655
Views
37
CrossRef citations to date
0
Altmetric
Reviews

Prostaglandin EP2 and EP4 receptor agonists in bone formation and bone healing: In vivo and in vitro evidence

, , , , , , , & show all
Pages 749-766 | Published online: 09 May 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Simona Daniele, Letizia Natali, Chiara Giacomelli, Pietro Campiglia, Ettore Novellino, Claudia Martini & Maria Letizia Trincavelli. (2017) Osteogenesis Is Improved by Low Tumor Necrosis Factor Alpha Concentration through the Modulation of Gs-Coupled Receptor Signals. Molecular and Cellular Biology 37:8.
Read now
Dragos Apostu, Ondine Lucaciu, Gheorghe Dan Osvald Lucaciu, Bogdan Crisan, Liana Crisan, Mihaela Baciut, Florin Onisor, Grigore Baciut, Radu Septimiu Câmpian & Simion Bran. (2017) Systemic drugs that influence titanium implant osseointegration. Drug Metabolism Reviews 49:1, pages 92-104.
Read now
Yu-Cong Zou, Xian-Wen Yang, Shi-Guo Yuan, Pei Zhang & Yi-Kai Li. (2016) Celastrol inhibits prostaglandin E2-induced proliferation and osteogenic differentiation of fibroblasts isolated from ankylosing spondylitis hip tissues in vitro. Drug Design, Development and Therapy 10, pages 933-948.
Read now
Simon M Graham, Andreas Leonidou, Nayef Aslam-Pervez, Ahmed Hamza, Pavlos Panteliadis, Manolis Heliotis, Athanasios Mantalaris & Eleftherios Tsiridis. (2010) Biological therapy of bone defects: the immunology of bone allo-transplantation. Expert Opinion on Biological Therapy 10:6, pages 885-901.
Read now
Keiichi Masuya & Naoki Teno. (2010) Small molecules for bone diseases. Expert Opinion on Therapeutic Patents 20:4, pages 563-582.
Read now

Articles from other publishers (32)

Yuhu Zhao, Xiaole Peng, Qing Wang, Zhiyu Zhang, Liangliang Wang, Yaozeng Xu, Huilin Yang, Jiaxiang Bai & Dechun Geng. (2023) Crosstalk Between the Neuroendocrine System and Bone Homeostasis. Endocrine Reviews.
Crossref
Chih-Chien Wang, Jeng-Wei Lu, Kuang-Hsing Chiang, Yu-Shuan Cheng, You-Hsiang Chu, Yi-Jen Peng, Chia-Hui Cheng, Chia-Yu Chang & Jiunn-Jye Chuu. (2022) Anti-Inflammatory and Chondro-Protective Effects of Acidic Polysaccharide from Enteromorpha Prolifera in Experimental Models of Osteoarthritis In-Vitro and In-Vivo . CARTILAGE 13:4, pages 157-170.
Crossref
Jen-Chieh Lai, Hsin-Pei Li, Gary Ro-Lin Chang, Ying-Wei Lan, Yu-Hsuan Chen, Yan-Shen Tseng, Min-Yu Tu, Chien-Fu Chen, Hsiao-Ling Chen & Chuan-Mu Chen. (2022) Kefir peptides promote osteogenic differentiation to enhance bone fracture healing in rats. Life Sciences 310, pages 121090.
Crossref
Dorit Naot, Bregina Pool, Ashika Chhana, Ryan Gao, Jacob T. Munro, Jillian Cornish & Nicola Dalbeth. (2022) Factors secreted by monosodium urate crystal-stimulated macrophages promote a proinflammatory state in osteoblasts: a potential indirect mechanism of bone erosion in gout. Arthritis Research & Therapy 24:1.
Crossref
Tadaaki Matsuzaka, Aira Matsugaki & Takayoshi Nakano. (2021) Control of osteoblast arrangement by osteocyte mechanoresponse through prostaglandin E2 signaling under oscillatory fluid flow stimuli. Biomaterials 279, pages 121203.
Crossref
Yan‐Hui Li, Dong Zhu, Tianye Yang, Long Cheng, Jian Sun & Lei Tan. (2020) Crosstalk between the COX2‐PGE2‐EP4 signaling pathway and primary cilia in osteoblasts after mechanical stimulation. Journal of Cellular Physiology 236:6, pages 4764-4777.
