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Expert Opinion on Investigational Drugs Volume 21, 2012 - Issue 6
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Original Research

Long-term survival of high-risk melanoma patients immunized with a Hyper-IL-6-modified allogeneic whole-cell vaccine after complete resection

Andrzej MackiewiczUniversity of Medical Sciences in Poznan, Chair of Medical Biotechnology, Poznan, Poland; [email protected];Greater Poland Cancer Centre, Department of Cancer Diagnostics and Immunology, Poznan, Poland;BioContract Sp z.o.o., Poznan, Poland
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Jacek MackiewiczGreater Poland Cancer Centre, Department of Cancer Diagnostics and Immunology, Poznan, Poland
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Piotr J. WysockiUniversity of Medical Sciences in Poznan, Chair of Medical Biotechnology, Poznan, Poland; [email protected]
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Maciej WiznerowiczUniversity of Medical Sciences in Poznan, Chair of Medical Biotechnology, Poznan, Poland; [email protected];Greater Poland Cancer Center, Department of Chemotherapy, Poznan, Poland
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Malgorzata KapcinskaUniversity of Medical Sciences in Poznan, Chair of Medical Biotechnology, Poznan, Poland; [email protected];Greater Poland Cancer Centre, Department of Cancer Diagnostics and Immunology, Poznan, Poland
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Maria LaciakUniversity of Medical Sciences in Poznan, Chair of Medical Biotechnology, Poznan, Poland; [email protected];BioContract Sp z.o.o., Poznan, Poland
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Stefan Rose-JohnUniversity of Medical Sciences in Poznan, Chair of Medical Biotechnology, Poznan, Poland; [email protected];BioContract Sp z.o.o., Poznan, Poland
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Dariusz IzyckiChristian-Albrechts-Universität zu Kiel, Kiel, Germany, Biochemisches Institut, Olshausenstrasse 40, Kiel, 24098, Germany
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Tomasz BurzykowskiUniversity of Medical Sciences in Poznan, Chair of Medical Biotechnology, Poznan, Poland; [email protected]
&
Aldona Karczewska-DzionkHasselt University, Interuniversity Institute for Biostatistics and statistical Bioinformatics, Diepenbeek, Belgium
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Pages 773-783 | Published online: 11 May 2012

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Patrycja Czerwinska, Marcin Rucinski, Nikola Wlodarczyk, Anna Jaworska, Iga Grzadzielewska, Katarzyna Gryska, Lukasz Galus, Jacek Mackiewicz & Andrzej Mackiewicz. (2020) Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6. OncoImmunology 9:1.
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Eliza Kwiatkowska-Borowczyk, Patrycja Czerwińska, Jacek Mackiewicz, Katarzyna Gryska, Urszula Kazimierczak, Katarzyna Tomela, Anna Przybyła, Anna Karolina Kozłowska, Łukasz Galus, Łukasz Kwinta, Ewelina Dondajewska, Agnieszka Gąbka-Buszek, Monika Żakowska & Andrzej Mackiewicz. (2018) Whole cell melanoma vaccine genetically modified to stem cells like phenotype generates specific immune responses to ALDH1A1 and long-term survival in advanced melanoma patients. OncoImmunology 7:11.
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Malgorzata Mackiewicz-Wysocka, Jakub Zolnierek & Piotr J Wysocki. (2013) New therapeutic options in systemic treatment of advanced cutaneous melanoma. Expert Opinion on Investigational Drugs 22:2, pages 181-190.
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Articles from other publishers (15)

