Citations (48)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (3)
John S Gibson & David C Rees. (2023) Emerging drug targets for sickle cell disease: shedding light on new knowledge and advances at the molecular level. Expert Opinion on Therapeutic Targets 27:2, pages 133-149.
Read now
Read now
Carlton Dampier. (2019) New and emerging treatments for vaso-occlusive pain in sickle cell disease. Expert Review of Hematology 12:10, pages 857-872.
Read now
Read now
Heike Wulff & Neil A Castle. (2010) Therapeutic potential of KCa3.1 blockers: recent advances and promising trends. Expert Review of Clinical Pharmacology 3:3, pages 385-396.
Read now
Read now
Articles from other publishers (45)
Ruth D. Lee, Yi-Je Chen, Hai M. Nguyen, Latika Singh, Connor J. Dietrich, Benjamin R. Pyles, Yanjun Cui, Jonathan R. Weinstein & Heike Wulff. (2023) Repurposing the KCa3.1 Blocker Senicapoc for Ischemic Stroke. Translational Stroke Research.
Crossref
Crossref
Christian P. Konken, Kathrin Heßling, Insa Thale, Sonja Schelhaas, Jennifer Dabel, Sarah Maskri, Etmar Bulk, Thomas Budde, Oliver Koch, Albrecht Schwab, Michael Schäfers & Bernhard Wünsch. (2022)
Imaging of the calcium activated potassium channel 3.1 (K
Ca
3.1) in vivo using a senicapoc‐derived positron emission tomography tracer
. Archiv der Pharmazie 355:12, pages 2200388.
Crossref
Crossref
Asbjørn Graver Petersen, Peter Carøe Lind, Susie Mogensen, Anne‐Sophie Bonde Jensen, Asger Granfeldt & Ulf Simonsen. (2022)
Treatment with senicapoc, a K
Ca
3.1 channel blocker, alleviates hypoxaemia in a mouse model of acute respiratory distress syndrome
. British Journal of Pharmacology 179:10, pages 2175-2192.
Crossref
Crossref
Asbjørn G. Petersen, Peter C. Lind, Anne-Sophie B. Jensen, Mark A. Eggertsen, Asger Granfeldt & Ulf Simonsen. (2021) Treatment with senicapoc in a porcine model of acute respiratory distress syndrome. Intensive Care Medicine Experimental 9:1.
Crossref
Crossref
Kathrin Brömmel, Christian Paul Konken, Frederik Börgel, Henry Obeng-Darko, Sonja Schelhaas, Etmar Bulk, Thomas Budde, Albrecht Schwab, Michael Schäfers & Bernhard Wünsch. (2021)
Synthesis and biological evaluation of PET tracers designed for imaging of calcium activated potassium channel 3.1 (K
Ca
3.1) channels
in vivo
. RSC Advances 11:48, pages 30295-30304.
Crossref
Crossref
Bo Chen, Donghong Sun, Xiuni Qin & Xing-Hua Gao. (2021) Screening and identification of potential biomarkers and therapeutic drugs in melanoma via integrated bioinformatics analysis. Investigational New Drugs 39:4, pages 928-948.
Crossref
Crossref
Donald J. AbrahamMartin K. Safo, Anfal Aljahdali, James Burnett, Donald J. Abraham & Osheiza Abdulmalik. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery
1
31
.
R. Wadud, A. Hannemann, D. C. Rees, J. N. Brewin & J. S. Gibson. (2020) Yoda1 and phosphatidylserine exposure in red cells from patients with sickle cell anaemia. Scientific Reports 10:1.
Crossref
Crossref
Gabriel Salinas Cisneros & Swee L. Thein. (2020) Recent Advances in the Treatment of Sickle Cell Disease. Frontiers in Physiology 11.
