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Berberine and its derivatives: a patent review (2009 – 2012)

, PhD & , MSc (Organic Chemistry)
Pages 215-231 | Published online: 12 Dec 2012

Keep up to date with the latest research on this topic with citation updates for this article.

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Moazzim Soudagar, Bhaskar Kurangi, H.B Chethan Kumar, Supriya Chimagave, Umesh Patil & Shruti Kolambkar. (2023) Development and validation of a simple stability-indicating HPLC method for the quantitation of berberine in pharmaceuticals, ayurvedic, homeopathic products and novel nanoformulation. Analytical Chemistry Letters 13:3, pages 244-256.
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Yuan Kong, Lin Li, Lin-Guo Zhao, Pan Yu & Dong-Dong Li. (2022) A patent review of berberine and its derivatives with various pharmacological activities (2016–2020). Expert Opinion on Therapeutic Patents 32:2, pages 211-223.
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Lei Chen, Ling Zhu, Jinli Chen, Wei Chen, Xuhong Qian & Qing Yang. (2020) Crystal structure-guided design of berberine-based novel chitinase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 1937-1943.
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Ryan S. Funk, Rakesh K. Singh, Robert D. Winefield, Sylvie E. Kandel, Janelle F. Ruisinger, Patrick M. Moriarty & James M. Backes. (2018) Variability in Potency Among Commercial Preparations of Berberine. Journal of Dietary Supplements 15:3, pages 343-351.
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Maryam Rameshrad, Bibi Marjan Razavi & Hossein Hosseinzadeh. (2018) Saffron and its derivatives, crocin, crocetin and safranal: a patent review. Expert Opinion on Therapeutic Patents 28:2, pages 147-165.
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Yifeng Jin, Daulat B. Khadka & Won-Jea Cho. (2016) Pharmacological effects of berberine and its derivatives: a patent update. Expert Opinion on Therapeutic Patents 26:2, pages 229-243.
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Francesco Di Pierro, Pietro Putignano, Nicola Villanova, Luca Montesi, Simona Moscatiello & Giulio Marchesini. (2013) Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes. Clinical Pharmacology: Advances and Applications 5, pages 167-174.
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Xi Yang, Baixia Yang, Jing Cai, Chi Zhang, Qu Zhang, Liping Xu, Qin Qin, Hongcheng Zhu, Jianxin Ma, Guangzhou Tao, Hongyan Cheng & Xinchen Sun. (2013) Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo. Cancer Biology & Therapy 14:11, pages 1068-1073.
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Articles from other publishers (114)

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Alireza Dodangeh, Elham Hoveizi & Sayed Reza Fatemi Tabatabaei. (2023) Simultaneous Administration of Berberine and Transplantation of Endometrial Stem Cell-Derived Insulin Precursor Cells on a Nanofibrous Scaffold to Treat Diabetes Mellitus in Mice. Molecular Neurobiology 60:12, pages 7032-7043.
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Chun-En Kuo, Sheng-Feng Hsu, Ching-Chih Chen, Szu-Ying Wu, Yu-Chiang Hung, Chung Y. Hsu, I.-Ju Tsai & Wen-Long Hu. (2023) Prescription characteristics of Xue-Fu-Zhu-Yu-Tang in pain management: a population-based study using the National Health Insurance Research Database in Taiwan. Frontiers in Pharmacology 14.
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Mohd. Jawed Khan, Abdul Hafeez & Mohd. Aftab Siddiqui. (2023) Nanocarrier Based Delivery of Berberine: A Critical Review on Pharmaceutical and Preclinical Characteristics of the Bioactive. Current Pharmaceutical Biotechnology 24:11, pages 1449-1464.
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Prashant Sharma, Abhinoy Kishore, Indranil De, Swarnima Negi, Gulshan Kumar, Sahil Bhardwaj & Manish Singh. (2023) Mitigating neuroinflammation in Parkinson's disease: Exploring the role of proinflammatory cytokines and the potential of phytochemicals as natural therapeutics. Neurochemistry International, pages 105604.
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Techi Mana, Oinam Bidyalaxmi Devi & Yengkhom Disco Singh. (2023) Therapeutic Application of Berberine: a Consolidated Review. Current Pharmacology Reports.
