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Expert Opinion on Investigational Drugs Volume 18, 2009 - Issue 6
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Key Paper Evaluation

Mepolizumab for difficult-to-control asthma with persistent sputum eosinophilia

Evaluation of: Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009;360:973-84Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009;360:985-93

Sabina A Antoniu University of Medicine and Pharmacy ‘Gr T Popa’, Pulmonary Disease University Hospital, Division of Pulmonary Disease, Iasi, Romania +40 232 239408; +40 232 217918; [email protected]
Pages 869-871 | Published online: 09 May 2009

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Patrick Mitchell & Richard Leigh. (2019) A drug safety review of treating eosinophilic asthma with monoclonal antibodies. Expert Opinion on Drug Safety 18:12, pages 1161-1170.
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Hyo-In Rhyou, Young-Hee Nam & Hae-Sim Park. (2023) Can we apply biomarkers in the management of non-steroidal anti-inflammatory drug exacerbated respiratory disease?. Exploration of Asthma & Allergy, pages 89-106.
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Willemijn E. de Rooij, Evan S. Dellon, Claire E. Parker, Brian G. Feagan, Vipul Jairath, Christopher Ma & Albert J. Bredenoord. (2019) Pharmacotherapies for the Treatment of Eosinophilic Esophagitis: State of the Art Review. Drugs 79:13, pages 1419-1434.
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J. Justin Mulvey, Cynthia Magro & Amy Chadburn. (2018) Resolution of a steroid-resistant, hypereosinophilic immune diathesis with mepolizumab and concomitant amelioration of a mixed thrombotic microangiopathy. Blood Cells, Molecules, and Diseases 69, pages 38-42.
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Steven W. Yancey, Hector G. Ortega, Oliver N. Keene, Bhabita Mayer, Necdet B. Gunsoy, Christopher E. Brightling, Eugene R. Bleecker, Pranabashis Haldar & Ian D. Pavord. (2017) Meta-analysis of asthma-related hospitalization in mepolizumab studies of severe eosinophilic asthma. Journal of Allergy and Clinical Immunology 139:4, pages 1167-1175.e2.
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Mia Cahill. (2016) Why, When, and How? Optimising the Management of Patients with Severe Eosinophilic Asthma. EMJ Respiratory, pages 51-59.
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Tabasum Mughal. (2015) Treating Inadequately Controlled Asthma: Exploring the Potential of Phenotype-Targeted Therapy. EMJ Respiratory, pages 42-48.
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Hui-ying Wang, Yu Dai, Jiao-li Wang, Xu-yan Yang & Xin-guo Jiang. (2015) Anti-CD69 monoclonal antibody treatment inhibits airway inflammation in a mouse model of asthma抗CD69 单克隆抗体对哮喘小鼠的气道炎症抑制作用研究. Journal of Zhejiang University-SCIENCE B 16:7, pages 622-631.
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Thiago Mamôru Sakae, Rosemeri Maurici, Daisson José Trevisol, Marcia Margaret Menezes Pizzichini & Emílio Pizzichini. (2014) Effects of prednisone on eosinophilic bronchitis in asthma: a systematic review and meta-analysis,. Jornal Brasileiro de Pneumologia 40:5, pages 552-563.
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C. M. H. H. T. Robroeks, D. van Vliet, Q. Jöbsis, R. Braekers, G. T. Rijkers, W. K. W. H. Wodzig, A. Bast, L. J. I. Zimmermann & E. Dompeling. (2012) Prediction of asthma exacerbations in children: results of a one‐year prospective study. Clinical & Experimental Allergy 42:5, pages 792-798.
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N. A. Molfino, D. Gossage, R. Kolbeck, J. M. Parker & G. P. Geba. (2011) Molecular and clinical rationale for therapeutic targeting of interleukin‐5 and its receptor. Clinical & Experimental Allergy 42:5, pages 712-737.
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Cara J. Bossley, Louise Fleming, Atul Gupta, Nicolas Regamey, Jennifer Frith, Timothy Oates, Lemonia Tsartsali, Clare M. Lloyd, Andrew Bush & Sejal Saglani. (2012) Pediatric severe asthma is characterized by eosinophilia and remodeling without TH2 cytokines. Journal of Allergy and Clinical Immunology 129:4, pages 974-982.e13.
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