Crossref
Crossref
Jayati Mookerjee‐Basu, Robert Hooper, Scott Gross, Bryant Schultz, Christina K Go, Elsie Samakai, Jonathan Ladner, Emmanuelle Nicolas, Yuanyuan Tian, Bo Zhou, M Raza Zaidi, Warren Tourtellotte, Shan He, Yi Zhang, Dietmar J Kappes & Jonathan Soboloff. (2020)
Suppression of Ca
2+
signals by
EGR
4 controls Th1 differentiation and anti‐cancer immunity
in vivo
. EMBO reports 21:5.
Crossref
Crossref
Aristote B. Buya, Bernard Ucakar, Ana Beloqui, Patrick B. Memvanga & Véronique Préat. (2020) Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDSs) for senicapoc. International Journal of Pharmaceutics 580, pages 119180.
Crossref
Crossref
Paulina Stokłosa, Anna Borgström, Sven Kappel & Christine Peinelt. (2020) TRP Channels in Digestive Tract Cancers. International Journal of Molecular Sciences 21:5, pages 1877.
Crossref
Crossref
Abhishek Gour, Ashish Dogra, Shipra Bhatt & Utpal Nandi. 2020. Botanical Leads for Drug Discovery. Botanical Leads for Drug Discovery
51
65
.
Antonio Nardi, Søren-Peter Olesen & Palle Christophersen. 2020. Studies of Epithelial Transporters and Ion Channels. Studies of Epithelial Transporters and Ion Channels
967
1010
.
Jia Lu, Fangfang Dou & Zhihua Yu. (2019) The potassium channel KCa3.1 represents a valid pharmacological target for microgliosis-induced neuronal impairment in a mouse model of Parkinson’s disease. Journal of Neuroinflammation 16:1.
Crossref
Crossref
Knut Biber, Anindya Bhattacharya, Brian M. Campbell, Justin R. Piro, Michael Rohe, Roland G.W. Staal, Robert V. Talanian & Thomas Möller. (2019) Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development. Frontiers in Pharmacology 10.
Crossref
Crossref
Lee‐Way Jin, Jacopo Di Lucente, Hai M. Nguyen, Vikrant Singh, Latika Singh, Monique Chavez, Trevor Bushong, Heike Wulff & Izumi Maezawa. (2019) Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease. Annals of Clinical and Translational Neurology 6:4, pages 723-738.
Crossref
Crossref
Halima Al Balushi, Kobina Dufu, David C. Rees, John N. Brewin, Anke Hannemann, Donna Oksenberg, David C.‐Y. Lu & John S. Gibson. (2019)
The effect of the antisickling compound
GBT
1118 on the permeability of red blood cells from patients with sickle cell anemia
. Physiological Reports 7:6, pages e14027.
Crossref
Crossref
Giuseppina D’Alessandro, Lucia Monaco, Luigi Catacuzzeno, Fabrizio Antonangeli, Antonio Santoro, Vincenzo Esposito, Fabio Franciolini, Heike Wulff & Cristina Limatola. (2019) Radiation Increases Functional KCa3.1 Expression and Invasiveness in Glioblastoma. Cancers 11:3, pages 279.
Crossref
Crossref
Tianying Duan, Onur Cil, Jay R. Thiagarajah & Alan S. Verkman. (2019) Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea. JCI Insight 4:4.
Crossref
Crossref
Kerry A. Morrone, Jennifer Davila, W. Beau Mitchell & Deepa Manwani. 2018. Sickle Cell Disease and Hematopoietic Stem Cell Transplantation. Sickle Cell Disease and Hematopoietic Stem Cell Transplantation
41
64
.
Ruirui Lu, Cathrin Flauaus, Lea Kennel, Jonas Petersen, Oliver Drees, Wiebke Kallenborn-Gerhardt, Peter Ruth, Robert Lukowski & Achim Schmidtko. (2017) KCa3.1 channels modulate the processing of noxious chemical stimuli in mice. Neuropharmacology 125, pages 386-395.
Crossref
Crossref
Roland G. W. Staal, Jonathan R. Weinstein, Megan Nattini, Manuel Cajina, Gamini Chandresana & Thomas Möller. (2017) Senicapoc: Repurposing a Drug to Target Microglia KCa3.1 in Stroke. Neurochemical Research 42:9, pages 2639-2645.