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Hesham Eed Desouky, Guang-zhen Jiang, Kenneth Prudence Abasubong, Yong-Jun Dai, Xiangyang Yuan, Jean-Jacques Y. Adjoumani & Wen-bin Liu. (2023) Plant-Based Additivities Improved the Growth Performance and Immune Response, and Mitigated the Inflammatory Signalling in Channel Catfish Fed a High-Fat Diet. Aquaculture Research 2023, pages 1-14.
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Qiong Lu, Huijie Xie, Mingbo Qu, Tian Liu & Qing Yang. (2023) Group h Chitinase: A Molecular Target for the Development of Lepidopteran-Specific Insecticides. Journal of Agricultural and Food Chemistry.
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Ya-Fei Liu, Huan-Huan Wang, Yin-Hong Geng, Liang Han, Sheng-Hao Tu & Hui Wang. (2023) Advances of berberine against metabolic syndrome-associated kidney disease: Regarding effect and mechanism. Frontiers in Pharmacology 14.
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Jingjia Liang & Aihua Gu. (2022) Biological targets of berberine hydrochloride and the mechanisms by which it alleviates metabolic-associated fatty liver disease. Chinese Science Bulletin 68:5, pages 469-478.
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Naina Rajak, Bentham Science Publisher Kavita, Praveen Kumar, Shikha Singh & Neha Garg. 2023. Bioactive Phytochemicals from Himalayas: A Phytotherapeutic Approach. Bioactive Phytochemicals from Himalayas: A Phytotherapeutic Approach 89 104 .
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Emad H.M. Hassanein, Islam M. Ibrahim, Esraa K. Abd-alhameed, Nesma M. Mohamed & Samir A. Ross. (2022) Protective effects of berberine on various kidney diseases: Emphasis on the promising effects and the underlined molecular mechanisms. Life Sciences 306, pages 120697.
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Rabia Ali, Atia-tul-Wahab, Sheeba Wajid, Maria Aqeel Khan, Sammer Yousuf, Muniza Shaikh, Gul Hassan Laghari, Atta-ur Rahman & M. Iqbal Choudhary. (2022) Isolation, derivatization, in-vitro, and in-silico studies of potent butyrylcholinesterase inhibitors from Berberis parkeriana Schneid. Bioorganic Chemistry 127, pages 105944.
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Alexandra Noites, Bruno Araújo, Jorge Machado & Eugénia Pinto. (2022) Antifungal Potential of Some Herb Decoctions and Essential Oils on Candida Species. Healthcare 10:10, pages 1820.
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Hanh My Tran, Diep Hong Le, Van-Anh Thi Nguyen, Tao Xuan Vu, Nguyen Thi Kim Thanh, Do Hoang Giang, Nguyen Tien Dat, Hai The Pham, Marc Muller, Huy Quang Nguyen & Van-Tuan Tran. (2022) Penicillium digitatum as a Model Fungus for Detecting Antifungal Activity of Botanicals: An Evaluation on Vietnamese Medicinal Plant Extracts. Journal of Fungi 8:9, pages 956.
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Xiao-Dan Zhong, Li-Juan Chen, Xin-Yang Xu, Yan-Jun Liu, Fan Tao, Ming-Hui Zhu, Chang-Yun Li, Dan Zhao, Guan-Jun Yang & Jiong Chen. (2022) Berberine as a potential agent for breast cancer therapy. Frontiers in Oncology 12.
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Lanlan Fu, Jiajia Mou, Yanru Deng & Xiaoliang Ren. (2022) Structural modifications of berberine and their binding effects towards polymorphic deoxyribonucleic acid structures: A review. Frontiers in Pharmacology 13.
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Jingjing Xue, Yuetong Wang, Fangshen Liu, Hangao Yang, Bin Lin, Zhanlin Li, Yongkui Jing, Dahong Li & Huiming Hua. (2022) Alkaloid Dimers Isolated from Thalictrum baicalense Have Antitumor Activities . Chinese Journal of Chemistry 40:15, pages 1831-1841.
