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Expert Opinion on Therapeutic Patents Volume 20, 2010 - Issue 1
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Radiation countermeasure agents: an update

Francis Dumont Université de Strasbourg, Centre Régional de Lutte contre le Cancer Paul Strauss, Laboratoire de Radiobiologie EA-3430, 3 rue de la Porte de l'Hôpital, F-67065 Strasbourg, France +33 3 88 25 85 42; +33 3 88 25 85 00; [email protected]
,
Antoine Le Roux Université de Strasbourg, Centre Régional de Lutte contre le Cancer Paul Strauss, Laboratoire de Radiobiologie EA-3430, 3 rue de la Porte de l'Hôpital, F-67065 Strasbourg, France +33 3 88 25 85 42; +33 3 88 25 85 00; [email protected]
&
Pierre Bischoff
Pages 73-101 | Published online: 20 Dec 2009

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Vijay K. Singh & Thomas M. Seed. (2017) A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures. International Journal of Radiation Biology 93:9, pages 851-869.
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Vijay K. Singh & Ayodele O. Olabisi. (2017) Nonhuman primates as models for the discovery and development of radiation countermeasures. Expert Opinion on Drug Discovery 12:7, pages 695-709.
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Vijay K Singh, Victoria L Newman, Allison N Berg & Thomas J MacVittie. (2015) Animal models for acute radiation syndrome drug discovery. Expert Opinion on Drug Discovery 10:5, pages 497-517.
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Vijay K Singh, Victoria L Newman, Patricia LP Romaine, Stephen Y Wise & Thomas M Seed. (2014) Radiation countermeasure agents: an update (2011 – 2014). Expert Opinion on Therapeutic Patents 24:11, pages 1229-1255.
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Vijay K. Singh, Stephen Y. Wise, Pankaj K. Singh, Ana Posarac, Oluseyi O. Fatanmi, Elizabeth J. Ducey, David L. Bolduc, Thomas B. Elliott & Thomas M. Seed. (2013) Alpha-tocopherol succinate-mobilized progenitors improve intestinal integrity after whole body irradiation. International Journal of Radiation Biology 89:5, pages 334-345.
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Daila S. Gridley, Asma Rizvi, Adeola Y. Makinde, Xian Luo-Owen, Xiao Wen Mao, Jian Tian, Jason M. Slater & Michael J. Pecaut. (2013) Space-relevant radiation modifies cytokine profiles, signaling proteins and Foxp3+ T cells. International Journal of Radiation Biology 89:1, pages 26-35.
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Xu Ping, Jia Junqing, Jia Junfeng & Jiang Enjin. (2012) Radioprotective effects of troxerutin against gamma irradiation in mice liver. International Journal of Radiation Biology 88:8, pages 607-612.
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Vijay K. Singh, Elizabeth J. Ducey, Darren S. Brown & Mark H. Whitnall. (2012) A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute. International Journal of Radiation Biology 88:4, pages 296-310.
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Francis Dumont & Pierre Bischoff. (2010) Non-erythropoietic tissue-protective peptides derived from erythropoietin: WO2009094172. Expert Opinion on Therapeutic Patents 20:5, pages 715-723.
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Articles from other publishers (43)

Ekaterina Karmanova, Anatoly Chernikov, Anna Usacheva, Vladimir Ivanov & Vadim Bruskov. (2023) Metformin counters oxidative stress and mitigates adverse effects of radiation exposure: An overview. Fundamental & Clinical Pharmacology 37:4, pages 713-725.
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Juan Yang, Rui Xu, Yingying Luan, Hancheng Fan, Shuo Yang, Jun Liu, Huihong Zeng & Lijian Shao. (2022) Rapamycin Ameliorates Radiation-Induced Testis Damage in Mice. Frontiers in Cell and Developmental Biology 10.
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Zahra Shaghaghi, Maryam Alvandi, Sahar Nosrati & Seyed Kamaledin Hadei. (2021) Potential utility of peptides against damage induced by ionizing radiation. Future Oncology 17:10, pages 1219-1235.
