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Drug Evaluation

Investigations on gossypol: past and present developments

Pages 1419-1434 | Published online: 28 Oct 2005

Keep up to date with the latest research on this topic with citation updates for this article.

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Doaa A. Ghareeb, Alshimaa Abd-Elgwad, Nihal El-Guindy, Galila Yacout & Hala H. Zaatout. (2021) Ulva lactuca methanolic extract improves oxidative stress-related male infertility induced in experimental animals. Archives of Physiology and Biochemistry 127:5, pages 397-405.
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Alessandra de Cássia Romero, Maria Antonia Calori-Domingues, Adibe Luiz Abdalla & Pedro Esteves Duarte Augusto. (2021) Evaluation of ozone technology as an alternative for degradation of free gossypol in cottonseed meal: a prospective study. Food Additives & Contaminants: Part A 38:4, pages 659-669.
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Chengyuan Qian, Mengxia Li, Jiangdong Sui, Tao Ren, Zheng Li, Liang Zhang, Liwei Zhou, Yi Cheng & Dong Wang. (2014) Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor. Drug Design, Development and Therapy 8, pages 485-496.
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Hoda Keshmiri-Neghab & Bahram Goliaei. (2014) Therapeutic potential of gossypol: An overview. Pharmaceutical Biology 52:1, pages 124-128.
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Selim Uzunoglu, Burcak Karaca, Harika Atmaca, Asli Kisim, Canfeza Sezgin, Bulent Karabulut & Ruchan Uslu. (2010) Comparison of XTT and Alamar blue assays in the assessment of the viability of various human cancer cell lines by AT-101 (−/− gossypol). Toxicology Mechanisms and Methods 20:8, pages 482-486.
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Martha Barba-Barajas, Georgina Hernández-Flores, José M. Lerma-Díaz, Pablo C. Ortiz-Lazareno, Jorge R. Domínguez-Rodríguez, Leticia Barba-Barajas, Ruth de Celis, Luis F. Jave-Suarez, Adriana C. Aguilar-Lemarroy, Mario G. Guevara-Barraza & Alejandro Bravo-Cuellar. (2009) Gossypol induced apoptosis of polymorphonuclear leukocytes and monocytes: Involvement of mitochondrial pathway and reactive oxygen species. Immunopharmacology and Immunotoxicology 31:2, pages 320-330.
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Zhenting Zhang, Danlu Yang, Ling Liu, Zhangbing Chang & Nan Peng. (2022) Effective gossypol removal from cottonseed meal through optimized solid-state fermentation by Bacillus coagulans. Microbial Cell Factories 21:1.
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Yaning Gao, Wanbo Tai, Xinyi Wang, Shibo Jiang, Asim K. Debnath, Lanying Du & Shizhong Chen. (2022) A gossypol derivative effectively protects against Zika and dengue virus infection without toxicity. BMC Biology 20:1.
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Miroslava Šudomová & Sherif T. S. Hassan. (2022) Gossypol from Gossypium spp. Inhibits Helicobacter pylori Clinical Strains and Urease Enzyme Activity: Bioactivity and Safety Assessments. Scientia Pharmaceutica 90:2, pages 29.
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Jian Zhang, Han Ran, Wei Xiong, Tianyi Yang, Yunjun Mei, Dongping He, Ye Liu, Qunpeng Cheng, Shenglan Li & Guangsen Song. (2019) Structures of Complexes of Gossypol with Ferrous Sulfate Based on High‐Performance Liquid Chromatography Separation, Spectroscopic Analysis, and PM3 calculations. ChemistrySelect 4:19, pages 5484-5488.
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Burcu Cakar, Ugur Muslu, Emir Bozkurt, Harika Atmaca, Burcak Karaca, Bulent Karabulut & Ruchan Uslu. (2018) Angiogenesis inhibition on glioblastoma multiforme cell lines (U-87 MG and T98G) by AT-101. Journal of Oncological Sciences 4:2, pages 65-69.
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