Crossref
Crossref
Nicole Glaser, Christopher Little, Weei Lo, Michael Cohen, Daniel Tancredi, Heike Wulff & Martha O'Donnell. (2017) Treatment with the KCa3.1 inhibitor TRAM-34 during diabetic ketoacidosis reduces inflammatory changes in the brain. Pediatric Diabetes 18:5, pages 356-366.
Crossref
Crossref
Elisa Fermo, Anna Bogdanova, Polina Petkova-Kirova, Anna Zaninoni, Anna Paola Marcello, Asya Makhro, Pascal Hänggi, Laura Hertz, Jens Danielczok, Cristina Vercellati, Nadia Mirra, Alberto Zanella, Agostino Cortelezzi, Wilma Barcellini, Lars Kaestner & Paola Bianchi. (2017) ‘Gardos Channelopathy’: a variant of hereditary Stomatocytosis with complex molecular regulation. Scientific Reports 7:1.
Crossref
Crossref
Latha Paka, David E Smith, Dawoon Jung, Siobhan McCormack, Ping Zhou, Bin Duan, Jing-Song Li, Jiaqi Shi, Yong-Jie Hao, Kai Jiang, Michael Yamin, Itzhak D Goldberg & Prakash Narayan. (2017) Anti-steatotic and anti-fibrotic effects of the KCa3.1 channel inhibitor, Senicapoc, in non-alcoholic liver disease. World Journal of Gastroenterology 23:23, pages 4181.
Crossref
Crossref
Shahida A. Khan, Ghazi Damanhouri, Ashraf Ali, Sarah A. Khan, Aziz Khan, Ahmed Bakillah, Samy Marouf, Ghazi Al Harbi, Saeed H. Halawani & Ahmad Makki. (2016) Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration. Nutrition & Metabolism 13:1.
Crossref
Crossref
Elena Dale, Roland G. W. Staal, Claudia Eder & Thomas Möller. (2016)
K
Ca
3.1—a microglial target ready for drug repurposing?
. Glia 64:10, pages 1733-1741.
Crossref
Crossref
Giuseppina D'Alessandro, Alfonso Grimaldi, Giuseppina Chece, Alessandra Porzia, Vincenzo Esposito, Antonio Santoro, Maurizio Salvati, Fabrizio Mainiero, Davide Ragozzino, Silvia Di Angelantonio, Heike Wulff, Myriam Catalano & Cristina Limatola. (2016) KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment. Oncotarget 7:21, pages 30781-30796.
Crossref
Crossref
A Grimaldi, G D'Alessandro, M T Golia, E M Grössinger, S Di Angelantonio, D Ragozzino, A Santoro, V Esposito, H Wulff, M Catalano & C Limatola. (2016) KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages. Cell Death & Disease 7:4, pages e2174-e2174.
Crossref
Crossref
Marilyn J. Telen. (2016) Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease. Blood 127:7, pages 810-819.
Crossref
Crossref
Antonio Nardi, Søren-Peter Olesen & Palle Christophersen. 2016. Ion Channels and Transporters of Epithelia in Health and Disease. Ion Channels and Transporters of Epithelia in Health and Disease
857
899
.
Immacolata Andolfo, Roberta Russo, Francesco Manna, Boris E. Shmukler, Antonella Gambale, Giuseppina Vitiello, Gianluca De Rosa, Carlo Brugnara, Seth L. Alper, L. Michael Snyder & Achille Iolascon. (2015) Novel Gardos channel mutations linked to dehydrated hereditary stomatocytosis (xerocytosis). American Journal of Hematology 90:10, pages 921-926.
Crossref
Crossref
Benjamin StegenLena ButzLukas KlumppDaniel ZipsKlaus DittmannPeter RuthStephan M. Huber. (2015) Ca2+-Activated IK K+ Channel Blockade Radiosensitizes Glioblastoma Cells. Molecular Cancer Research 13:9, pages 1283-1295.