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Muhammad Adnan, Azhar Rasul, Muhammad A. Shah, Ghulam Hussain, Muhammad Asrar, Ammara Riaz, Iqra Sarfraz, Arif Hussain, Khatereh Khorsandi, Ngit S. Lai & Syed M. Hussain. (2021) Radioprotective Role of Natural Polyphenols: From Sources to Mechanisms. Anti-Cancer Agents in Medicinal Chemistry 22:1, pages 30-39.
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Wensi Liu, Zhaojin Yu, Haichao Tang, Xiangyi Wang, Bing Zhang, Jianhang Zhao, Xinli Liu, Jingdong Zhang & Minjie Wei. (2020) Silencing KIF18B enhances radiosensitivity: identification of a promising therapeutic target in sarcoma. EBioMedicine 61, pages 103056.
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Elena Obrador, Rosario Salvador, Juan I. Villaescusa, José M. Soriano, José M. Estrela & Alegría Montoro. (2020) Radioprotection and Radiomitigation: From the Bench to Clinical Practice. Biomedicines 8:11, pages 461.
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Ahmed Eleojo Musa, Dheyauldeen Shabeeb, Nnamdi O. E. Okoro & Alaba Tolulope Agbele. (2020) Radiation protection by Ex-RAD: a systematic review. Environmental Science and Pollution Research 27:27, pages 33592-33600.
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Gil-Im Mun, Seoyoung Kim, Eun Choi, Cha Soon Kim & Yun-Sil Lee. (2018) Pharmacology of natural radioprotectors. Archives of Pharmacal Research 41:11, pages 1033-1050.
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Hiroki Ide, Satoshi Inoue, Taichi Mizushima, Guiyang Jiang, Kuang-Hsiang Chuang, Mototsugu Oya & Hiroshi Miyamoto. (2018) Androgen Receptor Signaling Reduces Radiosensitivity in Bladder Cancer. Molecular Cancer Therapeutics 17:7, pages 1566-1574.
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Ujwani Nukala, Shraddha Thakkar, Kimberly Krager, Philip Breen, Cesar Compadre & Nukhet Aykin-Burns. (2018) Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans). Antioxidants 7:2, pages 33.
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Ikuo KASHIWAKURA. (2017) Overview of Radiation-protective Agent Research and Prospects for the Future. Japanese Journal of Health Physics 52:4, pages 285-295.
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T Chen, L Wang, K Chen, S Qiu, X Cen, H Li & C Hu. (2016) Evaluation of gamma ray-induced gastrointestinal tract morphological and proliferative activity changes in rhesus monkeys. Human & Experimental Toxicology 35:10, pages 1133-1144.
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JIANGUO LI, GUOWEI ZHANG, ZHUANGZHI MENG, LINGZHAN WANG, HAIYING LIU, QIANG LIU & BATU BUREN. (2016) Neuroprotective effect of acute melatonin treatment on hippocampal neurons against irradiation by inhibition of caspase-3. Experimental and Therapeutic Medicine 11:6, pages 2385-2390.
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Vijay Singh & Martin Hauer-Jensen. (2016) γ-Tocotrienol as a Promising Countermeasure for Acute Radiation Syndrome: Current Status. International Journal of Molecular Sciences 17:5, pages 663.
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F. Marampon, G. L. Gravina, C. Festuccia, V. M. Popov, E. A. Colapietro, P. Sanità, D. Musio, F. De Felice, A. Lenzi, E. A. Jannini, E. Di Cesare & V. Tombolini. (2015) Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis. Journal of Endocrinological Investigation 39:4, pages 411-422.
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Chia-Hung Chen, Min-Liang Kuo, Jen-Ling Wang, Wei-Chuan Liao, Li-Ching Chang, Leong-Perng Chan & Johnson Lin. (2015) CCM-AMI, a Polyethylene Glycol Micelle with Amifostine, as an Acute Radiation Syndrome Protectant in C57BL/6 Mice. Health Physics 109:3, pages 242-248.
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Vijay K. Singh, Patricia L.P. Romaine & Thomas M. Seed. (2015) Medical Countermeasures for Radiation Exposure and Related Injuries. Health Physics 108:6, pages 607-630.
