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Review

Current synthetic inhibitors of human neutrophil elastase

Pages 65-84 | Published online: 25 Feb 2005

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Jalmira Mulchande, Sandra I. Simões, Maria M. Gaspar, Carla V. Eleutério, Rudi Oliveira, Maria E.M. Cruz, Rui Moreira & Jim Iley. (2011) Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase. Journal of Enzyme Inhibition and Medicinal Chemistry 26:2, pages 169-175.
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Hiroyuki Ohbayashi. (2005) Current synthetic inhibitors of human neutrophil elastase in 2005. Expert Opinion on Therapeutic Patents 15:7, pages 759-771.
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Hiroyuki Ohbayashi. (2002) Neutrophil elastase inhibitors as treatment for COPD. Expert Opinion on Investigational Drugs 11:7, pages 965-980.
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Articles from other publishers (5)

D. Rivera, K. Rommi, M. M. Fernandes, R. Lantto & T. Tzanov. (2015) Biocompounds from rapeseed oil industry co-stream as active ingredients for skin care applications. International Journal of Cosmetic Science 37:5, pages 496-505.
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Kevin R. Shreder, Julia Cajica, Lingling Du, Allister Fraser, Yi Hu, Yasushi Kohno, Emme C.K. Lin, Steve J. Liu, Eric Okerberg, Lan Pham, Jiangyue Wu & John W. Kozarich. (2009) Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase. Bioorganic & Medicinal Chemistry Letters 19:16, pages 4743-4746.
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Wing-Yin Tsang, Naveed Ahmed, Karl Hemming & Michael I. Page. (2007) Reactivity and selectivity in the inhibition of elastase by 3-oxo-β-sultams and in their hydrolysis. Organic & Biomolecular Chemistry 5:24, pages 3993.
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Haridas Rode, Stefanie Koerbe, Anita Besch, Karen Methling, Jutta Loose & Hans-Hartwig Otto. (2006) Synthesis and in vitro evaluation of pseudosaccharinamine derivatives as potential elastase inhibitors. Bioorganic & Medicinal Chemistry 14:8, pages 2789-2798.
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Yoshisuke Nakayama, Yoshihiko Odagaki, Setsuko Fujita, Shozo Matsuoka, Nobuyuki Hamanaka, Hisao Nakai & Masaaki Toda. (2002) Clarification of Mechanism of Human Sputum Elastase Inhibition by a New Inhibitor, ONO-5046, Using Electrospray Ionization Mass Spectrometry. Bioorganic & Medicinal Chemistry Letters 12:17, pages 2349-2353.
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