Crossref
Crossref
Stefan FeskeHeike Wulff & Edward Y. Skolnik. (2015) Ion Channels in Innate and Adaptive Immunity. Annual Review of Immunology 33:1, pages 291-353.
Crossref
Crossref
Aida Oliván-Viguera, Marta Sofía Valero, Nicole Coleman, Brandon M. Brown, Celia Laría, María Divina Murillo, José A. Gálvez, María D. Díaz-de-Villegas, Heike Wulff, Ramón Badorrey & Ralf Köhler. (2015)
A Novel Pan-Negative-Gating Modulator of K
Ca
2/3 Channels, Fluoro-Di-Benzoate, RA-2, Inhibits Endothelium-Derived Hyperpolarization–Type Relaxation in Coronary Artery and Produces Bradycardia In Vivo
. Molecular Pharmacology 87:2, pages 338-348.
Crossref
Crossref
Ademola Samson Adewoyin. (2015) Management of Sickle Cell Disease: A Review for Physician Education in Nigeria (Sub-Saharan Africa). Anemia 2015, pages 1-21.
Crossref
Crossref
Lars Koch Hansen, Linda Sevelsted-Møller, Maj Rabjerg, Dorte Larsen, Tine Plato Hansen, Lone Klinge, Heike Wulff, Torben Knudsen, Jens Kjeldsen & Ralf Köhler. (2014) Expression of T-cell KV1.3 potassium channel correlates with pro-inflammatory cytokines and disease activity in ulcerative colitis. Journal of Crohn's and Colitis 8:11, pages 1378-1391.
Crossref
Crossref
Pascal Hänggi, Asya Makhro, Max Gassmann, Markus Schmugge, Jeroen S. Goede, Oliver Speer & Anna Bogdanova. (2014)
Red blood cells of sickle cell disease patients exhibit abnormally high abundance of
N
‐methyl D‐aspartate receptors mediating excessive calcium uptake
. British Journal of Haematology 167:2, pages 252-264.
Crossref
Crossref
Chunling Huang, Carol A. Pollock & Xin-Ming Chen. (2014) Role of the potassium channel KCa3.1 in diabetic nephropathy. Clinical Science 127:7, pages 423-433.
Crossref
Crossref
Zachary Bergeron & Jon-Paul Bingham. (2012) Scorpion Toxins Specific for Potassium (K+) Channels: A Historical Overview of Peptide Bioengineering. Toxins 4:11, pages 1082-1119.
Crossref
Crossref
Sandra-Annika Quast, Anja Berger, Nicole Buttstädt, Kristin Friebel, Roland Schönherr & Jürgen Eberle. (2012) General Sensitization of Melanoma Cells for TRAIL-Induced Apoptosis by the Potassium Channel Inhibitor TRAM-34 Depends on Release of SMAC. PLoS ONE 7:6, pages e39290.
Crossref
Crossref
Yi-Je Chen, Girija Raman, Silke Bodendiek, Martha E O'Donnell & Heike Wulff. (2011) The KCa3.1 Blocker TRAM-34 Reduces Infarction and Neurological Deficit in a Rat Model of Ischemia/Reperfusion Stroke. Journal of Cerebral Blood Flow & Metabolism 31:12, pages 2363-2374.
Crossref
Crossref
Jenny Lam & Heike Wulff. (2011) The lymphocyte potassium channels Kv1.3 and KCa3.1 as targets for immunosuppression. Drug Development Research 72:7, pages 573-584.
Crossref
Crossref
Marie-Claude Durpès, Danitza Nebor, Pierre Couespel du Mesnil, Danièle Mougenel, Monique Decastel, Jacques Elion & Marie-Dominique Hardy-Dessources. (2010) Effect of interleukin-8 and RANTES on the Gardos channel activity in sickle human red blood cells: Role of the Duffy antigen receptor for chemokines. Blood Cells, Molecules, and Diseases 44:4, pages 219-223.
Crossref
Crossref