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Taylor A. Choi, Anna M. Furimsky, Robert Swezey, Deborah I. Bunin, Patricia Byrge, Lalitha V. Iyer, Polly Y. Chang & Rebecca J. Abergel. (2015) In Vitro Metabolism and Stability of the Actinide Chelating Agent 3,4,3-LI(1,2-HOPO). Journal of Pharmaceutical Sciences 104:5, pages 1832-1838.
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Pankaj K. Singh & Sunil Krishnan. (2015) Vitamin E Analogs as Radiation Response Modifiers. Evidence-Based Complementary and Alternative Medicine 2015, pages 1-16.
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Kimberly J. Krager, E. Nathalie Pineda, Sujay V. Kharade, Mary Kordsmeier, Luke Howard, Philip J. Breen, Cesar M. Compadre, Martin Hauer-Jensen & Nukhet Aykin-Burns. (2015) Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity. Evidence-Based Complementary and Alternative Medicine 2015, pages 1-9.
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Zoya Gluzman-Poltorak, Sarita R Mendonca, Vladimir Vainstein, Hue Kha & Lena A Basile. (2014) Randomized comparison of single dose of recombinant human IL-12 versus placebo for restoration of hematopoiesis and improved survival in rhesus monkeys exposed to lethal radiation. Journal of Hematology & Oncology 7:1.
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Haseeb Ahsan, Amjid Ahad, Jahangir Iqbal & Waseem A Siddiqui. (2014) Pharmacological potential of tocotrienols: a review. Nutrition & Metabolism 11:1.
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Vijay K Singh, Stephen Y Wise, Oluseyi O Fatanmi, Lindsay A Beattie & Thomas M Seed. (2014) Preclinical Development of a Bridging Therapy for Radiation Casualties. Health Physics 106:6, pages 689-698.
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Vijay K. Singh, Stephen Y. Wise, Jessica R. Scott, Patricia L.P. Romaine, Victoria L. Newman & Oluseyi O. Fatanmi. (2014) Radioprotective efficacy of delta-tocotrienol, a vitamin E isoform, is mediated through granulocyte colony-stimulating factor. Life Sciences 98:2, pages 113-122.
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Vijay K. Singh, Lindsay A. Beattie & Thomas M. Seed. (2013) Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures. Journal of Radiation Research 54:6, pages 973-988.
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Shilpa Kulkarni, Kushal Chakraborty, K. Sree Kumar, Tzu-Cheg Kao, Martin Hauer-Jensen & Sanchita P. Ghosh. (2013) Synergistic Radioprotection by Gamma-Tocotrienol and Pentoxifylline: Role of cAMP Signaling. ISRN Radiology 2013, pages 1-11.
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Michael De Lisio, Jeff M. Baker & Gianni Parise. (2013) Exercise promotes bone marrow cell survival and recipient reconstitution post-bone marrow transplantation, which is associated with increased survival. Experimental Hematology 41:2, pages 143-154.
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C. Norman Coleman. (2013) Fukushima and the Future of Radiation Research. Radiation Research 179:1, pages 1-8.
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S. MehrotraM. J. PecautT. L. FreemanJ. D. CrapoA. RizviX. Luo-OwenJ. M. SlaterD. S. Gridley. (2012) Analysis of a Metalloporphyrin Antioxidant Mimetic (MnTE-2-PyP) as a Radiomitigator: Prostate Tumor and Immune Status. Technology in Cancer Research & Treatment 11:5, pages 447-457.
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Vijay K Singh, Julie Christensen, Oluseyi O Fatanmi, Daphne Gille, Elizabeth J Ducey, Stephen Y Wise, Holger Karsunky & Anna K Sedello. (2012) Myeloid Progenitors: A Radiation Countermeasure that is Effective when Initiated Days after Irradiation. Radiation Research 177:6, pages 781-791.
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Vijay K. Singh, Oluseyi O. Fatanmi, Pankaj K. Singh & Mark H. Whitnall. (2012) Role of radiation-induced granulocyte colony-stimulating factor in recovery from whole body gamma-irradiation. Cytokine 58:3, pages 406-414.