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Yiting Liu, Ebuka-Olisaemeka Nwafor, Ziwei Li, Jilin Wang, Xiaojiao Feng, Huihui Li, Bei Jia, Hongfei Ma, Jiachen He, Jiaxin Pi & Zhidong Liu. (2022) Effects of Berberine on Liver Cancer. Natural Product Communications 17:5, pages 1934578X2211020.
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Jing-jing Tian, Ya-qi Jin, Er-meng Yu, Jin-hui Sun, Yun Xia, Kai Zhang, Zhi-fei Li, Wang-bao Gong, Guang-jun Wang & Jun Xie. (2022) Intestinal farnesoid X receptor mediates the effect of dietary berberine on lipid accumulation in grass carp (Ctenopharyngodon idella). Aquaculture 553, pages 738055.
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Nguyen Phi Long, Nghiem Duc Thuan, Do Lan Huong, Vu Van Minh, Bui Thanh Son, Quan Thanh Nam, Chu Thi Hong Ninh, Pham Minh Tuan, Nguyen Anh Cuong, Nguyen Van Thinh, Le Van Quan, Nguyen Trong Nghia, Dinh Viet Hung, Nguyen Khanh & Pham Ngoc Thao. (2022) Efficiency of a biodegradable gel containing hyaluronic acid and berberine hydrochloride in endoscopic sinus surgery (ESS): A prospective comparative study. American Journal of Otolaryngology 43:3, pages 103397.
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Zhong-Rui LI, Meng-Zhen GU, Xiao XU, Jing-Han ZHANG, Hai-Li ZHANG & Chao HAN. (2022) Promising natural lysine specific demethylase 1 inhibitors for cancer treatment: advances and outlooks. Chinese Journal of Natural Medicines 20:4, pages 241-257.
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Stephen A. Adefegha, Felix A. Dada, Sunday I. Oyeleye & Ganiyu Oboh. (2022) Effect of oral berberine administration on the renal profiles of adenosine deaminase, arginase, and nitric oxide in streptozotocin-induced diabetic nephropathy of rats. Comparative Clinical Pathology 31:2, pages 255-263.
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Alba Calvo, Esther Moreno, Irati Aldalur, Carmen Sanmartín, Esther Larrea, Elena González-Peñas, Juan Manuel Irache & Socorro Espuelas. (2022) Effect of topical berberine in murine cutaneous leishmaniasis lesions. Journal of Antimicrobial Chemotherapy 77:4, pages 1072-1081.
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Mensura Sied Filli, Ahmed Abdalla Ibrahim, Samuel Kesse, Md Aquib, Kofi Oti Boakye-Yiadom, Muhammad Asim Farooq, Faisal Raza, Yubin Zhang & Bo Wang. (2022) Synthetic berberine derivatives as potential new drugs. Brazilian Journal of Pharmaceutical Sciences 58.
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P.S. Tresina, M. Santhiya Selvam, A. Doss & V.R. Mohan. 2022. Bioactive Natural Products. Bioactive Natural Products 75 118 .
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Ghadha Ibrahim Fouad & Kawkab A. Ahmed. (2021) Neuroprotective Potential of Berberine Against Doxorubicin-Induced Toxicity in Rat’s Brain. Neurochemical Research 46:12, pages 3247-3263.
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E. D. Gladkova, O. A. Luzina & N. F. Salakhutdinov. (2021) Stereoselective Cycloaddition of Alkanesulfonyl Chlorides to Dihydroberberine. Chemistry of Natural Compounds 57:6, pages 1062-1065.
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Parth Patel. (2021) A bird's eye view on a therapeutically ‘wonder molecule’: Berberine. Phytomedicine Plus 1:3, pages 100070.
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Giovanni Sartore, Eugenio Ragazzi, Giulia Antonello, Chiara Cosma & Annunziata Lapolla. (2021) Effect of a New Formulation of Nutraceuticals as an Add-On to Metformin Monotherapy for Patients with Type 2 Diabetes and Suboptimal Glycemic Control: A Randomized Controlled Trial. Nutrients 13:7, pages 2373.
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Sobhi Gaba, Anjali Saini, Gurpreet Singh & Vikramdeep Monga. (2021) An insight into the medicinal attributes of berberine derivatives: A review. Bioorganic & Medicinal Chemistry 38, pages 116143.
