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The impact of multi-targeted cyclin-dependent kinase inhibition in breast cancer cells: clinical implications

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Pages 1611-1628 | Published online: 21 Oct 2011

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Neelima Vidula & Hope S. Rugo. (2018) Emerging data on improving response to hormone therapy: the role of novel targeted agents. Expert Review of Anticancer Therapy 18:1, pages 3-18.
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Carmen Di Giovanni, Ettore Novellino, Adriana Chilin, Antonio Lavecchia & Giovanni Marzaro. (2016) Investigational drugs targeting cyclin-dependent kinases for the treatment of cancer: an update on recent findings (2013-2016). Expert Opinion on Investigational Drugs 25:10, pages 1215-1230.
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Abanoub S. Sedeky, Islam A. Khalil, Amr Hefnawy & Ibrahim M. El-Sherbiny. (2018) Development of core-shell nanocarrier system for augmenting piperine cytotoxic activity against human brain cancer cell line. European Journal of Pharmaceutical Sciences 118, pages 103-112.
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Pascale Hazel, Sebastian H. B. Kroll, Alexander Bondke, Marion Barbazanges, Hetal Patel, Matthew J. Fuchter, R Charles Coombes, Simak Ali, Anthony G. M. Barrett & Paul S. Freemont. (2017) Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. ChemMedChem 12:5, pages 372-380.
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Yuan Zhao, Meng-lei Huan, Miao Liu, Ying Cheng, Yang Sun, Han Cui, Dao-zhou Liu, Qi-bing Mei & Si-yuan Zhou. (2016) Doxorubicin and resveratrol co-delivery nanoparticle to overcome doxorubicin resistance. Scientific Reports 6:1.
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Helen Sadik, Preethi Korangath, Nguyen K. Nguyen, Balazs Gyorffy, Rakesh Kumar, Mohammad Hedayati, Wei Wen Teo, Sunju Park, Hardik Panday, Teresa Gonzalez Munoz, Otilia Menyhart, Nilay Shah, Raj K. Pandita, Jenny C. Chang, Theodore DeWeese, Howard Y. Chang, Tej K. Pandita & Saraswati Sukumar. (2016) HOXC10 Expression Supports the Development of Chemotherapy Resistance by Fine Tuning DNA Repair in Breast Cancer Cells. Cancer Research 76:15, pages 4443-4456.
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Neelima Vidula & Hope S. Rugo. (2016) Cyclin-Dependent Kinase 4/6 Inhibitors for the Treatment of Breast Cancer: A Review of Preclinical and Clinical Data. Clinical Breast Cancer 16:1, pages 8-17.
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Józefa Węsierska-Gądek & Matthias Mauritz. (2016) Why (multi)targeting of cyclin-dependent kinases is a promising therapeutic option for hormone-positive breast cancer and beyond. Future Medicinal Chemistry 8:1, pages 55-72.
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Jeffrey S. Ross, Sunil Badve, Kai Wang, Christine E. Sheehan, Ann B. Boguniewicz, Geoff A. Otto, Roman Yelensky, Doron Lipson, Siraj Ali, Deborah Morosini, Juliann Chliemlecki, Julia A. Elvin, Vincent A. Miller & Philip J. Stephens. (2015) Genomic Profiling of Advanced-Stage, Metaplastic Breast Carcinoma by Next-Generation Sequencing Reveals Frequent, Targetable Genomic Abnormalities and Potential New Treatment Options. Archives of Pathology & Laboratory Medicine 139:5, pages 642-649.
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C Delehouzé, K Godl, N Loaëc, C Bruyère, N Desban, N Oumata, H Galons, T I Roumeliotis, E G Giannopoulou, J Grenet, D Twitchell, J Lahti, N Mouchet, M-D Galibert, S D Garbis & L Meijer. (2013) CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells. Oncogene 33:50, pages 5675-5687.
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Andrea Y. Angstadt, Venugopal Thayanithy, Subbaya Subramanian, Jaime F. Modiano & Matthew Breen. (2012) A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations. Cancer Genetics 205:11, pages 572-587.
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Jason M. Held, David J. Britton, Gary K. Scott, Elbert L. Lee, Birgit Schilling, Michael A. Baldwin, Bradford W. Gibson & Christopher C. Benz. (2012) Ligand Binding Promotes CDK-Dependent Phosphorylation of ER-Alpha on Hinge Serine 294 but Inhibits Ligand-Independent Phosphorylation of Serine 305. Molecular Cancer Research 10:8, pages 1120-1132.
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C. Elizabeth Caldon, C. Marcelo Sergio, Jian Kang, Anita Muthukaruppan, Marijke N. Boersma, Andrew Stone, Jane Barraclough, Christine S. Lee, Michael A. Black, Lance D. Miller, Julia M. Gee, Rob I. Nicholson, Robert L. Sutherland, Cristin G. Print & Elizabeth A. Musgrove. (2012) Cyclin E2 Overexpression Is Associated with Endocrine Resistance but not Insensitivity to CDK2 Inhibition in Human Breast Cancer Cells. Molecular Cancer Therapeutics 11:7, pages 1488-1499.
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Józefa Węsierska-GądekMatthias P Kramer. (2012) The impact of CDK inhibition in human malignancies associated with pronounced defects in apoptosis: advantages of multi-targeting small molecules. Future Medicinal Chemistry 4:4, pages 395-424.
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