Mariusz Kaczmarek, Justyna Poznańska, Filip Fechner, Natasza Michalska, Sara Paszkowska, Adrianna Napierała & Andrzej Mackiewicz. (2023) Cancer Vaccine Therapeutics: Limitations and Effectiveness—A Literature Review. Cells 12:17, pages 2159.
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Charles L. Wiseman, Alexander Kharazi, Vivekananda G. Sunkari, Jacqueline L. Galeas, Vito Dozio, Hind Hashwah, Eva Macúchová, William V. Williams & Markus D. Lacher. (2023) Regression of Breast Cancer Metastases Following Treatment with Irradiated SV-BR-1-GM, a GM-CSF Overexpressing Breast Cancer Cell Line: Intellectual Property and Immune Markers of Response. Recent Patents on Anti-Cancer Drug Discovery 18:2, pages 224-240.
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Anna Przybyla, Alexander A. Lehmann, Ting Zhang, Jacek Mackiewicz, Łukasz Galus, Greg A. Kirchenbaum, Andrzej Mackiewicz & Paul V. Lehmann. (2021) Functional T Cell Reactivity to Melanocyte Antigens Is Lost during the Progression of Malignant Melanoma, but Is Restored by Immunization. Cancers 13:2, pages 223.
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Halina Was, Tomasz Cichon, Ryszard Smolarczyk, Bozena Lackowska, Agnieszka Mazur-Bialy, Magdalena Mazur, Agata Szade, Pawel Dominik, Milena Mazan, Jerzy Kotlinowski, Anna Zebzda, Anna Kusienicka, Claudine Kieda, Jozef Dulak & Alicja Jozkowicz. (2020) Effect of Heme Oxygenase-1 on Melanoma Development in Mice—Role of Tumor-Infiltrating Immune Cells. Antioxidants 9:12, pages 1223.
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Agnieszka Gąbka-Buszek, Eliza Kwiatkowska-Borowczyk, Jakub Jankowski, Anna Karolina Kozłowska & Andrzej Mackiewicz. (2020) Novel Genetic Melanoma Vaccines Based on Induced Pluripotent Stem Cells or Melanosphere-Derived Stem-Like Cells Display High Efficacy in a murine Tumor Rejection Model. Vaccines 8:2, pages 147.
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Izabela Łasińska, Tomasz Kolenda, Anna Teresiak, Katarzyna M. Lamperska, Łukasz Galus & Jacek Mackiewicz. (2019) Immunotherapy in Patients with Recurrent and Metastatic Squamous Cell Carcinoma of the Head and Neck. Anti-Cancer Agents in Medicinal Chemistry 19:3, pages 290-303.
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Alessandra Tuccitto, Chiara Castelli, Malcolm Ronald Alison & Michela Perego. 2019. Cancer Stem Cell Resistance to Targeted Therapy. Cancer Stem Cell Resistance to Targeted Therapy 115 135 .
Jacek Mackiewicz, Tomasz Burzykowski, Dariusz Iżycki & Andrzej Mackiewicz. (2018) Re-induction using whole cell melanoma vaccine genetically modified to melanoma stem cells-like beyond recurrence extends long term survival of high risk resected patients - updated results. Journal for ImmunoTherapy of Cancer 6:1.
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Alessandra Tuccitto, Marcella Tazzari, Valeria Beretta, Francesca Rini, Claudia Miranda, Angela Greco, Mario Santinami, Roberto Patuzzo, Barbara Vergani, Antonello Villa, Giacomo Manenti, Loredana Cleris, Daniele Giardiello, Malcolm Alison, Licia Rivoltini, Chiara Castelli & Michela Perego. (2016) Immunomodulatory Factors Control the Fate of Melanoma Tumor Initiating Cells. Stem Cells 34:10, pages 2449-2460.
Crossref
Julia M. Greene, Erika J. Schneble, Doreen O. Jackson, Diane F. Hale, Timothy J. Vreeland, Madeline Flores, Jonathan Martin, Garth S. Herbert, Mark O. Hardin, Xianzhong Yu, Thomas E. Wagner & George E. Peoples. (2016) A phase I/IIa clinical trial in stage IV melanoma of an autologous tumor–dendritic cell fusion (dendritoma) vaccine with low dose interleukin-2. Cancer Immunology, Immunotherapy 65:4, pages 383-392.
Crossref
M-C Chang, Y-L Chen, Y-C Chiang, T-C Chen, Y-C Tang, C-A Chen, W-Z Sun & W-F Cheng. (2015) Mesothelin-specific cell-based vaccine generates antigen-specific immunity and potent antitumor effects by combining with IL-12 immunomodulator. Gene Therapy 23:1, pages 38-49.
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Jacek Mackiewicz, Aldona Karczewska-Dzionk, Maria Laciak, Malgorzata Kapcinska, Maciej Wiznerowicz, Tomasz Burzykowski, Monika Zakowska, Stefan Rose-John & Andrzej Mackiewicz. (2015) Whole Cell Therapeutic Vaccine Modified With Hyper-IL6 for Combinational Treatment of Nonresected Advanced Melanoma. Medicine 94:21, pages e853.
Crossref
Miles C Andrews, Katherine Woods, Jonathan Cebon & Andreas Behren. (2014) Evolving role of tumor antigens for future melanoma therapies. Future Oncology 10:8, pages 1457-1468.
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Sarah A. Weiss, Sunandana Chandra & Anna C. Pavlick. (2014) Update on Vaccines for High-Risk Melanoma. Current Treatment Options in Oncology 15:2, pages 269-280.
Crossref
Anna Kozłowska, Jacek Mackiewicz & Andrzej Mackiewicz. (2013) Therapeutic gene modified cell based cancer vaccines. Gene 525:2, pages 200-207.
Crossref

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