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Janiqua Rolle, Dorothy O Asante, Linsey L Kok-Fong, Hamza Boucetta, Theodora A Seidu, Lesieli L K Tai & Raphael N Alolga. (2021) Jatrorrhizine: a review of its pharmacological effects. Journal of Pharmacy and Pharmacology 73:6, pages 709-719.
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Elizaveta D. Gladkova, Arina A. Chepanova, Ekaterina S. Ilina, Alexandra L. Zakharenko, Jóhannes Reynisson, Olga A. Luzina, Konstantin P. Volcho, Olga I. Lavrik & Nariman F. Salakhutdinov. (2021) Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors. Molecules 26:7, pages 1945.
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Xianxian Gao, Chen Zhang, Yanjie Wang, Ping Zhang, Jingyu Zhang & Tie Hong. (2021) Berberine and Cisplatin Exhibit Synergistic Anticancer Effects on Osteosarcoma MG-63 Cells by Inhibiting the MAPK Pathway. Molecules 26:6, pages 1666.
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Fatma H. Shaker, Marwa O. El-Derany, Sara A. Wahdan, Ebtehal El-Demerdash & Hala O. El-Mesallamy. (2021) Berberine ameliorates doxorubicin-induced cognitive impairment (chemobrain) in rats. Life Sciences 269, pages 119078.
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Jin Huang, Wei Feng, Shanshan Li, Huiling Tang, Siru Qin, Wei Li, Yinan Gong, Yuxin Fang, Yangyang Liu, Shenjun Wang, Yi Guo, Zhifang Xu & Qian Shen. (2021) Berberine Exerts Anti-cancer Activity by Modulating Adenosine Monophosphate- Activated Protein Kinase (AMPK) and the Phosphatidylinositol 3-Kinase/ Protein Kinase B (PI3K/AKT) Signaling Pathways. Current Pharmaceutical Design 27:4, pages 565-574.
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Mohammed Ajebli, Haroun Khan & Mohamed Eddouks. (2021) Natural Alkaloids and Diabetes Mellitus: A Review. Endocrine, Metabolic & Immune Disorders - Drug Targets 21:1, pages 111-130.
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Xinmei Xu, Huan Yi, Jiasi Wu, Tingting Kuang, Jing Zhang, Qi Li, Huan Du, Tong Xu, Guihua Jiang & Gang Fan. (2021) Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence. Biomedicine & Pharmacotherapy 133, pages 110984.
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Víctor Fajardo Morales, Loreto Manosalva & Marisel Araya. 2021. Medicinal and Aromatic Plants of South America Vol. 2. Medicinal and Aromatic Plants of South America Vol. 2 119 126 .
Giulia Vanti, Meng Wang, Maria Camilla Bergonzi, Liu Zhidong & Anna Rita Bilia. (2020) Hydroxypropyl methylcellulose hydrogel of berberine chloride-loaded escinosomes: Dermal absorption and biocompatibility. International Journal of Biological Macromolecules 164, pages 232-241.
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Ayesha Shaikh, Satishkumar Tekale, Sandip Wagh & Manohar Padul. (2020) Metabolite profiling of arginase inhibitor activity guided fraction of Ficus religiosa leaves by LC–HRMS . Biomedical Chromatography 34:12.
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Charles Oluwaseun Adetunji, Oluwaseyi Olaniyan, Juliana Bunmi Adetunji & Itoan Roli. 2020. Poisonous Plants and Phytochemicals in Drug Discovery. Poisonous Plants and Phytochemicals in Drug Discovery 295 321 .
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Fang Bai, Hai Tao, Peng Wang, Lihua Wang, Xibin Zhou, Fei Wang, Chuan Liu & Yifei Huang. (2020) Berberine hydrochloride inhibits inflammation and fibrosis after canalicular laceration repair in rabbits. Life Sciences 261, pages 118479.