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Vijay K. Singh, Elizabeth J. Ducey, Oluseyi O. Fatanmi, Pankaj K. Singh, Darren S. Brown, Andrei Purmal, Vera V. Shakhova, Andrei V. Gudkov, Elena Feinstein & Alexander Shakhov. (2012) CBLB613: A TLR 2/6 Agonist, Natural Lipopeptide of Mycoplasma arginini , as a Novel Radiation Countermeasure . Radiation Research 177:5, pages 628-642.
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Vijay K. Singh, Stephen Y. Wise, Pankaj K. Singh, Elizabeth J. Ducey, Oluseyi O. Fatanmi & Thomas M. Seed. (2012) α-Tocopherol succinate– and AMD3100-mobilized progenitors mitigate radiation-induced gastrointestinal injury in mice. Experimental Hematology 40:5, pages 407-417.
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Lena A. Basile, Dolph Ellefson, Zoya Gluzman-Poltorak, Katiana Junes-Gill, Vernon Mar, Sarita Mendonca, Joseph D. Miller, Jamie Tom, Alice Trinh & Timothy K. Gallaher. (2012) HemaMax™, a Recombinant Human Interleukin-12, Is a Potent Mitigator of Acute Radiation Injury in Mice and Non-Human Primates. PLoS ONE 7:2, pages e30434.
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Pankaj K Singh, Stephen Y Wise, Elizabeth J Ducey, Oluseyi O Fatanmi, Thomas B Elliott & Vijay K Singh. (2012) α-Tocopherol Succinate Protects Mice against Radiation-Induced Gastrointestinal Injury. Radiation Research 177:2, pages 133-145.
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MEETHA MEDHORA, FENG GAO, ELIZABETH R. JACOBS & JOHN E. MOULDER. (2012) Radiation damage to the lung: Mitigation by angiotensin-converting enzyme (ACE) inhibitors. Respirology 17:1, pages 66-71.
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Harald Dörr & Viktor Meineke. (2011) Acute radiation syndrome caused by accidental radiation exposure - therapeutic principles. BMC Medicine 9:1.
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Julie L. Ryan, Sunil Krishnan, Benjamin Movsas, C. Norman Coleman, Bhadrasain Vikram & Stephen S. Yoo. (2011) Decreasing the Adverse Effects of Cancer Therapy: An NCI Workshop on the Preclinical Development of Radiation Injury Mitigators/Protectors. Radiation Research 176:5, pages 688-691.
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Antoine Le RouxStéphane MeunierThierry Le GallJean‐Marc DenisPierre Bischoff & Alain Wagner. (2011) Synthesis and Radioprotective Properties of Pulvinic Acid Derivatives. ChemMedChem 6:3, pages 561-569.
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Fred A. MettlerJr.Jr., David BrennerC. Norman ColemanJoseph M. KaminskiAnn R. KennedyLouis K. Wagner. (2011) Can Radiation Risks to Patients Be Reduced Without Reducing Radiation Exposure? The Status of Chemical Radioprotectants. American Journal of Roentgenology 196:3, pages 616-618.
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Benjamin Movsas, Bhadrasain Vikram, Martin Hauer-Jensen, John E. Moulder, Ethan Basch, Stephen L. Brown, Lisa A. Kachnic, Adam P. Dicker, C. Norman Coleman & Paul Okunieff. (2011) Decreasing the Adverse Effects of Cancer Therapy: National Cancer Institute Guidance for the Clinical Development of Radiation Injury Mitigators. Clinical Cancer Research 17:2, pages 222-228.
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Aaron P Brown, Eun Joo Chung, Mary Ellen Urick, William P ShieldIIIIII, Anastasia L Sowers, Angela Thetford, Uma T Shankavaram, James B Mitchell & Deborah E Citrin. (2010) Evaluation of the fullerene compound DF-1 as a radiation protector. Radiation Oncology 5:1.
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Daila S. GridleyXian Luo-OwenAsma RizviAdeola Y. MakindeMichael J. PecautXiao Wen MaoJames M. Slater. (2010) Low-dose Photon and Simulated Solar Particle Event Proton Effects on Foxp3 + T Regulatory Cells and other Leukocytes . Technology in Cancer Research & Treatment 9:6, pages 637-649.
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