Crossref
Yi-Jen Peng, Jeng-Wei Lu, Chian-Her Lee, Herng-Sheng Lee, You-Hsiang Chu, Yi-Jung Ho, Feng-Cheng Liu, Chun-Jung Huang, Chia-Chun Wu & Chih-Chien Wang. (2021) Cardamonin Attenuates Inflammation and Oxidative Stress in Interleukin-1β-Stimulated Osteoarthritis Chondrocyte through the Nrf2 Pathway. Antioxidants 10:6, pages 862.
Crossref
Tobias Russell, Charlie Bridgewood, Hannah Rowe, Ala Altaie, Elena Jones & Dennis McGonagle. (2021) Cytokine “fine tuning” of enthesis tissue homeostasis as a pointer to spondyloarthritis pathogenesis with a focus on relevant TNF and IL-17 targeted therapies. Seminars in Immunopathology 43:2, pages 193-206.
Crossref
Zeeshan Sheikh, Mohamed‐Nur Abdallah, Faik Al‐Jaf, Gang Chen, Nader Hamdan, Robert N. Young, Marc D. Grynpas & Michael Glogauer. (2020) Improved bone regeneration using bone anabolic drug conjugates (C3 and C6) with deproteinized bovine bone mineral as a carrier in rat mandibular defects. Journal of Periodontology 91:11, pages 1521-1531.
Crossref
Xavier Norel, Yukihiko Sugimoto, Gulsev Ozen, Heba Abdelazeem, Yasmine Amgoud, Amel Bouhadoun, Wesam Bassiouni, Marie Goepp, Salma Mani, Hasanga D. Manikpurage, Amira Senbel, Dan Longrois, Akos Heinemann, Chengcan Yao & Lucie H. Clapp. (2020) International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E 2 Receptors (EP1–4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions . Pharmacological Reviews 72:4, pages 910-968.
Crossref
Rebecca Rothe, Sabine Schulze, Christin Neuber, Sandra Hauser, Stefan Rammelt & Jens Pietzsch. (2020) Adjuvant drug-assisted bone healing: Part I – Modulation of inflammation. Clinical Hemorheology and Microcirculation 73:3, pages 381-408.
Crossref
Yong Xie, Meng Pan, Yanpan Gao, Licheng Zhang, Wei Ge & Peifu Tang. (2019) Dose-dependent roles of aspirin and other non-steroidal anti-inflammatory drugs in abnormal bone remodeling and skeletal regeneration. Cell & Bioscience 9:1.
Crossref
Anna Kats, Natalija Gerasimcik, Tuomas Näreoja, Jonas Nederberg, Simon Grenlöv, Ekaterina Lagnöhed, Suchita Desai, Göran Andersson & Tülay Yucel-Lindberg. (2019) Aminothiazoles inhibit osteoclastogenesis and PGE 2 production in LPS-stimulated co-cultures of periodontal ligament and RAW 264.7 cells, and RANKL-mediated osteoclastogenesis and bone resorption in PBMCs . Journal of Cellular and Molecular Medicine 23:2, pages 1152-1163.
Crossref
Takahiro Makino, Hiroyuki Tsukazaki, Yuichiro Ukon, Daisuke Tateiwa, Hideki Yoshikawa & Takashi Kaito. (2018) The Biological Enhancement of Spinal Fusion for Spinal Degenerative Disease. International Journal of Molecular Sciences 19:8, pages 2430.
Crossref
Jesse Li, Remi M. Ajiboye, Michael H. Orden, Akshay Sharma, Austin Drysch & Sina Pourtaheri. (2018) The Effect of Ketorolac on Thoracolumbar Posterolateral Fusion. Clinical Spine Surgery: A Spine Publication 31:2, pages 65-72.
Crossref
Jin-Woo Jeong, Hye Lee, Ki Lee, Ki Kim, Sung Kim, Su Hong, Gi-Young Kim, Cheol Park, Ho Kim, Young Choi & Yung Choi. (2015) Mori folium inhibits interleukin-1β-induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF-κB and p38�MAPK in SW1353 human chondrocytes. International Journal of Molecular Medicine.
