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The clinical development of histone deacetylase inhibitors as targeted anticancer drugs

Pages 1049-1066 | Published online: 05 Aug 2010

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Wenqi Wang, Daoquan Fang, Hao Zhang, Jiao Xue, Drugyel Wangchuk, Jimei Du & Lei Jiang. (2020) Sodium Butyrate Selectively Kills Cancer Cells and Inhibits Migration in Colorectal Cancer by Targeting Thioredoxin-1. OncoTargets and Therapy 13, pages 4691-4704.
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Bolun Wang, Hui Lyu, Shanshan Pei, Deye Song, Jiangdong Ni & Bolin Liu. (2018) Cladribine in combination with entinostat synergistically elicits anti-proliferative/anti-survival effects on multiple myeloma cells. Cell Cycle 17:8, pages 985-996.
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Susmitha Apuri & Lubomir Sokol. (2016) An overview of investigational Histone deacetylase inhibitors (HDACis) for the treatment of non-Hodgkin’s lymphoma. Expert Opinion on Investigational Drugs 25:6, pages 687-696.
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Wenxiu Qi, Wenbo Zhang, Holly Edwards, Roland Chu, Gerard J Madlambayan, Jeffrey W Taub, Zhihong Wang, Yue Wang, Chunhuai Li, Hai Lin & Yubin Ge. (2015) Synergistic anti-leukemic interactions between panobinostat and MK-1775 in acute myeloid leukemia ex vivo. Cancer Biology & Therapy 16:12, pages 1784-1793.
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Jenny Y Y Ooi, Natasha K Tuano, Haloom Rafehi, Xiao-Ming Gao, Mark Ziemann, Xiao-Jun Du & Assam El-Osta. (2015) HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes . Epigenetics 10:5, pages 418-430.
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Ahmed Sawas & Owen A O’Connor. (2015) Belinostat for the treatment of T-cell lymphoma. Expert Opinion on Orphan Drugs 3:2, pages 219-227.
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Andrey Poleshko, Andrew V Kossenkov, Natalia Shalginskikh, Anna Pecherskaya, Anna Pecherskaya, Margret B Einarson, Margret B Einarson, Anna Marie Skalka, Anna Marie Skalka, Richard A Katz & Richard A Katz. (2014) Human factors and pathways essential for mediating epigenetic gene silencing. Epigenetics 9:9, pages 1280-1289.
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Ramón Cacabelos & Clara Torrellas. (2014) Epigenetic drug discovery for Alzheimer’s disease. Expert Opinion on Drug Discovery 9:9, pages 1059-1086.
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Gopalan Balasubramanian, Narasimhan Kilambi, Suresh Rathinasamy, Praveen Rajendran, Shridhar Narayanan & Sridharan Rajagopal. (2014) Quinolone-based HDAC inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 29:4, pages 555-562.
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Sergio Valente & Antonello Mai. (2014) Small-molecule inhibitors of histone deacetylase for the treatment of cancer and non-cancer diseases: a patent review (2011 – 2013). Expert Opinion on Therapeutic Patents 24:4, pages 401-415.
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MarianaS. Gerova & OgnyanI. Petrov. (2014) A Convenient Synthesis of the New Histone Deacetylase Inhibitor Scriptaid. Organic Preparations and Procedures International 46:1, pages 76-79.
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Katherine Ververis, Alison Hiong, Tom C Karagiannis & Paul V Licciardi. (2013) Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents. Biologics: Targets and Therapy 7, pages 47-60.
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Syed F Zafar, Ganji Purnachandra Nagaraju & Bassel El-Rayes. (2012) Developing histone deacetylase inhibitors in the therapeutic armamentarium of pancreatic adenocarcinoma. Expert Opinion on Therapeutic Targets 16:7, pages 707-718.
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Wajana L. Labisso, Matthias Wirth, Natasa Stojanovic, Roland H. Stauber, Angelika Schnieke, Roland M. Schmid, Oliver H. Krämer, Dieter Saur & Günter Schneider. (2012) MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors. Cell Cycle 11:8, pages 1593-1602.
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Simon G. Royce & Tom C. Karagiannis. (2012) Histone Deacetylases and Their Role in Asthma. Journal of Asthma 49:2, pages 121-128.
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Edwin F. de Zoeten, Liqing Wang, Kyle Butler, Ulf H. Beier, Tatiana Akimova, Hong Sai, James E. Bradner, Ralph Mazitschek, Alan P. Kozikowski, Patrick Matthias & Wayne W. Hancock. (2011) Histone Deacetylase 6 and Heat Shock Protein 90 Control the Functions of Foxp3+ T-Regulatory Cells. Molecular and Cellular Biology 31:10, pages 2066-2078.
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