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Katerina Sobolova, Martina Hrabinova, Vendula Hepnarova, Tomas Kucera, Tereza Kobrlova, Marketa Benkova, Jana Janockova, Rafael Dolezal, Lukas Prchal, Ondrej Benek, Eva Mezeiova, Daniel Jun, Ondrej Soukup & Jan Korabecny. (2020) Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile. European Journal of Medicinal Chemistry 203, pages 112593.
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Parisa Samadi, Parisa Sarvarian, Elham Gholipour, Karim Shams Asenjan, Leili Aghebati‐Maleki, Roza Motavalli, Mohammad Hojjat‐Farsangi & Mehdi Yousefi. (2020) Berberine: A novel therapeutic strategy for cancer. IUBMB Life 72:10, pages 2065-2079.
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Alba Calvo, Esther Moreno, Esther Larrea, Carmen Sanmartín, Juan Manuel Irache & Socorro Espuelas. (2020) Berberine-Loaded Liposomes for the Treatment of Leishmania infantum-Infected BALB/c Mice. Pharmaceutics 12:9, pages 858.
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Hongying Kuang, Yuwei Duan, Dan Li, Yanwen Xu, Wenxia Ai, Wei Li, Ying Wang, Sha Liu, Mushan Li, Xiaoqiu Liu & Manqi Shao. (2020) The role of serum inflammatory cytokines and berberine in the insulin signaling pathway among women with polycystic ovary syndrome. PLOS ONE 15:8, pages e0235404.
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Maria Zych, Weronika Wojnar, Magdalena Kielanowska, Joanna Folwarczna & Ilona Kaczmarczyk-Sedlak. (2020) Effect of Berberine on Glycation, Aldose Reductase Activity, and Oxidative Stress in the Lenses of Streptozotocin-Induced Diabetic Rats In Vivo—A Preliminary Study. International Journal of Molecular Sciences 21:12, pages 4278.
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Yi Liu, Ke-xin Zhu, Lei Cao, Zhi-fu Xie, Min Gu, Wei Lü, Jing-ya Li & Fa-jun Nan. (2020) Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells. Acta Pharmacologica Sinica 41:6, pages 813-824.
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Reza Ghaffarzadegan, Sepideh Khoee & Shamsali Rezazadeh. (2020) Fabrication, characterization and optimization of berberine-loaded PLA nanoparticles using coaxial electrospray for sustained drug release. DARU Journal of Pharmaceutical Sciences 28:1, pages 237-252.
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Peifang Du, Jianhua Yan, Shuo Long, Hongjie Xiong, Nachuan Wen, Shundong Cai, Yirong Wang, Dongming Peng, Zhenbao Liu & Yanfei Liu. (2020) Tumor microenvironment and NIR laser dual-responsive release of berberine 9- O -pyrazole alkyl derivative loaded in graphene oxide nanosheets for chemo-photothermal synergetic cancer therapy . Journal of Materials Chemistry B 8:18, pages 4046-4055.
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Qianyu Zhang, Wen Wu, Jinqiang Zhang & Xuefeng Xia. (2020) Eradication of Helicobacter pylori : the power of nanosized formulations . Nanomedicine 15:5, pages 527-542.
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Hamed Mortazavi, Banafsheh Nikfar, Seyed-Alireza Esmaeili, Fatemeh Rafieenia, Ehsan Saburi, Shahla Chaichian, Mohammad Ali Heidari Gorji & Amir Abbas Momtazi-Borojeni. (2020) Potential cytotoxic and anti-metastatic effects of berberine on gynaecological cancers with drug-associated resistance. European Journal of Medicinal Chemistry 187, pages 111951.
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Alireza Fatahian, Saeed Mohammadian Haftcheshmeh, Sara Azhdari, Helaleh Kaboli Farshchi, Banafsheh Nikfar & Amir Abbas Momtazi-Borojeni. 2020. Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology 83 110 .
Li Liu, Jingyan Fan, Guihai Ai, Jie Liu, Ning Luo, Caixia Li & Zhongping Cheng. (2019) Berberine in combination with cisplatin induces necroptosis and apoptosis in ovarian cancer cells. Biological Research 52:1.
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Xiaopeng Zhu, Hua Bian, Liu Wang, Xiaoyang Sun, Xi Xu, Hongmei Yan, Mingfeng Xia, Xinxia Chang, Yan Lu, Yu Li, Pu Xia, Xiaoying Li & Xin Gao. (2019) Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway. Free Radical Biology and Medicine 141, pages 192-204.
