. Kamran, Abdul Ahad, Mohd. Aqil, Syed Sarim Imam, Yasmin Sultana & Asgar Ali. (2016) Design, formulation and optimization of novel soft nano-carriers for transdermal olmesartan medoxomil delivery: In vitro characterization and in vivo pharmacokinetic assessment. International Journal of Pharmaceutics 505:1-2, pages 147-158.
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Mohd. Aqil, Mohd. Kamran, Abdul Ahad & Syed Sarim Imam. (2016) Development of clove oil based nanoemulsion of olmesartan for transdermal delivery: Box–Behnken design optimization and pharmacokinetic evaluation. Journal of Molecular Liquids 214, pages 238-248.
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Nina Dragicevic, Daya Dass Verma & Alfred Fahr. 2016. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement 77 92 .
Abdul Ahad, Fahad I. Al-Jenoobi, Abdullah M. Al-Mohizea, Naseem Akhtar, Mohammad Raish & Mohd. Aqil. (2015) Systemic delivery of β-blockers via transdermal route for hypertension. Saudi Pharmaceutical Journal 23:6, pages 587-602.
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Shishu Goindi, Ramanpreet Kaur & Randeep Kaur. (2015) An ionic liquid-in-water microemulsion as a potential carrier for topical delivery of poorly water soluble drug: Development, ex-vivo and in-vivo evaluation. International Journal of Pharmaceutics 495:2, pages 913-923.
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Abdul Ahad, Abdulmohsen A. Al-Saleh, Naseem Akhtar, Abdullah M. Al-Mohizea & Fahad I. Al-Jenoobi. (2015) Transdermal delivery of antidiabetic drugs: formulation and delivery strategies. Drug Discovery Today 20:10, pages 1217-1227.
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Asgar Ali, Nitin Kumar, Abdul Ahad, Mohd. Aqil & Yasmin Sultana. (2015) Enhanced delivery of diclofenac diethylamine loaded Eudragit RL 100 ® transdermal system against inflammation . Journal of Polymer Engineering 35:7, pages 699-708.
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Man Ma, Jinping Wang, Fang Guo, Mingzhu Lei, Fengping Tan & Nan Li. (2015) Development of nanovesicular systems for dermal imiquimod delivery: physicochemical characterization and in vitro/in vivo evaluation. Journal of Materials Science: Materials in Medicine 26:6.
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Sunil T. Narishetty, David Garcia-Tapia & Kathleen J. Bonnema. 2015. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement 387 405 .
Alexandr Hrabálek & Kateřina Vávrová. 2015. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement 309 323 .
Jelena Predic Atkinson, Howard I. Maibach & Nina Dragicevic. 2015. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement 93 108 .
Philip W. Wertz. 2015. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement 13 18 .
Indu Vashisth, Abdul Ahad, Mohd. Aqil & Suraj P. Agarwal. (2014) Investigating the potential of essential oils as penetration enhancer for transdermal losartan delivery: Effectiveness and mechanism of action. Asian Journal of Pharmaceutical Sciences 9:5, pages 260-267.
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Shishu Goindi, Prabhleen Arora, Neeraj Kumar & Ashana Puri. (2014) Development of Novel Ionic Liquid-Based Microemulsion Formulation for Dermal Delivery of 5-Fluorouracil. AAPS PharmSciTech 15:4, pages 810-821.
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Zhijun Wang & Moses SS Chow. (2014) Overview and appraisal of the current concept and technologies for improvement of sublingual drug delivery. Therapeutic Delivery 5:7, pages 807-816.
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Abdul Ahad, Mohammad Raish, Abdullah M. Al-Mohizea, Fahad I. Al-Jenoobi & Mohd Aftab Alam. (2014) Enhanced anti-inflammatory activity of carbopol loaded meloxicam nanoethosomes gel. International Journal of Biological Macromolecules 67, pages 99-104.
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Hema Chaudhary, Kanchan Kohli & Vikash Kumar. (2014) A novel nano-carrier transdermal gel against inflammation. International Journal of Pharmaceutics 465:1-2, pages 175-186.
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Yang Chen, Peng Quan, Xiaochang Liu, Manli Wang & Liang Fang. (2014) Novel chemical permeation enhancers for transdermal drug delivery. Asian Journal of Pharmaceutical Sciences 9:2, pages 51-64.
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Abdul Ahad, Mohd. Aqil & Asgar Ali. (2014) Investigation of antihypertensive activity of carbopol valsartan transdermal gel containing 1,8-cineole. International Journal of Biological Macromolecules 64, pages 144-149.