Crossref
Alexandrine During, Guillaume Penel & Pierre Hardouin. (2015) Understanding the local actions of lipids in bone physiology. Progress in Lipid Research 59, pages 126-146.
Crossref
Carolin Noack, Ute Hempel, Carolin Preissler & Peter Dieter. (2015) Prostaglandin E2 impairs osteogenic and facilitates adipogenic differentiation of human bone marrow stromal cells. Prostaglandins, Leukotrienes and Essential Fatty Acids 94, pages 91-98.
Crossref
Hang-Korng Ea, Frédéric Lioté & Thomas Bardin. (2015) Complications rachidiennes de la spondyloarthrite ankylosante. Revue du Rhumatisme Monographies 82:1, pages 42-47.
Crossref
Laura Kyllönen, Matteo D’Este, Mauro Alini & David Eglin. (2015) Local drug delivery for enhancing fracture healing in osteoporotic bone. Acta Biomaterialia 11, pages 412-434.
Crossref
Stephanie G. Dakin, Jayesh Dudhia & Roger K.W. Smith. (2014) Resolving an inflammatory concept: The importance of inflammation and resolution in tendinopathy. Veterinary Immunology and Immunopathology 158:3-4, pages 121-127.
Crossref
Hulda S. Hreggvidsdottir, Troy Noordenbos & Dominique L. Baeten. (2014) Inflammatory pathways in spondyloarthritis. Molecular Immunology 57:1, pages 28-37.
Crossref
Utako Yokoyama, Kousaku Iwatsubo, Masanari Umemura, Takayuki Fujita & Yoshihiro Ishikawa. (2013) The Prostanoid EP4 Receptor and Its Signaling Pathway. Pharmacological Reviews 65:3, pages 1010-1052.
Crossref
Jean Pierre Salles, Sara Laurencin-Dalicieux, Fran?oise Conte-Auriol, Fabienne Briand-M?sange & Isabelle Gennero. (2013) Bone defects in LPA receptor genetically modified mice. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1831:1, pages 93-98.
Crossref
Stephanie Georgina Dakin, Jayesh Dudhia, Natalie Jayne Werling, Dirk Werling, Dilkush Robert Ephrem Abayasekara & Roger Kenneth Whealands Smith. (2012) Inflamm-Aging and Arachadonic Acid Metabolite Differences with Stage of Tendon Disease. PLoS ONE 7:11, pages e48978.
Crossref
Marcel HaversathIsabelle CatelasXinning LiTjark TassemeierMarcus Jäger. (2012) PGE 2 and BMP-2 in bone and cartilage metabolism: 2 intertwining pathways . Canadian Journal of Physiology and Pharmacology 90:11, pages 1434-1445.
Crossref
D. F. Woodward, R. L. Jones & S. Narumiya. (2011) International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of Prostanoid Receptors, Updating 15 Years of Progress. Pharmacological Reviews 63:3, pages 471-538.
Crossref
Toshiko Shibata-Nozaki, Hiroshi Ito, Hirofumi Mitomi, Jun Akaogi, Tatsuya Komagata, Toshiya Kanaji, Takayuki Maruyama, Toshihito Mori, So Nomoto, Shoichi Ozaki & Hidehiro Yamada. (2011) Endogenous prostaglandin E2 inhibits aberrant overgrowth of rheumatoid synovial tissue and the development of osteoclast activity through EP4 receptor. Arthritis & Rheumatism 63:9, pages 2595-2605.
Crossref
Antonio R. G. Susperregui, Cristina Gamell, Edgardo Rodríguez-Carballo, Maria José Ortuño, Ramon Bartrons, José Luis Rosa & Francesc Ventura. (2011) Noncanonical BMP Signaling Regulates Cyclooxygenase-2 Transcription. Molecular Endocrinology 25:6, pages 1006-1017.
Crossref
Kolja Gelse & Christian Beyer. (2011) The prostaglandin E 2 system: A toolbox for skeletal repair? . Arthritis & Rheumatism 63:4, pages 871-873.
Crossref
Jane B. Lian, Ellen M. Gravallese & Gary S. Stein. 2011. Osteoimmunology. Osteoimmunology 101 140 .
John G. Allen, Christopher Fotsch & Philip Babij. (2010) Emerging Targets in Osteoporosis Disease Modification. Journal of Medicinal Chemistry 53:11, pages 4332-4353.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.