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Reza Mohammadinejad, Zahra Ahmadi, Shima Tavakol & Milad Ashrafizadeh. (2019) Berberine as a potential autophagy modulator. Journal of Cellular Physiology 234:9, pages 14914-14926.
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Jyoti Tak, Akash Sabarwal, Ritis K. Shyanti & Rana P. Singh. (2019) Berberine enhances posttranslational protein stability of p21/cip1 in breast cancer cells via down-regulation of Akt. Molecular and Cellular Biochemistry 458:1-2, pages 49-59.
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I. V. Nechepurenko, E. D. Shirokova, M. V. Khvostov, T. S. Frolova, O. I. Sinitsyna, A. M. Maksimov, R. A. Bredikhin, N. I. Komarova, D. S. Fadeev, O. A. Luzina, T. G. Tolstikova & N. F. Salakhutdinova. (2019) Synthesis, hypolipidemic and antifungal activity of tetrahydroberberrubine sulfonates. Russian Chemical Bulletin 68:5, pages 1052-1060.
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Ayarivan Puratchikody, Navabshan Irfan & Sakthivel Balasubramaniyan. (2019) Conceptual design of hybrid PCSK9 lead inhibitors against coronary artery disease. Biocatalysis and Agricultural Biotechnology 17, pages 427-440.
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Haoyue Zhang, Xueping Wang, Ting Wang, Kaixian Chen, Heyao Wang, Qi Jia & Yiming Li. (2018) Enhancement of Berberine Hypoglycemic Activity by Oligomeric Proanthocyanidins. Molecules 23:12, pages 3318.
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Yanwei Duan, Tian Liu, Yong Zhou, Tongyi Dou & Qing Yang. (2018) Glycoside hydrolase family 18 and 20 enzymes are novel targets of the traditional medicine berberine. Journal of Biological Chemistry 293:40, pages 15429-15438.
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Fatemeh Hashemi- Niasari, Azra Rabbani-Chadegani, Mahdieh Razmi & Soudabeh Fallah. (2018) Synergy of theophylline reduces necrotic effect of berberine, induces cell cycle arrest and PARP, HMGB1, Bcl-2 family mediated apoptosis in MDA-MB-231 breast cancer cells. Biomedicine & Pharmacotherapy 106, pages 858-867.
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Maria A. Neag, Andrei Mocan, Javier Echeverría, Raluca M. Pop, Corina I. Bocsan, Gianina Crişan & Anca D. Buzoianu. (2018) Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders. Frontiers in Pharmacology 9.
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Qiao Li, Yan Yang, Ting Zhou, Rui Wang, Na Li, Min Zheng, Yuan-Yuan Li, Ji-Quan Zhang, Fei Wu, Bai-Can Yang, Yue-Ming Ma & Bing-Liang Ma. (2018) A Compositive Strategy to Study the Pharmacokinetics of TCMs: Taking Coptidis Rhizoma, and Coptidis Rhizoma-Glycyrrhizae Radix et Rhizoma as Examples. Molecules 23:8, pages 2042.
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Elaheh Mirhadi, Mehdi Rezaee & Bizhan Malaekeh-Nikouei. (2018) Nano strategies for berberine delivery, a natural alkaloid of Berberis. Biomedicine & Pharmacotherapy 104, pages 465-473.
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Xueling Ma, Zhongjun Chen, Le Wang, Gesheng Wang, Zihui Wang, XiaoBo Dong, Binyu Wen & Zhichen Zhang. (2018) The Pathogenesis of Diabetes Mellitus by Oxidative Stress and Inflammation: Its Inhibition by Berberine. Frontiers in Pharmacology 9.
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Juan Wu, Jingya Li, Wei Li, Bei Sun, Jin Xie, Wenming Cheng & Qunlin Zhang. (2018) Achyranthis bidentatae radix enhanced articular distribution and anti-inflammatory effect of berberine in Sanmiao Wan using an acute gouty arthritis rat model. Journal of Ethnopharmacology 221, pages 100-108.