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Jaspreet Singh Kochhar, Ten Cheer Quek, Wei Jun Soon, Jaewoong Choi, Shui Zou & Lifeng Kang. (2013) Effect of Microneedle Geometry and Supporting Substrate on Microneedle Array Penetration into Skin. Journal of Pharmaceutical Sciences 102:11, pages 4100-4108.
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Yu. A. Boiko, I. A. Kravchenko, N. S. Novikova, A. V. Egorova & D. I. Aleksandrova. (2013) Effects of Liquid Crystal Systems Based on Cholesterol Esters on Skin Permeability. Pharmaceutical Chemistry Journal 47:7, pages 393-396.
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Bart De Spiegeleer, Jente Boonen, Svetlana V. Malysheva, José Diana Di Mavungu, Sarah De Saeger, Nathalie Roche, Phillip Blondeel, Lien Taevernier & Lieselotte Veryser. (2013) Skin penetration enhancing properties of the plant N-alkylamide spilanthol. Journal of Ethnopharmacology 148:1, pages 117-125.
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Abdul Ahad, Mohd. Aqil, Kanchan Kohli, Yasmin Sultana & Mohd. Mujeeb. (2013) Enhanced transdermal delivery of an anti-hypertensive agent via nanoethosomes: Statistical optimization, characterization and pharmacokinetic assessment. International Journal of Pharmaceutics 443:1-2, pages 26-38.
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Yang Yang, Jason Bugno & Seungpyo Hong. (2013) Nanoscale polymeric penetration enhancers in topical drug delivery. Polymer Chemistry 4:9, pages 2651.
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Bram Baert, Nathalie Roche, Christian Burvenich & Bart De Spiegeleer. (2012) Increase of the transdermal penetration of testosterone by miconazole nitrate. Archives of Pharmacal Research 35:12, pages 2163-2170.
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Sevgi GüngörYıldız Özsoy. (2012) Systemic delivery of antihypertensive drugs via skin. Therapeutic Delivery 3:9, pages 1101-1116.
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Yara Peluso Cid, Vinícius Pedrazzi, Valéria Pereira de Sousa & Maria Bernadete Riemma Pierre. (2011) In Vitro Characterization of Chitosan Gels for Buccal Delivery of Celecoxib: Influence of a Penetration Enhancer. AAPS PharmSciTech 13:1, pages 101-111.
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Abdul Ahad, Mohammed Aqil, Kanchan Kohli, Yasmin Sultana, Mohammed Mujeeb & Asgar Ali. (2012) Formulation and optimization of nanotransfersomes using experimental design technique for accentuated transdermal delivery of valsartan. Nanomedicine: Nanotechnology, Biology and Medicine 8:2, pages 237-249.
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Gabriela Oliveira, Anthony E. Beezer, Jonathan Hadgraft & Majella E. Lane. (2011) Alcohol enhanced permeation in model membranes. Part II. Thermodynamic analysis of membrane partitioning. International Journal of Pharmaceutics 420:2, pages 216-222.
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HAIRUI LI, JASPREET SINGH KOCHHAR, JING PAN, SUI YUNG CHAN & LIFENG KANG. (2011) NANO/MICROSCALE TECHNOLOGIES FOR DRUG DELIVERY. Journal of Mechanics in Medicine and Biology 11:02, pages 337-367.
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Hema Chaudhary, Kanchan Kohli, Saima Amin, Permender Rathee & Vikash Kumar. (2011) Optimization and Formulation Design of Gels of Diclofenac and Curcumin for Transdermal Drug Delivery by Box-Behnken Statistical Design. Journal of Pharmaceutical Sciences 100:2, pages 580-593.
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Cristina Balaguer-Fernández, Andrés Femenía-Font, Vicente Muedra, Virginia Merino & Alicia López-Castellano. (2010) Combined strategies for enhancing the transdermal absorption of midazolam through human skin. Journal of Pharmacy and Pharmacology 62:9, pages 1096-1102.
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Saqib Zafar, Asgar Ali, Mohammed Aqil & Abdul Ahad. (2010) Transdermal drug delivery of labetalol hydrochloride: Feasibility and effect of penetration enhancers. Journal of Pharmacy And Bioallied Sciences 2:4, pages 321.
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V. Rai, I. Ghosh, S. Bose, S.M.C. Silva, P. Chandra & B. Michniak-Kohn. (2010) A transdermal review on permeation of drug formulations, modifier compounds and delivery methods. Journal of Drug Delivery Science and Technology 20:2, pages 75-88.
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