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Drug Evaluations

Dolutegravir for the treatment of HIV

, MD & , MD
Pages 523-530 | Published online: 02 Mar 2012

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Karina Kapusta, Natalia Sizochenko, Micah L. Anderson, Wojciech Kolodziejczyk, Eugene O. Voronkov, Julia Saloni, Jerzy Leszczynski & Glake A. Hill. (2021) N-arylnaphthylamines as inhibitors of human immunodeficiency virus integrase - lens epithelium-derived growth factor interactions: theoretical studies. Journal of Biomolecular Structure and Dynamics 39:3, pages 867-880.
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Lidija Kovač & Zdenko Časar. (2020) A literature review of the patent application publications on cabotegravir – an HIV integrase strand transfer inhibitor. Expert Opinion on Therapeutic Patents 30:3, pages 195-208.
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Xiqiang Cheng, Ping Gao, Lin Sun, Ye Tian, Peng Zhan & Xinyong Liu. (2017) Identification of spirocyclic or phosphate substituted quinolizine derivatives as novel HIV-1 integrase inhibitors: a patent evaluation of WO2016094197A1, WO2016094198A1 and WO2016154527A1. Expert Opinion on Therapeutic Patents 27:11, pages 1277-1286.
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Thibault Mesplède, Peter K. Quashie, Veronica Zanichelli & Mark A. Wainberg. (2014) Integrase strand transfer inhibitors in the management of HIV-positive individuals. Annals of Medicine 46:3, pages 123-129.
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Alessandra Fantauzzi, Ombretta Turriziani & Ivano Mezzaroma. (2013) Potential benefit of dolutegravir once daily: efficacy and safety. HIV/AIDS - Research and Palliative Care 5, pages 29-40.
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Rik Schrijvers & Zeger Debyser. (2012) Combinational therapies for HIV: a focus on EVG/COBI/FTC/TDF. Expert Opinion on Pharmacotherapy 13:13, pages 1969-1983.
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Shijie Wang, Xiuqing Song, Runzhi Sun, Hong Yan & Yeming Wang. (2023) Insight for the photochemical reaction of 4-aryl-4H-pyran: Experimental and theoretical studies. Tetrahedron 131, pages 133212.
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Anil Kumar KotaMukthinuthalapati Mathrusri Annapurna. (2022) A new Stability-indicating UHPLC for the simultaneous determination of a combination of Anti-viral drugs: Dolutegravir sodium, Lamivudine and Tenofovir disoproxil fumarate. Research Journal of Pharmacy and Technology, pages 3823-3830.
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Subhra Mandal, Shawnalyn W. Sunagawa, Pavan Kumar Prathipati, Michael Belshan, Annemarie Shibata & Christopher J. Destache. (2022) Targeted Immuno-Antiretroviral to Promote Dual Protection against HIV: A Proof-of-Concept Study. Nanomaterials 12:11, pages 1942.
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Yared Belete Belay, Eskinder Eshetu Ali, Karen Y. Chung, Gebremedhin Beedemariam Gebretekle & Beate Sander. (2021) Cost-Utility Analysis of Dolutegravir- Versus Efavirenz-Based Regimens as a First-Line Treatment in Adult HIV/AIDS Patients in Ethiopia. PharmacoEconomics - Open 5:4, pages 655-664.
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Nikunj S. PatelMr.Mr., Priyanka A. ShahDr.Dr., Rohit J. GajeraMr.Mr. & Hitesh D. PatelDr.Dr.. (2021) DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF RELATED SUBSTANCES PRESENT IN THE PHARMACEUTICAL DOSAGE FORM OF EMTRICITABINE, TENOFOVIR ALAFENAMIDE AND DOLUTEGRAVIR. Towards Excellence, pages 627-644.
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Nikunj S. PatelMr.Mr., Priyanka A. ShahDr.Dr., Rohit J. GajeraMr.Mr. & Hitesh D. PatelDr.Dr.. (2021) STABILITY INDICATING HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF EMTRICITABINE, DOLUTEGRAVIR AND TENOFOVIR ALAFENAMIDE IN THEIR COMBINED PHARMACEUTICAL DOSAGE FORM. Towards Excellence, pages 548-567.
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Zaikuan J. YuEric P. MosherNamandjé N. Bumpus. (2021) Pharmacogenomics of Antiretroviral Drug Metabolism and Transport. Annual Review of Pharmacology and Toxicology 61:1, pages 565-585.
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Tamyres dos Santos Vieira, Isabela dos Santos Vieira, Matheus Bresser, Letícia Coutinho Lopes Moura & Marcos de Assis Moura. (2019) O papel do dolutegravir na terapia antiretroviral. HU Revista 44:3, pages 379-385.
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Kaitlin Anstett, Bluma Brenner, Thibault Mesplède & Mark A. Wainberg. (2017) HIV-1 Resistance to Dolutegravir Is Affected by Cellular Histone Acetyltransferase Activity. Journal of Virology 91:21.
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Jose Ángel Fernández-Caballero, Natalia Chueca, Marta Álvarez, María Dolores Mérida, Josefa López, José Antonio Sánchez, David Vinuesa, María Ángeles Martínez, José Hernández & Federico García. (2016) Usefulness of Integrase resistance testing in proviral HIV-1 DNA in patients with Raltegravir prior failure. BMC Infectious Diseases 16:1.
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Jeffrey T. Kuethe, Guy R. Humphrey, Michel Journet, Zhihui Peng & Karla G. Childers. (2016) Asymmetric Synthesis of a Potent HIV-1 Integrase Inhibitor. The Journal of Organic Chemistry 81:21, pages 10256-10265.
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Guan-Nan Liu, Rong-Hua Luo, Yu Zhou, Xing-Jie Zhang, Jian Li, Liu-Meng Yang, Yong-Tang Zheng & Hong Liu. (2016) Synthesis and Anti-HIV-1 Activity Evaluation for Novel 3a,6a-Dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives. Molecules 21:9, pages 1198.
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Nagasarapu Mallikarjuna Rao & Dannana Gowri Sankar. (2015) Development and validation of stability-indicating HPLC method for simeltaneous determination of Lamivudine, Tenofovir, and Dolutegravir in bulk and their tablet dosage form. Future Journal of Pharmaceutical Sciences 1:2, pages 73-77.
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Kaitlin Anstett, Robert Fusco, Vincent Cutillas, Thibault Mesplède & Mark A. Wainberg. (2015) Dolutegravir-Selected HIV-1 Containing the N155H and R263K Resistance Substitutions Does Not Acquire Additional Compensatory Mutations under Drug Pressure That Lead to Higher-Level Resistance and Increased Replicative Capacity. Journal of Virology 89:20, pages 10482-10488.
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Pradipbhai D. Kalariya, Prinesh N. Patel, R. Srinivas & M. V. N. Kumar Talluri. (2015) Quality by design based development of a selective stability-indicating UPLC method of dolutegravir and characterization of its degradation products by UPLC-QTOF-MS/MS. New Journal of Chemistry 39:8, pages 6303-6314.
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Melissa Wares, Thibault Mesplède, Peter K Quashie, Nathan Osman, Yingshan Han & Mark A Wainberg. (2014) The M50I polymorphic substitution in association with the R263K mutation in HIV-1 subtype B integrase increases drug resistance but does not restore viral replicative fitness. Retrovirology 11:1.
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