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Review

Targeting cannabinoid agonists for inflammatory and neuropathic pain

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Pages 951-965 | Published online: 26 Jun 2007

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Gabor Xantus, Laszlo Zavori, Candice Matheson, V. Anna Gyarmathy, Laszlo M Fazekas & Peter Kanizsai. (2021) Cannabidiol in low back pain: scientific rationale for clinical trials in low back pain. Expert Review of Clinical Pharmacology 14:6, pages 671-675.
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Praveen PN Rao & Tarek Mohamed. (2011) Current and emerging “at-site” pain medications: a review. Journal of Pain Research 4, pages 279-286.
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David R Janero & Alexandros Makriyannis. (2009) Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis. Expert Opinion on Emerging Drugs 14:1, pages 43-65.
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Wayne E Childers, Adam M Gilbert, Jeffrey D Kennedy & Garth T Whiteside. (2008) Advances in the development of novel analgesics. Expert Opinion on Therapeutic Patents 18:9, pages 1027-1067.
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William John Redmond, Philippe Goffaux, Stéphane Potvin & Serge Marchand. (2008) Analgesic and antihyperalgesic effects of nabilone on experimental heat pain. Current Medical Research and Opinion 24:4, pages 1017-1024.
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Fabian Docagne, Leyre Mestre, Frida Loría, Miriam Hernangómez, Fernando Correa & Carmen Guaza. (2008) Therapeutic potential of CB2 targeting in multiple sclerosis. Expert Opinion on Therapeutic Targets 12:2, pages 185-195.
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D. S. Reddy & V. M. Golub. (2016) The Pharmacological Basis of Cannabis Therapy for Epilepsy. Journal of Pharmacology and Experimental Therapeutics 357:1, pages 45-55.
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GomesWardmanStockton Jr.Devi. (2013) Neuropeptide Receptors. Colloquium Series on Neuropeptides 2:1, pages 1-167.
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Crossref
E. Ma Sánchez Robles, A. Bagües Arias & Ma I. Martín Fontelles. (2012) Cannabinoids and muscular pain. Effectiveness of the local administration in rat. European Journal of Pain 16:8, pages 1116-1127.
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Brady K. Atwood, Alex Straiker & Ken Mackie. (2012) CB2: Therapeutic target-in-waiting. Progress in Neuro-Psychopharmacology and Biological Psychiatry 38:1, pages 16-20.
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Crossref
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Crossref
Jose Cumella, Laura Hern?ndez-Folgado, Rocio Gir?n, Eva S?nchez, Paula Morales, Dow P. Hurst, Maria G?mez-Ca?as, Maria G?mez-Ruiz, Diana C. G. A. Pinto, Pilar Goya, Patricia H. Reggio, Mar?a Isabel Martin, Javier Fern?ndez-Ruiz, Artur M. S. Silva & Nadine Jagerovic. (2012) Chromenopyrazoles: Non-psychoactive and Selective CB 1 Cannabinoid Agonists with Peripheral Antinociceptive Properties . ChemMedChem 7:3, pages 452-463.
Crossref
Yun-Xing Cheng, Mehrnaz Pourashraf, Xuehong Luo, Sanjay Srivastava, Christopher Walpole, Dominic Salois, Stephane St-Onge, Kemal Payza, Etienne Lessard, Xiao Hong Yu & Mirosław J. Tomaszewski. (2012) γ-Carbolines: A novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration. Bioorganic & Medicinal Chemistry Letters 22:4, pages 1619-1624.
Crossref
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Crossref
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Crossref
Shu-Wei Yang, Jennifer Smotryski, Julius Matasi, Ginny Ho, Deen Tulshian, William J. Greenlee, Rossella Brusa, Massimiliano Beltramo & Kathleen Cox. (2011) Structure?activity relationships of 2,4-diphenyl-1H-imidazole analogs as CB2 receptor agonists for the treatment of chronic pain. Bioorganic & Medicinal Chemistry Letters 21:1, pages 182-185.
Crossref
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Crossref
Divyanshoo R. Kohli, Yunfang Li, Sergey G. KhasabovPankaj GuptaLois J. KehlMarna E. Ericson, Julia Nguyen, Vinita Gupta, Robert P. Hebbel, Donald A. SimoneKalpna Gupta. (2010) Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids. Blood 116:3, pages 456-465.
Crossref
V Curto-Reyes, S Llames, A Hidalgo, L Menéndez & A Baamonde. (2010) Spinal and peripheral analgesic effects of the CB 2 cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain . British Journal of Pharmacology 160:3, pages 561-573.
