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Drug Evaluations

Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia

, MD PhD &
Pages 701-712 | Published online: 22 Mar 2011

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Kholoud I. Eissa, Mona M. Kamel, Lamia W. Mohamed & Asmaa E. Kassab. (2022) Development of new Alzheimer's disease drug candidates using donepezil as a key model. Archiv der Pharmazie 356:1.
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Mirim Jin & Miwon Son. (2018) DA-9701 (Motilitone): A Multi-Targeting Botanical Drug for the Treatment of Functional Dyspepsia. International Journal of Molecular Sciences 19:12, pages 4035.
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Shravan Kumar Porika, Krishna Chaitanya Veligandla, Shashi Kanth Muni, Shivani Acharya, Suyog C. Mehta & Akhilesh D. Sharma. (2018) Real-World, Non-Interventional, Observational Study to Evaluate Effectiveness and Tolerability of Acotiamide Hydrochloride Hydrate in Treatment of Functional Dyspepsia. Advances in Therapy 35:11, pages 1884-1893.
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Qi Li, Siyu He, Yao Chen, Feng Feng, Wei Qu & Haopeng Sun. (2018) Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease. European Journal of Medicinal Chemistry 158, pages 463-477.
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J. Tack, J. Pokrotnieks, G. Urbonas, C. Banciu, V. Yakusevich, I. Bunganic, H. Törnblom, Y. Kleban, P. Eavis, M. Tsuchikawa & T. Miyagawa. (2018) Long-term safety and efficacy of acotiamide in functional dyspepsia (postprandial distress syndrome)-results from the European phase 3 open-label safety trial. Neurogastroenterology & Motility 30:6, pages e13284.
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S. Naganuma, T. Shiina, S. Yasuda, Y. Suzuki & Y. Shimizu. (2018) Histamine-enhanced contractile responses of gastric smooth muscle via interstitial cells of Cajal in the Syrian hamster. Neurogastroenterology & Motility 30:4, pages e13255.
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Hiroshi Yamawaki, Seiji Futagami, Mako Wakabayashi, Noriko Sakasegawa, Shuhei Agawa, Kazutoshi Higuchi, Yasuhiro Kodaka & Katsuhiko Iwakiri. (2017) Management of functional dyspepsia: state of the art and emerging therapies. Therapeutic Advances in Chronic Disease 9:1, pages 23-32.
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Masayuki Uchida, Orie Kobayashi & Chizuru Saito. (2017) Correlation Between Gastric Emptying and Gastric Adaptive Relaxation Influenced by Amino Acids. Journal of Neurogastroenterology and Motility 23:3, pages 400-408.
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Kumiko Nakamura, Toshihiko Tomita, Tadayuki Oshima, Haruki Asano, Takahisa Yamasaki, Takuya Okugawa, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Yoshio Ohda, Hirokazu Fukui, Fukushima Kazuhito, Shozo Hirota, Jiro Watari & Hiroto Miwa. (2016) A double-blind placebo controlled study of acotiamide hydrochloride for efficacy on gastrointestinal motility of patients with functional dyspepsia. Journal of Gastroenterology 52:5, pages 602-610.
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Shintaro Hoshino, Nana Takenouchi, Yuriko Hanada, Mariko Umezawa, Hirohito Sano, Noriyuki Kawami, Yoshimasa Hoshikawa, Tetsuro Kawagoe, Tsutomu Nomura, Yoshio Hoshihara & Katsuhiko Iwakiri. (2016) Effects of acotiamide on esophageal motility in healthy subjects: a randomized, double-blind, placebo-controlled crossover study. Esophagus 14:2, pages 146-152.
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Feng-Yun Wang, Linda L.D. Zhong, Nan Kang, Liang Dai, Lin Lv, Li-Qun Bian, Ting Chen, Bei-Hua Zhang, Zhao-Xiang Bian, Xiao-Ge Wang, En-Lin Zhu & Xu-Dong Tang. (2016) Chinese herbal formula for postprandial distress syndrome: Study protocol of a double-blinded, randomized, placebo-controlled trial. European Journal of Integrative Medicine 8:5, pages 688-694.
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Jing Li, Rui Huang, Zhi Wang, Haijun Qu, Meijuan Sun & Zhenhuan Zhao. (2016) Development and Validation of a Sensitive and Specific LC?MS-MS Method for the Determination of Acotiamide in Rat Plasma. Journal of Chromatographic Science 54:6, pages 1004-1009.
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