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Rajiv Gandhi Sathiyabama, Gopalsamy Rajiv Gandhi, Marina Denadai, Gurunagarajan Sridharan, Gnanasekaran Jothi, Ponnusamy Sasikumar, Jullyana de Souza Siqueira Quintans, Narendra Narain, Luis Eduardo Cuevas, Henrique Douglas Melo Coutinho, Andreza Guedes Barbosa Ramos, Lucindo José Quintans-Júnior & Ricardo Queiroz Gurgel. (2018) Evidence of insulin-dependent signalling mechanisms produced by Citrus sinensis (L.) Osbeck fruit peel in an insulin resistant diabetic animal model. Food and Chemical Toxicology 116, pages 86-99.
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Li Liu, Ning Luo, Jing Guo, Yan Xie, Li Chen & Zhongping Cheng. (2018) Berberine inhibits growth and inflammatory invasive phenotypes of ectopic stromal cells: Imply the possible treatment of adenomyosis. Journal of Pharmacological Sciences 137:1, pages 5-11.
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Catarina A. B. Rodrigues, Iris Neto, Patricia Rijo & Carlos A. M. Afonso. (2018) Synthesizing a Berberine Derivative and Evaluating Antimicrobial Activity To Reinforce with Students the Potential Significance of Small Chemical Structure Changes for Biological Systems. Journal of Chemical Education 95:3, pages 492-495.
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Ghaith Al-Badri, GianMarco Leggio, Giuseppe Musumeci, Rubina Marzagalli, Filippo Drago & Alessandro Castorina. (2018) Tackling dipeptidyl peptidase IV in neurological disorders. Neural Regeneration Research 13:1, pages 26.
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Li Liu, Li Chen, Caixia Jiang, Jing Guo, Yan Xie, Le Kang & Zhongping Cheng. (2017) Berberine inhibits the LPS‑induced proliferation and inflammatory response of stromal cells of adenomyosis tissues mediated by the LPS/TLR4 signaling pathway. Experimental and Therapeutic Medicine.
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Seyed Hasan Ayati, Badrieh Fazeli, Amir Abbas Momtazi-borojeni, Arrigo F.G. Cicero, Matteo Pirro & Amirhossein Sahebkar. (2017) Regulatory effects of berberine on microRNome in Cancer and other conditions. Critical Reviews in Oncology/Hematology 116, pages 147-158.
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Katerina Babkova, Jan Korabecny, Ondrej Soukup, Eugenie Nepovimova, Daniel Jun & Kamil Kuca. (2017) Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors. Future Medicinal Chemistry 9:10, pages 1015-1038.
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Zhong Li & Wei Zhang. (2017) Protective effect of berberine on renal fibrosis caused by diabetic nephropathy. Molecular Medicine Reports 16:2, pages 1055-1062.
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Laxmi Rathor, Aakanksha Pant, Harshika Awasthi, Dayanandan Mani & Rakesh Pandey. (2016) An antidiabetic polyherbal phytomedicine confers stress resistance and extends lifespan in Caenorhabditis elegans. Biogerontology 18:1, pages 131-147.
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Chae-Min Yi, Jihyun Yu, Hyunbin Kim, Na-Rae Lee, Sang Won Kim, Noh-Jin Lee, Jun Lee, Jihye Seong, Nam-Jung Kim & Kyung-Soo Inn. (2017) Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly. Chemical Communications 53:52, pages 7045-7047.
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Dongqing Jiang, Dianhui Wang, Xianghua Zhuang, Zhanqing Wang, Yihong Ni, Shihong Chen & Fudun Sun. (2016) Berberine increases adipose triglyceride lipase in 3T3-L1 adipocytes through the AMPK pathway. Lipids in Health and Disease 15:1.
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Yan-hong Li, Man Zhang, Hai-bo Fu, Hai-tao Xiao & Zhao-xiang Bian. (2016) Pre-clinical toxicity of a combination of berberine and?5-aminosalicylic acid in mice. Food and Chemical Toxicology 97, pages 150-158.
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Xiaopeng Zhu, Hua Bian & Xin Gao. (2016) The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease. Molecules 21:10, pages 1336.
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