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L. Luongo, E. Palazzo, S. Tambaro, C. Giordano, L. Gatta, M.A. Scafuro, F.sca Rossi, P. Lazzari, L. Pani, V. de Novellis, M. Malcangio & S. Maione. (2010) 1-(2′,4′-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice. Neurobiology of Disease 37:1, pages 177-185.
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Crossref
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Arno Hazekamp, Justin T. Fischedick, Mónica Llano Díez, Andrea Lubbe & Renee L. Ruhaak. 2010. Comprehensive Natural Products II. Comprehensive Natural Products II 1033 1084 .
Robert J. Gleave, Paul J. Beswick, Andrew J. Brown, Gerard M.P. Giblin, Carl P. Haslam, David Livermore, Andrew Moses, Neville H. Nicholson, Lee W. Page, Brian Slingsby & Martin E. Swarbrick. (2009) 2-Amino-5-aryl-pyridines as selective CB2 agonists: Synthesis and investigation of structure–activity relationships. Bioorganic & Medicinal Chemistry Letters 19:23, pages 6578-6581.
Crossref
Anna Leichsenring, Michael Andriske, Ingo Bäcker, Christine C. Stichel & Hermann Lübbert. (2009) Analgesic and antiinflammatory effects of cannabinoid receptor agonists in a rat model of neuropathic pain. Naunyn-Schmiedeberg's Archives of Pharmacology 379:6, pages 627-636.
Crossref
Volker Neugebauer, Vasco Galhardo, Sabatino Maione & Sean C. Mackey. (2009) Forebrain pain mechanisms. Brain Research Reviews 60:1, pages 226-242.
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Ren?e Zindell, Doris Riether, Todd Bosanac, Angela Berry, Mark J. Gemkow, Andreas Ebneth, Sabine L?bbe, Ernest L. Raymond, Diane Thome, Daw-Tsun Shih & David Thomson. (2009) Morpholine containing CB2 selective agonists. Bioorganic & Medicinal Chemistry Letters 19:6, pages 1604-1609.
Crossref
Lumír Ondřej Hanuš. (2008) Pharmacological and therapeutic secrets of plant and brain (endo)cannabinoids. Medicinal Research Reviews 29:2, pages 213-271.
Crossref
S. McGaraughty, K.L. Chu, M.J. Dart, B.B. Yao & M.D. Meyer. (2009) A CB2 receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: Contributions of spinal and peripheral CB2 receptors. Neuroscience 158:4, pages 1652-1661.
Crossref
Debra Mcguinness, Asra Malikzay, Richard Visconti, Karen Lin, Marvin Bayne, Frederick Monsma & Charles A. Lunn. (2008) Characterizing Cannabinoid CB 2 Receptor Ligands Using DiscoveRx PathHunter™ β-Arrestin Assay . Journal of Biomolecular Screening 14:1, pages 49-58.
Crossref
John Malysz, Anthony V. Daza, Karen Kage, George K. Grayson, Betty B. Yao, Michael D. Meyer & Murali Gopalakrishnan. (2009) Characterization of human cannabinoid CB2 receptor coupled to chimeric G?qi5 and G?qo5 proteins. European Journal of Pharmacology 603:1-3, pages 12-21.
Crossref
Isaac E. Marx, Erin F. DiMauro, Alan Cheng, Renee Emkey, Stephen A. Hitchcock, Liyue Huang, Ming Y. Huang, Jason Human, Josie H. Lee, Xingwen Li, Matthew W. Martin, Ryan D. White, Robert T. FremeauJr.Jr. & Vinod F. Patel. (2009) Discovery of ?-amidosulfones as potent and selective agonists of CB2: Synthesis, SAR, and pharmacokinetic properties. Bioorganic & Medicinal Chemistry Letters 19:1, pages 31-35.
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Christian SinningBernhard WatzerOvidiu CosteRolf M. NüsingIngo OttAlessia LigrestiVincenzo Di MarzoPeter Imming. (2008) New Analgesics Synthetically Derived from the Paracetamol Metabolite N -(4-Hydroxyphenyl)-(5 Z ,8 Z ,11 Z ,14 Z )-icosatetra-5,8,11,14-enamide . Journal of Medicinal Chemistry 51:24, pages 7800-7805.
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Andrea S. HeimannIvone GomesCamila S. DaleRosana L. PaganoAchla GuptaLaura L. de SouzaAugusto D. LuchessiLeandro M. Castro, Renata GiorgiVanessa Rioli, Emer S. Ferro & Lakshmi A. Devi. (2007) Hemopressin is an inverse agonist of CB 1 cannabinoid receptors . Proceedings of the National Academy of Sciences 104:51, pages 20588-20593.
Crossref
Paul Cavuoto, Andrew J. McAinch, George Hatzinikolas, Alena Janovsk?Philip Game & Gary A. Wittert. (2007) The expression of receptors for endocannabinoids in human and rodent skeletal muscle. Biochemical and Biophysical Research Communications 364:1, pages 105-110.
Crossref
A J Brown. (2007) Novel cannabinoid receptors. British Journal of Pharmacology 152:5, pages 567-575.
Crossref

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